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  1. Book ; Thesis: Interaction between human innate leukocytes and irradiated tumor cells

    Liao, Boyu / Huber, Peter E.

    2022  

    Institution Universität Heidelberg
    Author's details vorgelegt von Boyu Liao ; Doktorvater: Herr Prof. Dr. Dr. Peter Huber
    Language English
    Size 113 Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    Note Text auf Englisch, Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT030638940
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 257 order for loan Magazin

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  2. Article ; Online: The impact of the monetary gold principle on the determination of jurisdiction in the mixed maritime disputes.

    Liao, Boyu / Chang, Yen-Chiang / Khan, Mehran Idris

    Science progress

    2023  Volume 106, Issue 2, Page(s) 368504231179814

    Abstract: Mixed maritime disputes are maritime disputes that involve the concurrent consideration of any dispute concerning sovereignty or other rights over continental or insular land territory, which according to Article 298(1)(a)(i) of United Nations Convention ...

    Abstract Mixed maritime disputes are maritime disputes that involve the concurrent consideration of any dispute concerning sovereignty or other rights over continental or insular land territory, which according to Article 298(1)(a)(i) of United Nations Convention on the Law of the Sea, should be excluded from the jurisdiction of a court or tribunal referred to in Article 287. However, by means of treaty interpretation or consensus of two parties, International Tribunal for the Law of the Sea and other Annex VII tribunals have increasingly broken through the limits to actively exercise jurisdiction. Judgements under the influence of this tendency will be firmly resisted by states whose sovereign interests are damaged. Moreover, these judgements will not only fail to resolve disputes, but will create more serious international law and international political disputes, such as the judgement on preliminary objections of
    MeSH term(s) Dissent and Disputes ; Maldives
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 128412-5
    ISSN 2047-7163 ; 0036-8504 ; 0302-1785
    ISSN (online) 2047-7163
    ISSN 0036-8504 ; 0302-1785
    DOI 10.1177/00368504231179814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 731: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Adjuvant activity of cordycepin, a natural derivative of adenosine from

    Chen, Xin / Liao, Boyu / Ren, Tianci / Liao, Zhipeng / Huang, Zijie / Lin, Yujuan / Zhong, Shouhao / Li, Jiaying / Wen, Shun / Li, Yingyan / Lin, Xiaohan / Du, Xingchen / Yang, Yuhui / Guo, Jiubiao / Zhu, Xiaohui / Lin, Haishu / Liu, Rui / Wang, Jingbo

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24612

    Abstract: Vaccination is the most feasible way of preventing rabies, an ancient zoonosis that remains a major public health concern globally. However, administration of inactivated rabies vaccination without adjuvants is always inefficient and necessitates four to ...

    Abstract Vaccination is the most feasible way of preventing rabies, an ancient zoonosis that remains a major public health concern globally. However, administration of inactivated rabies vaccination without adjuvants is always inefficient and necessitates four to five injections. In the current study, we explored the adjuvant characteristics of cordycepin, a major bioactive component of
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Platelet-rich plasma in combination with adipose-derived stem cells promotes skin wound healing through activating Rho GTPase-mediated signaling pathway.

    Zhang, Lei / Zhang, Baojian / Liao, Boyu / Yuan, Sha / Liu, Yanqun / Liao, Zhengyin / Cheng, Biao

    American journal of translational research

    2019  Volume 11, Issue 7, Page(s) 4100–4112

    Abstract: Adipose-derived stem cells (ADSCs) are multipotent stromal cells that provide an abundant source of cells for skin tissue engineering and wound healing. Platelet-rich plasma (PRP) is a concentrate of platelet-rich plasma protein, which contains several ... ...

    Abstract Adipose-derived stem cells (ADSCs) are multipotent stromal cells that provide an abundant source of cells for skin tissue engineering and wound healing. Platelet-rich plasma (PRP) is a concentrate of platelet-rich plasma protein, which contains several different growth factors and other cytokines. In this study, we combined ADSCs with PRP for wound healing. Herein, we found ADSCs in combination with PRP was able to promote wound healing, granulation formation, collagen deposition and re-epithelialization. The mechanism exploration discovered that PRP promoted stress fiber formation in ADSCs, leading to cell migration. Then, we demonstrated that PRP enhanced the expression of Rho GTP family proteins, including Cdc 42, Rac 1 and Rho A. Moreover, it promoted the expression of downstream Rho GTP signaling molecules, including PAK 1, ROCK 2, LIMK 1 and Cofilin. When PRP was used in combination with the Cdc 42 inhibitor ZCL278, the Rho A inhibitor CT04, Rac 1 inhibitor NSC23766, PAK inhibitor FRAX597, or Rock 2 inhibitor Y27632 to treat ADSCs, stress fiber formation was significantly reduced, resulting in decreased cell migration. Our findings may provide a promising approach to promote wound healing.
    Language English
    Publishing date 2019-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8.

    Walle, Thomas / Kraske, Joscha A / Liao, Boyu / Lenoir, Bénédicte / Timke, Carmen / von Bohlen Und Halbach, Emilia / Tran, Florian / Griebel, Paul / Albrecht, Dorothee / Ahmed, Azaz / Suarez-Carmona, Meggy / Jiménez-Sánchez, Alejandro / Beikert, Tizian / Tietz-Dahlfuß, Alexandra / Menevse, Ayse Nur / Schmidt, Gabriele / Brom, Manuela / Pahl, Jens H W / Antonopoulos, Wiebke /
    Miller, Matthias / Perez, Ramon Lopez / Bestvater, Felix / Giese, Nathalia A / Beckhove, Philipp / Rosenstiel, Philip / Jäger, Dirk / Strobel, Oliver / Pe'er, Dana / Halama, Niels / Debus, Jürgen / Cerwenka, Adelheid / Huber, Peter E

    Science advances

    2022  Volume 8, Issue 12, Page(s) eabh4050

    Abstract: Radiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains unclear. Here, using a reverse translational approach, we show a central role ... ...

    Abstract Radiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains unclear. Here, using a reverse translational approach, we show a central role of NK cells in the radiation-induced immune response involving a CXCL8/IL-8-dependent mechanism. In a randomized controlled pancreatic cancer trial, CXCL8 increased under radiotherapy, and NK cell positively correlated with prolonged overall survival. Accordingly, NK cells preferentially infiltrated irradiated pancreatic tumors and exhibited CD56
    MeSH term(s) Adoptive Transfer ; Animals ; Humans ; Immunity ; Interleukin-8/immunology ; Interleukin-8/metabolism ; Killer Cells, Natural/immunology ; Mice ; Neoplasms/immunology ; Neoplasms/radiotherapy ; Xenograft Model Antitumor Assays
    Chemical Substances CXCL8 protein, human ; Interleukin-8
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abh4050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Disturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer.

    Yin, Jun / Zhao, Jian / Hu, Weimin / Yang, Guangping / Yu, Hui / Wang, Ruihao / Wang, Linjing / Zhang, Guoqian / Fu, Wenfan / Dai, Lu / Li, Wanzhen / Liao, Boyu / Zhang, Shuxu

    PloS one

    2017  Volume 12, Issue 2, Page(s) e0172787

    Abstract: Radio- and chemo-resistance represent major obstacles in the therapy of non-small-cell lung cancer (NSCLC) and the underlying molecular mechanisms are not known. In the present study, during induction of radio- or chemo-resistance in NSCLC cells, dynamic ...

    Abstract Radio- and chemo-resistance represent major obstacles in the therapy of non-small-cell lung cancer (NSCLC) and the underlying molecular mechanisms are not known. In the present study, during induction of radio- or chemo-resistance in NSCLC cells, dynamic analyses revealed that decreased expression of let-7 induced by irradiation or cisplatin resulted in increased expression of its target gene LIN28, and increased expression of LIN28 then contributed to further decreased expression of let-7 by inhibiting its maturation and biogenesis. Moreover, we showed that down-regulation of let-7 and up-regulation of LIN28 expression promoted resistance to irradiation or cisplatin by regulating the single-cell proliferative capability of NSCLC cells. Consequently, in NSCLC cells, let-7 and LIN28 can form a double-negative feedback loop through mutual inhibition, and disturbance of the let-7/LIN28 double-negative feedback loop induced by irradiation or chemotherapeutic drugs can result in radio- and chemo-resistance. In addition, low expression of let-7 and high expression of LIN28 in NSCLC patients was associated significantly with resistance to radiotherapy or chemotherapy. Therefore, our study demonstrated that disturbance of the let-7/LIN28 double-negative feedback loop is involved in the regulation of radio- and chemo-resistance, and that let-7 and LIN28 could be employed as predictive biomarkers of response to radiotherapy or chemotherapy in NSCLC patients.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cisplatin/administration & dosage ; Drug Resistance, Neoplasm/genetics ; Feedback, Physiological ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/radiation effects ; Humans ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; RNA-Binding Proteins/biosynthesis ; RNA-Binding Proteins/genetics ; Radiation Tolerance/genetics ; Signal Transduction/genetics
    Chemical Substances Lin28A protein, human ; MicroRNAs ; RNA-Binding Proteins ; mirnlet7 microRNA, human ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2017-02-24
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0172787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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