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Article: Variance reduction in the inverse probability weighted estimators for the average treatment effect using the propensity score

Liao, Jiangang / Rohde, Charles

Biometrics. 2022 June, v. 78, no. 2

2022

Abstract: The propensity methodology is widely used in medical research to compare different treatments in designs with a nonrandomized treatment allocation. The inverse probability weighted (IPW) estimators are a primary tool for estimating the average treatment ... ...

Abstract	The propensity methodology is widely used in medical research to compare different treatments in designs with a nonrandomized treatment allocation. The inverse probability weighted (IPW) estimators are a primary tool for estimating the average treatment effect but the large variance of these estimators is often a significant concern for their reliable use in practice. Inspired by Rao‐Blackwellization, this paper proposes a method to smooth an IPW estimator by replacing the weights in the original estimator by their mean over a distribution of the potential treatment assignment. In our simulation study, the smoothed IPW estimator achieves a substantial variance reduction over its original version with only a small increased bias, for example two‐to‐sevenfold variance reduction for the three IPW estimators in Lunceford and Davidian [Statistics in Medicine, 23(19), 2937–2960]. In addition, our proposed smoothing can also be applied to the locally efficient and doubly robust estimator for added protection against model misspecification. An implementation in R is provided.
Keywords	biomedical research ; medicine ; probability ; variance
Language	English
Dates of publication	2022-06
Size	p. 660-667.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	213543-7
ISSN	0099-4987 ; 0006-341X
ISSN	0099-4987 ; 0006-341X
DOI	10.1111/biom.13454
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Variance reduction in the inverse probability weighted estimators for the average treatment effect using the propensity score.

Liao, Jiangang / Rohde, Charles

Biometrics

2021 Volume 78, Issue 2, Page(s) 660–667

Abstract	The propensity methodology is widely used in medical research to compare different treatments in designs with a nonrandomized treatment allocation. The inverse probability weighted (IPW) estimators are a primary tool for estimating the average treatment effect but the large variance of these estimators is often a significant concern for their reliable use in practice. Inspired by Rao-Blackwellization, this paper proposes a method to smooth an IPW estimator by replacing the weights in the original estimator by their mean over a distribution of the potential treatment assignment. In our simulation study, the smoothed IPW estimator achieves a substantial variance reduction over its original version with only a small increased bias, for example two-to-sevenfold variance reduction for the three IPW estimators in Lunceford and Davidian [Statistics in Medicine, 23(19), 2937-2960]. In addition, our proposed smoothing can also be applied to the locally efficient and doubly robust estimator for added protection against model misspecification. An implementation in R is provided.
MeSH term(s)	Bias ; Computer Simulation ; Models, Statistical ; Probability ; Propensity Score ; Research Design
Language	English
Publishing date	2021-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	213543-7
ISSN	1541-0420 ; 0099-4987 ; 0006-341X
ISSN (online)	1541-0420
ISSN	0099-4987 ; 0006-341X
DOI	10.1111/biom.13454
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Article: The Potential of Glioblastoma Patient Symptoms to Diagnose and Predict Survival.

Mrowczynski, Oliver D / Yang, Ae L / Liao, Jiangang / Rizk, Elias

Cureus

2021 Volume 13, Issue 7, Page(s) e16675

Abstract: Glioblastoma is a devastating malignancy with a dismal survival rate and median survival time of 14 months. Currently, the biomarkers for glioblastoma are mostly molecular and include EGFRvIII, ATRX, PTEN, IDH1, MGMT, and others. These prognostic tumor ... ...

Abstract	Glioblastoma is a devastating malignancy with a dismal survival rate and median survival time of 14 months. Currently, the biomarkers for glioblastoma are mostly molecular and include EGFRvIII, ATRX, PTEN, IDH1, MGMT, and others. These prognostic tumor biomarkers are obtained through a surgical biopsy and thus are not easily attainable. Clinicians would benefit from a robust, non-invasive, and readily available indicator for early diagnosis and accurate prognostication for glioblastoma patients. In this study, we assessed whether specific patient symptoms could provide an early diagnosis of glioblastoma. Further, we also assessed if any patient symptomatology could provide clinicians with the ability to prognosticate patient survival more accurately. We retrospectively reviewed the clinical data for 218 patients. We determined whether symptoms including headache, weakness, seizure, memory loss/confusion, visual changes, speech changes, and loss of consciousness led to a patient being diagnosed earlier and if any of these symptoms predicted diminished patient survival. Our study determined that weakness and memory loss/confusion were the symptoms that predicted diminished survival, and weakness alone was the symptom that predicted an earlier diagnosis. This study further elucidates the complexities of glioblastoma and provides clinicians with more data for their patients when discussing prognostication after diagnosis of glioblastoma.
Language	English
Publishing date	2021-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.16675
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Article ; Online: Self-sampling tools to increase cancer screening among underserved patients: a pilot randomized controlled trial.

Moss, Jennifer L / Entenman, Juliette / Stoltzfus, Kelsey / Liao, Jiangang / Onega, Tracy / Reiter, Paul L / Klesges, Lisa M / Garrow, George / Ruffin, Mack T

JNCI cancer spectrum

2023 Volume 8, Issue 1

Abstract: Background: Screening can reduce cancer mortality, but uptake is suboptimal and characterized by disparities. Home-based self-sampling can facilitate screening for colorectal cancer (with stool tests, eg, fecal immunochemical tests) and for cervical ... ...

Abstract	Background: Screening can reduce cancer mortality, but uptake is suboptimal and characterized by disparities. Home-based self-sampling can facilitate screening for colorectal cancer (with stool tests, eg, fecal immunochemical tests) and for cervical cancer (with self-collected human papillomavirus tests), especially among patients who face barriers to accessing health care. Additional data are needed on feasibility and potential effects of self-sampling tools for cancer screening among underserved patients. Methods: We conducted a pilot randomized controlled trial with patients (female, ages 50-65 years, out of date with colorectal and cervical cancer screening) recruited from federally qualified health centers in rural and racially segregated counties in Pennsylvania. Participants in the standard-of-care arm (n = 24) received screening reminder letters. Participants in the self-sampling arm (n = 24) received self-sampling tools for fecal immunochemical tests and human papillomavirus testing. We assessed uptake of screening (10-week follow-up), self-sampling screening outcomes, and psychosocial variables. Analyses used Fisher exact tests to assess the effect of study arm on outcomes. Results: Cancer screening was higher in the self-sampling arm than the standard-of-care arm (colorectal: 75% vs 13%, respectively, odds ratio = 31.32, 95% confidence interval = 5.20 to 289.33; cervical: 79% vs 8%, odds ratio = 72.03, 95% confidence interval = 9.15 to 1141.41). Among participants who returned the self-sampling tools, the prevalence of abnormal findings was 24% for colorectal and 18% for cervical cancer screening. Cancer screening knowledge was positively associated with uptake (P < .05). Conclusions: Self-sampling tools can increase colorectal and cervical cancer screening among unscreened, underserved patients. Increasing the use of self-sampling tools can improve primary care and cancer detection among underserved patients. Clinical trials registration number: STUDY00015480.
MeSH term(s)	Female ; Humans ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Early Detection of Cancer ; Papillomaviridae ; Papillomavirus Infections/complications ; Pilot Projects ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control ; Vulnerable Populations ; Middle Aged ; Aged
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2515-5091
ISSN (online)	2515-5091
DOI	10.1093/jncics/pkad103
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Article ; Online: The Effects of Black Raspberry as a Whole Food-Based Approach on Biomarkers of Oxidative Stress in Buccal Cells and Urine of Smokers.

Chen, Kun-Ming / Sun, Yuan-Wan / Krebs, Nicolle M / Reinhart, Lisa / Sun, Dongxiao / Liao, Jiangang / Cook, Rachel / Bond, Paige Elizabeth / Mallery, Susan R / El-Bayoumy, Karam

Cancer prevention research (Philadelphia, Pa.)

2024 Volume 17, Issue 4, Page(s) 157–167

Abstract: Cigarette smoke is a rich source of free radicals that can promote oxidative stress and carcinogenesis, including head and neck squamous cell carcinoma (HNSCC) development; importantly, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-iso- ... ...

Abstract	Cigarette smoke is a rich source of free radicals that can promote oxidative stress and carcinogenesis, including head and neck squamous cell carcinoma (HNSCC) development; importantly, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-iso-prostaglandin F2α (8-isoprostane) are biomarkers of oxidative stress. Several mechanisms, including the antioxidant properties of black raspberry (BRB), account for their chemopreventive effects. In the present clinical trial, we tested the hypothesis that BRB administration reduces biomarkers levels of oxidative stress in buccal cells and urine of smokers. One week after enrolling 21 smokers, baseline buccal cells and urine samples were collected before the administration of BRB lozenges for 8 weeks (5/day, 1 gm BRB/lozenge). Buccal cells and urine samples were collected at the middle and the end of BRB administration. The last samples were collected after the BRB cessation (washout period). We analyzed levels of 8-oxodG and 8-isoprostane (LC/MS-MS), urinary cotinine (ELISA), and creatinine (spectrophotometry). BRB significantly reduced the levels of 8-oxodG by 17.08% (P = 0.00079) in buccal cells and 12.44% (P = 0.034) in urine at the middle of BRB administration as compared with baseline; the corresponding values at the end of BRB administration were 16.46% (P = 0.026) in buccal cells and 25.72% (P = 0.202) in urine. BRB had no significant effect on the levels of urinary 8-isoprostane. BRB's capacity to inhibit 8-oxodG formation of smokers' buccal cells and urine is clearly evident and the reduction in 8-oxodG suggests that antioxidant abilities are central to BRB's HNSCC chemopreventive properties. Prevention relevance: Cigarette smoke contains highly active components namely free radicals that can promote oxidative stress and oral cancer. We found that black raspberry (BRB) inhibited the formation of oxidative stress markers in the oral cavity and urine of smokers suggesting the antioxidant abilities of BRB in preventing oral cancer.
MeSH term(s)	Humans ; 8-Hydroxy-2'-Deoxyguanosine/pharmacology ; 8-Hydroxy-2'-Deoxyguanosine/therapeutic use ; Antioxidants/pharmacology ; Biomarkers/urine ; Deoxyguanosine/pharmacology ; Deoxyguanosine/therapeutic use ; Deoxyguanosine/urine ; Free Radicals/pharmacology ; Free Radicals/therapeutic use ; Head and Neck Neoplasms ; Mouth Mucosa/pathology ; Mouth Neoplasms/etiology ; Mouth Neoplasms/prevention & control ; Mouth Neoplasms/drug therapy ; Oxidative Stress ; Rubus ; Smokers ; Squamous Cell Carcinoma of Head and Neck
Chemical Substances	8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Antioxidants ; Biomarkers ; Deoxyguanosine (G9481N71RO) ; Free Radicals
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	2434717-6
ISSN	1940-6215 ; 1940-6207
ISSN (online)	1940-6215
ISSN	1940-6207
DOI	10.1158/1940-6207.CAPR-23-0153
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Article ; Online: Racial/ethnic disparities in the trajectories of insomnia symptoms from childhood to young adulthood.

Singh, Rupsha / Atha, Raegan / Lenker, Kristina P / Calhoun, Susan L / Liao, Jiangang / He, Fan / Vgontzas, Alexandros N / Liao, Duanping / Bixler, Edward O / Jackson, Chandra L / Fernandez-Mendoza, Julio

Sleep

2024 Volume 47, Issue 5

Abstract: Study objectives: To examine differences in the longitudinal prevalence of childhood insomnia symptoms across black/African American, Hispanic/Latinx, and non-Hispanic white groups.: Methods: Participants were 519 children from the Penn State Child ... ...

Abstract	Study objectives: To examine differences in the longitudinal prevalence of childhood insomnia symptoms across black/African American, Hispanic/Latinx, and non-Hispanic white groups. Methods: Participants were 519 children from the Penn State Child Cohort (baseline [V1] from 2000-2005) who were followed up 8 years later as adolescents (V2) and 15 years later as young adults (S3). Mean age at S3 was 24.1 ± 2.7 years. Approximately, 76.5% identified as non-Hispanic white, 12.9% as black/African American, 7.1% as Hispanic/Latinx, and 3.5% as "other" race/ethnicity. Insomnia symptoms were defined as parent-reported (childhood) or self-reported (adolescence and young adulthood) moderate-to-severe difficulties initiating/maintaining sleep. Longitudinal trajectories of insomnia symptoms were identified across three-time points and the odds of each trajectory were compared between racial/ethnic groups, adjusting for sex, age, overweight, sleep apnea, periodic limb movements, psychiatric/behavioral disorders, and psychotropic medication use. Results: Black/African Americans compared to non-Hispanic whites were at significantly higher odds of having a childhood-onset persistent trajectory through young adulthood (OR = 2.58, 95% CI [1.29, 5.14]), while Hispanics/Latinx were at nonsignificantly higher odds to have the same trajectory (OR = 1.81, 95% CI [0.77, 4.25]). No significant racial/ethnic differences were observed for remitted and waxing-and-waning trajectories since childhood or incident/new-onset trajectories in young adulthood. Conclusions: The results indicate that disparities in insomnia symptoms among black/African American and, to a lesser extent, Hispanic/Latinx groups start early in childhood and persist into young adulthood. Identifying and intervening upon upstream determinants of racial/ethnic insomnia disparities are warranted to directly address these disparities and to prevent their adverse health sequelae. Clinical trial information: N/A; Not a clinical trial.
MeSH term(s)	Humans ; Sleep Initiation and Maintenance Disorders/ethnology ; Sleep Initiation and Maintenance Disorders/epidemiology ; Male ; Female ; Hispanic or Latino/statistics & numerical data ; Adolescent ; Young Adult ; White People/statistics & numerical data ; Child ; Black or African American/statistics & numerical data ; Longitudinal Studies ; Prevalence ; Health Status Disparities ; Adult ; Ethnicity/statistics & numerical data
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	424441-2
ISSN	1550-9109 ; 0161-8105
ISSN (online)	1550-9109
ISSN	0161-8105
DOI	10.1093/sleep/zsae021
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Article ; Online: Racial/ethnic disparity in habitual sleep is modified by caloric intake in adolescents.

He, Fan / Dong, Huamei / Fernandez-Mendoza, Julio / Bixler, Edward O / Liao, Jiangang / Liao, Duanping

Sleep medicine

2020 Volume 76, Page(s) 65–71

Abstract: Study objectives: We investigated the moderation of caloric intake on the association between race/ethnicity and habitual sleep in adolescents.: Methods: We analyzed the data obtained from 324 adolescents who completed the follow-up examination of ... ...

Abstract	Study objectives: We investigated the moderation of caloric intake on the association between race/ethnicity and habitual sleep in adolescents. Methods: We analyzed the data obtained from 324 adolescents who completed the follow-up examination of the Penn State Child Cohort study. We collected actigraphy-measured sleep duration on 7 consecutive nights and computed their mean and standard deviation as habitual sleep duration (HSD) and habitual sleep variability (HSV), respectively. We also measured participants' daily intakes of total calorie, total fat, carbohydrates, and protein, through the Youth/Adolescent Food Frequency Questionnaire. Adjusted mean HSD and HSV among non-Hispanic whites and racial/ethnic minorities were compared by using analysis of covariance (ANCOVA), while controlling for age, sex, BMI percentile, total caloric intake, and socioeconomic status. The significance of the interaction between race/ethnicity and caloric intake was further tested in ANCOVA models. Results: The study sample consisted of 79.3% non-Hispanic whites, 13.0% African American, 4.6% Hispanics, 2.2% Asian, and 0.9% American Indian. Adolescents who are racial/ethnic minorities showed shorter HSD (mean (SE): 6.80 (0.10) vs. 7.07 (0.05) hours/night, p = 0.02) and higher HSV (mean (SE): 1.31 (0.07) vs. 1.15 (0.04) hours/night, p = 0.04) than non-Hispanic whites. Racial/ethnic differences in HSV were significantly more pronounced among adolescents with high caloric intake (p interaction = 0.01), especially from carbohydrates (p interaction = 0.03) and fat (p interaction = 0.05). Conclusion: Adolescents who are racial/ethnic minorities slept objectively shorter and with greater night-to-night variability than non-Hispanic whites. The racial/ethnic disparity in habitual sleep variability was more pronounced among adolescents with high caloric intake, particularly from carbohydrates and fat.
MeSH term(s)	Adolescent ; Cohort Studies ; Diet ; Energy Intake ; Ethnic Groups ; Female ; Humans ; Male ; Minority Groups ; Sleep ; United States
Language	English
Publishing date	2020-10-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2020.10.001
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Article ; Online: Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: results from phase II study, BTCRC-GU15-023.

Journal for immunotherapy of cancer

2023 Volume 11, Issue 2

Abstract: Background: Patients with bladder cancer (BC) who are cisplatin ineligible or have unresectable disease have limited treatment options. Previously, we showed targeting programmed death-ligand 1 (PD-L1) with durvalumab (durva) and radiation therapy (RT) ... ...

Abstract	Background: Patients with bladder cancer (BC) who are cisplatin ineligible or have unresectable disease have limited treatment options. Previously, we showed targeting programmed death-ligand 1 (PD-L1) with durvalumab (durva) and radiation therapy (RT) combination was safe in BC. We now report results from a phase II study evaluating the toxicity and efficacy of durva and RT in localized BC. Methods: This is a single-arm, multi-institutional phase II study; N=26. Enrolled patients had pure or mixed urothelial BC (T2-4 N0-2 M0) with unresectable tumors and were unfit for surgery or cisplatin ineligible. Patients received durva concurrently with RT ×7 weeks, followed by adjuvant durva × 1 year. Primary endpoints: (A) progression-free survival (PFS) at 1 year and (B) disease control rate (DCR) post adjuvant durva. Key secondary endpoints: (A) complete response (CR) post durvaRT (8 weeks), (B) overall survival (OS), (C) PFS and (D) toxicity. Correlative studies included evaluation of baseline tumor and blood (baseline, post durvaRT) for biomarkers. Results: Median follow-up was 27 months. Evaluable patients: 24/26 post durvaRT, 22/26 for DCR post adjuvant durva, all patients for PFS and OS. Post adjuvant durva, DCR was seen in 72.7%, CR of 54.5%. 1-year PFS was 71.5%, median PFS was 21.8 months. 1-year OS was 83.8%, median OS was 30.8 months. CR at 8 weeks post durvaRT was 62.5%. Node positive (N+) patients had similar median PFS and OS. DurvaRT was well tolerated. Grade ≥3 treatment-related adverse events: anemia, high lipase/amylase, immune-nephritis, transaminitis, dyspnea (grade 4-COPD/immune), fatigue, rash, diarrhea and scleritis. No difference in outcome was observed with PD-L1 status of baseline tumor. Patients with CR/PR or SD had an increase in naïve CD4 T cells, a decrease in PD-1+CD4 T cells at baseline and an increase in cytokine-producing CD8 T cells, including interferon gamma (IFNγ) producing cells, in the peripheral blood. Conclusion: Durva with RT followed by adjuvant durva was safe with promising efficacy in localized BC patients with comorbidities, including N+ patients. Larger randomized studies, like S1806 and EA8185, are needed to evaluate the efficacy of combining immunotherapy and RT in BC. Trial registration number: NCT02891161.
MeSH term(s)	Humans ; Antibodies, Monoclonal/therapeutic use ; B7-H1 Antigen ; Cisplatin ; Urinary Bladder Neoplasms/drug therapy
Chemical Substances	Antibodies, Monoclonal ; B7-H1 Antigen ; Cisplatin (Q20Q21Q62J) ; durvalumab (28X28X9OKV)
Language	English
Publishing date	2023-02-23
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-006551
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Article ; Online: Trajectories of Insomnia Symptoms From Childhood Through Young Adulthood.

Fernandez-Mendoza, Julio / Lenker, Kristina P / Calhoun, Susan L / Qureshi, Myra / Ricci, Anna / Bourchtein, Elizaveta / He, Fan / Vgontzas, Alexandros N / Liao, Jiangang / Liao, Duanping / Bixler, Edward O

Pediatrics

2022 Volume 149, Issue 3

Abstract: Objectives: Insomnia symptoms are transdiagnostic to physical and mental health disorders. Given the lack of population-based cohorts with objective sleep measures and long-term follow-ups, little is known about the chronicity of childhood insomnia ... ...

Abstract	Objectives: Insomnia symptoms are transdiagnostic to physical and mental health disorders. Given the lack of population-based cohorts with objective sleep measures and long-term follow-ups, little is known about the chronicity of childhood insomnia symptoms. We determined the developmental trajectories of insomnia symptoms, their evolution into adult insomnia, and the role of objective sleep duration in the transition to adulthood. Methods: A total of 502 children (median 9 years old, 71.7% response rate) were studied 7.4 years later as adolescents (median 16 years old) and 15 years later as adults (median 24 years old). Insomnia symptoms were ascertained as moderate-to-severe difficulties initiating and/or maintaining sleep via parent- or self reports at all 3 time points, adult insomnia via self-report in young adulthood, and objective short-sleep duration via polysomnography in childhood and adolescence. Results: Among children with insomnia symptoms, the most frequent trajectory was persistence (43.3%), followed by remission (26.9% since childhood, 11.2% since adolescence) and a waxing-and-waning pattern (18.6%). Among children with normal sleep, the most frequent trajectory was persistence (48.1%), followed by developing insomnia symptoms (15.2% since adolescence, 20.7% in adulthood) and a waxing-and-waning pattern (16.0%). The odds of insomnia symptoms worsening into adult insomnia (22.0% of children, 20.8% of adolescents) were 2.6-fold and 5.5-fold among short-sleeping children and adolescents, respectively. Conclusions: Early sleep interventions are a health priority because pediatricians should not expect insomnia symptoms to developmentally remit in a high proportion of children. Objective sleep measures may be clinically useful in adolescence, a critical period for the adverse prognosis of the insomnia with short-sleep duration phenotype.
MeSH term(s)	Adolescent ; Adult ; Humans ; Polysomnography ; Self Report ; Sleep/physiology ; Sleep Initiation and Maintenance Disorders/epidemiology ; Sleep Wake Disorders ; Young Adult
Language	English
Publishing date	2022-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2021-053616
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Article ; Online: Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma.

LeBlanc, Francis R / Hasanali, Zainul S / Stuart, August / Shimko, Sara / Sharma, Kamal / Leshchenko, Violetta V / Parekh, Samir / Fu, Haiqing / Zhang, Ya / Martin, Melvenia M / Kester, Mark / Fox, Todd / Liao, Jiangang / Loughran, Thomas P / Evans, Juanita / Pu, Jeffrey J / Spurgeon, Stephen E / Aladjem, Mirit I / Epner, Elliot M

Oncotarget

2022 Volume 13, Page(s) 986–1002

Abstract: Classical MCL (cMCL) constitutes 6-8% of all B cell NHL. Despite recent advances, MCL is incurable except with allogeneic stem cell transplant. Blastic mantle cell lymphoma (bMCL) is a rarer subtype of cMCL associated with an aggressive clinical course ... ...

Abstract	Classical MCL (cMCL) constitutes 6-8% of all B cell NHL. Despite recent advances, MCL is incurable except with allogeneic stem cell transplant. Blastic mantle cell lymphoma (bMCL) is a rarer subtype of cMCL associated with an aggressive clinical course and poor treatment response, frequent relapse and poor outcomes. We treated 13 bMCL patients with combined epigenetic and immunotherapy treatment consisting of vorinostat, cladribine and rituximab (SCR). We report an increased OS greater than 40 months with several patients maintaining durable remissions without relapse for longer than 5 years. This is remarkably better then current treatment regimens which in bMCL range from 14.5-24 months with conventional chemotherapy regimens. We demonstrate that the G/A870
MeSH term(s)	Adult ; Antigens, CD20/immunology ; Cladribine ; Epigenesis, Genetic ; Humans ; Immunologic Factors/therapeutic use ; Immunotherapy ; Lymphoma, Mantle-Cell/drug therapy ; Lymphoma, Mantle-Cell/therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/therapy ; Rituximab/therapeutic use ; Vorinostat/therapeutic use
Chemical Substances	Antigens, CD20 ; Immunologic Factors ; Cladribine (47M74X9YT5) ; Rituximab (4F4X42SYQ6) ; Vorinostat (58IFB293JI)
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28258
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Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito