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  1. Article ; Online: Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin.

    Liao, Jia-Cheng / Wei, Zhao-Xia / Zhao, Chang / Ma, Zhong-Ping / Cai, Dao-Zhang

    International journal of molecular medicine

    2018  Volume 42, Issue 3, Page(s) 1257–1264

    Abstract: Periprosthetic osteolysis belongs to osteolytic diseases, which often occur due to an imbalance between osteoclast and osteoblast number or activity. Fraxetin, a natural plant extract, inhibits osteoblast apoptosis and has therapeutic potential for ... ...

    Abstract Periprosthetic osteolysis belongs to osteolytic diseases, which often occur due to an imbalance between osteoclast and osteoblast number or activity. Fraxetin, a natural plant extract, inhibits osteoblast apoptosis and has therapeutic potential for treating osteolytic diseases. However, data pertaining to the effects of fraxetin on osteoclasts are limited. In the present study, it was demonstrated that the inhibition of osteoclastogenesis by fraxetin had an important role on the therapy of titanium particle‑induced osteolysis in vivo. In addition, fraxetin was demonstrated to suppress receptor activator of nuclear factor‑κB ligand (RANKL)‑mediated osteoclast differentiation and bone resorption in vitro in a dose‑dependent manner. Fraxetin inhibited osteoclast differentiation and function through the suppression of p38 signaling and subsequently, the suppression of osteoclast‑specific gene expression, including tartrate‑resistant acid phosphatase, nuclear factor of activated T‑cells, cytoplasmic 1, and cathepsin K. In conclusion, fraxetin administration may have potential as a treatment method for periprosthetic osteolysis and other osteolytic diseases.
    MeSH term(s) Animals ; Coumarins/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Osteoclasts/cytology ; Osteoclasts/drug effects ; Osteogenesis/drug effects ; Osteolysis/metabolism ; RANK Ligand/metabolism ; RAW 264.7 Cells ; Reverse Transcriptase Polymerase Chain Reaction ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemical Substances Coumarins ; RANK Ligand ; fraxetin (CD3GD44O3K) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2018-05-21
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1444428-8
    ISSN 1791-244X ; 1107-3756
    ISSN (online) 1791-244X
    ISSN 1107-3756
    DOI 10.3892/ijmm.2018.3698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4942: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: Effects of the 1, 4-dihydropyridine L-type calcium channel blocker benidipine on bone marrow stromal cells.

    Ma, Zhong-ping / Liao, Jia-cheng / Zhao, Chang / Cai, Dao-zhang

    Cell and tissue research

    2015  Volume 361, Issue 2, Page(s) 467–476

    Abstract: Osteoporosis (OP) often increases the risk of bone fracture and other complications and is a major clinical problem. Previous studies have found that high blood pressure is associated with bone formation abnormalities, resulting in increased calcium loss. ...

    Abstract Osteoporosis (OP) often increases the risk of bone fracture and other complications and is a major clinical problem. Previous studies have found that high blood pressure is associated with bone formation abnormalities, resulting in increased calcium loss. We have investigated the effect of the antihypertensive drug benidipine on bone marrow stromal cell (BMSC) differentiation into osteoblasts and bone formation under osteoporotic conditions. We used a combination of in vitro and in vivo approaches to test the hypothesis that benidipine promotes murine BMSC differentiation into osteoblasts. Alkaline phosphatase (ALP), osteocalcin (OCN), runt-related transcription factor 2 (RUNX2), β-catenin, and low-density lipoprotein receptor-related protein 5 (LRP5) protein expression was evaluated in primary femoral BMSCs from C57/BL6 mice cultured under osteogenic conditions for 2 weeks to examine the effects of benidipine. An ovariectomized (OVX) mouse model was used to investigate the effect of benidipine treatment for 3 months in vivo. We found that ALP, OCN, and RUNX2 expression was up-regulated and WNT/β-catenin signaling was enhanced in vitro and in vivo. In OVX mice that were intragastrically administered benidipine, bone parameters (trabecular thickness, bone mineral density, and trabecular number) in the distal femoral metaphysis were significantly increased compared with control OVX mice. Consistently, benidipine promoted BMSC differentiation into osteoblasts and protected against bone loss in OVX mice. Therefore, benidipine might be a suitable candidate for the treatment of patients with postmenopausal osteoporosis and hypertension.
    MeSH term(s) Animals ; Calcium Channel Blockers/pharmacology ; Cell Differentiation/drug effects ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/analysis ; Dihydropyridines/pharmacology ; Female ; Femur/drug effects ; Femur/physiology ; Femur/ultrastructure ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/drug effects ; Mice, Inbred C57BL ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteocalcin/analysis ; Osteogenesis/drug effects ; Vasodilator Agents/pharmacology ; Wnt Signaling Pathway/drug effects
    Chemical Substances Calcium Channel Blockers ; Core Binding Factor Alpha 1 Subunit ; Dihydropyridines ; Runx2 protein, mouse ; Vasodilator Agents ; Osteocalcin (104982-03-8) ; benidipine (4G9T91JS7E)
    Language English
    Publishing date 2015-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-015-2115-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.94: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Humidity effect on the decay of second-order nonlinearity in thermally poled fused silica.

    Chen, Huai-Yi / Chang, Feng-Fan / Liao, Jia-Cheng / Chao, Shiuh

    Optics express

    2009  Volume 14, Issue 25, Page(s) 12334–12340

    Abstract: Type I (GE124) and Type II (KV) fused silica were thermally poled in a vacuum and in air under identical poling conditions. Second-order nonlinear (SON) strength and nonlinear depth were found all to be the same. Samples were then stored in high and low ... ...

    Abstract Type I (GE124) and Type II (KV) fused silica were thermally poled in a vacuum and in air under identical poling conditions. Second-order nonlinear (SON) strength and nonlinear depth were found all to be the same. Samples were then stored in high and low humidity to study their SON stability. The SON of poled GE124 was stable over time despite different poling atmospheres and humidity in storage. The SON of both the air-poled and vacuum-poled KV samples decayed over time in both low and high humidity, with the exception that the air-poled KV sample stored in low humidity remained stable. High humidity accelerated the decay process of the KV samples. A porous surface model was used to interpret the decay mechanism. The decay curves implied multiple carriers or a multiple-porosity model for the decay mechanism.
    Language English
    Publishing date 2009-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/oe.14.012334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effects of the 1, 4-dihydropyridine L-type calcium channel blocker benidipine on bone marrow stromal cells

    Ma, Zhong-ping / Liao, Jia-cheng / Zhao, Chang / Cai, Dao-zhang

    Cell and tissue research

    Volume v. 361,, Issue no. 2

    Abstract: Osteoporosis (OP) often increases the risk of bone fracture and other complications and is a major clinical problem. Previous studies have found that high blood pressure is associated with bone formation abnormalities, resulting in increased calcium loss. ...

    Abstract Osteoporosis (OP) often increases the risk of bone fracture and other complications and is a major clinical problem. Previous studies have found that high blood pressure is associated with bone formation abnormalities, resulting in increased calcium loss. We have investigated the effect of the antihypertensive drug benidipine on bone marrow stromal cell (BMSC) differentiation into osteoblasts and bone formation under osteoporotic conditions. We used a combination of in vitro and in vivo approaches to test the hypothesis that benidipine promotes murine BMSC differentiation into osteoblasts. Alkaline phosphatase (ALP), osteocalcin (OCN), runt-related transcription factor 2 (RUNX2), β-catenin, and low-density lipoprotein receptor-related protein 5 (LRP5) protein expression was evaluated in primary femoral BMSCs from C57/BL6 mice cultured under osteogenic conditions for 2 weeks to examine the effects of benidipine. An ovariectomized (OVX) mouse model was used to investigate the effect of benidipine treatment for 3 months in vivo. We found that ALP, OCN, and RUNX2 expression was up-regulated and WNT/β-catenin signaling was enhanced in vitro and in vivo. In OVX mice that were intragastrically administered benidipine, bone parameters (trabecular thickness, bone mineral density, and trabecular number) in the distal femoral metaphysis were significantly increased compared with control OVX mice. Consistently, benidipine promoted BMSC differentiation into osteoblasts and protected against bone loss in OVX mice. Therefore, benidipine might be a suitable candidate for the treatment of patients with postmenopausal osteoporosis and hypertension.
    Keywords calcium ; ovariectomy ; stromal cells ; antihypertensive agents ; alkaline phosphatase ; calcium channel blockers ; postmenopause ; animal models ; transcription factors ; bone formation ; bone marrow ; low density lipoprotein ; risk ; mice ; protein synthesis ; patients ; osteoporosis ; antihypertensive effect ; osteocalcin ; bone density ; hypertension ; osteoblasts ; bone resorption
    Language English
    Document type Article
    ISSN 0302-766X
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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