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Article ; Online: Reliability of a Squat Movement Competency Screen in Individuals With a Previous Knee Injury.

Edwards, Suzi / Liberatore, Mark

2018 Volume 27, Issue 2

Abstract: Context: Movement screens are a common method of assessing movement efficiency either against a specific criterion of segments/joint(s) motion (segmental method) or a summary label of general quality of the whole movement (overall method). While not as ... ...

Abstract	Context: Movement screens are a common method of assessing movement efficiency either against a specific criterion of segments/joint(s) motion (segmental method) or a summary label of general quality of the whole movement (overall method). While not as commonly utilized within clinical practice as the segmental method, the overall method is less time consuming to perform and more reliable. Objectives: The aim of this study was to assess the reliability of the "overall" method approach during a squat in individuals with a previous knee joint injury. Design: Cross-sectional, clinical measurement. Participants: Two-dimensional video recordings of 5 squat trials were recorded for 16 participants with a history of a major knee joint injury(s) and were visually rated by 3 novice and 3 expert raters. Main outcome measures: Weighted quadratic Kappa was used to determine the intra- and inter-rater reliability of the squat movement competency screen. Results: Good inter-rater reliability for the expert and novice groups was observed. Intra-rater reliability was very good between analysis sessions for 1 expert rater. Conclusions: The overall method is a reliable method that enables allied health professionals of different levels of clinical experience to utilize a framework to assess movement quality during a squat in patients with a previous knee joint injury.
MeSH term(s)	Adult ; Arthrometry, Articular/methods ; Cross-Sectional Studies ; Female ; Humans ; Knee Injuries/physiopathology ; Knee Joint/physiology ; Male ; Middle Aged ; Observer Variation ; Reproducibility of Results ; Video Recording
Language	English
Publishing date	2018--01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1106769-x
ISSN	1543-3072 ; 1056-6716
ISSN (online)	1543-3072
ISSN	1056-6716
DOI	10.1123/jsr.2017-0064
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Article ; Online: One-bloc percutaneous large biopsy of soft-tissue tumours: feasibility study and possible indications.

Iannessi, A / Bertrand, A S / Peyrottes, I / Thyss, A / Machiavello, J C / Liberatore, M

Clinical radiology

2019 Volume 74, Issue 8, Page(s) 649.e11–649.e17

Abstract: Aim: To report the early results of the Intact lesion excision system (LES) regarding feasibility, tolerance and efficiency in obtaining soft-tissue tumour samples under ultrasound guidance.: Materials and methods: The feasibility and tolerance of ... ...

Abstract	Aim: To report the early results of the Intact lesion excision system (LES) regarding feasibility, tolerance and efficiency in obtaining soft-tissue tumour samples under ultrasound guidance. Materials and methods: The feasibility and tolerance of Intact LES procedures under ultrasound guidance were studied prospectively in 15 patients. The procedure was performed on an outpatient basis under local anaesthesia by a single interventional radiologist with 6 years of experience and lasted around 30 min. Results: The feasibility of the Intact LES for soft-tissue masses was good except when lesions were hard and calcified. Tolerance was good, with median pain experienced during the procedure evaluated at 4.5/10 (SD 2.2) and median post-procedural pain at day 1 evaluated at 1.8/10 (SD 2.5). No major complications were observed; however, for vascularised lesions, one case of acute wound bleeding and two post-procedural haematomas led to delayed pain. Conclusion: Percutaneous biopsy of suspected soft-tissue sarcoma using the LES device under ultrasound guidance is well tolerated and feasible. After a first non-contributing core biopsy, and especially, in the case of lipomatous lesions, it is a valuable option to consider, as is surgical incision biopsy.
MeSH term(s)	Adult ; Aged ; Biopsy, Large-Core Needle ; Feasibility Studies ; Female ; Humans ; Image-Guided Biopsy ; Male ; Middle Aged ; Prospective Studies ; Sarcoma/diagnostic imaging ; Sarcoma/pathology ; Soft Tissue Neoplasms/diagnostic imaging ; Soft Tissue Neoplasms/pathology ; Ultrasonography, Interventional/methods ; Young Adult
Language	English
Publishing date	2019-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2019.05.004
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Article: Independent Prognostic and Predictive Role of Interstitial Macrophages in Kidney Biopsies of IgA Nephropathy Patients.

Aiello, Francesca Bianca / Ranelletti, Franco Oreste / Liberatore, Marcella / Felaco, Paolo / De Luca, Graziano / Lamolinara, Alessia / Schena, Francesco Paolo / Bonomini, Mario

Journal of personalized medicine

2023 Volume 13, Issue 6

Abstract: A relevant percentage of IgAN patients experience a progressive decline in kidney function. According to the KDIGO guidelines, proteinuria and eGFR are the only validated prognostic markers. The role of interstitial macrophages in kidney biopsies of IgAN ...

Abstract	A relevant percentage of IgAN patients experience a progressive decline in kidney function. According to the KDIGO guidelines, proteinuria and eGFR are the only validated prognostic markers. The role of interstitial macrophages in kidney biopsies of IgAN patients and the outcome of patients treated with renin-angiotensin system inhibitors (RASBs) alone or combined with glucocorticoids were evaluated. Clinical and laboratory records (age, gender, hypertension, hematuria, proteinuria, eGFR, serum creatinine, and therapy), MEST-C parameters of the Oxford classification, C4d deposition, peritubular capillaries, and glomerular and interstitial macrophages in 47 IgAN patients undergoing kidney biopsy consecutively between 2003 and 2016 were examined. A high number of interstitial macrophages significantly correlated with peritubular capillary rarefaction and impairment of kidney function. Cox's multivariable regression analysis revealed that a value > 19.5 macrophages/HPF behaved as an independent marker of an unfavorable outcome. Patients exhibiting > 19.5 macrophages/HPF treated at the time of diagnosis with RASBs combined with methylprednisolone had an estimated probability of a favorable outcome higher than patients treated with RASBs alone. Thus, a value > 19.5 macrophages/HPF in IgAN biopsies can predict an unfavorable outcome and endorse a well-timed administration of glucocorticoids. Studies evaluating urine biomarkers associated with peritubular capillary rarefaction in patients with marked macrophage infiltration may help personalized treatment decisions.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13060935
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Article ; Online: HMGB1 expression in leukocytes as a biomarker of cellular damage induced by [

Follacchio, Giulia Anna / Manganelli, Valeria / Monteleone, Francesco / Sorice, Maurizio / Garofalo, Tina / Liberatore, Mauro

Nuclear medicine and biology

2021 Volume 96-97, Page(s) 94–100

Abstract: Purpose: Autologous White Blood Cells (WBC) scintigraphy is based on a multi-step sequence of cell separation and radiolabelling. Besides in vivo imaging quality control, no molecular tool is available to evaluate WBC damage secondary to cell ... ...

Abstract	Purpose: Autologous White Blood Cells (WBC) scintigraphy is based on a multi-step sequence of cell separation and radiolabelling. Besides in vivo imaging quality control, no molecular tool is available to evaluate WBC damage secondary to cell manipulation. High Mobility Group Box 1 (HMGB1) is a protein of the alarmins family, secreted by innate immune cells and released from the nucleus of damaged cells following different types of injury. Aim of this study was to evaluate HMGB1 levels in WBC cytosolic extracts (CE) before and after [ Procedures: Patients with suspect of prosthetic joint infection were prospectively enrolled. HMGB1 levels were evaluated by immunoblotting analysis in plasma (t Results: Twenty consecutive patients referred for WBC scintigraphy and ten controls were enrolled. HMGB1 levels were significantly upregulated both in plasma (t Conclusions: The evaluation of HMGB1 levels in WBC-CE from each subject after radiolabelling with [
MeSH term(s)	Adult ; HMGB1 Protein ; Humans ; Leukocytes ; Middle Aged ; Quality Control ; Technetium Tc 99m Exametazime
Chemical Substances	HMGB1 Protein ; Technetium Tc 99m Exametazime (3B744AG22N)
Language	English
Publishing date	2021-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1138098-6
ISSN	1872-9614 ; 0883-2897 ; 0969-8051
ISSN (online)	1872-9614
ISSN	0883-2897 ; 0969-8051
DOI	10.1016/j.nucmedbio.2021.03.008
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Article: The Usefulness of Scintigraphic Studies in the Assessment of Asymptomatic Bowel Disease in Patients with Primary Antibody Diseases.

Milito, Cinzia / Cinetto, Francesco / Megna, Valentina / Spadaro, Giuseppe / Quinti, Isabella / Liberatore, Mauro

Journal of clinical medicine

2020 Volume 9, Issue 4

Abstract: Enteropathy may be the first presentation of immunodeficiency or it may occur during the course of the disease and in association with malabsorption in patients affected by primary antibody diseases. For these patients, immunoglobulin G (IgG) replacement ...

Abstract	Enteropathy may be the first presentation of immunodeficiency or it may occur during the course of the disease and in association with malabsorption in patients affected by primary antibody diseases. For these patients, immunoglobulin G (IgG) replacement therapy prevents infectious and non-infectious complications. Nonetheless some patients cannot achieve optimal IgG trough levels, even when treated with high Ig doses in absence of protein-losing syndromes. We investigated seven patients affected by common variable immunodeficiencies (CVIDs) and treated with high Ig doses (600-800 mg/kg/month) showing low IgG trough level. Patients underwent abdominal scintigraphy with human polyclonal immunoglobulin G labeled with 99mTc and with white blood cells labeled by 111 Indium-oxinate to investigate asymptomatic bowel inflammation. A concentration of labeled leukocytes in abdominal segments greater than that observed with human polyclonal immunoglobulin G was evident only in one patient. In five patients a slight concentration of both radiopharmaceuticals was reported, due to mild intestinal inflammatory response. These data might be related to mild increase of capillary permeability in the absence of inflammation leukocyte mediated. This study discloses a new cause of IgG-accelerated catabolism due to inflammatory bowel conditions without diarrhea in CVID patients.
Language	English
Publishing date	2020-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9040949
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Article ; Online: Measurements meet perceptions: rheology-texture-sensory relations when using green, bio-derived emollients in cosmetic emulsions.

Huynh, A / Garcia, A G / Young, L K / Szoboszlai, M / Liberatore, M W / Baki, G

International journal of cosmetic science

2020 Volume 43, Issue 1, Page(s) 11–19

Abstract: Objective: Product aesthetics and sensory performance can strongly influence a cosmetic product's acceptance by consumers. However, classic sensory analysis is time-consuming, expensive and does not provide information on the target group's preference. ... ...

Abstract	Objective: Product aesthetics and sensory performance can strongly influence a cosmetic product's acceptance by consumers. However, classic sensory analysis is time-consuming, expensive and does not provide information on the target group's preference. In the previous phase of this project, we had untrained consumers evaluate six cosmetic emulsions based on their aesthetics using a check-all-that-apply (CATA) survey. In this project, our goals were to quantitatively characterize the rheology and textural properties of the six cosmetic emulsions containing green, bio-derived emollients and identify statistical relationships between the consumers' description of products and the instrumental measurements. Methods: Six emulsions were prepared-three with olive oil and three with heptyl undecylenate as an emollient. Four sensory-like attributes, namely firmness, work of shear, stickiness and adhesiveness, were tested using a texture analyser. Rheological characterization included continuous flow testing and oscillatory measurements. Droplet size and stability were also evaluated. Statistical relationships were quantified between measurements in this study and sensory survey results published previously. Results: The textural and rheological results indicated that the emulsions were different-as designed. The texture and rheology measurements had analogous grouping outcomes to the consumers' discrimination. Emulsions 1 and 2 were the firmest, hardest to spread, stickiest and had the highest viscosity, while Emulsions 5 and 6 were the least firm, easiest to spread, less sticky than Emulsions 1 and 2, and had the lowest viscosity. Emulsions 3 and 4 fell in between the other two groups. Using olive oil instead of heptyl undecylenate as an emollient increased firmness, spreading, stickiness, viscosity and droplet size of the emulsions in every case-when comparing emulsions within each pair. All six emulsions had a shear-thinning behaviour. Viscosity and firmness directly correlated for the emulsions. Emulsions were visually stable at room temperature over the course of 6 months and viscosity remained relatively constant over this period also. Conclusion: Certain sensory attributes can be reliably predicted with instrumental measurements. Identifying and quantifying sensory-texture-rheology relationships can contribute to achieving appropriate product characteristics tailored to suit market needs.
MeSH term(s)	Cosmetics/chemistry ; Emollients/chemistry ; Green Chemistry Technology ; Perception ; Rheology
Chemical Substances	Cosmetics ; Emollients
Language	English
Publishing date	2020-10-02
Publishing country	England
Document type	Journal Article
ZDB-ID	198917-0
ISSN	1468-2494 ; 0142-5463
ISSN (online)	1468-2494
ISSN	0142-5463
DOI	10.1111/ics.12661
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Article ; Online: Locally vascularized pelvic accessory spleen.

Iorio, F / Frantellizzi, V / Drudi, Francesco M / Maghella, F / Liberatore, M

Journal of ultrasound

2016 Volume 19, Issue 2, Page(s) 141–144

Abstract: Polysplenism and accessory spleen are congenital, usually asymptomatic anomalies. A rare case of polysplenism with ectopic spleen in pelvis of a 67-year-old, Caucasian female is reported here. A transvaginal ultrasound found a soft well-defined ... ...

Abstract	Polysplenism and accessory spleen are congenital, usually asymptomatic anomalies. A rare case of polysplenism with ectopic spleen in pelvis of a 67-year-old, Caucasian female is reported here. A transvaginal ultrasound found a soft well-defined homogeneous and vascularized mass in the left pelvis. Patient underwent MRI evaluation and contrast-CT abdominal scan: images with parenchymal aspect, similar to spleen were obtained. Abdominal scintigraphy with 99mTc-albumin nanocolloid was performed and pelvic region was studied with planar scans and SPECT. The results showed the presence of an uptake area of the radiopharmaceutical in the pelvis, while the spleen was normally visualized. These findings confirmed the presence of an accessory spleen with an artery originated from the aorta and a vein that joined with the superior mesenteric vein. To our knowledge, in the literature, there is just only one case of a true ectopic, locally vascularized spleen in the pelvis.
MeSH term(s)	Aged ; Choristoma/diagnosis ; Female ; Humans ; Magnetic Resonance Imaging ; Pelvis ; Spleen/blood supply ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed ; Ultrasonography
Language	English
Publishing date	2016
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-015-0178-x
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Article ; Online: 99m

Frantellizzi, V / Morreale, M / Pontico, M / Francia, A / Drudi, F M / Farcomeni, A / Liberatore, M

Revista espanola de medicina nuclear e imagen molecular

2018 Volume 37, Issue 4, Page(s) 211–217

Abstract: Objective: The central nervous system (CNS) may be involved in a variety of inflammatory diseases of the blood vessels, generally known as vasculitis. The clinical diagnosis of such involvement in early stages is difficult, since a mild cognitive ... ...

Title translation	99m
Abstract	Objective: The central nervous system (CNS) may be involved in a variety of inflammatory diseases of the blood vessels, generally known as vasculitis. The clinical diagnosis of such involvement in early stages is difficult, since a mild cognitive impairment can be the only symptom. It was hypothesized that brain-perfusion SPECT would be able to reveal CNS involvement and to monitor the course of the disease. The purpose of this study was assess if and when an improvement of cerebral perfusion can be registered by SPECT during the follow-up of these diseases. Material and methods: Eighteen patients affected by Systemic Lupus Erythematosus (SLE), 22 by undifferentiated vasculitis (UV), 5 by Behcet's disease (BD) and 5 by primary Sjogren's Syndrome (pSS) were enrolled in this prospective study. A Results: In the SLE patients, no significant improvement of brain perfusion was found. On the contrary, in the UV the cerebral uptake of the tracer significantly improved from the twenty-fourth month (18/22 patients). Patients with BD showed an improvement of scintigraphic findings (5/5 patients), while a similar result was obtained only in 2 of the patients with pSS. Conclusions: In conclusion, brain SPECT seems to be able to monitor the disease in UV, indicating the moment when an improvement of the cerebral perfusion is achieved. In SLE patients this scintigraphic technique did not show a significant improvement in CNS perfusion.
MeSH term(s)	Adrenal Cortex Hormones/pharmacology ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Behcet Syndrome/complications ; Behcet Syndrome/drug therapy ; Brain/blood supply ; Brain/diagnostic imaging ; Cerebrovascular Circulation/drug effects ; Cognition Disorders/drug therapy ; Cognition Disorders/etiology ; Drug Monitoring ; Female ; Humans ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/drug therapy ; Male ; Neuroimaging/methods ; Neuropsychological Tests ; Prospective Studies ; Radiopharmaceuticals/pharmacokinetics ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/drug therapy ; Technetium Tc 99m Exametazime/pharmacokinetics ; Tomography, Emission-Computed, Single-Photon/methods ; Treatment Outcome ; Vasculitis, Central Nervous System/diagnostic imaging ; Vasculitis, Central Nervous System/drug therapy ; Vasculitis, Central Nervous System/etiology ; Vasculitis, Central Nervous System/psychology
Chemical Substances	Adrenal Cortex Hormones ; Immunosuppressive Agents ; Radiopharmaceuticals ; Technetium Tc 99m Exametazime (3B744AG22N)
Language	Spanish
Publishing date	2018-03-28
Publishing country	Spain
Document type	Journal Article
ISSN	2253-8089
ISSN (online)	2253-8089
DOI	10.1016/j.remn.2017.10.009
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Article: IRM de diffusion de la prostate.

Cornud, F / Liberatore, M / Beuvon, F / Barry, N

Journal de radiologie

2010 Volume 91, Issue 3 Pt 2, Page(s) 421–8; quiz 429–30

Abstract: Functional imaging complements T2-weighted imaging in the evaluation of the prostate. The most frequently used techniques are diffusion-weighted imaging and perfusion imaging following the intravenous administration of contrast material. Perfusion ... ...

Title translation	Diffusion-weighted MR imaging of the prostate.
Abstract	Functional imaging complements T2-weighted imaging in the evaluation of the prostate. The most frequently used techniques are diffusion-weighted imaging and perfusion imaging following the intravenous administration of contrast material. Perfusion imaging has high sensitivity and moderate specificity, even when using a quantitative technique, because contrast kinetics in some cases of peripheral zone prostatitis and benign transition zone hyperplasia may simulate cancer. Diffusion-weighted imaging is currently under evaluation but appears to be preferable to dynamic perfusion MR imaging because of its higher specificity and simpler acquisition. Functional imaging of the prostate is performed to detect cancers missed on biopsies or evaluate the volume of a newly diagnosed clinically localized cancer to assist in therapy selection. Future applications for image-guidance of targeted therapies to the tumor are currently investigational.
MeSH term(s)	Contrast Media ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Image Enhancement/methods ; Male ; Prostatic Diseases/diagnosis ; Prostatic Hyperplasia/diagnosis ; Prostatic Neoplasms/diagnosis
Chemical Substances	Contrast Media
Language	French
Publishing date	2010-05-01
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	423361-x
ISSN	1773-0384 ; 0221-0363
ISSN (online)	1773-0384
ISSN	0221-0363
DOI	10.1016/s0221-0363(10)70057-3
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Article ; Online: Functional lung volume mapping with perfusion Single-Photon Emission Computed Tomography scan for radiotherapy planning in patients with locally advanced nonsmall cell lung cancer.

Follacchio, Giulia Anna / D'Urso, Pasqualina / Cassese, Raffaele / Ferrara, Carla / Bulzonetti, Nadia / Monteleone, Francesco / Musio, Daniela / Liberatore, Mauro / Tombolini, Vincenzo

Nuclear medicine communications

2020 Volume 41, Issue 10, Page(s) 1026–1033

Abstract: Objectives: Radical chemotherapy-radiotherapy represents the standard treatment for locally-advanced nonsmall cell lung cancer (NSCLC). Conventional radiotherapy achieves limited local tumor control, but dose escalation to the primary tumor is prevented ...

Abstract	Objectives: Radical chemotherapy-radiotherapy represents the standard treatment for locally-advanced nonsmall cell lung cancer (NSCLC). Conventional radiotherapy achieves limited local tumor control, but dose escalation to the primary tumor is prevented by radiotherapy-induced toxicity. The aim of this study was to evaluate feasibility of tailored intensity-modulated radiotherapy (IMRT) planning based on lung single-photon emission computed tomography (SPECT) perfusion data and to compare functional and conventional dose-volume parameters. Methods: A total of 21 patients were prospectively enrolled. Patients underwent IMRT treatment with 2 Gy/fraction (median total dose of 60 Gy). Lung perfusion SPECT images were acquired before radiotherapy and 3 and 6 months after radiotherapy completion. SPECT and planning computed tomography images were co-registered using MIM-MAESTRO software with 3D-PET Edge algorithm. Lung volumes were defined anatomically as total lung and functionally as total not functional lung and total functional lung. Dose-volume histograms were calculated using QUANTEC constraints [mean lung dose (MLD)<20 Gy, V20<20%]. For each patient, conventional and functional radiotherapy plans were generated and compared. Results: A total of 19 of 21 patients with NSCLC were included (mean age 66 years, 11 stage IIIA, 8 stage IIIB), 12/19 patients completed the 6-months follow-up. A significant reduction of mean V20 was observed in functional radiotherapy planning compared to conventional plan (405.9 cc, P < 0.001). Mean MLD was also lower in the SPECT-based plans, but the difference was not statistically relevant (0.8 Gy, P = 0.299). G2 radiation pneumonitis was observed in two patients. Conclusions: Functional radiotherapy planning allowed to decrease functional lung irradiation compared to conventional planning. The possibility to limit radiotherapy-induced toxicity could allow us to perform an effective dose-escalation to target volume.
MeSH term(s)	Aged ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Feasibility Studies ; Female ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Male ; Middle Aged ; Organ Size ; Perfusion Imaging ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated ; Software ; Tomography, Emission-Computed, Single-Photon
Language	English
Publishing date	2020-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0000000000001247
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