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  1. Article: Clear cell adenocarcinoma of the urinary bladder: a case report and review of literature.

    Ahmadi, Maryam / Osman, Adam / Lee, Peng / Deng, Fangming / Liao, Guanghong

    American journal of clinical and experimental urology

    2023  Volume 11, Issue 4, Page(s) 344–347

    Abstract: The most common histological type of urinary bladder cancer is urothelial carcinoma (UC). Clear cell adenocarcinoma (CCA) of the urinary bladder is a rare histologic subtype of adenocarcinoma in the urinary tract. The tumor primarily affects women and ... ...

    Abstract The most common histological type of urinary bladder cancer is urothelial carcinoma (UC). Clear cell adenocarcinoma (CCA) of the urinary bladder is a rare histologic subtype of adenocarcinoma in the urinary tract. The tumor primarily affects women and has histomorphological features resembling CCA of the female genital tract (or Müllerian origin). Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns. Patients typically present with gross hematuria, dysuria, and discharge. In this study, we report a case of a 50-year-old male, presenting with gross hematuria, which was subsequently diagnosed with CCA at our pathology department. Furthermore, we provide a short systematic review of the literature for this rare histopathological entity and a brief discussion about its morphological and immunohistochemical (IHC) characteristics.
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1910
    ISSN 2330-1910
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  2. Article ; Online: A Physical Perspective of Recurrent Water Quality Degradation: A Case Study in the Jiangsu Coastal Waters, China

    Chen, Shufen / Jiang, Long / Cheng, Xuhua / Liao, Guanghong / Gerkema, Theo

    Journal of Geophysical Research: Oceans. 2023 Aug., v. 128, no. 8 p.e2022JC019607-

    2023  

    Abstract: Estuarine‐coastal systems receive pollutants from various sources at an alarming rate. Some systems are extremely susceptible to terrestrial input, as a relatively small amount of pollutant loading induces lasting water quality degradation. The Jiangsu ... ...

    Abstract Estuarine‐coastal systems receive pollutants from various sources at an alarming rate. Some systems are extremely susceptible to terrestrial input, as a relatively small amount of pollutant loading induces lasting water quality degradation. The Jiangsu coastal waters (JCWs), located in the southwestern Yellow Sea, are such areas that lack large river discharge but suffer from recurrent eutrophication recently. We hypothesize that the low flushing efficiency in the JCWs largely accounted for the susceptibility to coastal pollution. To test it, transit time (TT) and pollutant flushing rates in the JCWs were estimated under various scenarios using a validated three‐dimensional hydrodynamic model. Results show that TT in many inshore waters of the JCWs and the northern radial sand ridges is >240 days, which are consistent with the observed frequently eutrophic areas. The JCWs are better flushed and thus less eutrophic in summer, as a consequence of the stronger tidal residual coastal circulation. The baroclinic pressure gradient, modulated by the formation and destruction of thermal stratification in offshore waters, poses a dominant control on the seasonal variations of the coastal circulation and flushing rates, while wind effects are secondary. River‐borne pollutants from the Yangtze and Jiangsu local rivers are shown to primarily affect regions south and north of 32.5°N, respectively. Our study interprets the vulnerability of the JCWs to pollutant enrichment from a physical perspective and finds the flushing efficiency to be a good indicator of eutrophication, providing references for environmental managers of local and global estuarine‐coastal systems with recurrent pollution.
    Keywords case studies ; coastal water ; eutrophication ; geophysics ; hydrologic models ; pollutants ; pollution ; research ; river flow ; sand ; summer ; temperature profiles ; water quality ; wind ; China ; Yellow Sea
    Language English
    Dates of publication 2023-08
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 161667-5
    ISSN 2169-9291 ; 2169-9275 ; 0148-0227 ; 0196-2256
    ISSN (online) 2169-9291
    ISSN 2169-9275 ; 0148-0227 ; 0196-2256
    DOI 10.1029/2022JC019607
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  3. Article ; Online: Impacts of inertial internal wave breaking mixing parameterization on a global ocean model

    Hu, XiaoKai / Liao, Guanghong / Fan, ZhiSong / Liu, XiYing

    Progress in Oceanography. 2023 Mar., v. 212 p.102997-

    2023  

    Abstract: A parameterization of vertical mixing induced by fine-scale near-inertial internal waves (F-scheme) is implemented in the Parallel Ocean Program, version 2 (POP2). The F-scheme is based on the spectrum model via solving the non-traditional approximation ... ...

    Abstract A parameterization of vertical mixing induced by fine-scale near-inertial internal waves (F-scheme) is implemented in the Parallel Ocean Program, version 2 (POP2). The F-scheme is based on the spectrum model via solving the non-traditional approximation internal wave equations and the observed internal wave spectra. The structure of the resulting dissipation and diffusivity fields and its impacts on the ocean model simulations are investigated. The diffusivity coefficient derived from F-scheme varies spatiotemporally, and is generally in consistent magnitude with observed results in the middle to high latitude ocean, and show the similar latitude dependent characteristics with the current observations, depending on the product of the horizontal and vertical components of the Coriolis parameter (f·f∼) as well as the local stratification condition. The interior mixing induced by F-scheme has some noticeable impacts on the temperature and salinity structure near the main thermocline, the meridional overturning circulation and northward heat transport as has been demonstrated in the other two OGCMs (LICOM and MOM4). The temperature and salinity structure simulated using F-scheme are statistically closer to observations, especially it improves the simulation of the Pacific Ocean, Indian Ocean and Antarctic Circumpolar Circulation. But the involved background mixing coefficients or F-scheme enlarges the temperature and salinity biases in the Atlantic Ocean, the cause is related to the pre-existing weak Antarctic Intermediate Water intrusion toward north and the inexact Atlantic Meridional Overturn Circulation simulation in the present model. F-scheme provides weak mixing in some regions, where an appropriate parameterization of turbulent mixing induced by wave-wave interaction also should be considered in the future.
    Keywords diffusivity ; heat transfer ; latitude ; models ; oceanography ; oceans ; salinity ; temperature ; Antarctic region ; Atlantic Ocean ; Indian Ocean ; Pacific Ocean ; Diapycnal mixing ; Horizontal Coriolis parameter ; Near inertial internal wave ; Fine scale mixing parameterization
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 0079-6611
    DOI 10.1016/j.pocean.2023.102997
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  4. Article ; Online: Analysis of the Value of Helicobacter pylori Test in Combination with the Determination of Plasma Propepsin and Gastrin 17 in Screening the Precancerous Status of Gastric Cancer.

    Xiao, Meiping / Zhang, Zhiying / Liao, Guanghong / Liu, Min / Chen, Xuehong

    Cellular and molecular biology (Noisy-le-Grand, France)

    2022  Volume 68, Issue 8, Page(s) 110–115

    Abstract: To explore the value of the Helicobacter pylori test in combination with the determination of plasma pepsinogen (PG) and gastrin 17 in screening the precancerous status of gastric cancer and gastric cancer in the healthy population, between 2019 and 2022, ...

    Abstract To explore the value of the Helicobacter pylori test in combination with the determination of plasma pepsinogen (PG) and gastrin 17 in screening the precancerous status of gastric cancer and gastric cancer in the healthy population, between 2019 and 2022, we enrolled a total of 402 subjects who went to the physical examination in the Center of Health Management of Ganzhou people's Hospital and additionally underwent the urea (14C) breath test and determination of PGI, PGII and G-17. Anomalies in Hp, PG or G-17 ≥ 2, or a single anomaly in PG determination would be taken as positive, and the diagnosis should be further confirmed by the gastroscopy and pathological test. According to the results, subjects would be further divided into the gastric cancer group, precancerous lesion group, precancerous disease group and control group, aiming to clarify the relationship between Hp, PG and G-17 levels and the precancerous status and development of gastric cancer and the screening value. Results showed that Hp-positive infection was found in 341 subjects (84.82%). Hp infection rate in the control group was much lower than those in the precancerous disease group, precancerous lesion group and gastric cancer group (P < 0.05). The CagA positive rates in the gastric cancer group and precancerous lesion group were significantly higher than those in the precancerous disease group and control group, while the serum level of G-17 in the gastric cancer group was much higher than those in the precancerous lesion group, precancerous disease group and control group (P < 0.05), and the PG I/II ratio in the gastric cancer patients was also lower than those in the precancerous lesion group, precancerous disease group and control group (P < 0.05). As the disease progressed, the G-17 level also increased but PG I/II ratio decreased gradually (P < 0.001). Hp test in combination with PG and G-17 shows a high value in determining the precancerous status of gastric cancer and screening for gastric cancer in healthy subjects.
    MeSH term(s) Humans ; Stomach Neoplasms/diagnosis ; Helicobacter pylori ; Early Detection of Cancer ; Pepsinogen A ; Pepsinogen C ; Helicobacter Infections/diagnosis ; Precancerous Conditions/diagnosis
    Chemical Substances gastrin 17 (60748-06-3) ; Pepsinogen A (9001-10-9) ; Pepsinogen C (61536-72-9)
    Language English
    Publishing date 2022-08-31
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2022.68.8.20
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    Zs.A 3812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Improved ENSO and PDO Prediction Skill Resulting from Finer Parameterization Schemes in a CGCM

    Yang, Yuxing / Hu, Xiaokai / Liao, Guanghong / Cao, Qian / Chen, Sijie / Gao, Hui / Wei, Xiaowei

    Remote Sensing. 2022 July 13, v. 14, no. 14

    2022  

    Abstract: Coupled general circulation models (CGCMs), as tools of predicting climate variability, are constantly being improved due to their immense value in a host of theoretical and practical, real-world problems. Consequently, four new parameterization schemes ... ...

    Abstract Coupled general circulation models (CGCMs), as tools of predicting climate variability, are constantly being improved due to their immense value in a host of theoretical and practical, real-world problems. Consequently, four new parameterization schemes are introduced in the First Institute of Oceanography Earth System Model (FIO-ESM), and a new climate prediction System (CPS) is built up based on modified and original FIO-ESM. Here, turbulence from the sea surface to deep ocean were fully described, and seasonal forecasts of El Niño-Southern Oscillation (ENSO) and year-to-year prediction of Pacific Decadal Oscillation (PDO) were made with both the modified and original FIO-ESM-CPS. The results illustrate that the anomaly correlation coefficient (ACC) of the Niño 3.4 index significantly increased, and the root mean square error (RMSE) significantly decreased, respectively, in the modified FIO-ESM-CPS as compared to the original. The RMSE is improved by over 20% at 4- and 5-month lead times. Over longer leads, and in the modified FIO-ESM-CPS, forecast ENSO amplitudes are far closer to observations than the original CGCM, which significantly overestimates amplitudes. PDO prediction skill is also improved in the modified FIO-ESM-CPS with ACC improving by 36% at the 4-year lead time and RMSE decreasing by 21% at the 3-year lead time.
    Keywords climate ; oceanography ; prediction ; turbulent flow
    Language English
    Dates of publication 2022-0713
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs14143363
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  6. Article ; Online: Weight self-perception and weight loss attempts in Chinese cardiovascular patients and non-cardiovascular patients: evidence from a population-based study.

    Gao, Qingyuan / Li, Ruotong / Chen, Zhiteng / Yin, Wenyao / Liao, Guanghong / Zhang, Haifeng / Wang, Jingfeng / Chen, Yangxin

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 707

    Abstract: Background: Weight loss is a significant improvement for individuals with overweight or obesity, especially for cardiovascular patients. The driving effects of weight self-perception and attempts to lose weight are vital in weight management, yet weight ...

    Abstract Background: Weight loss is a significant improvement for individuals with overweight or obesity, especially for cardiovascular patients. The driving effects of weight self-perception and attempts to lose weight are vital in weight management, yet weight misperception is a direct culprit for the undesirability of weight control and obesity prevention. This study aimed to investigate weight self-perception and misperception and weight loss attempts in Chinese adults, especially among cardiovascular and non-cardiovascular patients.
    Methods: We collected data from China HeartRescue Global Evaluation Baseline Household Survey 2015. Questionnaires were used to assess self-reported weight and cardiovascular patients. We used kappa statistics to check the consistency between weight self-perception and BMI. Logistic regression models were fitted to identify risk factors associated with weight misperception.
    Results: A total of 2690 participants were enrolled in the household survey, while 157 respondents were cardiovascular patients. According to questionnaire results, 43.3% of cardiovascular patients thought they were overweight and obese, while the percentage is 35.3% among non-cardiovascular patients. Kappa statistics indicated higher consistency of self-reported weight and actual weight among cardiovascular patients. Multivariate analysis showed weight misperception was significantly associated with gender, education level, and actual BMI. Lastly, 34.5% of non-cardiovascular patients and 35.0% of cardiovascular patients were trying to lose weight or keep weight. The majority of these people adopted combined strategies of controlling diet and exercise to lose or maintain weight.
    Conclusions: Weight misperception was highly prevalent among cardiovascular or non-cardiovascular patients. Obese respondents, women, and individuals with lower education levels were more vulnerable to make weight misperception. However, no difference in the purpose of weight loss attempts was indicated among cardiovascular and non-cardiovascular patients.
    MeSH term(s) Adult ; Humans ; Body Mass Index ; Body Weight ; East Asian People ; Obesity/epidemiology ; Obesity/therapy ; Overweight/epidemiology ; Overweight/therapy ; Self Concept ; Weight Loss ; Cardiovascular Diseases/complications
    Language English
    Publishing date 2023-04-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-15380-w
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  7. Article ; Online: SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells.

    Ma, Rong / Gao, Qing-Yuan / Chen, Zhi-Teng / Liao, Guang-Hong / Li, Shu-Tai / Cai, Jie-Wen / Luo, Nian-Sang / Chen, Hao / Zhang, Hai-Feng

    Cell cycle (Georgetown, Tex.)

    2024  , Page(s) 1–13

    Abstract: The precise mechanisms underlying the inhibitory effects of SIRT3, a mitochondrial sirtuin protein, on hepatocellular carcinoma (HCC) development, as well as its impact on mitochondrial respiration, remain poorly understood. We assessed sirtuins 3 (SIRT3) ...

    Abstract The precise mechanisms underlying the inhibitory effects of SIRT3, a mitochondrial sirtuin protein, on hepatocellular carcinoma (HCC) development, as well as its impact on mitochondrial respiration, remain poorly understood. We assessed sirtuins 3 (SIRT3) levels in HCC tissues and Huh7 cells cultured under hypoxic condition. We investigated the effects of SIRT3 on cell proliferation, glycolytic metabolism, mitochondrial respiration, mitophagy, and mitochondrial biogenesis in Huh7 cells. Besides, we explored the potential mechanisms regulating SIRT3 expression in hypoxically cultured Huh7 cells. Gradual reduction in SIRT3 expressions were observed in both adjacent tumor tissues and tumor tissues. Similarly, SIRT3 expressions were diminished in Huh7 cells cultured under hypoxic condition. Forced expression of SIRT3 attenuated the growth of hypoxically cultured Huh7 cells. SIRT3 overexpression led to a decrease in extracellular acidification rate while increasing oxygen consumption rate. SIRT3 downregulated the levels of hexokinase 2 and pyruvate kinase M2. Moreover, SIRT3 enhanced mitophagy signaling, as indicated by mtKeima, and upregulated key proteins involved in various mitophagic pathways while reducing intracellular reactive oxygen species levels. Furthermore, SIRT3 increased proxisome proliferator-activated receptor-gamma coactivator 1α levels and the amount of mitochondrial DNA in Huh7 cells. Notably, β-catenin expressions were elevated in Huh7 cells cultured under hypoxic condition. Antagonists and agonists of β-catenin respectively upregulated and downregulated SIRT3 expressions in hypoxically cultured Huh7 cells. The modulationsof glycolysis and mitochondrial respiration represent the primary mechanism through which SIRT3, suppressed by β-catenin, inhibits HCC cell proliferation.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2024.2340864
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Dietary vitamin C and vitamin E with the risk of aortic aneurysm and dissection: A prospective population-based cohort study.

    Zeng, Chuan-Rui / Gao, Jing-Wei / Wu, Mao-Xiong / You, Si / Chen, Zhi-Teng / Gao, Qing-Yuan / Cai, Zhao-Xi / Liu, Pin-Ming / Cai, Yang-Wei / Liang, Xiao-Tian / Cai, Jie-Wen / Liao, Guang-Hong / Chen, Nuo / Huang, Ze-Gui / Wang, Jing-Feng / Zhang, Hai-Feng / Chen, Yang-Xin

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2024  

    Abstract: Background and aims: The associations between dietary vitamin C (VC), vitamin E (VE) intake and aortic aneurysm and dissection (AAD) remain unclear. This study aimed to prospectively investigate the associations between dietary VC and VE with the ... ...

    Abstract Background and aims: The associations between dietary vitamin C (VC), vitamin E (VE) intake and aortic aneurysm and dissection (AAD) remain unclear. This study aimed to prospectively investigate the associations between dietary VC and VE with the incident risk of AAD.
    Methods and results: A total of 139 477 participants of UK Biobank cohort were included in the analysis. Dietary VC and VE consumptions were acquired through a 24-h recall questionnaire. Cox proportional regression models were used to examine the associations between VC, VE intake and the risk of AAD. Incident AAD was ascertained through hospital inpatient records and death registers. During a median follow-up of 12.5 years, 962 incident AAD events were documented. Both dietary VC [adjusted hazard ratio (HR), 0.77; 95 % confidence intervals (CI), 0.63-0.93; P-trend = 0.008] and VE (adjusted HR, 0.70; 95 % CI, 0.57-0.87; P-trend = 0.002) were inversely associated with incident AAD when comparing the participants in the highest quartile with those in the lowest. In subgroup analyses, the associations were more pronounced in participants who were over 60 years old, participants with smoking history, hypertension or hyperlipidemia, who were under the high risk of AAD.
    Conclusion: Higher dietary VC and VE intakes are associated with reduced risk of AAD. Our study emphasizes the importance of diet adjustment strategies targeted on VC and VE to lower the incidence rate of AAD especially in the high-risk population.
    Language English
    Publishing date 2024-01-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2024.01.024
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  9. Article: Aspect Ratio of Eddies Inferred From Argo Floats and Satellite Altimeter Data in the Ocean

    Liu, ZhiYing / Liao, GuangHong / Hu, XiaoKai / Zhou, BeiFeng

    Journal of geophysical research. 2020 Jan., v. 125, no. 1

    2020  

    Abstract: Mesoscale eddies dominate the majority of oceanic kinetic energy. The size of eddies is one of the basic properties; however, little is known about it because of lack of observations. Especially, their global vertical extent has still not been well ... ...

    Abstract Mesoscale eddies dominate the majority of oceanic kinetic energy. The size of eddies is one of the basic properties; however, little is known about it because of lack of observations. Especially, their global vertical extent has still not been well investigated. Here, a ratio relationship of height to length scale for an eddy is derived based on dynamical constraints. Global satellite altimetry data combined with Argo float observations are used to calculate the aspect ratios of mesoscale eddies in the global ocean, and then their vertical scale is inferred. Approximately 25% of the total identified eddies with lifetimes ≥16 weeks from January 2002 to December 2017 trapped at least an Argo float near the eddy center. The result shows that the size of eddies has an obvious latitudinal dependence. Eddies at middle‐low latitudes tend to be “large and shallow” with small aspect ratios, and eddies at high latitudes tend to be “small and deep– reaching” with large aspect ratios. Such results are coarsely considered as a competition between rotation and stratification. Eddy aspect ratios in middle‐high‐latitude regions show enhanced variance compared to those in low‐latitude regions. More than half of eddies have a vertical extent smaller than 400 m. The majority of eddies extend over the mixed layer depth and are instead situated in the pycnocline. Some eddies at the middle‐high latitudes penetrate through the entire pycnocline and reach deep ocean; as such, these eddies may play an important role in linking the deep‐sea circulations and the surface circulations.
    Keywords altimeters ; geophysics ; kinetic energy ; latitude ; oceans ; research ; satellite altimetry ; satellites ; variance
    Language English
    Dates of publication 2020-01
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 161667-5
    ISSN 2169-9291 ; 2169-9275 ; 0148-0227 ; 0196-2256
    ISSN (online) 2169-9291
    ISSN 2169-9275 ; 0148-0227 ; 0196-2256
    DOI 10.1029/2019JC015555
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  10. Article ; Online: Serum albumin and risk of incident diabetes and diabetic microvascular complications in the UK Biobank cohort.

    Cai, Yang-Wei / Zhang, Hai-Feng / Gao, Jing-Wei / Cai, Zhao-Xi / Cai, Jie-Wen / Gao, Qing-Yuan / Chen, Zhi-Teng / Liao, Guang-Hong / Zeng, Chuan-Rui / Chen, Nuo / Liu, Pin-Ming / Wang, Jing-Feng / Chen, Yang-Xin

    Diabetes & metabolism

    2023  Volume 49, Issue 5, Page(s) 101472

    Abstract: Aim: To examine the associations between serum albumin and the incidences of diabetes and diabetic microvascular complications in participants of the UK Biobank cohort.: Methods: There were 398,146 participants without diabetes and 30,952 patients ... ...

    Abstract Aim: To examine the associations between serum albumin and the incidences of diabetes and diabetic microvascular complications in participants of the UK Biobank cohort.
    Methods: There were 398,146 participants without diabetes and 30,952 patients with diabetes from the UK Biobank cohort included in this study. Multivariate-adjusted Cox proportional hazard models were used to analyze the association of albumin with the incidences of diabetes and diabetic microvascular complications. Mendelian randomization (MR) analysis was used to determine the genetic relationships between serum albumin and diabetes.
    Results: After a median 12.90 years follow-up, 14,710 participants developed incident diabetes (58.83 ± 7.52 years, 56.10% male). After multivariate adjustment, serum albumin was inversely associated with incident diabetes: hazard ratio (HR) [95% confidence interval] per 10 g/l increase 0.88 [0.82;0.94]. MR analyses suggested a potential genetic influence of serum albumin on diabetes in both the UK Biobank and the FinnGen consortium: odds ratios (ORs) [95% confidence interval per 1 g/l increase 0.99 [0.98;1.00] and 0.78 [0.67;0.92], respectively. In patients with diabetes, higher serum albumin levels were significantly associated with lower risk for diabetic microvascular complications. Specifically, per 10 g/l increase in serum albumin, the HRs for diabetic nephropathy, ophthalmopathy, and neuropathy were 0.42 [0.30;0.58], 0.61 [0.52;0.72], and 0.67 [0.51;0.88], respectively.
    Conclusion: In this large prospective study, serum levels of albumin were inversely associated with the incidences of diabetes and diabetic microvascular complications. These findings underscore the importance of maintaining optimal nutrient status in reducing the risk of diabetes and its complications.
    MeSH term(s) Humans ; Male ; Female ; Prospective Studies ; Serum Albumin ; Biological Specimen Banks ; Diabetic Nephropathies/epidemiology ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/complications ; Diabetic Angiopathies/epidemiology ; Diabetic Angiopathies/genetics ; Diabetic Angiopathies/complications ; United Kingdom/epidemiology ; Risk Factors ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics
    Chemical Substances Serum Albumin
    Language English
    Publishing date 2023-09-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 1315751-6
    ISSN 1878-1780 ; 1262-3636 ; 0338-1684
    ISSN (online) 1878-1780
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/j.diabet.2023.101472
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