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  1. Article: Cysestermerol A, a rare stilbene sestermer with significant hypoglycemic activities from Cynodon dactylon

    Wang, Feng / Zhang, Li / Li, Bi-Jun / Liang, Qiu-Ming / Chen, A-Li / Fang, Zhen-Feng / Wang, Shu-Mei

    Natural product research. 2021 Sept. 17, v. 35, no. 18

    2021  

    Abstract: Cysestermerol A (1), a rare and new stilbene sestermer, was isolated from the whole herb of Cynodon dactylon. The planar and relative structures of 1 were elucidated based on HRESIMS, one- and two-dimensional NMR analyses, and its absolute configuration ... ...

    Abstract Cysestermerol A (1), a rare and new stilbene sestermer, was isolated from the whole herb of Cynodon dactylon. The planar and relative structures of 1 were elucidated based on HRESIMS, one- and two-dimensional NMR analyses, and its absolute configuration was further established by electronic circular dichroism calculations. Compound 1 obviously increased the glucose consumption in HepG2 cells equivalent to the positive control rosiglitazone and markedly inhibited the activity of α-glucosidase in vitro.
    Keywords Cynodon dactylon ; circular dichroism spectroscopy ; glucose ; research ; stilbenes
    Language English
    Dates of publication 2021-0917
    Size p. 3056-3062.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2019.1689501
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Analysis on oral medication rules of traditional Chinese medicine prescriptions for prevention of COVID-19.

    Wu, Dong-Yang / Hou, Xiao-Tao / Xia, Zhong-Shang / Hao, Er-Wei / Xie, Jin-Ling / Liang, Jing-Yan / Liang, Qiu-Ming / Du, Zheng-Cai / Deng, Jia-Gang

    Chinese herbal medicines

    2021  Volume 13, Issue 4, Page(s) 502–517

    Abstract: Objective: To analyze the medication rules of traditional Chinese medicine (TCM) preventive oral prescriptions for COVID-19.: Methods: The preventive oral prescriptions for COVID-19 published by national and provincial health and wellness committees, ...

    Abstract Objective: To analyze the medication rules of traditional Chinese medicine (TCM) preventive oral prescriptions for COVID-19.
    Methods: The preventive oral prescriptions for COVID-19 published by national and provincial health and wellness committees, administrations of TCM, medical institutions at all levels, medical masters and Chinese medicine experts were collected to establish a database, manual screening was carried out according to the inclusion and exclusion criteria, and frequency statistics, association rule analysis. The mutual information method, entropy hierarchical clustering and other methods were improved through Excel and the TCM inheritance auxiliary platform V2.5 to mine the rules and characteristics of medication.
    Results: The selected 157 prescriptions contained a total of 130 TCMs. The top five TCMs with the highest use frequency were
    Conclusion: We found that invigorating
    Language English
    Publishing date 2021-10-12
    Publishing country Singapore
    Document type Journal Article
    ISSN 1674-6384
    ISSN 1674-6384
    DOI 10.1016/j.chmed.2021.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cysestermerol A, a rare stilbene sestermer with significant hypoglycemic activities from

    Wang, Feng / Zhang, Li / Li, Bi-Jun / Liang, Qiu-Ming / Chen, A-Li / Fang, Zhen-Feng / Wang, Shu-Mei

    Natural product research

    2019  Volume 35, Issue 18, Page(s) 3056–3062

    Abstract: Cysestermerol A ( ...

    Abstract Cysestermerol A (
    MeSH term(s) Cynodon/chemistry ; Glycoside Hydrolase Inhibitors/isolation & purification ; Glycoside Hydrolase Inhibitors/pharmacology ; Hep G2 Cells ; Humans ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Extracts ; Stilbenes/isolation & purification ; Stilbenes/pharmacology ; alpha-Glucosidases
    Chemical Substances Glycoside Hydrolase Inhibitors ; Hypoglycemic Agents ; Phytochemicals ; Plant Extracts ; Stilbenes ; alpha-Glucosidases (EC 3.2.1.20)
    Language English
    Publishing date 2019-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2019.1689501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Effect of Xinling Wan in treatment of stable angina pectoris: a randomized, double-blinded, placebo parallel-controlled, multicenter trial].

    Gao, Jian-Wei / Gao, Xue-Min / Zou, Ting / Zhao, Tian-Meng / Wang, Dong-Hua / Wu, Zong-Gui / Ren, Chang-Jie / Wang, Xing / Geng, Nai-Zhi / Zhao, Ming-Jun / Liang, Qiu-Ming / Feng, Xing / Yang, Bai-Song / Shi, Jun-Ling / Hua, Qi

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2018  Volume 43, Issue 6, Page(s) 1268–1275

    Abstract: To evaluate the effectiveness and safety of Xinling Wan on patients with stable angina pectoris, a randomized, double-blinded, placebo parallel-controlled, multicenter clinical trial was conducted. A total of 232 subjects were enrolled and randomly ... ...

    Abstract To evaluate the effectiveness and safety of Xinling Wan on patients with stable angina pectoris, a randomized, double-blinded, placebo parallel-controlled, multicenter clinical trial was conducted. A total of 232 subjects were enrolled and randomly divided into experiment group and placebo group. The experiment group was treated with Xinling Wan (two pills each time, three times daily) for 4 weeks, and the placebo group was treated with placebo. The effectiveness evaluation showed that Xinling Wan could significantly increase the total duration of treadmill exercise among patients with stable angina pectoris. FAS analysis showed that the difference value of the total exercise duration was between experiment group (72.11±139.32) s and placebo group (31.25±108.32) s. Xinling Wan could remarkably increase the total effective rate of angina pectoris symptom score, and the analysis showed that the total effective rate was 78.95% in experiment group and 42.61% in placebo group. The reduction of nitroglycerin dose was (2.45±2.41) tablets in experiment group and (0.50±2.24) tablets in placebo group on the basis of FAS analysis. The decrease of symptom integral was (4.68±3.49) in experiment group and (3.19±3.31) in placebo group based on FAS analysis. Besides, Xinling Wan could decrease the weekly attack time and the duration of angina pectoris. PPS analysis results were similar to those of FAS analysis. In conclusion, Xinling Wan has an obvious therapeutic effect in treating stable angina pectoris, with a good safety and a low incidence of adverse event and adverse reaction in experiment group.
    MeSH term(s) Angina Pectoris/drug therapy ; Angina, Stable/drug therapy ; Double-Blind Method ; Drugs, Chinese Herbal/therapeutic use ; Exercise Test ; Humans ; Nitroglycerin
    Chemical Substances Drugs, Chinese Herbal ; Nitroglycerin (G59M7S0WS3)
    Language Chinese
    Publishing date 2018-04-16
    Publishing country China
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20171226.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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