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  1. Article ; Online: A commentary on 'The efficacy and safety of low dialysate sodium levels for patients with maintenance hemodialysis: a systematic review and meta-analysis'.

    Liang, Yong / Xu, Guangbiao

    International journal of surgery (London, England)

    2024  Volume 110, Issue 3, Page(s) 1825–1826

    MeSH term(s) Humans ; Renal Dialysis ; Dialysis Solutions/adverse effects ; Sodium
    Chemical Substances Dialysis Solutions ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  2. Article ; Online: Impact of temperature and forward osmosis membrane properties on the concentration polarization and specific energy consumption of hybrid desalination system.

    Goi, Yi Ken / Liang, Yong Yeow

    Environmental science and pollution research international

    2024  

    Abstract: This study investigates how temperature and forward osmosis (FO) membrane properties, such as water permeability (A), solute permeability (B), and structural parameter (S), affect the specific energy consumption (SEC) of forward osmosis-reverse osmosis ... ...

    Abstract This study investigates how temperature and forward osmosis (FO) membrane properties, such as water permeability (A), solute permeability (B), and structural parameter (S), affect the specific energy consumption (SEC) of forward osmosis-reverse osmosis system. The results show that further SEC reduction beyond the water permeability of 3 LMH bar
    Language English
    Publishing date 2024-04-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-33319-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mitochondrial support and local translation of mitochondrial proteins in synaptic plasticity and function.

    Liang, YongTian

    Histology and histopathology

    2021  Volume 36, Issue 10, Page(s) 1007–1019

    Abstract: Complex neural and brain functions are executed through structural and functional alterations of synapses and neurons. Neuronal compartmentalization requires neurons to allocate mitochondria and proteins in a spatiotemporal manner to allow their ... ...

    Abstract Complex neural and brain functions are executed through structural and functional alterations of synapses and neurons. Neuronal compartmentalization requires neurons to allocate mitochondria and proteins in a spatiotemporal manner to allow their plasticity, function and homeostasis. Importantly, mitochondria are known to interact with and modulate synaptic activities through their ATP supply, calcium buffering and signaling abilities. Over the years, mitochondrial support and local translation (including mitochondrial proteins) at neuronal sub-compartments and their synaptic specializations have been considered critical for maintaining synaptic plasticity and function. Recently, evidence has shown that late endosomes can serve as sites for local translation of mRNAs crucial for mitochondrial integrity and mitochondrial compartments can fuel plasticity-induced local translation. Indeed, failed mitochondrial homeostasis and subsequent synaptic dysfunction are often intricately linked in the malfunction of the central nervous system in synaptic aging and diseases. In this review, I will discuss the critical role of local translation (including mitochondrial proteins) in dendrites, axons and synapses on neuronal/synaptic plasticity and function.
    MeSH term(s) Animals ; Brain/physiology ; Humans ; Mitochondria/physiology ; Mitochondrial Proteins/metabolism ; Mitochondrial Proteins/physiology ; Neuronal Plasticity/physiology ; Protein Biosynthesis ; Synapses/physiology
    Chemical Substances Mitochondrial Proteins
    Language English
    Publishing date 2021-05-25
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 83911-5
    ISSN 1699-5848 ; 0213-3911
    ISSN (online) 1699-5848
    ISSN 0213-3911
    DOI 10.14670/HH-18-345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3013: Show issues Location:
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  4. Article ; Online: LIGHTing CAR T in the tumor microenvironment.

    Liang, Yong / Fu, Yang-Xin

    Molecular therapy : the journal of the American Society of Gene Therapy

    2023  Volume 31, Issue 9, Page(s) 2570–2571

    MeSH term(s) Receptors, Chimeric Antigen/genetics ; Tumor Microenvironment
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2023.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5640: Show issues Location:
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  5. Article ; Online: MUMA: a multi-omics meta-learning algorithm for data interpretation and classification.

    Huang, Hai-Hui / Shu, Jun / Liang, Yong

    IEEE journal of biomedical and health informatics

    2024  Volume PP

    Abstract: Multi-omics data integration is a promising field combining various types of omics data, such as genomics, transcriptomics, and proteomics, to comprehensively understand the molecular mechanisms underlying life and disease. However, the inherent noise, ... ...

    Abstract Multi-omics data integration is a promising field combining various types of omics data, such as genomics, transcriptomics, and proteomics, to comprehensively understand the molecular mechanisms underlying life and disease. However, the inherent noise, heterogeneity, and high dimensionality of multi-omics data present challenges for existing methods to extract meaningful biological information without overfitting. This paper introduces a novel Multi-Omics Meta-learning Algorithm (MUMA) that employs self-adaptive sample weighting and interaction-based regularization for enhanced diagnostic performance and interpretability in multi-omics data analysis. Specifically, MUMA captures crucial biological processes across different omics layers by learning a flexible sample reweighting function adaptable to various noise scenarios. Additionally, MUMA incorporates an interaction-based regularization term, encouraging the model to learn from the relationships among different omics modalities. We evaluate MUMA using simulations and eighteen real datasets, demonstrating its superior performance compared to state-of-the-art methods in classifying biological samples (e.g., cancer subtypes) and selecting relevant biomarkers from noisy multi-omics data. As a powerful tool for multi-omics data integration, MUMA can assist researchers in achieving a deeper understanding of the biological systems involved. The source code for MUMA is available at https://github.com/bio-ai-source/MUMA.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2695320-1
    ISSN 2168-2208 ; 2168-2194
    ISSN (online) 2168-2208
    ISSN 2168-2194
    DOI 10.1109/JBHI.2024.3363081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5483: Show issues Location:
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  6. Article ; Online: Differentially Private Consensus for Second-Order Multiagent Systems With Quantized Communication.

    Zhang, Wenjun / Wang, Bing-Chang / Liang, Yong

    IEEE transactions on neural networks and learning systems

    2024  Volume 35, Issue 4, Page(s) 5523–5535

    Abstract: This article considers the differentially private consensus problem of discrete-time second-order multiagent systems with partially measurable states and limited communication channel capacity, where only the integer-value information of agents can be ... ...

    Abstract This article considers the differentially private consensus problem of discrete-time second-order multiagent systems with partially measurable states and limited communication channel capacity, where only the integer-value information of agents can be transmitted. To reduce the potential risk of state information disclosure in digital communication, a differentially private consensus algorithm via dynamic encoding-decoding is proposed for the second-order multiagent system to make agents achieve mean-square consensus by transmitting quantized integer values with privacy protection. To deal with the uncertainty of the quantizer saturation, the statistical analysis is given for the boundedness of the input of quantizers. It is shown that the expectation of the minimum memory capacity of quantizers is 2 bits. Finally, some simulation results are given to visualize our conclusions.
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3207470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Botrytis cinerea transglycosylase BcCrh4 is a cell death‐inducing protein with cell death‐promoting and ‐suppressing domains

    Liang, Yong / Bi, Kai / Sharon, Amir

    Plant, Cell & Environment. 2024 Jan., v. 47, no. 1 p.354-371

    2024  

    Abstract: Botrytis cinerea is a necrotrophic fungal plant pathogen that causes grey mould and rot diseases in many crops. Here, we show that the B. cinerea BcCrh4 transglycosylase is secreted during plant infection and induces plant cell death and pattern‐ ... ...

    Abstract Botrytis cinerea is a necrotrophic fungal plant pathogen that causes grey mould and rot diseases in many crops. Here, we show that the B. cinerea BcCrh4 transglycosylase is secreted during plant infection and induces plant cell death and pattern‐triggered immunity (PTI), fulfilling the characteristics of a cell death‐inducing protein (CDIP). The CDIP activity of BcCrh4 is independent of the transglycosylase enzymatic activity, it takes place in the apoplast and does not involve the receptor‐like kinases BAK1 and SOBIR1. During saprophytic growth, BcCrh4 is localized in the endoplasmic reticulum and in vacuoles, but during plant infection, it accumulates in infection cushions (ICs) and is then secreted to the apoplast. Two domains within the BcCrh4 protein determine the CDIP activities: a 20aa domain at the N′ end activates intense cell death and PTI, while a stretch of 52aa in the middle of the protein induces a weaker response and suppresses the activity of the 20aa N′ domain. Deletion of bccrh4 affected fungal development and IC formation in particular, resulting in reduced virulence. Collectively, our findings demonstrate that BcCrh4 is required for fungal development and pathogenicity, and hint at a dual mechanism that balances the virulence activity of this, and potentially other CDIPs.
    Keywords Botrytis cinerea ; apoplast ; cell death ; endoplasmic reticulum ; environment ; enzyme activity ; gray mold ; immunity ; phosphotransferases (kinases) ; plant pathogenic fungi ; saprophytes ; virulence
    Language English
    Dates of publication 2024-01
    Size p. 354-371.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 391893-2
    ISSN 1365-3040 ; 0140-7791
    ISSN (online) 1365-3040
    ISSN 0140-7791
    DOI 10.1111/pce.14740
    Database NAL-Catalogue (AGRICOLA)

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    Z 80/729: Show issues

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  8. Article ; Online: A Preliminary Study of Dewatering of Filter Mud from Sugar Mills

    Liang Yong / Li Jie / Li Qingtao

    E3S Web of Conferences, Vol 393, p

    2023  Volume 02013

    Abstract: In order to facilitate the comprehensive reuse of the filter mud from sugar mills, the experiment of dewatering by expression of the filter mud was performed to investigate its dewatering properties. The results showed that the expression pressure has a ... ...

    Abstract In order to facilitate the comprehensive reuse of the filter mud from sugar mills, the experiment of dewatering by expression of the filter mud was performed to investigate its dewatering properties. The results showed that the expression pressure has a significant effect on the dewatering properties. The moisture content of the filter mud decreased significantly as pressure increased in the lower range, and gradually became equilibrium in higher range. During the expression, the moisture contents of the mud decreased dramatically at the beginning, and then approached equilibrium. A simplified model is established for pre-dicting the variation of moisture content of the filter mud with time. The developed model has a good agreement with the experiment data.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Integrating molecular interactions and gene expression to identify biomarkers and network modules of chronic obstructive pulmonary disease.

    Huang, Hai-Hui / Liang, Yong

    Technology and health care : official journal of the European Society for Engineering and Medicine

    2022  Volume 30, Issue S1, Page(s) 135–142

    Abstract: Background: Chronic obstructive pulmonary disease (COPD) causes chronic obstructive conditions, chronic bronchitis, and emphysema, and is a major cause of death worldwide. Although several efforts for identifying biomarkers and pathways have been made, ... ...

    Abstract Background: Chronic obstructive pulmonary disease (COPD) causes chronic obstructive conditions, chronic bronchitis, and emphysema, and is a major cause of death worldwide. Although several efforts for identifying biomarkers and pathways have been made, specific causal COPD mechanism remains unknown.
    Objective: This study combined biological interaction data with gene expression data for a better understanding of the biological process and network module for COPD.
    Methods: Using a sparse network-based method, we selected 49 genes from peripheral blood mononuclear cell expression data of 136 subjects, including 42 ex-smoking controls and 94 subjects with COPD.
    Results: These 49 genes might influence biological processes and molecular functions related to COPD. For example, our result suggests that FoxO signaling may contribute to the atrophy of COPD peripheral muscle tissues via oxidative stress.
    Conclusions: Our approach enhances the existing understanding of COPD disease pathogenesis and predicts new genetic markers and pathways that may influence COPD pathogenesis.
    MeSH term(s) Biomarkers ; Gene Expression ; Humans ; Leukocytes, Mononuclear/metabolism ; Pulmonary Disease, Chronic Obstructive/genetics ; Smoking
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-04-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1159961-3
    ISSN 1878-7401 ; 0928-7329
    ISSN (online) 1878-7401
    ISSN 0928-7329
    DOI 10.3233/THC-228013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3846: Show issues Location:
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  10. Article ; Online: Construction of a molecularly imprinted fluorescent sensor based on an amphiphilic block copolymer-metal-organic framework for the detection of oxytetracycline in milk.

    Liu, Wanqiong / Wu, Zixuan / Peng, Jianwei / Xu, Zebin / Liang, Yong

    Analytical methods : advancing methods and applications

    2024  Volume 16, Issue 2, Page(s) 196–204

    Abstract: A metal-organic framework (MOF) is a good carrier for molecular imprinting due to its high surface area and strong adsorption capacity, but its poor dispersibility in aqueous solution is one of the significant drawbacks, which can severely impede its ... ...

    Abstract A metal-organic framework (MOF) is a good carrier for molecular imprinting due to its high surface area and strong adsorption capacity, but its poor dispersibility in aqueous solution is one of the significant drawbacks, which can severely impede its effectiveness. Amphiphilic block copolymers are good hydrophilic materials and have the potential to overcome the shortcomings of MOFs. In order to improve the hydrophilicity of molecularly imprinted fluorescent materials, we have applied a combination of molecularly imprinted technology and amphiphilic block copolymers on MOFs for the first time. Amphiphilic PAVE copolymer is selected as the molecular imprinted functional monomer to improve the hydrophilicity of UiO-66-NH
    MeSH term(s) Animals ; Metal-Organic Frameworks ; Oxytetracycline/analysis ; Milk/chemistry ; Polymers ; Water
    Chemical Substances Metal-Organic Frameworks ; Oxytetracycline (X20I9EN955) ; Polymers ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay01567j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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