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Article ; Online: Health State Valuation and Its Socio-Economic Factors

Liang Wang

Medical Sciences Forum, Vol 4, Iss 4, p

Online Samples from the U.S. and Canada

2021 Volume 4

Abstract: This paper seeks to explore how people value the state of health and what socio-economic factors they might consider. I conducted an online experiment and a survey to elicit individuals’ decisions under hypothetical health states, which vary at three ... ...

Abstract	This paper seeks to explore how people value the state of health and what socio-economic factors they might consider. I conducted an online experiment and a survey to elicit individuals’ decisions under hypothetical health states, which vary at three levels: mild, moderate, and severe. The socio-economic factors mainly include payment, personal financial situation, hospital service, support from their family, etc. The subjects were from two separate online pools of the United States and Canada, which have similar socio-economic backgrounds and different health care systems. This paper presents that subjects are sensitive to different levels of health states. In those who choose the risky medical treatment under the same health states, the Canadian participants are willing to accept a lower success probability. Among the socio-economic factors that are significant to this health-related decision, some factors are only significant in one country’s participants. For the American sample, it is “access to health insurance”, while for the Canadian sample, it is “disturbances in everyday family life”.
Keywords	health state valuation ; socio-economic factors ; online survey ; Medicine ; R
Subject code	360
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dexmedetomidine promotes ferroptotic cell death in gastric cancer via hsa_circ_0008035/miR‐302a/E2F7 axis

Xiang Gao / Xiao‐Liang Wang

Kaohsiung Journal of Medical Sciences, Vol 39, Iss 4, Pp 390-

2023 Volume 403

Abstract: Abstract Dexmedetomidine (DEX), a common anesthetic, has significant effects on the biological features of cancer cells. Although numerous studies have been published on the impact of DEX on the biological characteristics of GC cells, the mechanism ... ...

Abstract	Abstract Dexmedetomidine (DEX), a common anesthetic, has significant effects on the biological features of cancer cells. Although numerous studies have been published on the impact of DEX on the biological characteristics of GC cells, the mechanism remains unknown. This study aimed to explore the effect of DEX on the biological properties of GC cells. DEX suppressed the viability and increased the apoptosis of GC cells in vitro and inhibited tumor growth in vivo. Besides, DEX raised the levels of reactive oxygen species (ROS) and iron, but decreased the levels of glutathione (GSH), glutathione peroxidase 4 (GPX4), and solute carrier family 7 member 11 (SLC7A11) in GC cells, which were abolished by Ferrostatin‐1 (the inhibitor of ferroptosis) treatment. In addition, the level of circ0008035 and E2F7 were downregulated, but miR‐302a level was upregulated in DEX‐treated GC cells. Circ0008035 increased the expression of E2F2 by acting as a sponge for miR‐302a. Circ0008035 inhibited DEX‐induced ferroptotic cell death in GC cells, which was reversed by miR‐302a overexpression or E2F7 reduction. Taken together, DEX mediated ferroptotic cell death in GC through regulating the circ0008035/miR‐302a/E2F7 axis, suggesting a feasible therapy option for GC.
Keywords	circular RNA ; dexmedetomidine ; ferroptosis ; gastric cancer ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A study on optimal share pledge rate based on bilateral risk-CVaR of pledgee

Liang Wang / Xiao Sheng

Heliyon, Vol 9, Iss 5, Pp e15592- (2023)

2023

Abstract: This paper proposes the optimal pledge rate model based on the pledgee's bilateral risk-CVaR and dual-objective planning. First, a bilateral risk-CVaR model is constructed, for which a nonparametric kernel estimation method is presented, with a ... ...

Abstract	This paper proposes the optimal pledge rate model based on the pledgee's bilateral risk-CVaR and dual-objective planning. First, a bilateral risk-CVaR model is constructed, for which a nonparametric kernel estimation method is presented, with a comparative analysis of the efficient frontier for “mean-variance”, “mean-CVaR”, and “mean-bilateral risk CVaR”. Second, it establishes a dual-objective planning model by the objectives of bilateral risk-CVaR and expected return of the pledgee, and accordingly develops an optimal pledge rate model combined with objective deviation, priority factor, and entropy method. Finally, the relationships between the pledge rate, the number of pledged shares, and the expected return are explored through simulation. The results illustrate that: (i) There are sequential inclusion relationships between the “mean-bilateral risk CVaR”, the “mean-CVaR” considering only the downside risk, and the “mean-variance” efficient sets of share pledge rate. (ii) As the number of shares increases, the pledgee's expected return also rises, and its sensitivity to the pledge rate grows. (iii) When the pledgee's expected return fixes, the number of pledged shares and the pledge rate have a U-shaped relationship. As it increases, the number of pledged shares rises, but the variation range of the pledge rate gradually decreases, and the pledgor's default risk declines.
Keywords	Share pledge ; Bilateral risk-CVaR ; Dual-objective planning ; Pledge rate ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	332
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Salvianolic acid A improves nerve regeneration and repairs nerve defects in rats with brain injury by downregulating miR‐212‐3p‐mediated SOX7

Shuai Huang / Hong‐Liang Wang

Kaohsiung Journal of Medical Sciences, Vol 39, Iss 12, Pp 1222-

2023 Volume 1232

Abstract: Abstract This study was to probe the protective effects and mechanisms of salvianolic acid A (SAA) on cerebral ischemia–reperfusion injury (CIRI). The middle cerebral artery occlusion model (MCAO) was established in rats. Rats' behavior, neurological ... ...

Abstract	Abstract This study was to probe the protective effects and mechanisms of salvianolic acid A (SAA) on cerebral ischemia–reperfusion injury (CIRI). The middle cerebral artery occlusion model (MCAO) was established in rats. Rats' behavior, neurological deficits, brain injury, inflammation, and apoptosis in the brain tissue were evaluated. The inflammatory response and apoptosis of PC12 cells induced by oxygen glucose deprivation/reperfusion (OGD/R) were detected. SAA‐mediated changes in miR‐212‐3p, SOX7, and Wnt/β‐catenin pathway were determined, and the targeting relationship between miR‐212‐3p and SOX7 was clarified. SAA alleviated the neurological deficits and brain injury of MCAO rats and inhibited the inflammatory response and apoptosis of OGD/R‐conditioned PC‐12 cells. SAA upregulated miR‐212‐3p, Wnt3a, and β‐catenin, whereas inhibited SOX7 levels. Silencing miR‐212‐3p counteracted the protective effect of SAA in the context of CIRI. SOX7 was a target protein of miR‐212‐3p. Silencing SOX7 based on SAA and miR‐212‐3p knockdown suppressed OGD/R‐induced inflammation and apoptosis and increased Wnt3a and β‐catenin levels in PC12 cells. SAA can improve the brain and nervous system injury caused by cerebral ischemia–reperfusion by upregulating miR‐212‐3p, thereby inhibiting SOX7 and activating the Wnt/βcatenin signaling pathway.
Keywords	cerebral ischemia–reperfusion injury ; miR‐212‐3p ; salvianolic acid A ; SOX7 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical significance of preoperative CALLY index for prognostication in patients with esophageal squamous cell carcinoma undergoing surgery

Jifeng Feng / Liang Wang / Xun Yang / Qixun Chen

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 10

Abstract: Abstract The C-reactive protein-albumin-lymphocyte (CALLY) index has been identified as a useful and sensitive predictive tool for stratification in cancers. This investigation aimed to validate the prognostic ability of CALLY in esophageal squamous cell ...

Abstract	Abstract The C-reactive protein-albumin-lymphocyte (CALLY) index has been identified as a useful and sensitive predictive tool for stratification in cancers. This investigation aimed to validate the prognostic ability of CALLY in esophageal squamous cell carcinoma (ESCC). Clinical characteristics of 318 patients with ESCC who underwent radical excision were gathered and analyzed retrospectively. A restricted cubic spline (RCS) model was used to determine an ideal threshold of CALLY due to the non-linear relation. To investigate the predictors, Cox hazard regression analysis was used. The recursive partitioning analysis (RPA), a method of risk categorization, was also developed for prognostic prediction. The receiver operating characteristic (ROC) curves and decision curve analysis (DCA) curves were used to distinguish from the traditional TNM stage. Patients were compared by groups according to the optimal threshold of CALLY index, which was depicted by the non-linear relation between the cancer-specific survival (CSS) and CALLY index (P < 0.0001). Compared to those with high CALLY index, patients with low CALLY index experienced significantly worse 5-year CSS (21.8% vs. 62.6%, P < 0.001). At different TNM stages, patients with high CALLY index also had better 5-year CSS (I: P = 0.029; II: P < 0.001; III: P < 0.001) in subgroup analyses. The hazard ratio for CSS was 0.368 and CALLY index was an independent predictive factor (P < 0.001). Using TNM stage and CALLY-based RPA algorithms, a new staging was created. The RPA model considerably outperformed the TNM classification for prognostication using ROC (P < 0.001). The DCA also demonstrated that the new model outperformed the TNM stage with significantly improved accuracy for CSS. The prognostic value of CALLY in ESCC undergoing radical resection was initially determined in this study. CALLY was substantially related to prognosis and might be utilized in conjunction with TNM to evaluate ESCC prior to surgery.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Value of serial cervical length measurement in prediction of spontaneous preterm birth in post-conization pregnancy without short mid-trimester cervix

Liang Wang

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 5

Abstract: Abstract Serial cervical length (CL) measurement in mid-trimester is recommended in post-conization pregnancy to estimate the risk of spontaneous preterm birth (SPTB). A short mid-trimester cervix (CL < 25 mm) has been considered as a strong predictor ... ...

Abstract	Abstract Serial cervical length (CL) measurement in mid-trimester is recommended in post-conization pregnancy to estimate the risk of spontaneous preterm birth (SPTB). A short mid-trimester cervix (CL < 25 mm) has been considered as a strong predictor for SPTB. However, the low incidence of short cervix limits the utility of mid-trimester CL measurement in prediction of SPTB. A great proportion of women who develop SPTB don’t have a short mid-trimester cervix. Therefore, this study was aimed to investigate the additional value of serial CL measurement in predicting SPTB in addition to detecting short cervix alone. A total of 613 post-conization pregnant women who did not have short mid-trimester cervix between January 2004 and January 2014 were included in this study. Serial CL measurements were taken by transvaginal ultrasound at three timepoints (A: 13 + 0–15 + 6 weeks, B: 16 + 0–18 + 6 weeks, and C: 20 + 0–22 + 6 weeks). Eight parameters were analyzed for predicting SPTB, including CL measurements at different timepoints (CLA, CLB, CLC), the maximum and minimum CL measurements (CLMAX, CLMIN), and the percentage change in CL measurement between different timepoints (%ΔCLAB, %ΔCLBC, %ΔCLAC). After univariate and multivariate analysis, CLMAX and %ΔCLAC were independent variables in predicting SPTB. Lower CLMAX (OR [95%CI]: 0.92 [0.90–0.93]) and higher %ΔCLAC (OR [95%CI]: 1.05 [1.01–1.09]) were related to an increasing risk of SPTB. In conclusion, our study for the first time in literature reported the value of serial CL measurement in prediction of SPTB in post-conization pregnancy without short mid-trimester cervix. In the subpopulation of pregnant women who did not have short mid-trimester cervix, CLMAX and %ΔCLAC were of value in predicting SPTB, which warranted further investigations.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Market Competition, Infrastructure Sharing, and Network Investment in China’s Mobile Telecommunications Industry

Liang Wang / Qiming Sun

Sustainability, Vol 14, Iss 3348, p

2022 Volume 3348

Abstract: The relationship between market competition and network investment in the mobile telecommunications industry has always been one of the focuses for scholars and regulatory agencies. The conclusions of previous studies on this topic remain ambiguous. ... ...

Abstract	The relationship between market competition and network investment in the mobile telecommunications industry has always been one of the focuses for scholars and regulatory agencies. The conclusions of previous studies on this topic remain ambiguous. Infrastructure sharing has become a noticeable trend in the global mobile telecommunications industry, but its impact on operators’ investment and innovation behaviors is controversial. This paper uses fixed effects and dynamic panel data models to empirically examine the relationship among the market competition, infrastructure sharing, and network investment in China’s mobile telecommunications industry. The results show that market competition has a significant positive impact on the total industry network investment, but the interaction of market competition and infrastructure sharing has undermined network investment, which indicates that the competitive strategy of rational operators will shift from facility-based competition to service-based competition when both deep infrastructure sharing and fierce market competition appear at the same time, and this is likely to cause insufficient incentives for investment in advanced technology. This paper suggests that China’s regulators should improve the market structure, enhance market competitiveness continuously, and support infrastructure sharing, but at the same time they should exercise caution when conducting in-depth infrastructure sharing. In addition, they should accelerate the development of 5G vertical industry applications to expand the market space for industry development.
Keywords	mobile telecommunications industry ; competition intensity ; infrastructure sharing ; network investment ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	303
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction Practices of Green Mines in China

Kun Du / Junjie Xie / Wenqin Xi / Liang Wang / Jian Zhou

Sustainability, Vol 16, Iss 1, p

2024 Volume 461

Abstract: To maintain high-level economic development, protect the ecological environment, and achieve carbon peaking and carbon neutrality goals, the construction of green mines has become a critical issue in China. In this study, the importance of mineral ... ...

Abstract	To maintain high-level economic development, protect the ecological environment, and achieve carbon peaking and carbon neutrality goals, the construction of green mines has become a critical issue in China. In this study, the importance of mineral resources to human society is discussed, and the construction experiences and sustainable development directions of green mines are summarized, which can provide valuable references for the global mining industry. The entry and management process in China was introduced to help understand green mines’ construction objectives and tasks. Moreover, based on the successful construction cases of green mines, four typical green mine models are concluded: the green technology mining model, operation modernization mining model, stability mining model, and ecological restoration mining model. In addition, the key construction elements of green mines are concluded, for example, the mining environment, mining methods, comprehensive utilization of resources, energy conservation, emission reduction, scientific and technological innovation and intelligence, and enterprise-land stability, which provided the directions and guidance for green mine construction.
Keywords	mineral resource ; green mine ; directory management ; construction model ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: S100A9 promotes tumor‐associated macrophage for M2 macrophage polarization to drive human liver cancer progression

Lan‐Fang Yang / Zhi‐Bo Zhang / Liang Wang

Kaohsiung Journal of Medical Sciences, Vol 39, Iss 4, Pp 345-

An in vitro study

2023 Volume 353

Abstract: Abstract Tumor‐associated macrophages (TAMs) and M2 macrophage polarization have been documented for their implication in various malignancies, but their implication in liver cancer remains to be determined. This study is intended to explore the effect ... ...

Abstract	Abstract Tumor‐associated macrophages (TAMs) and M2 macrophage polarization have been documented for their implication in various malignancies, but their implication in liver cancer remains to be determined. This study is intended to explore the effect of S100A9 regulated TAMs and macrophage polarization in liver cancer progression. THP‐1 cells were induced to differentiate into M1 and M2 macrophages, which were then cultured in liver cancer cell conditioned culture medium before the M1 and M2 macrophages were identified by measuring biomarkers using real‐time polymerase chain reaction. The differential expressed genes in macrophages in Gene Expression Omnibus (GEO) databases were screened. S100A9 overexpression and knockdown plasmid were transfected into macrophages to determine the effect of S100A9 on M2 macrophage polarization of TAMs and on proliferation ability of liver cancer cells. The proliferation, migration, invasion, and epithelial‐mesenchymal transition (EMT) abilities of liver cancer co‐cultured with TAMs. M1 and M2 macrophages were successfully induced and liver cancer cell conditioned culture medium can increase polarization of macrophages into M2 macrophages, in which elevated expression of S100A9 was detected. Data in GEO database showed that tumor microenvironment (TME) upregulated S1000A9 expression. Suppression on S1000A9 can significantly suppress M2 macrophage polarization. TAM can provide the necessary microenvironment for liver cancer cells, HepG2 and MHCC97H by increasing cell proliferation, migration, and invasion ability, while suppression on S1000A9 can reverse this expression pattern. Suppression on S100A9 expression can regulate M2 macrophage polarization of TAMs to suppress the progression of liver cancer.
Keywords	liver cancer ; macrophage polarization ; S100A9 ; tumor‐associated macrophages ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Dynamic Emergency Plan Generation Method Considering Different Situations and Limited Resources

Zixin Zhang / Liang Wang / Jiayan Lai / Yingming Wang

Sustainability, Vol 15, Iss 5996, p

2023 Volume 5996

Abstract: When an emergency event occurs, emergency plans are usually employed to respond the emergency situations in order to prevent or mitigate possible losses of life and property. Therefore, emergency plans play an important and indispensable part in ... ...

Abstract	When an emergency event occurs, emergency plans are usually employed to respond the emergency situations in order to prevent or mitigate possible losses of life and property. Therefore, emergency plans play an important and indispensable part in emergency decision-making. With regard to the question of how to generate emergency plans, extant studies have discussed the problem from various perspectives, and fruitful results have been obtained. Dynamic evolution is a typical feature of emergency events, and usually involves the updating of related information regarding an emergency event. Existing studies have considered dynamic evolution during the emergency plan generation process only from a single perspective, neglecting the related need to update information as dynamic evolution occurs. Information related to the emergency event plays a vital role in the emergency plan generation process, and needs to be considered. To overcome these limitations, the present study proposes a novel dynamic emergency plan generation method based on integer linear programming, which considers different emergency situations and limited resources. An illustrative example and descriptive comparisons are provided to demonstrate the novelty, superiority, and validity of the proposed method.
Keywords	emergency plan ; emergency management ; different situations ; limited resources ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	710
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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