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  1. Article: The impact of epidemic information on the public's worries and attitude toward epidemic prevention measures during the COVID-19 outbreak.

    Liao, Hai-Ping / Wang, Jin-Liang

    Current psychology (New Brunswick, N.J.)

    2021  Volume 42, Issue 1, Page(s) 145–153

    Abstract: Since the outbreak of 2019 coronavirus disease (COVID-19) in December 2019, the Chinese government has implemented effective epidemic prevention measures. To provide useful information for governments to manage this public health crisis, we conducted an ... ...

    Abstract Since the outbreak of 2019 coronavirus disease (COVID-19) in December 2019, the Chinese government has implemented effective epidemic prevention measures. To provide useful information for governments to manage this public health crisis, we conducted an online survey among Chinese general population from February 24 to 28, 2020. In this study, we examined the impact of epidemic information and rumors on public's worries and attitude toward prevention measures during the outbreak of COVID-19. A total of 853 valid questionnaires (641 women, 75.1%) were collected from 24 provincial regions in China. Most respondents' ages ranged from 18 to 60 (833 participants, 97.66%). A mediation model was built to analyze the influence of epidemic information and rumors on worries and attitude. The results showed that the amount of epidemic information positively predicted public's worries, which in turn predicted a supportive attitude toward the prevention measures. Worries partially mediated the relationship between the amount of epidemic information and the supportive attitude. The amount of rumors negatively predicted the supportive attitude. The results of this study implied the importance of timely and credible information providing to evoke a certain level of worry and promote public cooperation, and the necessary attention to refute and resist rumors for effective risk communication in a public health crisis.
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021598-8
    ISSN 1936-4733 ; 1046-1310
    ISSN (online) 1936-4733
    ISSN 1046-1310
    DOI 10.1007/s12144-021-01364-9
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  2. Article ; Online: Piezo-type mechanosensitive ion channel component 1 (Piezo1) in human cancer.

    Yu, Jia-Lin / Liao, Hai-Yang

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Volume 140, Page(s) 111692

    Abstract: Piezo-type mechanosensitive ion channel component 1 (Piezo1) is a mechanosensitive ion channel protein that is evolutionarily conserved and multifunctional. It plays an important role as an oncogenic mediator in several malignant tumors. It mediates the ... ...

    Abstract Piezo-type mechanosensitive ion channel component 1 (Piezo1) is a mechanosensitive ion channel protein that is evolutionarily conserved and multifunctional. It plays an important role as an oncogenic mediator in several malignant tumors. It mediates the proliferation, migration, and invasion of a variety of cancer cells through various mechanisms. Multiple studies have shown that the expression of Piezo1 is related to the clinical characteristics of senescence and cancer patients, making Piezo1 useful as a new biomarker for the diagnosis and prognosis of a variety of human cancers. Manipulating the expression or function of Piezo1 is a potential therapeutic strategy for different diseases. Piezo1 may be a promising tumor biomarker and therapeutic target. Here we review the biological function, mechanism of action, and potential clinical significance of Piezo1 in oncogenesis and progression.
    MeSH term(s) Animals ; Biomarkers, Tumor/metabolism ; Humans ; Ion Channel Gating/physiology ; Ion Channels/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Prognosis
    Chemical Substances Biomarkers, Tumor ; Ion Channels
    Language English
    Publishing date 2021-05-16
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.111692
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: A new isopimarane-type diterpene with anti-inflammatory activity from the

    Liao, Hai-Xia / Shi, Can-Can / Wang, Rui-Juan / Shao, Tai-Ming / Tan, Ming-Xiong

    Natural product research

    2024  , Page(s) 1–6

    Abstract: A new isopimarane-type diterpene clinacanoid A ( ...

    Abstract A new isopimarane-type diterpene clinacanoid A (
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2317874
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  4. Article ; Online: Triterpenoids and triterpenoid saponins from Vitex negundo and their anti-inflammatory activities.

    Gu, Chao / Wang, Ya-Qi / Su, Bao-Jun / Hu, Ya-Jie / Liao, Hai-Bing / Liang, Dong

    Phytochemistry

    2024  Volume 222, Page(s) 114068

    Abstract: Seven undescribed polyoxygenated ursane-type triterpenoids (vitnegundins A-G), three undescribed triterpenoid saponins (vitnegundins H-J), and 17 known ones were isolated from an EtOH extract of the aerial parts of Vitex negundo L. The structures of the ... ...

    Abstract Seven undescribed polyoxygenated ursane-type triterpenoids (vitnegundins A-G), three undescribed triterpenoid saponins (vitnegundins H-J), and 17 known ones were isolated from an EtOH extract of the aerial parts of Vitex negundo L. The structures of the undescribed compounds were established by extensive spectroscopic analysis. The absolute configurations of vitnegundins A, B, and E were determined by single-crystal X-ray diffraction data. Vitnegundins B-D are pentacyclic triterpenoids possessing rare cis-fused C/D rings and vitnegundins C-H represent undescribed ursane-type triterpenoids with 12,19-epoxy moiety. In the biological activity assay, vitnegundin A, vitnegundin E, and swinhoeic acid displayed inhibitory effects against LPS-induced NO release in BV-2 microglial cells, with IC
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2024.114068
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  5. Article ; Online: Uncovering the symptom relationship between anxiety, depression, and internet addiction among left-behind children: A large-scale purposive sampling network analysis.

    Shen, Xi / Zhou, Xinqi / Liao, Hai-Ping / McDonnell, Dean / Wang, Jin-Liang

    Journal of psychiatric research

    2024  Volume 171, Page(s) 43–51

    Abstract: Facing long-term separation from their parents, left-behind children are at risk of the co-occurrence of internalizing and externalizing problems. Although previous research has gained substantial information examining the relationship between anxiety, ... ...

    Abstract Facing long-term separation from their parents, left-behind children are at risk of the co-occurrence of internalizing and externalizing problems. Although previous research has gained substantial information examining the relationship between anxiety, depression, and internet addiction at the aggregate level of variables, little is known about the heterogeneity and interactions between these components at the symptom level with a large-scale purposive sample. Adopting the network approach, two network pathways, depression and anxiety, and associations between these variables and internet addiction were constructed. Our sample included 5367 left-behind children (M
    MeSH term(s) Child ; Female ; Humans ; Adolescent ; Infant ; Male ; Depression/epidemiology ; Internet Addiction Disorder ; Psychomotor Agitation ; Anxiety/epidemiology ; Tachycardia ; Internet
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2024.01.025
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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Coronavirus Usurps the Autophagy-Lysosome Pathway and Induces Membranes Rearrangement for Infection and Pathogenesis.

    Liang, Haowei / Luo, Dan / Liao, Hai / Li, Shun

    Frontiers in microbiology

    2022  Volume 13, Page(s) 846543

    Abstract: Autophagy is a crucial and conserved homeostatic mechanism for early defense against viral infections. Recent studies indicate that coronaviruses (CoVs) have evolved various strategies to evade the autophagy-lysosome pathway. In this minireview, we ... ...

    Abstract Autophagy is a crucial and conserved homeostatic mechanism for early defense against viral infections. Recent studies indicate that coronaviruses (CoVs) have evolved various strategies to evade the autophagy-lysosome pathway. In this minireview, we describe the source of double-membrane vesicles during CoV infection, which creates a microenvironment that promotes viral RNA replication and virion synthesis and protects the viral genome from detection by the host. Firstly, CoVs hijack autophagy initiation through non-structural proteins and open-reading frames, leading to the use of non-nucleated phagophores and omegasomes for autophagy-derived double-membrane vesicles. Contrastingly, membrane rearrangement by hijacking ER-associated degradation machinery to form ER-derived double-membrane vesicles independent from the typical autophagy process is another important routine for the production of double-membrane vesicles. Furthermore, we summarize the molecular mechanisms by which CoV non-structural proteins and open-reading frames are used to intercept autophagic flux and thereby evade host clearance and innate immunity. A comprehensive understanding of the above mechanisms may contribute to developing novel therapies and clinical drugs against coronavirus disease 2019 (COVID-19) in the future.
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.846543
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  7. Article: The role of Wnt/mTOR signaling in spinal cord injury.

    Cheng, Peng / Liao, Hai-Yang / Zhang, Hai-Hong

    Journal of clinical orthopaedics and trauma

    2022  Volume 25, Page(s) 101760

    Abstract: Spinal cord injury (SCI) is the most common disabling spinal injury, a complex pathologic process that can eventually lead to severe neurological dysfunction. The Wnt/mTOR signaling pathway is a pervasive signaling cascade that regulates a wide range of ... ...

    Abstract Spinal cord injury (SCI) is the most common disabling spinal injury, a complex pathologic process that can eventually lead to severe neurological dysfunction. The Wnt/mTOR signaling pathway is a pervasive signaling cascade that regulates a wide range of physiological processes during embryonic development, from stem cell pluripotency to cell fate. Numerous studies have reported that Wnt/mTOR signaling pathway plays an important role in neural development, synaptogenesis, neuron growth, differentiation and survival after the central nervous system (CNS) is damaged. Wnt/mTOR also plays an important role in regulating various pathophysiological processes after spinal cord injury (SCI). After SCI, Wnt/mTOR signal regulates the physiological and pathological processes of neural stem cell proliferation and differentiation, neuronal axon regeneration, neuroinflammation and pain through multiple pathways. Due to the characteristics of the Wnt signal in SCI make it a potential therapeutic target of SCI. In this paper, the characteristics of Wnt/mTOR signal, the role of Wnt/mTOR pathway on SCI and related mechanisms are reviewed, and some unsolved problems are discussed. It is hoped to provide reference value for the research field of the role of Wnt/mTOR pathway in SCI, and provide a theoretical basis for biological therapy of SCI.
    Language English
    Publishing date 2022-01-04
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2596956-0
    ISSN 2213-3445 ; 0976-5662
    ISSN (online) 2213-3445
    ISSN 0976-5662
    DOI 10.1016/j.jcot.2022.101760
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  8. Article ; Online: Reply to Peihua Liu, Yangle Li's Letter to the Editor regarding the article "Radical prostatectomy after previous transurethral resection of the prostate: oncological, surgical and functional outcomes-a meta-analysis".

    Liao, Hai / Wu, Tao

    World journal of urology

    2020  Volume 39, Issue 9, Page(s) 3697

    MeSH term(s) Humans ; Male ; Prostate ; Prostatectomy ; Seminal Vesicles ; Transurethral Resection of Prostate
    Language English
    Publishing date 2020-06-23
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-020-03308-7
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Alternative autophagy: mechanisms and roles in different diseases.

    Feng, Hong / Wang, Nian / Zhang, Nan / Liao, Hai-Han

    Cell communication and signaling : CCS

    2022  Volume 20, Issue 1, Page(s) 43

    Abstract: As an important mechanism to maintain cellular homeostasis, autophagy exerts critical functions via degrading misfolded proteins and damaged organelles. Recent years, alternative autophagy, a new type of autophagy has been revealed, which shares similar ... ...

    Abstract As an important mechanism to maintain cellular homeostasis, autophagy exerts critical functions via degrading misfolded proteins and damaged organelles. Recent years, alternative autophagy, a new type of autophagy has been revealed, which shares similar morphology with canonical autophagy but is independent of Atg5/Atg7. Investigations on different diseases showed the pivotal role of alternative autophagy during their physio-pathological processes, including heart diseases, neurodegenerative diseases, oncogenesis, inflammatory bowel disease (IBD), and bacterial infection. However, the studies are limited and the precise roles and mechanisms of alternative autophagy are far from clear. It is necessary to review current research on alternative autophagy and get some hint in order to provide new insight for further study. Video Abstract.
    MeSH term(s) Autophagy ; Homeostasis ; Humans ; Neurodegenerative Diseases ; Proteins
    Chemical Substances Proteins
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article ; Review ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-022-00851-1
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  10. Article ; Online: Effects of microplastics and cadmium on growth rate, photosynthetic pigment content and antioxidant enzymes of duckweed (Lemma minor).

    Yang, Xiao / Liao, Hai-Min / Tan, Ai-Juan / Gan, Sheng-Xian / Yang, Gui-Li

    Environmental science and pollution research international

    2023  Volume 30, Issue 42, Page(s) 96181–96190

    Abstract: Cadmium (Cd) and polyethylene (PE) seriously contaminate the aquatic environment and threaten human health. Many studies have reported the toxic effects of Cd and PE on plants, whereas few have reported the combined contamination of these two pollutants. ...

    Abstract Cadmium (Cd) and polyethylene (PE) seriously contaminate the aquatic environment and threaten human health. Many studies have reported the toxic effects of Cd and PE on plants, whereas few have reported the combined contamination of these two pollutants. In this study, duckweed (Lemma minor) was used as an indicator to explore the effect of PE microplastics (PE-MPs) at concentrations of 10, 50, 100, 200, and 500 mg/L on tolerance to 1 mg/L Cd. The results showed that different concentrations of PE-MPs inhibited the growth rate and chlorophyll content of duckweed to different degrees, both of which were minimal at 50 mg/L PE-MPs, 0.11 g/d, and 0.32 mg/g, respectively. The highest Cd enrichment (7.77 mg/kg) and bioaccumulation factors (94.22) of duckweed were detected when Cd was co-exposed with 50 mg/L of PE-MPs. Catalase and peroxidase activity first decreased and then increased with increasing PE-MPs concentrations, showing "hormesis effects", with minimum values of 11.47 U/g and 196.00 U/g, respectively. With increasing concentrations of PE-MPs, the effect on superoxide dismutase activity increased and then declined, peaking at 162.05 U/g, and displaying an "inverted V" trend. The amount of malondialdehyde rose with different PE-MPs concentrations. This research lay a foundation for using duckweed to purify water contaminated with MPs and heavy metals.
    MeSH term(s) Humans ; Cadmium/toxicity ; Microplastics ; Antioxidants/pharmacology ; Plastics/toxicity ; Polyethylenes ; Araceae
    Chemical Substances Cadmium (00BH33GNGH) ; Microplastics ; Antioxidants ; Plastics ; Polyethylenes
    Language English
    Publishing date 2023-08-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-29164-7
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