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  1. Article: Focusing on early detection and diagnosis-a way to eradicate deadly lung cancer.

    Liang, Wenhua

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 7, Page(s) S777–S778

    Language English
    Publishing date 2018-04-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.04.78
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterization of Mouse CD4 TCR and Its Targeting Antigen.

    Liang, Wenhua / Wang, Feng

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2574, Page(s) 221–232

    Abstract: The initial step of activation and differentiation of naïve ... ...

    Abstract The initial step of activation and differentiation of naïve CD4
    MeSH term(s) Animals ; Antigen-Presenting Cells ; Antigens ; Mice ; Peptides ; Receptors, Antigen, T-Cell ; T-Lymphocytes, Helper-Inducer
    Chemical Substances Antigens ; Peptides ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-09-10
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2712-9_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characterization of platelet-related genes and constructing signature combined with immune-related genes for predicting outcomes and immunotherapy response in lung squamous cell carcinoma.

    Zhao, Siyi / Gong, Han / Liang, Wenhua

    Aging

    2023  Volume 15, Issue 14, Page(s) 6969–6992

    Abstract: Lung squamous cell carcinoma (LUSC) is a highly malignant subtype of non-small cell lung cancer with poor prognosis. Platelets are known to play a critical role in cancer development and progression, and recent studies suggest that they can also regulate ...

    Abstract Lung squamous cell carcinoma (LUSC) is a highly malignant subtype of non-small cell lung cancer with poor prognosis. Platelets are known to play a critical role in cancer development and progression, and recent studies suggest that they can also regulate immune response in tumors. However, the relationship between platelet-related genes (PRGs) and LUSC prognosis and tumor microenvironments remains unclear. In this study, we used multiple bioinformatics algorithms to identify 25 dysregulated PRGs that were significantly associated with LUSC prognosis. We found that PRGs were involved in multiple biological processes, particularly in the tumor microenvironment, and that platelet-related scores (PRS) were a risk factor. Additionally, we established a 6-gene prognostic signature combining PRGs and immune-related genes that accurately predicted outcomes and immunotherapy efficacy in LUSC patients. Our study provides a comprehensive analysis of the biological functions and potential therapeutic targets of PRGs in LUSC, which may inform the development of new treatments for this disease.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/therapy ; Blood Platelets ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/therapy ; Immunotherapy ; Tumor Microenvironment/genetics ; Lung ; Prognosis
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A highly sensitive ratiometric fluorescence immunoassay based on bioorthogonal nanozymes.

    Liu, Xiajian / Wang, Nianhua / Hou, Yixuan / Dong, He / Liang, Wenhua / Li, Xinchun / Yuan, Youyong

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 29, Page(s) 3978–3981

    Abstract: We designed a novel ratiometric fluorescence immunoassay based on bioorthogonal nanozymes for carcinoembryonic antigen detection. The analytical performance of our designed immunoassay showed a wide linear range, a low detection limit, good ... ...

    Abstract We designed a novel ratiometric fluorescence immunoassay based on bioorthogonal nanozymes for carcinoembryonic antigen detection. The analytical performance of our designed immunoassay showed a wide linear range, a low detection limit, good reproducibility, selectivity and stability. Thus, bioorthogonal nanozymes hold great potential applications in clinical diagnoses.
    MeSH term(s) Carcinoembryonic Antigen ; Reproducibility of Results ; Immunoassay
    Chemical Substances Carcinoembryonic Antigen
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00731j
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  5. Article: Exploration of the mechanism of Baitong decoction in the treatment of cold asthma based on network pharmacology and molecular docking

    Jiang, Qian / Yin, Bin / Liang, Wenhua

    Phytomedicine plus. 2022 Aug., v. 2, no. 3

    2022  

    Abstract: To investigate the mechanism of Baitong decoction in the treatment of cold asthma through network pharmacology. The pharmacological database and analysis platform of the traditional Chinese medicine system (TCMSP) was used to search and screen for active ...

    Abstract To investigate the mechanism of Baitong decoction in the treatment of cold asthma through network pharmacology. The pharmacological database and analysis platform of the traditional Chinese medicine system (TCMSP) was used to search and screen for active components and potential targets of the three herbs in Baitong decoction (Fuzi, Ganjiang, and Congbai). The asthma disease targets were searched and screened using the GeneCards database and the parts intersecting with the action targets of the Baitong decoction was obtained. The interactions among the various targets were counted on the STRING website. Cytoscape 3.8.2 software was used for network analysis, and R program was used for biological process analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Molecular docking between drug components and targets was performed using the Protein Data Bank (PDB) and PubChem website, and Autodock and PyMOL software. Forty-seven key target genes of Baitong decoction were found to interfere with cold asthma. The final core targets are JUN, PTGS2, and HMOX1. Cell biological processes, including oxidative stress, lipopolysaccharide response, heme binding, oxidoreductase activity, and G-protein-coupled amine receptor activity, were studied using Gene Ontology (GO) enrichment analysis. KEGG enrichment analysis revealed that the signaling pathways found in this study included the tumor necrosis factor (TNF), lipid metabolism, and atherosclerosis signaling pathways. The docking results showed that PTGS2 has a high affinity for kaempferol, catechin (+), and deltoin, and that JUN has a great affinity for kaempferol. Lipopolysaccharide response and the TNF signaling pathway may play a key role in the therapeutic effect of Baitong decoction on cold asthma. Drug components, including kaempferol, catechin (+), and deltoin, may affect the TNF signaling pathway by targeting PTGS2 and JUN, thereby regulating the immune inflammatory response.
    Keywords Internet ; Oriental traditional medicine ; asthma ; atherosclerosis ; catechin ; cold ; computer software ; drugs ; gene ontology ; heme ; inflammation ; kaempferol ; lipid metabolism ; lipopolysaccharides ; oxidative stress ; pharmacology ; therapeutics ; tumor necrosis factors
    Language English
    Dates of publication 2022-08
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2667-0313
    DOI 10.1016/j.phyplu.2022.100309
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Osimertinib in EGFR-Mutated Lung Cancer.

    Liang, Wenhua / Zhong, Ran / He, Jianxing

    The New England journal of medicine

    2021  Volume 384, Issue 7, Page(s) 675

    MeSH term(s) Acrylamides ; Aniline Compounds ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics
    Chemical Substances Acrylamides ; Aniline Compounds ; osimertinib (3C06JJ0Z2O) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-02-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2033951
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    Ua VI Zs.34: Show issues Location:
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  7. Article: Microbiota modulate lung squamous cell carcinoma lymph node metastasis through microbiota-geneset correlation network.

    Liang, Peng / Deng, Hongsheng / Zhao, Yi / Chen, Ying / Zhang, Jingna / He, Jianxing / Liang, Wenhua

    Translational lung cancer research

    2023  Volume 12, Issue 11, Page(s) 2245–2259

    Abstract: Background: The tumor-resident microbiota in lung squamous cell carcinoma (LUSC) has been reported to be associated with the initiation and progression of cancer. And the gut microbiome can modulate the efficacy of immunotherapies. However, it remains ... ...

    Abstract Background: The tumor-resident microbiota in lung squamous cell carcinoma (LUSC) has been reported to be associated with the initiation and progression of cancer. And the gut microbiome can modulate the efficacy of immunotherapies. However, it remains to be understood whether the tumor-resident microbiome promotes lymph node (LN) metastasis, which is important for clinical decision-making and prediction of a patient's prognosis. To investigate the potential role of tumor-resident microbiota in LN metastasis, we worked on the microbiota-geneset interaction profiles to characterize the molecular pathogenesis.
    Methods: RNA sequencing data and their matched clinical and genomic information were obtained from The Cancer Genome Atlas database. The matched microorganism quantification data were accessed via the cBioPortal database. The mutational signature analysis, transcriptome analysis, gene set enrichment analysis, immune infiltration, and microbiota-geneset network analysis were performed.
    Results: In this paper, we identified the tumor microbiota composition and microbial biomarkers in patients with and without LN metastases. In addition, significantly upregulated gene sets characterize the transcript profiles of patients with LN metastases, for example, Myc Targets, E2F Targets, G2M Checkpoint, Mitotic Spindle, DNA Repair, and Oxidative Phosphorylation. Finally, we found that
    Conclusions: We found the associations between intratumor microbiota and transcripts. Our results shed light on the correlation network of
    Language English
    Publishing date 2023-11-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-357
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  8. Article ; Online: Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study.

    Cheng, Xiaoxue / Shi, Jiang / Zhang, Ding / Li, Caichen / Xu, Haoxiang / He, Jianxing / Liang, Wenhua

    BMC pulmonary medicine

    2023  Volume 23, Issue 1, Page(s) 243

    Abstract: Background: Previous observational studies have found an association between gastroesophageal reflux disease (GERD) and chronic respiratory diseases, but it remains uncertain whether GERD causally influences these diseases. In this study, we aimed to ... ...

    Abstract Background: Previous observational studies have found an association between gastroesophageal reflux disease (GERD) and chronic respiratory diseases, but it remains uncertain whether GERD causally influences these diseases. In this study, we aimed to estimate the causal associations between GERD and 5 chronic respiratory diseases.
    Methods: 88 GERD-associated single nucleotide polymorphisms (SNPs) identified by the latest genome-wide association study were included as instrumental variables. Individual-level genetic summary data of participants were obtained from corresponding studies and the FinnGen consortium. We applied the inverse-variance weighted method to estimate the causality between genetically predicted GERD and 5 chronic respiratory diseases. Furthermore, the associations between GERD and common risk factors were investigated, and mediation analyses were conducted using multivariable MR. Various sensitivity analyses were also performed to verify the robustness of the findings.
    Results: Our study demonstrated that genetically predicted GERD was causally associated with an increased risk of asthma (OR 1.39, 95%CI 1.25-1.56, P < 0.001), idiopathic pulmonary fibrosis (IPF) (OR 1.43, 95%CI 1.05-1.95, P = 0.022), chronic obstructive disease (COPD) (OR 1.64, 95%CI 1.41-1.93, P < 0.001), chronic bronchitis (OR 1.77, 95%CI 1.15-2.74, P = 0.009), while no correlation was observed for bronchiectasis (OR 0.93, 95%CI 0.68-1.27, P = 0.645). Additionally, GERD was associated with 12 common risk factors for chronic respiratory diseases. Nevertheless, no significant mediators were discovered.
    Conclusions: Our study suggested that GERD was a causal factor in the development of asthma, IPF, COPD and chronic bronchitis, indicating that GERD-associated micro-aspiration of gastric contents process might play a role in the development of pulmonary fibrosis in these diseases.
    MeSH term(s) Humans ; Bronchitis, Chronic/complications ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/genetics ; Asthma/epidemiology ; Asthma/genetics ; Asthma/complications ; Respiration Disorders/complications ; Idiopathic Pulmonary Fibrosis
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-023-02502-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Driving the Improvement of Lung Cancer Prognosis.

    Liang, Wenhua / Liu, Jun / He, Jianxing

    Cancer cell

    2020  Volume 38, Issue 4, Page(s) 449–451

    Abstract: An article in the New England Journal of Medicine reveals a significant reduction of incidence-based mortality of non-small cell lung cancer in the U.S. and attributes this improvement to the approval of targeted therapies. ...

    Abstract An article in the New England Journal of Medicine reveals a significant reduction of incidence-based mortality of non-small cell lung cancer in the U.S. and attributes this improvement to the approval of targeted therapies.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Incidence ; Lung ; Lung Neoplasms/drug therapy ; Prognosis
    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2020.09.008
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    Zs.A 5650: Show issues Location:
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  10. Article: Beyond finding druggable targets and tumor mutational burden: to measure heterogeneity by ctDNA.

    Liu, Zhichao / He, Jianxing / Liang, Wenhua

    Annals of translational medicine

    2020  Volume 8, Issue 11, Page(s) 723

    Language English
    Publishing date 2020-06-29
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2020.01.86
    Database MEDical Literature Analysis and Retrieval System OnLINE

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