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  1. Article ; Online: Unravelling the underlying mechanism of the reduction of aldehydes/ketones with metal borohydride in an aprotic solvent.

    Li, Xinying / Kang, Jia-Xin / Liang, Shasha / Long, Xi-Hong / Ma, Yan-Na / Chen, Xuenian

    Chemical communications (Cambridge, England)

    2024  

    Abstract: The reduction mechanism of aldehyde/ketones with M( ... ...

    Abstract The reduction mechanism of aldehyde/ketones with M(BH
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc06108f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evolutionary Analysis of OAT Gene Family in River and Swamp Buffalo: Potential Role of SLCO3A1 Gene in Milk Performance

    Ma, Xiaoya / Liang, Shasha / Liang, Aixin / Rushdi, Hossam E. / Deng, Tingxian

    Genes. 2021 Sept. 10, v. 12, no. 9

    2021  

    Abstract: The organic anion transporter (OAT) family is the subfamily of the solute carrier (SLC) superfamily, which plays a vital role in regulating essential nutrients in milk. However, little is known about the members’ identification, evolutionary basis, and ... ...

    Abstract The organic anion transporter (OAT) family is the subfamily of the solute carrier (SLC) superfamily, which plays a vital role in regulating essential nutrients in milk. However, little is known about the members’ identification, evolutionary basis, and function characteristics of OAT genes associated with milk performance in buffalo. Comparative genomic analyses were performed to identify the potential role of buffalo OAT genes in milk performance in this study. The results showed that a total of 10 and 7 OAT genes were identified in river buffalo and swamp buffalo, respectively. These sequences clustered into three groups based on their phylogenetic relationship and had similar motif patterns and gene structures in the same groups. Moreover, the river-specific expansions and homologous loss of OAT genes occurred in the two buffalo subspecies during the evolutionary process. Notably, the duplicated SLCO3A1 gene specific to river buffalo showed higher expression level in mammary gland tissue than that of swamp buffalo. These findings highlight some promising candidate genes that could be potentially utilized to accelerate the genetic progress in buffalo breeding programs. However, the identified candidate genes require further validation in a larger cohort for use in the genomic selection of buffalo for milk production.
    Keywords buffaloes ; genes ; genomics ; mammary glands ; marker-assisted selection ; milk ; milk production ; phylogeny ; rivers ; solutes
    Language English
    Dates of publication 2021-0910
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12091394
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Genomic Identification, Evolution, and Expression Analysis of Collagen Genes Family in Water Buffalo during Lactation.

    Lu, Xingrong / Duan, Anqin / Liang, Shasha / Ma, Xiaoya / Deng, Tingxian

    Genes

    2020  Volume 11, Issue 5

    Abstract: Collagens, as extracellular matrix proteins, support cells for structural integrity and contribute to support mammary basic structure and development. This study aims to perform the genomic identification, evolution, and expression analyses of the ... ...

    Abstract Collagens, as extracellular matrix proteins, support cells for structural integrity and contribute to support mammary basic structure and development. This study aims to perform the genomic identification, evolution, and expression analyses of the collagen gene family in water buffalo (
    MeSH term(s) Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Buffaloes/genetics ; Buffaloes/metabolism ; Cattle/genetics ; Cattle/metabolism ; Chromosome Mapping ; Collagen/biosynthesis ; Collagen/genetics ; Evolution, Molecular ; Female ; Gene Duplication ; Gene Expression Profiling ; Gene Expression Regulation ; Genome ; Lactation/genetics ; Milk/chemistry ; Real-Time Polymerase Chain Reaction ; Species Specificity
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2020-05-06
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11050515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Knockdown of CYP19A1 in Buffalo Follicular Granulosa Cells Results in Increased Progesterone Secretion and Promotes Cell Proliferation.

    Lu, Xingrong / Duan, Anqin / Ma, Xiaoya / Liang, Shasha / Deng, Tingxian

    Frontiers in veterinary science

    2020  Volume 7, Page(s) 539496

    Abstract: Cytochrome P450 aromatase 19A1 (CYP19A1) is a critical enzyme in estrogen synthesis. However, the effect of CYP19A1 on cell growth and hormone secretion of buffalo follicular granulosa cells (BFGCs) is poorly understood. The objective of this study was ... ...

    Abstract Cytochrome P450 aromatase 19A1 (CYP19A1) is a critical enzyme in estrogen synthesis. However, the effect of CYP19A1 on cell growth and hormone secretion of buffalo follicular granulosa cells (BFGCs) is poorly understood. The objective of this study was to assess the role of CYP19A1 in cell proliferation and hormone secretion of BFGCs by knocking down CYP19A1 mRNA expression. The mRNA expression level of CYP19A1 gene was knocked down in BFGCs using the siCYP19A1-296 fragment with the best interference efficiency of 72.63%, as affirmed by real-time quantitative PCR (qPCR) and cell morphology analysis. The CYP19A1 knockdown promoted the proliferation of BFGCs through upregulating the mRNA expression levels of six proliferation-related genes (CCND1, CCNE1, CCNB1, CDK2, CDKN1A, and CDKN1B). Moreover, CYP19A1 knockdown increased (
    Language English
    Publishing date 2020-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.539496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evolutionary Analysis of OAT Gene Family in River and Swamp Buffalo: Potential Role of

    Ma, Xiaoya / Liang, Shasha / Liang, Aixin / Rushdi, Hossam E / Deng, Tingxian

    Genes

    2021  Volume 12, Issue 9

    Abstract: The organic anion transporter (OAT) family is the subfamily of the solute carrier (SLC) superfamily, which plays a vital role in regulating essential nutrients in milk. However, little is known about the members' identification, evolutionary basis, and ... ...

    Abstract The organic anion transporter (OAT) family is the subfamily of the solute carrier (SLC) superfamily, which plays a vital role in regulating essential nutrients in milk. However, little is known about the members' identification, evolutionary basis, and function characteristics of OAT genes associated with milk performance in buffalo. Comparative genomic analyses were performed to identify the potential role of buffalo OAT genes in milk performance in this study. The results showed that a total of 10 and 7 OAT genes were identified in river buffalo and swamp buffalo, respectively. These sequences clustered into three groups based on their phylogenetic relationship and had similar motif patterns and gene structures in the same groups. Moreover, the river-specific expansions and homologous loss of OAT genes occurred in the two buffalo subspecies during the evolutionary process. Notably, the duplicated
    MeSH term(s) Animals ; Buffaloes/genetics ; Buffaloes/metabolism ; Cattle ; Evolution, Molecular ; Female ; Lactation/genetics ; Milk/metabolism ; Multigene Family ; Organic Anion Transporters/genetics ; Phylogeny ; Rivers ; Wetlands
    Chemical Substances Organic Anion Transporters
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12091394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Genomic Identification, Evolution, and Expression Analysis of Collagen Genes Family in Water Buffalo during Lactation

    Lu, Xingrong / Duan, Anqin / Liang, Shasha / Ma, Xiaoya / Deng, Tingxian

    Genes. 2020 May 06, v. 11, no. 5

    2020  

    Abstract: Collagens, as extracellular matrix proteins, support cells for structural integrity and contribute to support mammary basic structure and development. This study aims to perform the genomic identification, evolution, and expression analyses of the ... ...

    Abstract Collagens, as extracellular matrix proteins, support cells for structural integrity and contribute to support mammary basic structure and development. This study aims to perform the genomic identification, evolution, and expression analyses of the collagen gene family in water buffalo (Bubalus bubalis) during lactation. A total of 128 buffalo collagen protein sequences were deduced from the 45 collagen genes identified in silico from buffalo genome, which classified into six groups based on their phylogenetic relationships, conserved motifs, and gene structure analyses. The identified collagen sequences were unequally distributed on 16 chromosomes. The tandem duplicated genes were found within three chromosomes, while only one segmental event occurred between Chr3 and Chr8. Collinearity analysis revealed that a total of 36 collagen gene pairs were orthologous between buffalo and cattle genomes despite having different chromosome numbers. Comparative transcription analyses revealed that a total of 23 orthologous collagen genes were detected in the milk samples at different lactation periods between the two species. Notably, the duplicated gene pair of COL4A1-COL4A2 during lactation had a higher mRNA expression level than that of cattle, while a higher expression level of COL6A1-COL6A2 pair was found in cattle compared with that of buffalo. The present study provides useful information for investigating the potential functions of the collagen family in buffalo during lactation and helps in the functional characterization of collagen genes in additional research.
    Keywords Bubalus bubalis ; amino acid sequences ; buffaloes ; cattle ; chromosome number ; chromosomes ; collagen ; computer simulation ; gene duplication ; gene expression ; genes ; genomics ; lactation ; messenger RNA ; milk ; phylogeny ; transcription (genetics)
    Language English
    Dates of publication 2020-0506
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11050515
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Novel Insight into the Potential Role of Acylglycerophosphate Acyltransferases Family Members on Triacylglycerols Synthesis in Buffalo.

    Ma, Xiao-Ya / Duan, An-Qin / Lu, Xing-Rong / Liang, Sha-Sha / Sun, Pei-Hao / Sohel, Md Mahmodul Hasan / Abdel-Shafy, Hamdy / Amin, Ahmed / Liang, Ai-Xin / Deng, Ting-Xian

    International journal of molecular sciences

    2022  Volume 23, Issue 12

    Abstract: Acylglycerophosphate acyltransferases (AGPATs) are the rate-limiting enzymes for the de novo pathway of triacylglycerols (TAG) synthesis. Although AGPATs have been extensively explored by evolution, expression and functional studies, little is known on ... ...

    Abstract Acylglycerophosphate acyltransferases (AGPATs) are the rate-limiting enzymes for the de novo pathway of triacylglycerols (TAG) synthesis. Although AGPATs have been extensively explored by evolution, expression and functional studies, little is known on functional characterization of how many members of the AGPAT family are involved in TAG synthesis and their impact on the cell proliferation and apoptosis. Here, 13 AGPAT genes in buffalo were identified, of which 12 AGPAT gene pairs were orthologous between buffalo and cattle. Comparative transcriptomic analysis and real-time quantitative reverse transcription PCR (qRT-PCR) further showed that both AGPAT1 and AGPAT6 were highly expressed in milk samples of buffalo and cattle during lactation. Knockdown of AGPAT1 or AGPAT6 significantly decreased the TAG content of buffalo mammary epithelial cells (BuMECs) and bovine mammary epithelial cells (BoMECs) by regulating lipogenic gene expression (p < 0.05). Knockdown of AGPAT1 or AGPAT6 inhibited proliferation and apoptosis of BuMECs through the expression of marker genes associated with the proliferation and apoptosis (p < 0.05). Our data confirmed that both AGPAT1 and AGPAT6 could regulate TAG synthesis and growth of mammary epithelial cells in buffalo. These findings will have important implications for understanding the role of the AGPAT gene in buffalo milk performance.
    MeSH term(s) Animals ; Cattle ; Female ; Acyltransferases/genetics ; Acyltransferases/metabolism ; Buffaloes/genetics ; Buffaloes/metabolism ; Epithelial Cells/metabolism ; Lactation/genetics ; Mammary Glands, Animal/metabolism ; Milk/metabolism ; Triglycerides/metabolism
    Chemical Substances Acyltransferases (EC 2.3.-) ; Triglycerides
    Language English
    Publishing date 2022-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23126561
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  8. Article: Molecular characterisation of the buffalo SCAP gene and its association with milk production traits in water buffaloes

    Deng, Tingxian / Ma, Xiaoya / Pang, Chunying / Liang, Shasha / Lu, Xingrong / Duan, Anqin / Liang, Xianwei

    Journal of dairy research. 2018 May, v. 85, no. 2

    2018  

    Abstract: The study reported in this Research Communication was conducted to investigate the molecular characterisation of buffalo SCAP gene, expression analysis, and the association between single nucleotide polymorphisms and milk production traits in 384 ... ...

    Abstract The study reported in this Research Communication was conducted to investigate the molecular characterisation of buffalo SCAP gene, expression analysis, and the association between single nucleotide polymorphisms and milk production traits in 384 buffaloes. Sequence analysis revealed the SCAP gene had an open reading frame of 3837 bp encoding 1279 amino acids. A ubiquitous expression profile of SCAP gene was detected in various tissues with extreme predominance in the mammary gland during early lactation. Moreover, eleven SNPs in buffalo SCAP gene were identified, six of them (g.1717600A>G, g.1757922C>T, g.1758953G>A, g.1759142C>T, g.1760740G>A, and g.1766036T>C) were found to be significantly associated with 305-day milk yield. Thus, buffalo SCAP could sever as a candidate gene affecting milk production traits in buffalo and the identified SNPs might potentially be genetic markers.
    Keywords amino acids ; buffaloes ; early lactation ; genes ; genetic markers ; mammary glands ; milk yield ; open reading frames ; sequence analysis ; single nucleotide polymorphism ; tissues
    Language English
    Dates of publication 2018-05
    Size p. 133-137.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 242089-2
    ISSN 1469-7629 ; 0022-0299
    ISSN (online) 1469-7629
    ISSN 0022-0299
    DOI 10.1017/S0022029918000195
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    In stock of ZB MED Bonn / Germany

    Z 1073: Show issues

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  9. Article ; Online: Molecular characterisation of the buffalo SCAP gene and its association with milk production traits in water buffaloes.

    Deng, Tingxian / Ma, Xiaoya / Pang, Chunying / Liang, Shasha / Lu, Xingrong / Duan, Anqin / Liang, Xianwei

    The Journal of dairy research

    2018  Volume 85, Issue 2, Page(s) 133–137

    Abstract: The study reported in this Research Communication was conducted to investigate the molecular characterisation of buffalo SCAP gene, expression analysis, and the association between single nucleotide polymorphisms and milk production traits in 384 ... ...

    Abstract The study reported in this Research Communication was conducted to investigate the molecular characterisation of buffalo SCAP gene, expression analysis, and the association between single nucleotide polymorphisms and milk production traits in 384 buffaloes. Sequence analysis revealed the SCAP gene had an open reading frame of 3837 bp encoding 1279 amino acids. A ubiquitous expression profile of SCAP gene was detected in various tissues with extreme predominance in the mammary gland during early lactation. Moreover, eleven SNPs in buffalo SCAP gene were identified, six of them (g.1717600A>G, g.1757922C>T, g.1758953G>A, g.1759142C>T, g.1760740G>A, and g.1766036T>C) were found to be significantly associated with 305-day milk yield. Thus, buffalo SCAP could sever as a candidate gene affecting milk production traits in buffalo and the identified SNPs might potentially be genetic markers.
    MeSH term(s) Animals ; Breeding/methods ; Buffaloes/genetics ; China ; Female ; Gene Expression ; Genetic Markers ; Genotype ; Intracellular Signaling Peptides and Proteins/genetics ; Lactation/genetics ; Membrane Proteins/genetics ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Sequence Analysis, DNA
    Chemical Substances Genetic Markers ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; SREBP cleavage-activating protein
    Language English
    Publishing date 2018-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 242089-2
    ISSN 1469-7629 ; 0022-0299
    ISSN (online) 1469-7629
    ISSN 0022-0299
    DOI 10.1017/S0022029918000195
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  10. Article ; Online: Buffalo SREBP1: molecular cloning, expression and association analysis with milk production traits.

    Deng, Tingxian / Pang, Chunying / Ma, Xiaoya / Duan, Anqin / Liang, Shasha / Lu, Xingrong / Liang, Xianwei

    Animal genetics

    2017  Volume 48, Issue 6, Page(s) 720–721

    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 632766-7
    ISSN 1365-2052 ; 0268-9146 ; 0268-9154
    ISSN (online) 1365-2052
    ISSN 0268-9146 ; 0268-9154
    DOI 10.1111/age.12587
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