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  1. Book ; Thesis: Expression of Hepatitis B surface antigen in vivo and in vitro induces endoplasmic reticulum stress, impairs autophagic flux and promotes proliferation

    Liang, Yaojie / Bröring, Ruth

    2022  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Yaojie Liang. Gutachter/in: 1. Frau Priv.-Doz. Dr. rer. nat. R. Bröring, 2. Frau Priv.-Doz. Dr. rer. nat. K. Sutter
    Language English
    Size 75 Blätter, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2022
    HBZ-ID HT021471173
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Chemical compound identification and antibacterial activity evaluation of cinnamon extracts obtained by subcritical n‐butane and ethanol extraction

    Liang, Ying

    Food Science & Nutrition, 7(6):2186-2193

    2019  

    Abstract: Four important Cinnamomum species in China including C. cassia, C. loureiroi, C. wilsonii, and C. burmannii were chosen to be extracted by subcritical n‐butane and ethanol. The chemical compounds of extracts were identified by GC‐MS and HPLC‐MS, and the ... ...

    Abstract Four important Cinnamomum species in China including C. cassia, C. loureiroi, C. wilsonii, and C. burmannii were chosen to be extracted by subcritical n‐butane and ethanol. The chemical compounds of extracts were identified by GC‐MS and HPLC‐MS, and the antibacterial activities were evaluated by agar‐well diffusion assay and twofold microdilution broth method. There were 47 compounds identified in n‐butane extracts and 11 compounds in ethanol extracts totally. The major compounds in n‐butane extracts varied significantly among different Cinnamomum species, and (E)‐cinnamaldehyde and coumarin were major compounds for C. cassia with area percentage of 74.32%; (E)‐cinnamaldehyde and α‐copaene for C. loureiroi with area percentage of 67.83%; linalool, (E)‐cinnamaldehyde, and citral for C. wilsonii with area percentage of 58.74%; and eugenol, (E)‐cinnamaldehyde, and coumarin for C. burmannii with area percentage of 76.43%. The maximum compounds in ethanol extracts were (E)‐cinnamaldehyde and (Z)‐cinnamaldehyde, and others varied among the Cinnamomum species. All cinnamon extracts showed antibacterial activities that n‐butane extracts were much more sensitive than ethanol extracts. The inhibition zone for N‐butane extracts against Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Salmonella anatum was from 18.98 to 37.45 mm while for ethanol extracts from 7.11 to 10.11 mm. The minimum bactericidal concentrations for n‐butane extracts were ranged from 0.31 to 2.50 mg/ml and for ethanol extracts ranged from 20.00 to 160.00 mg/ml. N‐butane extracts of C. cassia and C. loureiroi processed much higher antibacterial activities than C. wilsonii and C. burmannii. N‐butane extracts of C. cassia and C. loureiroi have the potential to be used as food biopreservative.
    Keywords GC‐MS ; HPLC‐MS ; cinnamon ; antibacterial activity ; subcritical extraction
    Language English
    Document type Article
    Database Repository for Life Sciences

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  3. Article ; Online: Life course socioeconomic status, chronic pain, and the mediating role of allostatic load: findings from the midlife in the United States.

    Liang, Yunlong

    Frontiers in public health

    2024  Volume 12, Page(s) 1365105

    Abstract: Introduction: Low socioeconomic status (SES) has been linked to chronic pain (CP); however, the mechanisms by which SES over the life course influences downstream CP outcomes remain unclear.: Methods: This study utilizes data from the Midlife in the ... ...

    Abstract Introduction: Low socioeconomic status (SES) has been linked to chronic pain (CP); however, the mechanisms by which SES over the life course influences downstream CP outcomes remain unclear.
    Methods: This study utilizes data from the Midlife in the United States (MIDUS) survey, a prospective sample of community-dwelling individuals (
    Results: Results indicated lower SES in MIDUS 2 was associated with greater high-interference CP odds in MIDUS 3 (OR=1.069, 95% CI=1.006-1.136,
    Discussion: The present study emphasizes the importance of directly proximal effects of SES on CP, underscoring the need for equitable distribution of health resources and the implementation of policies focused on diminishing socioeconomic inequalities. Further research is needed to examine alternative pathways by which proximal SES impact CP.
    MeSH term(s) Humans ; United States ; Allostasis ; Chronic Pain ; Life Change Events ; Prospective Studies ; Social Class
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1365105
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  4. Article ; Online: Attachment Anxiety and Nomophobia: A Moderated Parallel Mediation Model.

    Liang, Yuan

    Psychological reports

    2024  , Page(s) 332941241226907

    Abstract: ... ...

    Abstract Nomophobia
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205658-6
    ISSN 1558-691X ; 0033-2941
    ISSN (online) 1558-691X
    ISSN 0033-2941
    DOI 10.1177/00332941241226907
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  5. Article ; Online: Technology diplomacy in early Communist China: the visit to the Jingjiang Flood Diversion Project in 1952.

    Liang, Yue

    British journal for the history of science

    2024  , Page(s) 1–13

    Abstract: This article focuses on the 1952 visit to the Jingjiang Flood Diversion Project, the first large-scale water infrastructure built on the Yangzi river after the founding of the People's Republic of China, by a foreign delegation from the Asia-Pacific ... ...

    Abstract This article focuses on the 1952 visit to the Jingjiang Flood Diversion Project, the first large-scale water infrastructure built on the Yangzi river after the founding of the People's Republic of China, by a foreign delegation from the Asia-Pacific Peace Conference. Serving as a form of technology diplomacy, this trip advanced two main purposes for the newly established country - to build up closer ties with 'foreign friends' who advocated international peace in the context of the Korean War, and to demonstrate China's own technical capabilities and achievements as part of the national campaign of 'peaceful construction' of the early 1950s. I argue that vernacular technologies, which were grounded in indigenous knowledge and practices for water control in the mid-Yangzi region, were essential in shaping China's self-reliant modernization and China's public diplomacy, which targeted individuals without scientific or technical backgrounds.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2017943-1
    ISSN 1474-001X ; 0007-0874
    ISSN (online) 1474-001X
    ISSN 0007-0874
    DOI 10.1017/S0007087424000463
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  6. Article ; Online: The mediating effect of allostatic load on the association between life course socioeconomic disadvantage and chronic pain: a prospective finding from the National Survey of Midlife Development in the United States.

    Liang, Yunlong

    Frontiers in pain research (Lausanne, Switzerland)

    2023  Volume 4, Page(s) 1213750

    Abstract: Background: Socioeconomic disadvantages (SEDs) are associated with chronic pain (CP) and allostatic load (AL). Few prospective population-based studies have examined the relationship between life course SED, CP interference, and CP widespreadness, and ... ...

    Abstract Background: Socioeconomic disadvantages (SEDs) are associated with chronic pain (CP) and allostatic load (AL). Few prospective population-based studies have examined the relationship between life course SED, CP interference, and CP widespreadness, and there is no prospective population-based study on whether AL mediates the association between SED and CP.
    Objective: In this study, we investigated whether the prospective effect of SED on CP at Midlife in the United States (MIDUS) 3 is consistent with the accumulation of risk model and social mobility model, using the National Survey of MIDUS (
    Method: SED was measured using cumulative scores and disadvantage trajectories derived from latent class trajectory modeling (LCTM). After multiple imputations, analyses were conducted using multinomial logistic regression for CP and negative binomial regression for AL, respectively. Finally, mediation analyses and moderated mediation analyses were performed.
    Results: LCTM identified three SED trajectories, namely, constant low, high to low, and medium to high. The results showed that proximal cumulative SED was associated with high-interference CP. Furthermore, compared with the group with constant low SED, the group with medium-to-high SED was significantly associated with high-interference pain and experienced pain in at least three different sites. Cumulative SED and deteriorating SED trajectories were associated with higher AL, consistent with previous studies. Furthermore, childhood SED moderated the effect of AL on CP widespreadness and unexpectedly demonstrated a protective effect, while other associations between AL and CP were not significant. Subsequent mediation analysis did not yield statistically significant evidence.
    Conclusions: People who experienced more recent SED or increasing disadvantage throughout their lives were more likely to suffer from CP, and this association was not mediated by physiological system dysregulation caused by chronic stress. Therefore, measures to alleviate AL may not be effective in protecting socioeconomically disadvantaged populations from CP.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-561X
    ISSN (online) 2673-561X
    DOI 10.3389/fpain.2023.1213750
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  7. Article ; Online: Pathogenicity and virulence of influenza.

    Liang, Yuying

    Virulence

    2023  Volume 14, Issue 1, Page(s) 2223057

    Abstract: Influenza viruses, including four major types (A, B, C, and D), can cause mild-to-severe and lethal diseases in humans and animals. Influenza viruses evolve rapidly through antigenic drift (mutation) and shift (reassortment of the segmented viral genome). ...

    Abstract Influenza viruses, including four major types (A, B, C, and D), can cause mild-to-severe and lethal diseases in humans and animals. Influenza viruses evolve rapidly through antigenic drift (mutation) and shift (reassortment of the segmented viral genome). New variants, strains, and subtypes have emerged frequently, causing epidemic, zoonotic, and pandemic infections, despite currently available vaccines and antiviral drugs. In recent years, avian influenza viruses, such as H5 and H7 subtypes, have caused hundreds to thousands of zoonotic infections in humans with high case fatality rates. The likelihood of these animal influenza viruses acquiring airborne transmission in humans through viral evolution poses great concern for the next pandemic. Severe influenza viral disease is caused by both direct viral cytopathic effects and exacerbated host immune response against high viral loads. Studies have identified various mutations in viral genes that increase viral replication and transmission, alter tissue tropism or species specificity, and evade antivirals or pre-existing immunity. Significant progress has also been made in identifying and characterizing the host components that mediate antiviral responses, pro-viral functions, or immunopathogenesis following influenza viral infections. This review summarizes the current knowledge on viral determinants of influenza virulence and pathogenicity, protective and immunopathogenic aspects of host innate and adaptive immune responses, and antiviral and pro-viral roles of host factors and cellular signalling pathways. Understanding the molecular mechanisms of viral virulence factors and virus-host interactions is critical for the development of preventive and therapeutic measures against influenza diseases.
    MeSH term(s) Humans ; Animals ; Influenza, Human ; Virulence ; Orthomyxoviridae Infections ; Influenza A virus ; Orthomyxoviridae ; Influenza Vaccines ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Virus Replication ; Influenza in Birds
    Chemical Substances Influenza Vaccines ; Antiviral Agents
    Language English
    Publishing date 2023-01-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2023.2223057
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  8. Article ; Online: Phagophore-lysosome/vacuole fusion in mutant yeast and mammalian cells.

    Liang, Yongheng

    Autophagy

    2023  Volume 19, Issue 9, Page(s) 2595–2600

    Abstract: Macroautophagy/autophagy is a process through which the phagophores engulf non-essential or damaged cellular materials, forming double-membrane autophagosomes (APs) and fusing with lysosomes/vacuoles, after which the materials are degraded for recycling ... ...

    Abstract Macroautophagy/autophagy is a process through which the phagophores engulf non-essential or damaged cellular materials, forming double-membrane autophagosomes (APs) and fusing with lysosomes/vacuoles, after which the materials are degraded for recycling purposes. Autophagy is associated with increased cell survival under different stress conditions. AP-lysosome/vacuole fusion is a critical step in autophagy. Some mutant cells can accumulate phagophores under autophagy-induction conditions. Autophagy is interrupted when accumulated phagophores cannot fuse with lysosomes/vacuoles, resulting in a significant decrease in cell survivability. However, phagophore-lysosome/vacuole fusion has been reported in related mammalian cells and yeast mutant cells. This observation indicates that it is possible to restore a partial autophagy process after interruption. Furthermore, these findings indicate that phagophore closure is not a prerequisite for its fusion with the lysosome/vacuole in the mutant cells. The phagophore-lysosome/vacuole fusion strategy can significantly rescue defective autophagy due to failed phagophore closure. This commentary discusses the fusion of phagophores and lysosomes/vacuoles and implications of such fusion events.
    MeSH term(s) Animals ; Autophagosomes/metabolism ; Vacuoles/metabolism ; Saccharomyces cerevisiae/genetics ; Autophagy/genetics ; Lysosomes/metabolism ; Membrane Fusion ; Mammals
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2205272
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  9. Book ; Online: Ultrafast Dynamics of Metalloporphyrins, DNA and Iron-Lanthanide Clusters in the Liquid Phase

    Liang, Yu

    2013  

    Abstract: Ultraschnelle Dynamik von verschiedenen organischen und anorganischen molekularen Systemen wurde unter Verwendung der zeitaufgelöste Anregungs-Abfrage-Technik in Kombination mit anderen spektroskopischen Methoden untersucht. Diese Dynamik umfasst, z.B. ... ...

    Abstract Ultraschnelle Dynamik von verschiedenen organischen und anorganischen molekularen Systemen wurde unter Verwendung der zeitaufgelöste Anregungs-Abfrage-Technik in Kombination mit anderen spektroskopischen Methoden untersucht. Diese Dynamik umfasst, z.B. die Relaxationsprozesse in Metalloporphyrins, die Ladungstransfer zwischen Donor und Akzeptor durch DANN-Doppelhelix sowie die Dynamik von Ladungsträger in anorganischen nanostrukturierten zyklischen koordinierten Eisen-Lanthanoide Clustern
    Keywords Chemistry
    Size 1 electronic resource (XII, 159 p. p.)
    Publisher KIT Scientific Publishing
    Publishing place Verlagsort nicht ermittelbar
    Document type Book ; Online
    Note ENGLISH ; Open Access
    HBZ-ID HT020197333
    ISBN 9783866449992 ; 3866449992
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article: [The influencing factors on the spinal sagittal alignment and global balance status of degenerative thoracolumbar kyphosis].

    Ge, R L / Liang, Y / Xu, S

    Zhonghua yi xue za zhi

    2024  Volume 104, Issue 13, Page(s) 1036–1042

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Middle Aged ; Case-Control Studies ; Retrospective Studies ; Kyphosis ; Lordosis ; Lumbar Vertebrae ; Osteoporosis/complications
    Language Chinese
    Publishing date 2024-04-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20231027-00913
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