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  1. Article ; Online: Efficacy of Daily Text Messaging to Support Adherence to HIV Pre-Exposure Prophylaxis (PrEP) among Stimulant-Using Men Who Have Sex with Men.

    Serrano, Vanessa B / Moore, David J / Morris, Sheldon / Tang, Bin / Liao, Antony / Hoenigl, Martin / Montoya, Jessica L

    Substance use & misuse

    2023  Volume 58, Issue 3, Page(s) 465–469

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Male ; Central Nervous System Stimulants/therapeutic use ; HIV Infections/prevention & control ; HIV Infections/drug therapy ; Homosexuality, Male ; Medication Adherence ; Pre-Exposure Prophylaxis/methods ; Sexual and Gender Minorities ; Text Messaging
    Chemical Substances Central Nervous System Stimulants
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1310358-1
    ISSN 1532-2491 ; 1082-6084
    ISSN (online) 1532-2491
    ISSN 1082-6084
    DOI 10.1080/10826084.2023.2165409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 935: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Integrated proteome and phosphoproteome analysis of gastric adenocarcinoma reveals molecular signatures capable of stratifying patient outcome.

    Lu, Xue / Fu, Yunyun / Gu, Lei / Zhang, Yunpeng / Liao, Antony Y / Wang, Tingting / Jia, Bin / Zhou, Donglei / Liao, Lujian

    Molecular oncology

    2022  Volume 17, Issue 2, Page(s) 261–283

    Abstract: Metastasis is one of the main causes of low survival rate of gastric cancer patients. Exploring key proteins in the progression of gastric adenocarcinoma (GAC) may provide new candidates for prognostic biomarker development and therapeutic intervention. ... ...

    Abstract Metastasis is one of the main causes of low survival rate of gastric cancer patients. Exploring key proteins in the progression of gastric adenocarcinoma (GAC) may provide new candidates for prognostic biomarker development and therapeutic intervention. We applied quantitative mass spectrometry to compare the proteome and phosphoproteome of primary tumor tissues between GAC patients with and without lymph node metastasis (LNM). We then performed an integrated analysis of the proteomic and transcriptomic data to reveal the molecular features. We quantified a total of 5536 proteins, and we found 218 upregulated and 49 downregulated proteins in tumor samples from patients with LNM compared to those without LNM. Clustering analysis identified a number of hub proteins that have been previously shown to play important roles in gastric cancer progression. We also found that two extracellular proteins, TNXB and SPON1, are overexpressed in patients with LNM, which correlates with poor survival of GAC patients. Overexpression of TNXB and SPON1 was validated by western blotting and immunohistochemistry. Furthermore, treating gastric cancer cells with anti-TNXB antibody significantly reduced cell migration. Finally, quantitative phosphoproteomic analysis combined with activity-based kinase capture revealed a number of activated kinases in primary tumor tissues from patients with LNM, among which GSK3 might be a new target that warrants further study. Our study provides a snapshot of the proteome and phosphoproteome of GAC tumor tissues that have metastatic potential, and identifies potential biomarkers for GAC progression.
    MeSH term(s) Humans ; Proteome/metabolism ; Biomarkers, Tumor/metabolism ; Stomach Neoplasms/metabolism ; Proteomics ; Glycogen Synthase Kinase 3 ; Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Lymphatic Metastasis
    Chemical Substances Proteome ; Biomarkers, Tumor ; Glycogen Synthase Kinase 3 (EC 2.7.11.26)
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2415106-3
    ISSN 1878-0261 ; 1574-7891
    ISSN (online) 1878-0261
    ISSN 1574-7891
    DOI 10.1002/1878-0261.13361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6637: Show issues Location:
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  3. Article ; Online: CD3

    de Almeida, Sergio M / Beltrame, Miriam Perlingeiro / Tang, Bin / Rotta, Indianara / Justus, Julie Lilian P / Schluga, Yara / da Rocha, Maria Tadeu / Martins, Edna / Liao, Antony / Abramson, Ian / Vaida, Florin / Schrier, Rachel / Ellis, Ronald J

    Journal of neuroimmunology

    2023  Volume 377, Page(s) 578067

    Abstract: The transactivator of transcription (Tat) is a HIV regulatory protein which promotes viral replication and chemotaxis. HIV-1 shows extensive genetic diversity, HIV-1 subtype C being the most dominant subtype in the world. Our hypothesis is the frequency ... ...

    Abstract The transactivator of transcription (Tat) is a HIV regulatory protein which promotes viral replication and chemotaxis. HIV-1 shows extensive genetic diversity, HIV-1 subtype C being the most dominant subtype in the world. Our hypothesis is the frequency of CSF CD3
    MeSH term(s) Humans ; HIV-1/metabolism ; Killer Cells, Natural/metabolism ; CD56 Antigen/metabolism ; Natural Killer T-Cells/metabolism ; HIV Infections/metabolism ; CD3 Complex ; Flow Cytometry
    Chemical Substances CD56 Antigen ; CD3 Complex
    Language English
    Publishing date 2023-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 8335-5
    ISSN 1872-8421 ; 0165-5728
    ISSN (online) 1872-8421
    ISSN 0165-5728
    DOI 10.1016/j.jneuroim.2023.578067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1646: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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