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  1. Book ; Thesis: The knockout of fatty acid synthase decreases the proliferation but increases fatty acid uptake in A431 cells

    Liao, Juan

    2018  

    Author's details vorgelegt von Juan Liao
    Language English
    Size ix, 85 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2018
    HBZ-ID HT019965339
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 E 201 order for loan Magazin

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  2. Book ; Online ; Conference proceedings: The critical public health value of vaccines

    Liao, Julie / Minicucci, Charles / Nicholson, Anna

    tackling issues of access and hesitancy : proceedings of a workshop

    2021  

    Event/congress National Academies of Sciences, Engineering, and Medicine (U.S.) (Forum on Microbial Threats)
    Author's details Julie Liao, Charles Minicucci, and Anna Nicholson, rapporteurs ; Forum on Microbial Threats, Board on Global Health, Health and Medicine Division, the National Academies of Sciences, Engineering, and Medicine
    Keywords Vaccination Hesitancy ; Healthcare Disparities ; Health Services Accessibility
    Language English
    Size 1 Online-Ressource (XX, 209 pages), figures, tables
    Publisher The National Academies Press
    Publishing place Washington DC
    Publishing country United States
    Document type Book ; Online ; Conference proceedings
    Note Kostenfreier Zugang nach Registrierung ; Open Access
    HBZ-ID HT021288671
    ISBN 9780309461566 ; 0309461561
    DOI 10.17226/26134
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The role mathematics can play in physics of life: Comment to "What is life? Active particles tools towards behavioral dynamics in social-biology and economics", by B. Bellomo, M. Esfahanian, V. Secchini, and P. Terna.

    Liao, Jie

    Physics of life reviews

    2023  Volume 46, Page(s) 281–282

    MeSH term(s) Physics ; Biology
    Language English
    Publishing date 2023-08-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2148883-6
    ISSN 1873-1457 ; 1571-0645
    ISSN (online) 1873-1457
    ISSN 1571-0645
    DOI 10.1016/j.plrev.2023.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The study on the relationship between venous ulcer and ankle joint range of motion using ultrasound.

    Liao, Jianyu / Wu, Zhoupeng

    Phlebology

    2024  , Page(s) 2683555241233626

    Abstract: Background: Chronic venous insufficiency (CVI) often leads to venous ulcers. The relationship between ankle joint range of motion (ROM) and venous ulcers remains under-investigated. This study aims to clarify this relationship using ultrasound imaging.!# ...

    Abstract Background: Chronic venous insufficiency (CVI) often leads to venous ulcers. The relationship between ankle joint range of motion (ROM) and venous ulcers remains under-investigated. This study aims to clarify this relationship using ultrasound imaging.
    Methods: We conducted a study on 20 patients with unilateral venous ulcers. Ankle ROM and popliteal vein blood flow were measured using a goniometer and ultrasound, respectively. The measurements were compared between the affected and unaffected limbs.
    Results: A significant reduction in ROM and popliteal vein blood flow was observed in the limbs with venous ulcers compared to the unaffected limbs. The data suggest a correlation between reduced ankle mobility and the development of venous ulcers.
    Conclusion: The study underscores the importance of maintaining ankle mobility in patients with CVI to prevent venous ulcers. A multifactorial approach is essential for managing these conditions effectively.
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 645172-x
    ISSN 1758-1125 ; 0268-3555
    ISSN (online) 1758-1125
    ISSN 0268-3555
    DOI 10.1177/02683555241233626
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Gene Editing in Hematopoietic Stem Cells.

    Liao, Jiaoyang / Wu, Yuxuan

    Advances in experimental medicine and biology

    2024  Volume 1442, Page(s) 177–199

    Abstract: Hematopoietic stem cells (HSCs) can be isolated and collected from the body, genetically modified, and expanded ex vivo. The invention of innovative and powerful gene editing tools has provided researchers with great convenience in genetically modifying ... ...

    Abstract Hematopoietic stem cells (HSCs) can be isolated and collected from the body, genetically modified, and expanded ex vivo. The invention of innovative and powerful gene editing tools has provided researchers with great convenience in genetically modifying a wide range of cells, including hematopoietic stem and progenitor cells (HSPCs). In addition to being used to modify genes to study the functional role that specific genes play in the hematopoietic system, the application of gene editing platforms in HSCs is largely focused on the development of cell-based gene editing therapies to treat diseases such as immune deficiency disorders and inherited blood disorders. Here, we review the application of gene editing tools in HSPCs. In particular, we provide a broad overview of the development of gene editing tools, multiple strategies for the application of gene editing tools in HSPCs, and exciting clinical advances in HSPC gene editing therapies. We also outline the various challenges integral to clinical translation of HSPC gene editing and provide the possible corresponding solutions.
    MeSH term(s) Humans ; Gene Editing ; Hematopoietic Stem Cells ; Hematologic Diseases ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-981-99-7471-9_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3192: Show issues Location:
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    Einzelsignatur: Show issues

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  6. Article ; Online: Association between interleukin-12 +1188A/C polymorphism and the risk of tuberculosis: A meta-analysis.

    Wang, Pengcheng / Liao, Jiadan

    African health sciences

    2024  Volume 23, Issue 2, Page(s) 133–138

    Abstract: Background: The role of : Objectives: This meta-analysis focused on examining the association between : Methods: EMBASE and PubMed databases were searched to identify relevant studies for retrospective analysis. Then, a random- or fixed-effects ... ...

    Abstract Background: The role of
    Objectives: This meta-analysis focused on examining the association between
    Methods: EMBASE and PubMed databases were searched to identify relevant studies for retrospective analysis. Then, a random- or fixed-effects model was utilized to calculate the combined odds ratios (ORs) as well as corresponding 95% confidence intervals (CIs).
    Results: A total of 9 related articles were discovered. The result of meta-analysis showed that
    Conclusion: The present findings indicated that
    MeSH term(s) Humans ; Genetic Predisposition to Disease ; Interleukin-12/genetics ; Polymorphism, Single Nucleotide ; Retrospective Studies ; Risk Factors ; Tuberculosis/genetics ; Tuberculosis/epidemiology
    Chemical Substances Interleukin-12 (187348-17-0) ; IL12A protein, human
    Language English
    Publishing date 2024-01-10
    Publishing country Uganda
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2240308-5
    ISSN 1729-0503 ; 1680-6905
    ISSN (online) 1729-0503
    ISSN 1680-6905
    DOI 10.4314/ahs.v23i2.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Coordination of transcription factors and SWI-SNF complexes regulates chromatin priming in developing T cells.

    Liao, Jingwen / Hargreaves, Diana C

    Nature immunology

    2024  Volume 25, Issue 5, Page(s) 725–727

    MeSH term(s) Chromatin/metabolism ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Animals ; Chromosomal Proteins, Non-Histone/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Mice ; Humans ; Cell Differentiation/immunology
    Chemical Substances Chromatin ; Transcription Factors ; Chromosomal Proteins, Non-Histone ; SWI-SNF-B chromatin-remodeling complex
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-024-01822-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 42: Show issues

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  8. Article: [Laparoscopic radical resection of large (223 g) solitary fibrous tumor of the prostate: a case report].

    Liao, J / Liu, X / DU, W / Guo, K / Xu, Y

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2024  Volume 43, Issue 12, Page(s) 2158–2162

    Abstract: A 67-year-old male patient was referred to our hospital by the community health service center for "sudden dysuria for half a day". The diagnosis of solitary fibrous tumor of the prostate was established after transrectal prostate biopsy. After excluding ...

    Abstract A 67-year-old male patient was referred to our hospital by the community health service center for "sudden dysuria for half a day". The diagnosis of solitary fibrous tumor of the prostate was established after transrectal prostate biopsy. After excluding contraindications, laparoscopic radical prostatectomy with bladder neck urethrostomy was performed. The operation was completed in 3 h and 15 min with an intraoperative blood loss of about 100 mL. Postoperative examination of the resected tumor revealed a large spherical tumor mass measuring about 11 cm×7.5 cm×6 cm with a net weight of 223 g. Postoperative pathology suggested solitary fibrous tumor of the prostate (medium-risk type). The abdominal drainage tube was removed 5 days after the operation and the catheter was removed 1 week after operation. The patient had good urine control at night without incontinence but with occasional urine leakage during daytime, and the overall therapeutic effect was satisfactory. Postoperative follow-up found good urine control of the patient without signs of tumor recurrence or metastasis. Laparoscopic radical prostatectomy often is difficult for large prostate tumors with a weight exceeding 200 g, and requires the surgeon to have rich experience in laparoscopic surgery with good understanding of prostate anatomy and close cooperation of the operation team to achieve satisfactory oncology control and functional protection of the urinary system.
    MeSH term(s) Aged ; Humans ; Male ; Biopsy ; Laparoscopy ; Neoplasm Recurrence, Local ; Prostate ; Solitary Fibrous Tumors/surgery ; Prostatic Neoplasms/surgery
    Language Chinese
    Publishing date 2024-01-08
    Publishing country China
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2023.12.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6344: Show issues Location:
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  9. Article: [Construction of an epileptic seizure prediction model using a semi-supervised method of generative adversarial and long short term memory network combined with Stockwell transform].

    Liao, J / Li, H / Zhan, C / Yang, F

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2023  Volume 43, Issue 1, Page(s) 17–28

    Abstract: Objective: To propose a semi-supervised epileptic seizure prediction model (ST-WGAN-GP-Bi-LSTM) to enhance the prediction performance by improving time-frequency analysis of electroencephalogram (EEG) signals, enhancing the stability of the unsupervised ...

    Abstract Objective: To propose a semi-supervised epileptic seizure prediction model (ST-WGAN-GP-Bi-LSTM) to enhance the prediction performance by improving time-frequency analysis of electroencephalogram (EEG) signals, enhancing the stability of the unsupervised feature learning model and improving the design of back-end classifier.
    Methods: Stockwell transform (ST) of the epileptic EEG signals was performed to locate the time-frequency information by adaptive adjustment of the resolution and retaining the absolute phase to obtain the time-frequency inputs. When there was no overlap between the generated data distribution and the real EEG data distribution, to avoid failure of feature learning due to a constant JS divergence, Wasserstein GAN was used as a feature learning model, and the cost function based on EM distance and gradient penalty strategy was adopted to constrain the unsupervised training process to allow the generation of a high-order feature extractor. A temporal prediction model was finally constructed based on a bi-directional long short term memory network (Bi-LSTM), and the classification performance was improved by obtaining the temporal correlation between high-order time-frequency features. The CHB-MIT scalp EEG dataset was used to validate the proposed patient-specific seizure prediction method.
    Results: The AUC, sensitivity, and specificity of the proposed method reached 90.40%, 83.62%, and 86.69%, respectively. Compared with the existing semi-supervised methods, the propose method improved the original performance by 17.77%, 15.41%, and 53.66%. The performance of this method was comparable to that of a supervised prediction model based on CNN.
    Conclusion: The utilization of ST, WGAN-GP, and Bi-LSTM effectively improves the prediction performance of the semi-supervised deep learning model, which can be used for optimization of unsupervised feature extraction in epileptic seizure prediction.
    MeSH term(s) Humans ; Memory, Short-Term ; Seizures/diagnosis ; Electroencephalography
    Language Chinese
    Publishing date 2023-03-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2023.01.03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Rift Propagation Interacting With Pre‐Existing Microcontinental Blocks

    Qing, J. / Liao, J. / Brune, S.

    Journal of Geophysical Research: Solid Earth

    2024  

    Abstract: Rift propagation is a 3D thermo-mechanical process that often precedes continental breakup. Pre-existing microcontinental blocks and the associated lithospheric strength heterogeneities influence the style of rift propagation. Interestingly, some rifts ... ...

    Abstract Rift propagation is a 3D thermo-mechanical process that often precedes continental breakup. Pre-existing microcontinental blocks and the associated lithospheric strength heterogeneities influence the style of rift propagation. Interestingly, some rifts propagate into pre-existing blocks and eventually cut through them (e.g., the Zhongsha Block and the Reed Bank), while others bypass these microcontinental blocks forming distinct overlapping rift branches (e.g., the East African Rift System). In this study, we use 3D numerical models to investigate the interaction between microcontinental blocks and rift propagation under different far-field extension rates. In doing so, we assess the impact of mantle lithospheric thicknesses and lower crustal rheology on the style of rift propagation. Our models reproduce the two types of rift propagation, characterized by propagating rifts that either split or bypass the pre-existing microcontinental blocks. We find that lithospheric thickness exerts dominant control, while lower crustal rheology of microcontinental blocks and the extension rate have less effect on rift propagation. Our model results can explain rift propagation patterns, block rotation and strong lithospheric thinning in the South China Sea, the East African Rift System, and the Woodlark Basin.
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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