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  1. AU="Liang, Zhen Hua"
  2. AU="Malliaras, Peter"
  3. AU="Juan Prieto-Villalobos"
  4. AU="Blot, Guillaume"
  5. AU="Sanchez, Gabriela"
  6. AU=Mitton Julian A
  7. AU="Han, Hyunho"
  8. AU="Shama, Noura M Abo"
  9. AU=Uehara Akira
  10. AU=Fransen Justin H AU=Fransen Justin H
  11. AU="Memon, Roha Saeed"
  12. AU="Lipworth, Samuel"
  13. AU="Killian, Michael O"
  14. AU=Smaldino Paul E.
  15. AU=Bi Hai
  16. AU="Pintore, Giorgio"
  17. AU="Signorini C."
  18. AU="Mameli, Maria Sabrina"
  19. AU="Yong-ming GAO"
  20. AU="Paquette, Kimberly"
  21. AU="Sharawat, Indar Kumar"
  22. AU="Alexandre Alanio"
  23. AU="Caron, Jeffrey G"
  24. AU="Lubisi, Baratang A"
  25. AU="Edelman, Robert R."
  26. AU="van der Werf, Steffie"
  27. AU="Sam, Andrew"

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  1. Artikel ; Online: An Unusual Cause of Macroscopic T-Wave Alternans in a Patient With Acute Promyelocytic Leukemia.

    Liang, Zhen-Hua / Zhao, Yun-Tao / Zhou, Yi-Chang

    JAMA internal medicine

    2021  Band 181, Heft 7, Seite(n) 985–987

    Mesh-Begriff(e) Arrhythmias, Cardiac/physiopathology ; Electrocardiography ; Humans ; Leukemia, Promyelocytic, Acute/physiopathology ; Male ; Middle Aged
    Sprache Englisch
    Erscheinungsdatum 2021-05-17
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2021.1631
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  2. Artikel ; Online: Two truxinate derivatives and a phenyldilactone from the leaves of

    Wang, Ya-Feng / Pang, Nao / Liang, Zhen-Hua / Huang, Yong-Lin / He, Rui-Jie / Yang, Bing-Yuan / Liu, Zhang-Bin

    Natural product research

    2022  Band 37, Heft 21, Seite(n) 3605–3609

    Abstract: Phytochemical investigation of the Leaves ... ...

    Abstract Phytochemical investigation of the Leaves of
    Sprache Englisch
    Erscheinungsdatum 2022-07-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2095636
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  3. Artikel: Isolation, culture, and identification of duck intestinal epithelial cells and oxidative stress model constructed

    Zhang, Hao / Chen, Fang / Liang, Zhen-Hua / Wu, Yan / Pi, Jin-Song

    In vitro cellular & developmental biology. 2019 Oct., v. 55, no. 9

    2019  

    Abstract: Intestinal epithelial cells (IECs) not only have an absorption function but also act as a physical barrier between the body and the intestinal bacterial flora. Damage to IECs leads to the breakdown of this barrier and has negative effects on animal ... ...

    Abstract Intestinal epithelial cells (IECs) not only have an absorption function but also act as a physical barrier between the body and the intestinal bacterial flora. Damage to IECs leads to the breakdown of this barrier and has negative effects on animal health. Intestinal epithelial damage is frequently associated with long-term acute stress, such as increased temperature and new stress management models. The intestinal epithelial damage caused by environmental stress has been linked to oxidative stress. Until now, the effects of intestinal epithelial antioxidant activity from feed additives and treatments could be tested in ducks only in vivo because of the lack of in vitro cell culture systems. In this study, we describe our protocol for the easy isolation and culture of IECs from the small intestine of duck embryos. Immunofluorescence was used for the cytological identification of IECs. In addition, IEC marker genes (IAP and CDH1) could also be detected in cultured cells. And cell status assessments were performed, and cell proliferation viability was analyzed by CCK-8 assay. Furthermore, we constructed an oxidative stress model to be used to research the oxidative stress response mechanism, and drugs acting on the cell signal transduction pathway. In conclusion, we have developed an effective and rapid protocol for obtaining duck primary IECs and constructed an oxidative stress model. These IECs exhibit features consistent with epithelial cells and could be used to explore the physiological mechanisms of oxidative stress ex vivo.
    Schlagwörter antioxidant activity ; bacteria ; cell culture ; cell proliferation ; cultured cells ; drugs ; ducks ; embryo (animal) ; epithelial cells ; feed additives ; fluorescent antibody technique ; genetic markers ; intestinal absorption ; intestinal mucosa ; models ; oxidative stress ; signal transduction ; small intestine ; stress management ; stress response ; temperature ; viability
    Sprache Englisch
    Erscheinungsverlauf 2019-10
    Umfang p. 733-740.
    Erscheinungsort Springer US
    Dokumenttyp Artikel
    ISSN 1071-2690
    DOI 10.1007/s11626-019-00388-7
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  4. Artikel ; Online: Isolation, culture, and identification of duck intestinal epithelial cells and oxidative stress model constructed.

    Zhang, Hao / Chen, Fang / Liang, Zhen-Hua / Wu, Yan / Pi, Jin-Song

    In vitro cellular & developmental biology. Animal

    2019  Band 55, Heft 9, Seite(n) 733–740

    Abstract: Intestinal epithelial cells (IECs) not only have an absorption function but also act as a physical barrier between the body and the intestinal bacterial flora. Damage to IECs leads to the breakdown of this barrier and has negative effects on animal ... ...

    Abstract Intestinal epithelial cells (IECs) not only have an absorption function but also act as a physical barrier between the body and the intestinal bacterial flora. Damage to IECs leads to the breakdown of this barrier and has negative effects on animal health. Intestinal epithelial damage is frequently associated with long-term acute stress, such as increased temperature and new stress management models. The intestinal epithelial damage caused by environmental stress has been linked to oxidative stress. Until now, the effects of intestinal epithelial antioxidant activity from feed additives and treatments could be tested in ducks only in vivo because of the lack of in vitro cell culture systems. In this study, we describe our protocol for the easy isolation and culture of IECs from the small intestine of duck embryos. Immunofluorescence was used for the cytological identification of IECs. In addition, IEC marker genes (IAP and CDH1) could also be detected in cultured cells. And cell status assessments were performed, and cell proliferation viability was analyzed by CCK-8 assay. Furthermore, we constructed an oxidative stress model to be used to research the oxidative stress response mechanism, and drugs acting on the cell signal transduction pathway. In conclusion, we have developed an effective and rapid protocol for obtaining duck primary IECs and constructed an oxidative stress model. These IECs exhibit features consistent with epithelial cells and could be used to explore the physiological mechanisms of oxidative stress ex vivo.
    Mesh-Begriff(e) Animals ; Cell Proliferation/genetics ; Cell Survival/genetics ; Cells, Cultured ; Ducks/genetics ; Ducks/growth & development ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Intestines/cytology ; Oxidative Stress/genetics ; Signal Transduction/genetics
    Sprache Englisch
    Erscheinungsdatum 2019-08-05
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1077810-x
    ISSN 1543-706X ; 0883-8364 ; 1071-2690
    ISSN (online) 1543-706X
    ISSN 0883-8364 ; 1071-2690
    DOI 10.1007/s11626-019-00388-7
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  5. Artikel: Plasma metabolites associated with physiological and biochemical indexes indicate the effect of caging stress on mallard ducks (Anas platyrhynchos).

    Zheng, Chao / Wu, Yan / Liang, Zhen Hua / Pi, Jin Song / Cheng, Shi Bin / Wei, Wen Zhuo / Liu, Jing Bo / Lu, Li Zhi / Zhang, Hao

    Animal bioscience

    2021  Band 35, Heft 2, Seite(n) 224–235

    Abstract: Objective: Cage rearing has critical implications for the laying duck industry because it is convenient for feeding and management. However, caging stress is a type of chronic stress that induces maladaptation. Environmental stress responses have been ... ...

    Abstract Objective: Cage rearing has critical implications for the laying duck industry because it is convenient for feeding and management. However, caging stress is a type of chronic stress that induces maladaptation. Environmental stress responses have been extensively studied, but no detailed information is available about the comprehensive changes in plasma metabolites at different stages of caging stress in ducks. We designed this experiment to analyze the effects of caging stress on performance parameters and oxidative stress indexes in ducks.
    Methods: Liquid chromatography tandem mass spectrometry (LC/MS-MS) was used to determine the changes in metabolites in duck plasma at 5 (CR5), 10 (CR10), and 15 (CR15) days after cage rearing and traditional breeding (TB). The associated pathways of differentially altered metabolites were analyzed using Kyoto encyclopedia of genes and genomes (KEGG) database.
    Results: The results of this study indicate that caging stress decreased performance parameters, and the plasma total superoxide dismutase levels were increased in the CR10 group compared with the other groups. In addition, 1,431 metabolites were detected. Compared with the TB group, 134, 381, and 190 differentially produced metabolites were identified in the CR5, CR10, and CR15 groups, respectively. The results of principal component analysis (PCA) show that the selected components sufficiently distinguish the TB group and CR10 group. KEGG analysis results revealed that the differentially altered metabolites in duck plasma from the CR5 and TB groups were mainly associated with ovarian steroidogenesis, biosynthesis of unsaturated fatty acids, and phenylalanine metabolism.
    Conclusion: In this study, the production performance, blood indexes, number of metabolites and PCA were compared to determine effect of the caging stress stage on ducks. We inferred from the experimental results that caging-stressed ducks were in the sensitive phase in the first 5 days after caging, caging for approximately 10 days was an important transition phase, and then the duck continually adapted.
    Sprache Englisch
    Erscheinungsdatum 2021-08-25
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ISSN 2765-0189
    ISSN 2765-0189
    DOI 10.5713/ab.21.0241
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  6. Artikel ; Online: DNA-Binding, Photocleavage, and Photodynamic Anti-cancer Activities of Pyridyl Corroles.

    Liang, Zhen-Hua / Liu, Hai-Yang / Zhou, Rong / Zhang, Zao / Ali, Atif / Han, Bing-Jie / Liu, Yun-Jun / Xiao, Xin-Yan

    The Journal of membrane biology

    2016  Band 249, Heft 4, Seite(n) 419–428

    Abstract: The DNA-binding, photocleavage, and antitumor activity of three free base pyridyl corroles 1, 2, and 3 have been investigated. The binding affinity toward CT-DNA decreases with increasing number of pentafluorophenyl, whereas the photocleavage activity ... ...

    Abstract The DNA-binding, photocleavage, and antitumor activity of three free base pyridyl corroles 1, 2, and 3 have been investigated. The binding affinity toward CT-DNA decreases with increasing number of pentafluorophenyl, whereas the photocleavage activity toward pBR322 DNA becomes more efficient. Singlet oxygen was demonstrated as active species responsible for DNA cleavage. These corroles exhibited high cytotoxicity against three tested cancer cells (Hela, HapG2, and A549) and the cytotoxicity could be further enhanced under irradiation. Intracellular reactive oxygen species level was also monitored using HeLa Cells upon the combined treatment of corroles and light. These corroles could be absorbed by HeLa cells at low concentration. They can induce the decrease of mitochondrial membrane potential and apoptosis of tumor cells under irradiation.
    Mesh-Begriff(e) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA/chemistry ; DNA/metabolism ; DNA Cleavage/drug effects ; DNA Cleavage/radiation effects ; Humans ; Inhibitory Concentration 50 ; Light ; Membrane Potential, Mitochondrial/drug effects ; Molecular Structure ; Porphyrins/chemistry ; Porphyrins/pharmacology ; Reactive Oxygen Species/metabolism
    Chemische Substanzen Antineoplastic Agents ; Porphyrins ; Reactive Oxygen Species ; corrole ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3082-x
    ISSN 1432-1424 ; 0022-2631
    ISSN (online) 1432-1424
    ISSN 0022-2631
    DOI 10.1007/s00232-016-9879-0
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  7. Artikel: Ruthenium(II) complexes: Cellular uptake, cytotoxicity, DNA-binding, photocleavage and antioxidant activity studies

    Li, Zheng-Zheng / Liang, Zhen-Hua / Huang, Hong-Liang / Liu, Yun-Jun

    Journal of molecular structure. 2011 Aug. 24, v. 1001, no. 1-3

    2011  

    Abstract: Two new ruthenium(II) complexes [Ru(dmp)₂(DNPIP)]²⁺1 and [Ru(dmp)₂(DAPIP)]²⁺2 were synthesized and characterized. The DNA-binding behaviors of these complexes were investigated by absorption spectra, viscosity measurements and photocleavage. The DNA- ... ...

    Abstract Two new ruthenium(II) complexes [Ru(dmp)₂(DNPIP)]²⁺1 and [Ru(dmp)₂(DAPIP)]²⁺2 were synthesized and characterized. The DNA-binding behaviors of these complexes were investigated by absorption spectra, viscosity measurements and photocleavage. The DNA-binding constants for complexes 1 and 2 have been determined to be 6.24 (±0.11)×10⁴ and 1.64 (±0.49)×10⁴M⁻¹. The results suggest that complexes 1 and 2 intercalate between the DNA base pairs. Binding stoichiometries were studied through a luminescence-based Job plot. The major inflection points for complexes 1 and 2 at χ=0.31 and χ=0.51 were observed. The data were consistent with 2:1 and 1:1bp [complex]/[DNA] binding mode. Complex 1 shows higher activity than complex 2 against the selected tumor cell lines. In addition, the cellular uptake and antioxidant activity on hydroxyl radical were also explored.
    Schlagwörter DNA ; absorption ; antioxidant activity ; cytotoxicity ; hydroxyl radicals ; ruthenium ; viscosity
    Sprache Englisch
    Erscheinungsverlauf 2011-0824
    Umfang p. 36-42.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 194476-9
    ISSN 0022-2860 ; 0377-046X
    ISSN 0022-2860 ; 0377-046X
    DOI 10.1016/j.molstruc.2011.06.011
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  8. Artikel: RbCa(2)Nb(3)O(10) from X-ray powder data.

    Liang, Zhen-Hua / Tang, Kai-Bin / Chen, Qian-Wang / Zheng, Hua-Gui

    Acta crystallographica. Section E, Structure reports online

    2009  Band 65, Heft Pt 6, Seite(n) i44

    Abstract: Rubidium dicalcium triniobate(V), RbCa(2)Nb(3)O(10), has been synthesized by solid-state reaction and its crystal structure refined from X-ray powder diffraction data using Rietveld analysis. The compound is a three-layer perovskite Dion-Jacobson phase ... ...

    Abstract Rubidium dicalcium triniobate(V), RbCa(2)Nb(3)O(10), has been synthesized by solid-state reaction and its crystal structure refined from X-ray powder diffraction data using Rietveld analysis. The compound is a three-layer perovskite Dion-Jacobson phase with the perovskite-like slabs derived by termination of the three-dimensional CaNbO(3) perovskite structure along the ab plane. The rubidium ions (4/mmm symmetry) are located in the inter-stitial space.
    Sprache Englisch
    Erscheinungsdatum 2009-05-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2041947-8
    ISSN 1600-5368
    ISSN 1600-5368
    DOI 10.1107/S1600536809018157
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  9. Artikel ; Online: Synthesis, cellular uptake, apopotosis, cytotoxicity, cell cycle arrest, interaction with DNA and antioxidant activity of ruthenium(II) complexes.

    Huang, Hong-Liang / Li, Zheng-Zheng / Liang, Zhen-Hua / Yao, Jun-Hua / Liu, Yun-Jun

    European journal of medicinal chemistry

    2011  Band 46, Heft 8, Seite(n) 3282–3290

    Abstract: A new ligand and two ruthenium(II) complexes [Ru(bpy)(2)(DNPIP)](ClO(4))(2)1 and [Ru(bpy)(2)(DAPIP)](ClO(4))(2)2 were synthesized and characterized. The DNA-binding constants for complexes 1 and 2 were determined to be 2.24 (±0.30) × 10(5) M(-1) (s = 1 ... ...

    Abstract A new ligand and two ruthenium(II) complexes [Ru(bpy)(2)(DNPIP)](ClO(4))(2)1 and [Ru(bpy)(2)(DAPIP)](ClO(4))(2)2 were synthesized and characterized. The DNA-binding constants for complexes 1 and 2 were determined to be 2.24 (±0.30) × 10(5) M(-1) (s = 1.29) and 6.34 (±0.32) × 10(4) M(-1) (s = 2.84). The photocleavage of pBR322 DNA by Ru(II) complexes was investigated. The cytotoxicity of complexes 1 and 2 were assessed against three tumor cell lines. The apoptosis and cellular uptake were studied. The retardation assay of pGL 3 plasmid DNA was explored. The cell cycle arrest was analysized by flow cytometry. The antioxidant activities of the ligand and complexes were also investigated.
    Mesh-Begriff(e) 2,2'-Dipyridyl/chemistry ; 2,2'-Dipyridyl/metabolism ; 2,2'-Dipyridyl/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Antioxidants/chemical synthesis ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Coordination Complexes/chemical synthesis ; Coordination Complexes/pharmacology ; DNA/chemistry ; DNA/metabolism ; DNA Cleavage/drug effects ; Differential Thermal Analysis ; Electrophoretic Mobility Shift Assay ; Flow Cytometry ; Humans ; Intercalating Agents/chemical synthesis ; Intercalating Agents/pharmacology ; Ligands ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Phenanthrolines/chemistry ; Phenanthrolines/metabolism ; Phenanthrolines/pharmacology ; Plasmids ; Ruthenium/chemistry ; Ruthenium/metabolism ; Ruthenium/pharmacology
    Chemische Substanzen Antineoplastic Agents ; Antioxidants ; Coordination Complexes ; Intercalating Agents ; Ligands ; Phenanthrolines ; 2,2'-Dipyridyl (551W113ZEP) ; Ruthenium (7UI0TKC3U5) ; DNA (9007-49-2) ; calf thymus DNA (91080-16-9)
    Sprache Englisch
    Erscheinungsdatum 2011-08
    Erscheinungsland France
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2011.04.049
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  10. Artikel ; Online: Ruthenium(II) polypyridyl complexes: synthesis and studies of DNA binding, photocleavage, cytotoxicity, apoptosis, cellular uptake, and antioxidant activity.

    Liu, Yun-Jun / Liang, Zhen-Hua / Li, Zheng-Zheng / Yao, Jun-Hua / Huang, Hong-Liang

    DNA and cell biology

    2011  Band 30, Heft 10, Seite(n) 829–838

    Abstract: Two ruthenium (II) complexes [Ru(dmb)2(APIP)](ClO4)2 (APIP=2-(2-aminophenyl)imidazo[4,5-f ][1,10]phenanthroline, dmb=4,4'-dimethyl-2,2'-bipyridine; 1) and [Ru(dmb)2(HAPIP)](ClO4)2 (HAPIP=2-(2-hydroxyl-4-aminophenyl)imidazo[4,5-f ][1,10]phenanthroline; 2) ...

    Abstract Two ruthenium (II) complexes [Ru(dmb)2(APIP)](ClO4)2 (APIP=2-(2-aminophenyl)imidazo[4,5-f ][1,10]phenanthroline, dmb=4,4'-dimethyl-2,2'-bipyridine; 1) and [Ru(dmb)2(HAPIP)](ClO4)2 (HAPIP=2-(2-hydroxyl-4-aminophenyl)imidazo[4,5-f ][1,10]phenanthroline; 2) were synthesized and characterized. DNA binding was investigated by electronic absorption titration, luminescence spectra, thermal denaturation, viscosity measurements, and photocleavage. The DNA binding constants for complexes 1 and 2 were 4.20 (±0.14)×10(4) and 5.45 (±0.15)×10(4) M(-1). The results suggest that these complexes partially intercalate between the base pairs. The cytotoxicity of complexes 1 and 2 was evaluated by MTT assay. Cellular uptake was observed under fluorescence microscopy; complexes 1 and 2 can enter into the cytoplasm and accumulate in the nuclei. Apoptosis and the antioxidant activity against hydroxyl radicals (•OH) were also explored.
    Mesh-Begriff(e) 2,2'-Dipyridyl/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Antioxidants/chemical synthesis ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Survival/drug effects ; Cell Survival/radiation effects ; DNA/chemistry ; DNA/metabolism ; Electrophoretic Mobility Shift Assay ; Female ; Fluorescence ; Humans ; Hydroxyl Radical/antagonists & inhibitors ; Hydroxyl Radical/metabolism ; Intercalating Agents/chemical synthesis ; Intercalating Agents/pharmacology ; Kinetics ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/pharmacology ; Oxidation-Reduction/drug effects ; Oxidation-Reduction/radiation effects ; Phenanthrolines/chemistry ; Photolysis/radiation effects ; Plasmids/metabolism ; Ruthenium/chemistry ; Ruthenium/metabolism ; Spectrum Analysis ; Ultraviolet Rays
    Chemische Substanzen Antineoplastic Agents ; Antioxidants ; Intercalating Agents ; Organometallic Compounds ; Phenanthrolines ; Hydroxyl Radical (3352-57-6) ; 2,2'-Dipyridyl (551W113ZEP) ; Ruthenium (7UI0TKC3U5) ; DNA (9007-49-2) ; calf thymus DNA (91080-16-9)
    Sprache Englisch
    Erscheinungsdatum 2011-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2010.1170
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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