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Article ; Online: Finite-horizon optimal secure tracking control under denial-of-service attacks.

Wang, Jian / Wang, Wei / Liang, Xiaofeng

2024

Abstract: The finite-horizon optimal secure tracking control (FHOSTC) problem for cyber-physical systems under actuator denial-of-service (DoS) attacks is addressed in this paper. A model-free method based on the Q-function is designed to achieve FHOSTC without ... ...

Abstract	The finite-horizon optimal secure tracking control (FHOSTC) problem for cyber-physical systems under actuator denial-of-service (DoS) attacks is addressed in this paper. A model-free method based on the Q-function is designed to achieve FHOSTC without the system model information. First, an augmented time-varying Riccati equation (TVRE) is derived by integrating the system with the reference system into a unified augmented system. Then, a lower bound on malicious DoS attacks probability that guarantees the solutions of the TVRE is provided. Third, a Q-function that changes over time (time-varying Q-function, TVQF) is devised. A TVQF-based method is then proposed to solve the TVRE without the need for the knowledge of the augmented system dynamics. The developed method works backward-in-time and uses the least-squares method. To validate the performance and features of the developed method, simulation studies are conducted in the end.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012746-7
ISSN	1879-2022 ; 0019-0578
ISSN (online)	1879-2022
ISSN	0019-0578
DOI	10.1016/j.isatra.2024.04.025
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Article ; Online: Less‐Well‐Developed Crustal Channel‐Flow in the Central Tibetan Plateau Revealed by Receiver Function and Surface Wave Joint Inversion

Nie, Shitan / Tian, Xiaobo / Liang, Xiaofeng / Wan, Bo

Journal of Geophysical Research: Solid Earth. 2023 Apr., v. 128, no. 4 p.e2022JB025747-

2023

Abstract: A crustal channel‐flow model has been previously used to explain the formation of crustal extensional structures in the Tibetan Plateau. However, the existence of massive crustal channel‐flow in the central plateau is still controversial. To reveal the ... ...

Abstract	A crustal channel‐flow model has been previously used to explain the formation of crustal extensional structures in the Tibetan Plateau. However, the existence of massive crustal channel‐flow in the central plateau is still controversial. To reveal the crustal S‐wave velocity structure with high vertical resolution, we conducted a joint inversion of receiver functions and surface wave dispersions from the 2‐D broadband seismic array SANDWICH deployed in the central plateau. Our results show a low‐velocity layer (LVL) in the middle‐lower crust beneath all stations. The minimum S‐wave velocity in each LVL is mostly within 3.0–3.4 km/s, which result in the maximum velocity reductions are less than 17.5%. It deduces a melt volume percentage (MVP) less than 7% even attributing all velocity reduction to partial melting of rocks. Our study suggests that there is not a high enough melt volume in central Tibet to develop crustal channel‐flow, which requires a larger MVP to decrease rock strength more than an order of magnitude. The formation of extensional structures in the central plateau may contribute to ductile deformation in the middle‐lower crust but not crustal channel‐flow.
Keywords	deformation ; geophysics ; models ; research ; China
Language	English
Dates of publication	2023-04
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ISSN	2169-9313
DOI	10.1029/2022JB025747
Database	NAL-Catalogue (AGRICOLA)

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Book: Zhongguo man xing bing yu fang kong zhi neng li diao cha bao gao

Liang, Xiaofeng

2011

2016

Author's details	Liang Xiaofeng, Shi Xiaoming zhu bian
MeSH term(s)	Chronic Disease/prevention & control ; Chronic Disease/epidemiology ; Health Surveys ; Health Policy
Keywords	China
Language	Chinese
Size	10, 13, 140 pages :, illustrations
Edition	Di 1 ban.
Document type	Book
Note	In Chinese; summary also in English.
ISBN	9787567903098 ; 7567903091
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: [Promotion and application on the injury prevention strategy research in China].

Liang, Xiaofeng

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2015 Volume 36, Issue 1, Page(s) 1–2

MeSH term(s)	China ; Humans ; Research ; Wounds and Injuries/prevention & control
Language	Chinese
Publishing date	2015-01
Publishing country	China
Document type	Editorial
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
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Article ; Online: Multilayer factors associated with excess all-cause mortality during the omicron and non-omicron waves of the COVID-19 pandemic: time series analysis in 29 countries.

Zou, Fengjuan / Xiao, Jianpeng / Jin, Yingying / Jian, Ronghua / Hu, Yijun / Liang, Xiaofeng / Ma, Wenjun / Zhu, Sui

BMC public health

2024 Volume 24, Issue 1, Page(s) 350

Abstract: Background: The COVID-19 pandemic has resulted in significant excess mortality globally. However, the differences in excess mortality between the Omicron and non-Omicron waves, as well as the contribution of local epidemiological characteristics, ... ...

Abstract	Background: The COVID-19 pandemic has resulted in significant excess mortality globally. However, the differences in excess mortality between the Omicron and non-Omicron waves, as well as the contribution of local epidemiological characteristics, population immunity, and social factors to excess mortality, remain poorly understood. This study aims to solve the above problems. Methods: Weekly all-cause death data and covariates from 29 countries for the period 2015-2022 were collected and used. The Bayesian Structured Time Series Model predicted expected weekly deaths, stratified by gender and age groups for the period 2020-2022. The quantile-based g-computation approach accounted for the effects of factors on the excess all-cause mortality rate. Sensitivity analyses were conducted using alternative Omicron proportion thresholds. Results: From the first week of 2021 to the 30th week of 2022, the estimated cumulative number of excess deaths due to COVID-19 globally was nearly 1.39 million. The estimated weekly excess all-cause mortality rate in the 29 countries was approximately 2.17 per 100,000 (95% CI: 1.47 to 2.86). Weekly all-cause excess mortality rates were significantly higher in both male and female groups and all age groups during the non-Omicron wave, except for those younger than 15 years (P < 0.001). Sensitivity analysis confirmed the stability of the results. Positive associations with all-cause excess mortality were found for the constituent ratio of non-Omicron in all variants, new cases per million, positive rate, cardiovascular death rate, people fully vaccinated per hundred, extreme poverty, hospital patients per million humans, people vaccinated per hundred, and stringency index. Conversely, other factors demonstrated negative associations with all-cause excess mortality from the first week of 2021 to the 30th week of 2022. Conclusion: Our findings indicate that the COVID-19 Omicron wave was associated with lower excess mortality compared to the non-Omicron wave. This study's analysis of the factors influencing excess deaths suggests that effective strategies to mitigate all-cause mortality include improving economic conditions, promoting widespread vaccination, and enhancing overall population health. Implementing these measures could significantly reduce the burden of COVID-19, facilitate coexistence with the virus, and potentially contribute to its elimination.
MeSH term(s)	Humans ; Female ; Male ; Adolescent ; COVID-19 ; Bayes Theorem ; Pandemics ; Time Factors ; Research Design ; Mortality
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-17803-8
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Article ; Online: Integrated analysis and clinical correlation analysis of hub genes, immune infiltration, and potential therapeutic agents related to lupus nephritis.

Lin, Weiyi / Lin, Zien / Lin, Xiaobing / Peng, Zhishen / Liang, Xiaofeng / Wei, Shanshan

Lupus

2023 Volume 32, Issue 5, Page(s) 633–643

Abstract: Background: Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). This study aimed to explore biomarkers, mechanisms, and potential novel agents regarding LN through bioinformatic analysis.: Method: Four ... ...

Abstract	Background: Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). This study aimed to explore biomarkers, mechanisms, and potential novel agents regarding LN through bioinformatic analysis. Method: Four expression profiles were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were acquired. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGGs) pathway enrichment analyses of DEGs were performed using the R software. The protein-protein interaction (PPI) network was developed using the STRING database. Additionally, five algorithms were used to screen out the hub genes. Expression of the hub genes were validated using Nephroseq v5. CIBERSORT was used to evaluate the infiltration of immune cells. Finally, The Drug-Gene Interaction Database was used to predict potential targeted drugs. Result: FOS and IGF1 were identified as hub genes, with excellent specificity and sensitivity diagnosis of LN. FOS was also related to renal injury. LN patients had lower activated and resting dendritic cells (DCs) and higher M1 macrophages and activated NK cells than healthy control (HC). FOS had a positive correlation with activated mast cells and a negative correlation with resting mast cells. IGF1 had a positive correlation with activated DCs and a negative correlation with monocytes. The targeted drugs were dusigitumab and xentuzumab target for IGF1. Conclusion: We analyzed the transcriptomic signature of LN along with the landscape of the immune cell. FOS and IGF1 are promising biomarkers for diagnosing and evaluating the progression of LN. The drug-gene interaction analyses provide a list of candidate drugs for the precise treatment of LN.
MeSH term(s)	Humans ; Lupus Nephritis ; Lupus Erythematosus, Systemic ; Algorithms ; Computational Biology ; Databases, Factual
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/09612033231161587
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Article ; Online: Failure mechanical properties of lumbar intervertebral disc under high loading rate.

Liu, Qing / Liang, Xiao-Feng / Wang, Ai-Guo / Liu, Ying / Jia, Tong-Ju / Li, Kun / Zhang, Chun-Qiu

Journal of orthopaedic surgery and research

2024 Volume 19, Issue 1, Page(s) 15

Abstract: Background: Lumbar disc herniation (LDH) is the main clinical cause of low back pain. The pathogenesis of lumbar disc herniation is still uncertain, while it is often accompanied by disc rupture. In order to explore relationship between loading rate and ...

Abstract	Background: Lumbar disc herniation (LDH) is the main clinical cause of low back pain. The pathogenesis of lumbar disc herniation is still uncertain, while it is often accompanied by disc rupture. In order to explore relationship between loading rate and failure mechanics that may lead to lumbar disc herniation, the failure mechanical properties of the intervertebral disc under high rates of loading were analyzed. Method: Bend the lumbar motion segment of a healthy sheep by 5° and compress it to the ultimate strength point at a strain rate of 0.008/s, making a damaged sample. Within the normal strain range, the sample is subjected to quasi-static loading and high loading rate at different strain rates. Results: For healthy samples, the stress-strain curve appears collapsed only at high rates of compression; for damaged samples, the stress-strain curves collapse both at quasi-static and high-rate compression. For damaged samples, the strengthening stage becomes significantly shorter as the strain rate increases, indicating that its ability to prevent the destruction is significantly reduced. For damaged intervertebral disc, when subjected to quasi-static or high rates loading until failure, the phenomenon of nucleus pulposus (NP) prolapse occurs, indicating the occurrence of herniation. When subjected to quasi-static loading, the AF moves away from the NP, and inner AF has the greatest displacement; when subjected to high rates loading, the AF moves closer to the NP, and outer AF has the greatest displacement. The Zhu-Wang-Tang (ZWT) nonlinear viscoelastic constitutive model was used to describe the mechanical behavior of the intervertebral disc, and the fitting results were in good agreement with the experimental curve. Conclusion: Experimental results show that, both damage and strain rate have a significant effect on the mechanical behavior of the disc fracture. The research work in this article has important theoretical guiding significance for preventing LDH in daily life.
MeSH term(s)	Animals ; Sheep ; Intervertebral Disc Displacement/pathology ; Lumbar Vertebrae/pathology ; Weight-Bearing ; Biomechanical Phenomena ; Stress, Mechanical ; Intervertebral Disc/pathology
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-023-04424-x
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Article ; Online: Genes associated with cellular senescence favor melanoma prognosis by stimulating immune responses in tumor microenvironment.

Liang, Xiaofeng / Lin, Xiaobing / Lin, Zien / Lin, Weiyi / Peng, Zhishen / Wei, Shanshan

Computers in biology and medicine

2023 Volume 158, Page(s) 106850

Abstract: Purpose: Skin cutaneous melanoma (SKCM), a malignant tumor from melanocytes, is the fifth most prevalent tumor. Immune checkpoint inhibitor (ICI) immunotherapy improves prognosis of SKCM, but immune response varies for different populations. Cellular ... ...

Abstract	Purpose: Skin cutaneous melanoma (SKCM), a malignant tumor from melanocytes, is the fifth most prevalent tumor. Immune checkpoint inhibitor (ICI) immunotherapy improves prognosis of SKCM, but immune response varies for different populations. Cellular senescence in the tumor microenvironment (TME) promotes antitumor immunity, mediated by dendritic cells (DC) and CD8 Methods: First, we obtained 93 cellular senescence-prognosis genes (CSPGs) by univariate survival analysis. Thereafter, 23 optimal CSPGs were obtained by least absolute shrinkage and selection operator (lasso) analysis. Based on the riskscore obtained by lasso analysis and clinical information from multivariate cox, we obtained the nomogram of SKCM, which was validated in the validation cohort. Based on the riskscore, the patients were split into low- and high-risk groups. Functional differences between the two groups were analyzed using Metascape and GSEA, and immune infiltration differences were achieved by multiple algorithms. We obtained a risk prediction nomogram for the validated SKCM based on the lasso model by univariate and multivariate cox regression analysis. Results: In the low-risk group, immune responses were in an active state. NK, CD8 Conclusion: Genes associated with cellular senescence favor SKCM prognosis by stimulating immune responses in TME. Patients with high expression of cellular senescence associated genes in the TME might have better benefit from ICI immunotherapy. Cellular senescence functions as a pro-tumor agent in mesenchymal cells and needs further study.
MeSH term(s)	Humans ; Cellular Senescence/genetics ; Immunity/genetics ; Melanoma/genetics ; Melanoma/immunology ; Melanoma/therapy ; Prognosis ; Skin Neoplasms/genetics ; Skin Neoplasms/immunology ; Skin Neoplasms/therapy ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Immunotherapy ; Immune Checkpoint Inhibitors/therapeutic use ; Melanoma, Cutaneous Malignant
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2023.106850
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Article ; Online: Roll-out of vaccination against COVID-19 pandemic.

Liang, Xiao-Feng / He, Guan-Hao / Ma, Wen-Jun / Xiao, Jian-Peng

Infectious diseases of poverty

2021 Volume 10, Issue 1, Page(s) 125

MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Humans ; Mass Vaccination/organization & administration ; Pandemics/prevention & control
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-10-18
Publishing country	England
Document type	Letter
ZDB-ID	2689396-4
ISSN	2049-9957 ; 2049-9957
ISSN (online)	2049-9957
ISSN	2049-9957
DOI	10.1186/s40249-021-00902-8
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Article ; Online: Change in adverse event reporting following immunization of hepatitis B vaccine among infants between 2013 to 2020 before and after the vaccine administration law in China.

Wang, Chao / Huang, Ninghua / Lu, Qing-Bin / Black, Steven / Liang, Xiaofeng / Cui, Fuqiang

Frontiers in immunology

2022 Volume 13, Page(s) 956473

Abstract: Background: Hepatitis B vaccine (HepB) has been routinely recommended as part of the immunization program in China and has had a satisfactory safety and effectiveness profile in protecting infants from hepatitis B virus infection. We evaluated the ... ...

Abstract	Background: Hepatitis B vaccine (HepB) has been routinely recommended as part of the immunization program in China and has had a satisfactory safety and effectiveness profile in protecting infants from hepatitis B virus infection. We evaluated the surveillance sensitivity and changes over time of AEFI reports related to HepB among infants based on the consistent national data before and after the introduction of vaccine administration law (LAW) from 2013 to 2020 in China. Methods: AEFI records were extracted from the Chinese National AEFI Surveillance System from 2013 to 2020. According to the proportion of different kinds of HepB vaccines distributed, the annual administration data of the most distributed HepB produced by Bio-Kangtai and its corresponding adverse reaction reports were collected and analyzed. We categorized the time interval into the pre-LAW period (2013 to 2017), transition period (2018 to 2019), and LAW period (2020) to demonstrate the impact of LAW on the surveillance patterns of AEFIs. Results: The annual AEFI rates increased from 3.1/100,000 to 14.8/100,000 over this period in total. The rate ratio for the post-LAW period and pre-LAW period was 2.19 (95%CI: 2.10, 2.29). Common reactions occupied 87.6% of the total reported AEFIs whose rate was recorded as 7.9/100,000. Rare reactions occupied 9.1% of the total AEFIs showing an average rate of 0.8/100,000, of which anaphylaxis accounted for over 80%, with the rate ratio of the transition period and LAW period as 1.36 (95%CI:1.22, 1.52) and 1.14 (95%CI:0.95, 1.35), respectively. Children receiving more than one vaccine showed a higher proportion of fever, anaphylaxis, and febrile convulsions, which were suggested to be a result of vaccine co-administration vaccines, such as the DPT and Polio vaccine. Conclusion: Most reactions were mild and self-limited and the rates of rare more serious events remained stable. The LAW has largely increased the surveillance capability and sensitivity on AEFIs of HepB and also contributes to enhancing public confidence in HepB immunization. Hepatitis B vaccination is a safe and effective means of preventing the complications of hepatitis B disease and continuous standardized AEFI investigation and assessment of causal association should be maintained.
MeSH term(s)	Adverse Drug Reaction Reporting Systems ; Anaphylaxis/chemically induced ; Anaphylaxis/etiology ; Child ; China/epidemiology ; Hepatitis B/epidemiology ; Hepatitis B/prevention & control ; Hepatitis B Vaccines ; Humans ; Immunization/adverse effects ; Infant ; Phenylbutyrates ; Vaccination/adverse effects
Chemical Substances	Hepatitis B Vaccines ; Phenylbutyrates ; gamma-hydroxy-gamma-ethyl-gamma-phenylbutyramide (67880-30-2)
Language	English
Publishing date	2022-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.956473
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