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  1. Article ; Online: 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.

    Liao, Shan-Ting / Han, Chao / Xu, Ding-Qiao / Fu, Xiao-Wei / Wang, Jun-Song / Kong, Ling-Yi

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 5091

    Abstract: Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has been reported to regulate ... ...

    Abstract Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has been reported to regulate macrophage function, but its precise mechanism is not clear. Here, we show that 4-octyl itaconate (4-OI, a cell-permeable itaconate derivative) directly alkylates cysteine residue 22 on the glycolytic enzyme GAPDH and decreases its enzyme activity. Glycolytic flux analysis by U
    MeSH term(s) Alkylation ; Animals ; Antimetabolites/pharmacology ; Cysteine/drug effects ; Cysteine/genetics ; Cysteine/metabolism ; Deoxyglucose/pharmacology ; Down-Regulation ; Endotoxemia/immunology ; Glucose/metabolism ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/antagonists & inhibitors ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/drug effects ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/metabolism ; Glycolysis/drug effects ; Inflammation/immunology ; Interleukin-1beta/drug effects ; Interleukin-1beta/immunology ; Lipopolysaccharides/pharmacology ; Macrophage Activation/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Nitric Oxide Synthase Type II/drug effects ; Nitric Oxide Synthase Type II/immunology ; Oxidative Phosphorylation/drug effects ; RAW 264.7 Cells ; Sesquiterpenes/pharmacology ; Succinates/pharmacology
    Chemical Substances Antimetabolites ; IL1B protein, mouse ; Interleukin-1beta ; Lipopolysaccharides ; Sesquiterpenes ; Succinates ; heptelidic acid (57710-57-3) ; Deoxyglucose (9G2MP84A8W) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39) ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) (EC 1.2.1.12) ; Glucose (IY9XDZ35W2) ; Cysteine (K848JZ4886) ; itaconic acid (Q4516562YH)
    Language English
    Publishing date 2019-11-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-13078-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Protection by Huang-Lian-Jie-Du decoction and its constituent herbs of lipopolysaccharide-induced acute kidney injury.

    Li, Pei / Liao, Shan-Ting / Wang, Jun-Song / Zhang, Qian / Xu, Ding-Qiao / Lv, Yan / Yang, Ming-Hua / Kong, Ling-Yi

    FEBS open bio

    2017  Volume 7, Issue 2, Page(s) 221–236

    Abstract: Sepsis, characterized by systemic inflammation, often leads to end-organ dysfunction, such as acute kidney injury (AKI). Despite of the severity and frequency of septic AKI in clinic, its pathogenesis is still poorly understood. Combined with ... ...

    Abstract Sepsis, characterized by systemic inflammation, often leads to end-organ dysfunction, such as acute kidney injury (AKI). Despite of the severity and frequency of septic AKI in clinic, its pathogenesis is still poorly understood. Combined with histopathology evaluations, mortality assessments, biochemical evaluations, reverse transcription (RT) reaction and quantitative real-time PCR, and western blot,
    Language English
    Publishing date 2017-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2651702-4
    ISSN 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.12178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Protection by Huang‐Lian‐Jie‐Du decoction and its constituent herbs of lipopolysaccharide‐induced acute kidney injury

    Li, Pei / Liao, Shan‐Ting / Wang, Jun‐Song / Zhang, Qian / Xu, Ding‐Qiao / Lv, Yan / Yang, Ming‐Hua / Kong, Ling‐Yi

    FEBS Open Bio. 2017 Feb., v. 7, no. 2

    2017  

    Abstract: Sepsis, characterized by systemic inflammation, often leads to end‐organ dysfunction, such as acute kidney injury (AKI). Despite of the severity and frequency of septic AKI in clinic, its pathogenesis is still poorly understood. Combined with ... ...

    Abstract Sepsis, characterized by systemic inflammation, often leads to end‐organ dysfunction, such as acute kidney injury (AKI). Despite of the severity and frequency of septic AKI in clinic, its pathogenesis is still poorly understood. Combined with histopathology evaluations, mortality assessments, biochemical evaluations, reverse transcription (RT) reaction and quantitative real‐time PCR, and western blot, ¹H NMR‐based metabolomics approach was applied to investigate effects of Huang‐Lian‐Jie‐Du‐Decotion (HLJDD), a traditional Chinese medicine prescription, and its four component herbs on lipopolysaccharide (LPS)‐induced septic AKI and the underlying mechanism. LPS induced kidney dysfunction via activation of NF‐κB and mitogen‐activated protein kinases (MAPKs), by excessive production of IL‐6, tumor necrosis factor‐α, inducible nitric oxide synthase, and COX‐2, producing perturbance in energy metabolism and oxidative stress. HLJDD and its component herbs could effectively inhibit LPS‐induced AKI in mice by inhibiting NF‐κB and MAPK activation and activating the Akt/HO‐1 pathway, and by markedly ameliorating disturbances in oxidative stress and energy metabolism induced by LPS. The four‐component herbs could complement each other.
    Keywords Oriental traditional medicine ; Western blotting ; acute kidney injury ; energy metabolism ; histopathology ; inducible nitric oxide synthase ; inflammation ; interleukin-6 ; kidneys ; lipopolysaccharides ; metabolomics ; mitogen-activated protein kinase ; mortality ; necrosis ; neoplasms ; oxidative stress ; pathogenesis ; quantitative polymerase chain reaction ; reverse transcription
    Language English
    Dates of publication 2017-02
    Size p. 221-236.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2651702-4
    ISSN 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.12178
    Database NAL-Catalogue (AGRICOLA)

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