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Article ; Online: Probiotics mitigated sepsis-related mortality through antioxidant and inflammatory-mediated mechanisms

Jianjun Chen / Xia Peng / Xinxin Li / Xufeng Wu / Yingbin Li / Liangliang Zhou

Arabian Journal of Chemistry, Vol 17, Iss 3, Pp 105590- (2024)

2024

Abstract: The current therapies used to treat sepsis are ineffective and sepsis-related mortality is high. Therefore, it is important to find new treatment options that reduce mortality from that disease. In the present study, the effects of probiotic pretreatment ...

Abstract	The current therapies used to treat sepsis are ineffective and sepsis-related mortality is high. Therefore, it is important to find new treatment options that reduce mortality from that disease. In the present study, the effects of probiotic pretreatment in septic rats were studied on morality, hematological parameters, oxidative stress, antioxidant capacity, and inflammation. After preparation of rats and administration of probiotic VSL # 3, cecal ligation and puncture (CLP) surgery was used to induce sepsis. Then, the animals were divided into four groups: sham, sham + VSL # 3, septic, and septic + VSL # 3. Sepsis-related mortality, hematological parameters, and biochemical factors were assessed. Also, the expression of inflammatory cytokines IL-6, TNF-α and IL-10 in serum were studied using enzyme-linked immunosorbent assay (ELISA). Then, the NF-κB gene and protein expression in intestinal tissue was studied by RT-qPCR and western blot techniques, respectively. Daily pretreatment with VSL # 3 in septic rats resulted in a 20 % reduction in mortality over 10 days and a significant modulation in hematological parameters. Evaluation of oxidant and antioxidant indices showed a decrease in oxidative stress and an increase in antioxidant capacity in septic rats receiving VSL # 3. Also, decreased expressions of inflammatory cytokines IL-6, TNF-α, IL-10, and NF-κB were observed in septic rats receiving VSL # 3. In general, it can be concluded that the administration of probiotic VSL # 3, which resulted in the improved survival of septic rats and better antioxidant and anti-inflammatory conditions, can be considered as a new adjutant therapeutic approach in the treatment of sepsis.
Keywords	Sepsis ; Cytokine ; Antioxidant ; Rat ; Probiotics ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2024-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Did Industrial Centralization Strategy in Shanghai’s Suburbs Lead to Economic Growth?

Qianqian Yang / Yishao Shi / Liangliang Zhou

Sustainability, Vol 14, Iss 856, p

2022 Volume 856

Abstract: Industrial centralization is an important policy choice in the industrial economy era. The purpose of this paper is to evaluate the overall performance and the influential effects of the industrial centralization strategy in the suburbs of Shanghai. The ... ...

Abstract	Industrial centralization is an important policy choice in the industrial economy era. The purpose of this paper is to evaluate the overall performance and the influential effects of the industrial centralization strategy in the suburbs of Shanghai. The results show that (1) the strategy of industrial concentration in the suburbs of Shanghai effectively promoted economic growth; (2) on different spatial scales, there are visible differences in the impact of industrial concentration on the performance of industrial land; (3) industrial concentration has significantly improved industrial energy utilization efficiency; and (4) industrial concentration has narrowed the gap of economic development among the suburbs, but it has not resulted in a corresponding narrowing of the urban-rural gap. The main recommendations are to pay more attention to the high-end and centralization of urban industries in the central city, promote the interactive development of manufacturing and service industries as well as the integrated development of industry and city, moderately control the scale and speed of industrial suburbanization and residential suburbanization, promote the transformation of the traditional industrial land into “industry + R&D + business and office + exhibition” and further narrow the income gap between and within regions.
Keywords	industrial concentration strategy ; performance appraisal ; influential effects ; industrial suburbanization ; Shanghai suburbs ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	941
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quality Evaluation of Pulsatilla chinensis Total Saponin Extracts via Quantitative Analysis of Multicomponents by Single Marker Method Combined with Systematic Quantified Fingerprint Method

Long Chen / Suzhen Liu / Shuhan Feng / Liangliang Zhou / Zhenhua Chen

Journal of Analytical Methods in Chemistry, Vol

2022 Volume 2022

Abstract: Chinese medicine extracts are complex in composition. The combination of the quantitative analysis of multicomponents by single marker (QAMS) and the systematic quantified fingerprint method (SQFM) can be used for better quantitative analysis. The ... ...

Abstract	Chinese medicine extracts are complex in composition. The combination of the quantitative analysis of multicomponents by single marker (QAMS) and the systematic quantified fingerprint method (SQFM) can be used for better quantitative analysis. The contents of Pulsatilla saponin D, Pulsatilla saponin A, Pulsatilla saponin F, and oleanolic acid 3-o-β-d-pyranoglucosyl-(1⟶4)-β-d-pyranoglucosyl-(1⟶3)-α-l-pyridine rhamnosyl-(1⟶2)-α-l-pyranosine arabinoside (B9) were determined by HPLC and QAMS. The methodological verification was carried out. The relative correction factor (RCF) was calculated, and the reproducibility of the RCF was investigated. The experimental results of the external standard method (ESM) and the QAMS were compared. Meanwhile, the fingerprint of the extract of Pulsatilla chinensis total saponins was established and the quality of the extract was evaluated by SQFM and hierarchical cluster analysis (HCA). The results showed that there was no significant difference between the QAMS and ESM. QAMS could be used for the rapid determination of various saponins in the extract of Pulsatilla chinensis. SQFM and HCA could objectively and comprehensively reflect the overall quality difference of total saponin extract of Pulsatilla chinensis. Therefore, QAMS and SQFM could provide a more convenient and effective selection for the quality evaluation of total saponin extract from this plant.
Keywords	Analytical chemistry ; QD71-142
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Business Circle Identification and Spatiotemporal Characteristics in the Main Urban Area of Yiwu City Based on POI and Night-Time Light Data

Liangliang Zhou / Yishao Shi / Jianwen Zheng

Remote Sensing, Vol 13, Iss 5153, p

2021 Volume 5153

Abstract: The activity of the urban night-time economy is one of the most important indicators reflecting the prosperity of an urban economy. The business circle is an important carrier of urban commercial activities and the core area of urban nightlife. This ... ...

Abstract	The activity of the urban night-time economy is one of the most important indicators reflecting the prosperity of an urban economy. The business circle is an important carrier of urban commercial activities and the core area of urban nightlife. This paper takes the main urban area of Yiwu city as the research object. Based on POI data and night-time light remote sensing data, two-factor mapping, kernel density analysis, DBSCAN clustering, and local contour tree methods are adopted to identify the business circle structure of the main urban area of Yiwu city and analyse the relationship between business circle characteristics and the night-time economy. The following conclusions can be drawn. (1) The spatial superimposition relationship between the night-time remote sensing data and points of interest (POI) data in the main urban area of Yiwu city is good, and the overall coupling results show obvious circle structure characteristics. (2) The spatial distribution of different business combinations has obvious regularity: comprehensive shopping business shows a multicentre distribution pattern and has a hierarchical feature. In contrast, professional food and beverage and leisure and entertainment businesses are close to urban residential areas, and different groups of people live in different places with their own characteristics. (3) From 2015 to 2019, the brightness value of each business circle showed a continuously increasing trend. In 2020, due to the impact of COVID-19, most of them declined. (4) Overall, the difference in business circle tiers reflects the difference in the level of night-time economic activities.
Keywords	POI data ; night-time remote sensing data ; business circle ; night-time economy ; business circle characteristics ; Yiwu city ; Science ; Q
Subject code	720
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on Urban Carrying Capacity Based on Multisource Data Fusion—A Case Study of Shanghai

Xiangyang Cao / Yishao Shi / Liangliang Zhou

Remote Sensing, Vol 13, Iss 2695, p

2021 Volume 2695

Abstract: Taking Shanghai as an example, this paper uses remote sensing (RS) and geographical information systems (GIS) technology to conduct multisource data fusion and a spatial pattern analysis of urban carrying capacity at the micro scale. The main conclusions ...

Abstract	Taking Shanghai as an example, this paper uses remote sensing (RS) and geographical information systems (GIS) technology to conduct multisource data fusion and a spatial pattern analysis of urban carrying capacity at the micro scale. The main conclusions are as follows: (1) based on the “production, living and ecology” land functions framework and land use data, Shanghai is divided into seven types of urban spaces to reveal their heterogeneity and compatibility in terms of land use functions. (2) We propose an urban carrying capacity coupling model ( UCCCM ) based on multisource data. The model incorporates threshold and saturation effects, which improve its power to explain urban carrying capacity. (3) Using the exploratory spatial data analysis (ESDA) technique, this paper studies the spatial pattern of carrying capacity in different urban spaces of Shanghai. (4) We analyse the causes of the cold spots in each urban space and propose strategies to improve the urban carrying capacity according to local conditions.
Keywords	urban carrying capacity ; spatial heterogeneity ; multisource data fusion ; ESDA ; Science ; Q
Subject code	910
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Factors Influencing the Urban Carrying Capacity of the Shanghai Metropolis Based on a Multiscale Geographically Weighted Regression (MGWR) Model

Xiangyang Cao / Yishao Shi / Liangliang Zhou / Tianhui Tao / Qianqian Yang

Land, Vol 10, Iss 578, p

2021 Volume 578

Abstract: With the rapid development of urban economy and the continuous expansion of urban scale, the limitations of urban carrying capacity begin to appear. For the sustainable development of the city, more and more scholars are paying attention to the research ... ...

Abstract	With the rapid development of urban economy and the continuous expansion of urban scale, the limitations of urban carrying capacity begin to appear. For the sustainable development of the city, more and more scholars are paying attention to the research onurban carrying capacity. Basedon the continuous research of the authors’ research group over the past ten years, this paper uses a multiscale geographically weighted regression model and method to explore the impact of geographical location, floor area ratio, public transportation, residents’ consumption level, the density of high-tech enterprises, and the ecological environment on the carrying capacity of the Shanghai metropolis. The results show that (1) the impact of geographical location on the bearing capacity decreases from downtown to the outer areas and from the northeastern area to the southwestern area of Shanghai. (2) On the whole, the elasticity of the average floor area ratio to the urban carrying capacity is 0.52%. In different regions, most of the central urban areas have exceeded the optimal average plot ratio. With an increase in the average plot ratio, the urban carrying capacity presents a downward trend. Other sample areas generally did not reach the average optimal plot ratio, especially the southwestern area of Shanghai. With an increase in the average plot ratio, the urban carrying capacity of this area improved significantly. (3) The elasticity of public transportation convenience to the urban carrying capacity is 0.23%; that is, the average increase in the urban carrying capacity is 0.23% for every 1% increase in public transportation convenience. The elasticity of residents’ consumption level is −0.18%; in other words, every 1% increase in residents’ consumption level will reduce the urban carrying capacity by 0.18% on average. The elasticity of the density of high-tech enterprises is 0.08%; hence, when the density of high-tech enterprises increases by 1%, the urban carrying capacity increases by 0.08% on average. Lastly, the ...
Keywords	influencing factors ; multiscale geographically weighted regression model ; Shanghai ; urban carrying capacity ; Agriculture ; S
Subject code	380
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Public Health Services, Health Human Capital, and Relative Poverty of Rural Families

Yingya Yang / Liangliang Zhou / Chongmei Zhang / Xin Luo / Yihan Luo / Wei Wang

International Journal of Environmental Research and Public Health, Vol 19, Iss 11089, p

2022 Volume 11089

Abstract: With the successful completion of the battle against poverty, after 2020, the focus and difficulty of China’s poverty governance will change from solving absolute poverty to alleviating relative poverty. Analyzing and studying the alleviation of relative ...

Abstract	With the successful completion of the battle against poverty, after 2020, the focus and difficulty of China’s poverty governance will change from solving absolute poverty to alleviating relative poverty. Analyzing and studying the alleviation of relative poverty from the perspective of public health services is in line with the current needs of consolidating and expanding poverty alleviation in China, and it is also of great significance to building a long-term solution mechanism for relative poverty. In this study, basic panel data were constructed by using the data of five CFPS surveys in 2010, 2012, 2014, 2016, and 2018 and matched with the macro data. The correlation between public health services and rural households’ relative poverty was also analyzed by using logit regression analysis and the KHB mediation effect decomposition method. The results show that (1) public health services play a significant role in promoting the accumulation of health human capital, improving individual feasible ability, and alleviating the relative poverty of rural families; (2) the improvement of public health services is conducive to the alleviation of the relative poverty of rural families; (3) we should continue to increase investment in public health care in underdeveloped areas and strive to promote the balanced development of public health services, so as to further consolidate and expand the achievements of poverty eradication.
Keywords	public health services ; healthy human capital ; relative poverty ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of Land Intensive Use in Shanghai Pilot Free Trade Zone

Liangliang Zhou / Yishao Shi / Xiangyang Cao

Land, Vol 8, Iss 6, p

2019 Volume 87

Abstract: Free trade zones represent an important system innovation space to realize economic agglomeration advantages with high-level openings. However, its evaluation of land intensive use has not received enough attention. The goal of this paper is to build a ... ...

Abstract	Free trade zones represent an important system innovation space to realize economic agglomeration advantages with high-level openings. However, its evaluation of land intensive use has not received enough attention. The goal of this paper is to build a land use performance evaluation index system in line with the development trend of industrial economy and the characteristics of mixed land use in the free trade zones. An evaluation index system is constructed based on the three factors of land use status, land use efficiency and pilot free trade zone influence. Using the Delphi method and the entropy method, an empirical evaluation of the intensive land use level in the Shanghai Pilot Free Trade Zone is conducted. The results show the following: (1) integrating new indicators such as the free trade zone influence, social and ecological benefits into the evaluation index system show a characteristic and innovative land use evaluation; (2) in terms of the level of intensive land use, the Waigaoqiao Free Trade Zone has the highest intensity, followed by the Yangshan Free Trade Port Zone, and the Pudong Airport Comprehensive Free Trade Zone has the lowest intensity; and (3) development time, degree of land use, differences in leading functions, industrial land structures, and the diversification of employment structures are important factors that influence the differences in the levels of intensive land use in the Shanghai Pilot Free Trade Zone. This study also expands the performance evaluation of industrial land to the performance evaluation of construction land and provides references for industrial transformation and urban renewal of the Shanghai Pilot Free Trade Zone.
Keywords	intensive land use ; evaluation index system ; Delphi method ; entropy method ; impact factors ; Shanghai Pilot Free Trade Zone ; Agriculture ; S
Subject code	910
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of Fluorescence Polarization Immunoassay for Imidacloprid in Environmental and Agricultural Samples

Liangliang Zhou / Jiachuan Yang / Zhexuan Tao / Sergei A. Eremin / Xiude Hua / Minghua Wang

Frontiers in Chemistry, Vol

2020 Volume 8

Abstract: A fluorescence polarization immunoassay (FPIA) for the determination of imidacloprid (IMI) was developed with advantages of simple operation and short assay time. The haptens of IMI, acetamiprid (ACE), and thiamethoxam (THI) were conjugated with ... ...

Abstract	A fluorescence polarization immunoassay (FPIA) for the determination of imidacloprid (IMI) was developed with advantages of simple operation and short assay time. The haptens of IMI, acetamiprid (ACE), and thiamethoxam (THI) were conjugated with fluorescein isothiocyanate ethylenediamine (EDF) and 4′-Aminomethyl fluorescein (AMF), respectively, to prepare six fluorescence tracers. The conjugation of IMI hapten and EDF (IMI-EDF) was selected to develop the FPIA due to the largest fluorescent polarization value increase in the presence of anti-IMI monoclonal antibody. Under the optimum condition, the limit of detection, 50% inhibition concentration and detection range of the FPIA were 1.7, 4.8, and 1.7–16.3 μg/L, respectively. The cross-reactivities (CRs) with the analogs of IMI were negligible except for imidaclothiz with CR of 79.13%. The average recovery of spiked paddy water, corn and cucumber samples were 82.4–118.5% with the RSDs of 7.0–15.9%, which indicated the FPIA had good accuracy. Thus, the developed FPIA was a potential tool for the rapid and accurate determination of IMI in agricultural and environmental samples.
Keywords	imidacloprid ; fluorescence polarization immunoassay ; fluorescent tracers ; pesticide residue ; high throughput detection ; Chemistry ; QD1-999
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: R-Fluoxetine Increases Melanin Synthesis Through a 5-HT1A/2A Receptor and p38 MAPK Signaling Pathways

Li Liu / Mengsi Fu / Siran Pei / Liangliang Zhou / Jing Shang

International Journal of Molecular Sciences, Vol 20, Iss 1, p

2018 Volume 80

Abstract: Fluoxetine, a member of the class of selective serotonin reuptake inhibitors, is a racemic mixture and has an anxiolytic effect in rodents. Previously, we have shown that fluoxetine can up-regulate melanin synthesis in B16F10 melanoma cells and normal ... ...

Abstract	Fluoxetine, a member of the class of selective serotonin reuptake inhibitors, is a racemic mixture and has an anxiolytic effect in rodents. Previously, we have shown that fluoxetine can up-regulate melanin synthesis in B16F10 melanoma cells and normal human melanocytes (NMHM). However, the role of r-fluoxetine and s-fluoxetine, in the regulation of melanin synthesis, is still unknown. Here, we show how r-fluoxetine plays a critical role in fluoxetine enhancing melanogenesis, both in vivo and vitro, by up-regulating tyrosinase (TYR) and the microphthalmia-associated transcription factor (MITF) expression, whereas, s-fluoxetine does not show any effect in the vivo and vitro systems. In addition, we found that r-fluoxetine induced melanin synthesis through the serotonin1A receptor (5-HT1A) and serotonin 2A receptor (5-HT2A). Furthermore, r-fluoxetine increased the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), without affecting the phosphorylation of extracellularly responsive kinase (ERK1/2) and c-Jun N-terminal kinase (JNK). These data suggest that r-fluoxetine may be used as a drug for skin hypopigmentation disorders.
Keywords	r-fluoxetine ; zebrafish ; melanin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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