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  1. Article ; Online: Risk Factors Related to Early Biliary Complications After Liver Transplantation: a Single-Center Analysis.

    Suo, Lida / Liang, Xiangnan / Zhang, Weibin / Ma, Taiheng / Gao, Zhenming

    Transplantation proceedings

    2023  Volume 55, Issue 1, Page(s) 164–169

    Abstract: Background: The aim of this study was to evaluate the risk factors of early biliary complications (EBC) after liver transplantation (LT) and seek effective treatments based on our single-center experience.: Methods: A total of 124 adult patients were ...

    Abstract Background: The aim of this study was to evaluate the risk factors of early biliary complications (EBC) after liver transplantation (LT) and seek effective treatments based on our single-center experience.
    Methods: A total of 124 adult patients were divided into a non-EBC group and EBC group. EBC usually accounts for biliary leakage, biliary stricture, biliary stones, sphincter of Oddi dysfunction, and transient jaundice within 3 months after LT. Statistical analysis including logistic regression was performed to determine EBC risk factors. All procedures complied with the Helsinki Congress and the Declaration of Istanbul.
    Results: Non-EBC (n = 95) and EBC (n = 29) were finally compared, which had no difference in their general characteristics. EBC occurred in 29 patients (26.92%): 1 biliary hemorrhage (3.45%), 7 biliary leakage (24.13%), and 16 biliary stricture (55.18%), and 5 others (17.24%). Of all EBC patients, endoscopic retrograde cholangiopancreatography (68.96%) was higher used to deal with complications than conservative treatment (10.35%), percutaneous transhepatic cholangial drainage (17.24%), and surgical treatment (3.45%). On univariate analyses, risk factors for EBC were bilirubin (P = .014), warm ischemia time (WIT) (P = .020), second WIT (P = .042), and operative time (OT) (P = .033). On multivariate analysis, independent risk factors for BC were WIT (P = .011) and OT (P = .049).
    Conclusions: The presence of WIT and OT were the independent risk factors for the development of EBC. In addition, we also confirmed that endoscopic retrograde cholangiopancreatography was beneficial and safe in the management of EBC after LT.
    MeSH term(s) Adult ; Humans ; Liver Transplantation/methods ; Constriction, Pathologic/etiology ; Retrospective Studies ; Biliary Tract Diseases/etiology ; Cholestasis/etiology ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Risk Factors ; Treatment Outcome ; Postoperative Complications/etiology
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy.

    Song, Yilin / Song, Quanlin / Hu, Daosheng / Sun, Binwen / Gao, Mingwei / Liang, Xiangnan / Qu, Boxin / Suo, Lida / Yin, Zeli / Wang, Liming

    Frontiers in oncology

    2024  Volume 13, Page(s) 1299384

    Abstract: Mesenchymal stem cells (MSCs) have tumor-homing ability and play critical roles in tumor treatment, but their dual influences on tumor progression limit their therapeutic applications. Exosomes derived from MSCs (MSC-exosomes) exhibit great potential in ... ...

    Abstract Mesenchymal stem cells (MSCs) have tumor-homing ability and play critical roles in tumor treatment, but their dual influences on tumor progression limit their therapeutic applications. Exosomes derived from MSCs (MSC-exosomes) exhibit great potential in targeted tumor treatment due to their advantages of high stability, low immunogenicity, good biocompatibility, long circulation time and homing characteristics. Furthermore, the artificial modification of MSC-exosomes could amplify their advantages and their inhibitory effect on tumors and could overcome the limit of tumor-promoting effect. In this review, we summarize the latest therapeutic strategies involving artificially modified MSC-exosomes in tumor treatment, including employing these exosomes as nanomaterials to carry noncoding RNAs or their inhibitors and anticancer drugs, and genetic engineering modification of MSC-exosomes. We also discuss the feasibility of utilizing artificially modified MSC-exosomes as an emerging cell-free method for tumor treatment and related challenges.
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1299384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Potential prognostic biomarkers of hepatocellular carcinoma based on 4D label-free quantitative proteomics analysis pilot investigation.

    Suo, Lida / Liang, Xiangnan / Zhang, Weibin / Gao, Mingwei / Ma, Taiheng / Hu, Daosheng / Song, Yilin / Gao, Zhenming

    The International journal of biological markers

    2023  Volume 39, Issue 1, Page(s) 59–69

    Abstract: Background: Hepatocellular carcinoma carries a poor prognosis and poses a serious threat to global health. Currently, there are few potential prognostic biomarkers available for the prognosis of hepatocellular carcinoma.: Methods: This pilot study ... ...

    Abstract Background: Hepatocellular carcinoma carries a poor prognosis and poses a serious threat to global health. Currently, there are few potential prognostic biomarkers available for the prognosis of hepatocellular carcinoma.
    Methods: This pilot study used 4D label-free quantitative proteomics to compare the proteomes of hepatocellular carcinoma and adjacent non-tumor tissue. A total of 66,075 peptides, 6363 identified proteins, and 772 differentially expressed proteins were identified in specimens from three hepatocellular carcinoma patients. Through functional enrichment analysis of differentially expressed proteins by Gene Ontology, KEGG pathway, and protein domain, we identified proteins with similar functions.
    Results: Twelve differentially expressed proteins (RPL17, RPL27, RPL27A, RPS5, RPS16, RSL1D1, DDX18, RRP12, TARS2, YARS2, MARS2, and NARS1) were selected for identification and validation by parallel reaction monitoring. Subsequent Western blotting confirmed overexpression of RPL27, RPS16, and TARS2 in hepatocellular carcinoma compared to non-tumor tissue in 16 pairs of clinical samples. Analysis of The Cancer Genome Atlas datasets associated the increased expression of these proteins with poor prognosis. Tissue microarray revealed a negative association between high expression of RPL27 and TARS2 and the prognosis of hepatocellular carcinoma patients, although RPS16 was not significant.
    Conclusions: These data suggest that RPL27 and TARS2 play an important role in hepatocellular carcinoma progression and may be potential prognostic biomarkers of overall survival in hepatocellular carcinoma patients.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Pilot Projects ; Liver Neoplasms/pathology ; Prognosis ; Proteomics ; Biomarkers, Tumor/metabolism ; Gene Expression Regulation, Neoplastic ; Pregnancy Proteins/genetics ; Pregnancy Proteins/metabolism ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism
    Chemical Substances Biomarkers, Tumor ; RSL1D1 protein, human ; Pregnancy Proteins ; Ribosomal Proteins
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645113-5
    ISSN 1724-6008 ; 0393-6155
    ISSN (online) 1724-6008
    ISSN 0393-6155
    DOI 10.1177/03936155231212925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2491: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Multi-omics pan-cancer study of SPTBN2 and its value as a potential therapeutic target in pancreatic cancer.

    Chang, Hongliang / Chen, Hong / Ma, Taiheng / Ma, Kexin / Li, Yi / Suo, Lida / Liang, Xiangnan / Jia, Kunyu / Ma, Jiahong / Li, Jing / Sun, Deguang

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9764

    Abstract: SPTBN2 is a protein-coding gene that is closely related to the development of malignant tumors. However, its prognostic value and biological function in pan-cancer, especially pancreatic cancer (PAAD), have not been reported. In the present study, a ... ...

    Abstract SPTBN2 is a protein-coding gene that is closely related to the development of malignant tumors. However, its prognostic value and biological function in pan-cancer, especially pancreatic cancer (PAAD), have not been reported. In the present study, a novel exploration of the value and potential mechanism of SPTBN2 in PAAD was conducted using multi-omics in the background of pan-cancer. Via various database analysis, up-regulated expression of SPTBN2 was detected in most of the tumor tissues examined. Overexpression of SPTBN2 in PAAD and kidney renal clear cell cancer patients potentially affected overall survival, disease-specific survival, and progression-free interval. In PAAD, SPTBN2 can be used as an independent factor affecting prognosis. Mutations and amplification of SPTBN2 were detected, with abnormal methylation of SPTBN2 affecting its expression and the survival outcome of PAAD patients. Immunoassay results demonstrate that SPTBN2 was a potential biomarker for predicting therapeutic response in PAAD, and may influence the immunotherapy efficacy of PAAD by regulating levels of CD8 + T cells and neutrophil infiltration. Results from an enrichment analysis indicated that SPTBN2 may regulate the development of PAAD via immune pathways. Thus, SPTBN2 is a potential prognostic biomarker and immunotherapy target based on its crucial role in the development of PAAD.
    MeSH term(s) Humans ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Prognosis ; Gene Expression Regulation, Neoplastic ; Spectrin/metabolism ; Spectrin/genetics ; Male ; Female ; Mutation ; DNA Methylation ; Multiomics
    Chemical Substances Biomarkers, Tumor ; Spectrin (12634-43-4)
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60780-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Circulating miR-129-3p in combination with clinical factors predicts vascular calcification in hemodialysis patients.

    Jin, Jingjing / Cheng, Meijuan / Wu, Xueying / Zhang, Haixia / Zhang, Dongxue / Liang, Xiangnan / Qian, Yuetong / Guo, Liping / Zhang, Shenglei / Bai, Yaling / Xu, Jinsheng

    Clinical kidney journal

    2024  Volume 17, Issue 3, Page(s) sfae038

    Abstract: Background: Vascular calcification (VC) commonly occurs and seriously increases the risk of cardiovascular events and mortality in patients with hemodialysis. For optimizing individual management, we will develop a diagnostic multivariable prediction ... ...

    Abstract Background: Vascular calcification (VC) commonly occurs and seriously increases the risk of cardiovascular events and mortality in patients with hemodialysis. For optimizing individual management, we will develop a diagnostic multivariable prediction model for evaluating the probability of VC.
    Methods: The study was conducted in four steps. First, identification of miRNAs regulating osteogenic differentiation of vascular smooth muscle cells (VSMCs) in calcified condition. Second, observing the role of miR-129-3p on VC
    Results: In cell experiments, miR-129-3p was found to attenuate vascular calcification, and in human, serum miR-129-3p exhibited a negative correlation with vascular calcification, suggesting that miR-129-3p could be one of the candidate predictor variables. Regression analysis demonstrated that miR-129-3p, age, dialysis duration and smoking were valid factors to establish the prediction model and nomogram for VC. The area under receiver operating characteristic curve of the model was 0.8698. The calibration curve showed that predicted probability of the model was in good agreement with actual probability and decision curve analysis indicated better net benefit of the model. Furthermore, internal validation through bootstrap process and external validation by another independent cohort confirmed the stability of the model.
    Conclusion: We build a diagnostic prediction model and present it as an intuitive tool based on miR-129-3p and clinical indicators to evaluate the probability of VC in hemodialysis patients, facilitating risk stratification and effective decision, which may be of great importance for reducing the risk of serious cardiovascular events.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfae038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6587: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article: [Three-dimensional Medical Electronic Laparoscope System].

    Cao, Lun / Mao, Haoyang / Liang, Xiangnan / He, Yuyuan / Zhu, Xiang / Mao, LiangLiang / Shao, Hui / He, Chao

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2019  Volume 43, Issue 1, Page(s) 14–16

    Abstract: This paper presents a three-dimensional electronic laparoscopy system, including three-dimensional laparoscope pipe and medical video system. The three-dimensional laparoscope pipe adopts a dual-optical structure, which can collect three-dimensional ... ...

    Abstract This paper presents a three-dimensional electronic laparoscopy system, including three-dimensional laparoscope pipe and medical video system. The three-dimensional laparoscope pipe adopts a dual-optical structure, which can collect three-dimensional information of the surgical region. By selecting a reasonable initial structure, the MTF curve of the objective lens is close to the diffraction limit, and the distortion is less than 25%. The medical video system also achieved high-definition image with 1 080 P, 30 Hz by GPU. At the mean time, the three-dimensional electronic laparoscope has achieved quantitative production and has been tested in a number of animals, which has broad application prospects and significant clinical application value.
    MeSH term(s) Electronics, Medical ; Imaging, Three-Dimensional ; Laparoscopes ; Laparoscopy
    Language Chinese
    Publishing date 2019-02-15
    Publishing country China
    Document type Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    DOI 10.3969/j.issn.1671-7104.2019.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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