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Article ; Online: Adverse drug reactions and organ damage: The liver.

Licata, Anna

2016 Volume 28, Page(s) 9–16

Abstract: Drug-induced liver injury (DILI) is among the most challenging acute or chronic liver conditions to be handled by physicians. Despite its low incidence in the general population, DILI is a frequent cause of acute liver failure. As such, the possibility ... ...

Abstract	Drug-induced liver injury (DILI) is among the most challenging acute or chronic liver conditions to be handled by physicians. Despite its low incidence in the general population, DILI is a frequent cause of acute liver failure. As such, the possibility of DILI should be considered in all patients who present with acute liver damage, independent of any known pre-existing liver disease. DILI can be classified as intrinsic/dose-dependent (e.g., acetaminophen toxicity) or idiosyncratic/dose-independent, with the latter form being relatively uncommon. Amoxicillin-clavulanate is the antimicrobial that is most frequently associated with idiosyncratic DILI. Large, ongoing, prospective studies in western countries have reported other drugs associated with DILI, including nonsteroidal anti-inflammatory drugs, statins, and herbal and dietary supplements. An important safety issue, DILI is one of the most frequently cited reasons for cessation of drug development during or after preclinical studies and for withdrawal of a drug from the market. This review summarizes the epidemiology, risk factors, commonly implicated drugs, clinical features, and diagnosis of DILI, with the aim of aiding physicians in the management of this debated problem. Old and new biomarkers for DILI and pharmacogenetic studies are also described.
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/epidemiology ; Chemical and Drug Induced Liver Injury/etiology ; Dietary Supplements/adverse effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Incidence ; Plant Preparations/adverse effects ; Risk Factors
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Plant Preparations
Language	English
Publishing date	2016-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2015.12.017
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Article ; Online: Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol,

Citarrella, Roberto / Chianetta, Roberta / Amodeo, Simona / Mirarchi, Luigi / Licata, Anna / Soresi, Maurizio / Veronese, Nicola / Barbagallo, Mario / Giannitrapani, Lydia

Nutrients

2024 Volume 16, Issue 2

Abstract: Metabolic syndrome (MetS) is associated with cardiovascular risk factors, such as insulin resistance, dyslipidaemia, hypertension and abdominal obesity. Given the growing need to investigate food supplements with positive health effects, this study was ... ...

Abstract	Metabolic syndrome (MetS) is associated with cardiovascular risk factors, such as insulin resistance, dyslipidaemia, hypertension and abdominal obesity. Given the growing need to investigate food supplements with positive health effects, this study was aimed at testing the benefits of a specific supplement for people with MetS. Fifty-eight subjects with MetS and T2DM or impaired glucose tolerance assuming metformin, were randomly assigned to take a food supplement of glucomannan, D-chiro-inositol,
MeSH term(s)	Humans ; Metabolic Syndrome/drug therapy ; Insulin Resistance ; Cinnamomum zeylanicum ; Inulin ; Inositol ; Dietary Supplements ; Body Weight ; Metformin ; Lipids ; Diabetes Mellitus, Type 2 ; Mannans
Chemical Substances	(1-6)-alpha-glucomannan (36W3E5TAMG) ; Inulin (9005-80-5) ; Inositol (4L6452S749) ; Metformin (9100L32L2N) ; Lipids ; Mannans
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020249
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Article ; Online: Changes in the ultrasound presentation of hepatocellular carcinoma: a center's three decades of experience.

Giannitrapani, Lydia / Amodeo, Simona / Mirarchi, Luigi / Terranova, Antonino / Seidita, Aurelio / Mozzini, Chiara / Cabibi, Daniela / Brancatelli, Giuseppe / Licata, Anna / Soresi, Maurizio

Journal of ultrasound

2024

Abstract: Purpose: Ultrasound (US) surveillance is a cornerstone for early diagnosis of HCC, anyway US presentation has undergone significant changes. With the aim of evaluating the effects of US surveillance program in the real-world clinical practice, we wanted ...

Abstract	Purpose: Ultrasound (US) surveillance is a cornerstone for early diagnosis of HCC, anyway US presentation has undergone significant changes. With the aim of evaluating the effects of US surveillance program in the real-world clinical practice, we wanted to evaluate US presentation of HCCs over the last 30 years and the differences of HCCs presentation according to etiology. Methods: 174 patients diagnosed between 1993 and 98 (G1), 96 between 2003 and 08 (G2), 102 between 2013 and 18 (G3), were compared. US patterns were: single, multiple or diffuse nodules. The echo-patterns: iso-, hypo-, hyper-echoic, or mixed. In G1, the HCC diagnosis was mainly histologic; in G2 by EASL 2001 and AASLD 2005, in G3 AASLD 2011, EASL 2012, and AISF 2013 guidelines. Results: HCV was the most frequent etiology, dropping between G1 (81%) and G3 (66%) (P < 0.01), metabolic increased between G1 (5%) and G3 (14%) (P < 0.01). Single HCC was more prevalent in G3 vs G1 (65.6% vs 40%) (P < 0.0001), multiple nodules in G1 (50%) vs G3 (33.3%) (P < 0.02) and diffuse in G1 (16%) vs G2 (2%) and vs G3 (1%) (P < 0.001). The most frequent echo-pattern was hypo-echoic G1 (50%) vs G2 (79%) and G1 vs G3 (65%) (P < 0.01). Iso-echoic pattern was the least frequent (7-12%). Mixed pattern decreased from G1 (28%) to G3 (12%) (P < 0.002). In G3 there were more multiple or diffuse HCCs in metabolic (P < 0.03). Conclusion: US presentation became less severe due to surveillance programs. HCV remains the most frequent cause, an increase in metabolic etiology has been shown throughout the decades.
Language	English
Publishing date	2024-04-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-024-00888-7
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Article: Impact of Sex and Gender on Clinical Management of Patients with Advanced Chronic Liver Disease and Type 2 Diabetes.

Licata, Anna / Russo, Giuseppina T / Giandalia, Annalisa / Cammilleri, Marcella / Asero, Clelia / Cacciola, Irene

Journal of personalized medicine

2023 Volume 13, Issue 3

Abstract: Gender differences in the epidemiology, pathophysiological mechanisms and clinical features in chronic liver diseases that may be associated with type 2 diabetes (T2D) have been increasingly reported in recent years. This sexual dimorphism is due to a ... ...

Abstract	Gender differences in the epidemiology, pathophysiological mechanisms and clinical features in chronic liver diseases that may be associated with type 2 diabetes (T2D) have been increasingly reported in recent years. This sexual dimorphism is due to a complex interaction between sex- and gender-related factors, including biological, hormonal, psychological and socio-cultural variables. However, the impact of sex and gender on the management of T2D subjects with liver disease is still unclear. In this regard, sex-related differences deserve careful consideration in pharmacology, aimed at improving drug safety and optimising medical therapy, both in men and women with T2D; moreover, low adherence to and persistence of long-term drug treatment is more common among women. A better understanding of sex- and gender-related differences in this field would provide an opportunity for a tailored diagnostic and therapeutic approach to the management of T2D subjects with chronic liver disease. In this narrative review, we summarized available data on sex- and gender-related differences in chronic liver disease, including metabolic, autoimmune, alcoholic and virus-related forms and their potential evolution towards cirrhosis and/or hepatocarcinoma in T2D subjects, to support their appropriate and personalized clinical management.
Language	English
Publishing date	2023-03-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13030558
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Article ; Online: Weight-loss supplementation and acute liver failure: the case of Garcinia Cambogia.

Licata, Anna / Minissale, Maria Giovanna

Internal and emergency medicine

2018 Volume 13, Issue 6, Page(s) 833–835

MeSH term(s)	Garcinia cambogia ; Humans ; Liver Failure, Acute ; Weight Loss
Language	English
Publishing date	2018-07-21
Publishing country	Italy
Document type	Journal Article ; Comment
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-018-1912-0
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Article ; Online: Liver injury, SARS-COV-2 infection and COVID-19: What physicians should really know?

Licata, Anna / Minissale, Maria Giovanna / Distefano, Marco / Montalto, Giuseppe

GastroHep

2021 Volume 3, Issue 3, Page(s) 121–130

Abstract: Background & aims: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), which in males, especially in advanced age, can sometimes evolve into acute respiratory distress syndrome. In ... ...

Abstract	Background & aims: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), which in males, especially in advanced age, can sometimes evolve into acute respiratory distress syndrome. In addition, mild to moderate alterations in liver function tests (LFTs) have been reported in the worst affected patients. Our review aims to analyse data on the incidence and prognostic value of LFT alterations, the underlying mechanisms and the management of pre-existing liver disease in COVID-19 affected patients. Methods: We searched available literature through online PubMed database using terms as "SARS-CoV-2," "Liver damage," "Liver Function tests," "COVID-19," "pre-existing liver disease," "drug-induced liver injury." Results: Available evidence suggest that there could be a relationship between SARS-CoV-2 infection and liver damage, although the underlying involved mechanism remains unclear. Cohort studies have shown that high ALT levels, low platelet counts and low albumin levels at admission and during hospitalisation are associated with a high mortality rate. Unfortunately, little is known about the impact of COVID-19 on pre-existing liver damage. While chronic viral infections or NAFLD are associated with an increased risk of COVID-19 progression, patients with cirrhosis may have increased susceptibility to SARS-CoV-2 infection due to their systemic immunocompromised status. DILI seems common among hospitalised patient with severe pneumonia. Conclusion: Mild to moderate liver impairment during Covid-19 is common, especially in patients with pre-existing liver disease. Further studies should be performed in order to understand how pre-existing liver conditions may influence and worsen progression of liver disease in COVID-19 patients.
Language	English
Publishing date	2021-05-03
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1478-1239
ISSN (online)	1478-1239
DOI	10.1002/ygh2.455
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Article ; Online: SGLT2 Inhibitors as the Most Promising Influencers on the Outcome of Non-Alcoholic Fatty Liver Disease.

Mirarchi, Luigi / Amodeo, Simona / Citarrella, Roberto / Licata, Anna / Soresi, Maurizio / Giannitrapani, Lydia

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: Non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease in the Western world, is a common hepatic manifestation of metabolic syndrome (MetS). A specific cure has not yet been identified, and its treatment is currently based on risk ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease in the Western world, is a common hepatic manifestation of metabolic syndrome (MetS). A specific cure has not yet been identified, and its treatment is currently based on risk factor therapy. Given that the initial accumulation of triglycerides in the liver parenchyma, in the presence of inflammatory processes, mitochondrial dysfunction, lipotoxicity, glucotoxicity, and oxidative stress, can evolve into non-alcoholic steatohepatitis (NASH). The main goal is to identify the factors contributing to this evolution because, once established, untreated NASH can progress through fibrosis to cirrhosis and, ultimately, be complicated by hepatocellular carcinoma (HCC). Several drugs have been tested in clinical trials for use as specific therapy for NAFLD; most of them are molecules used to cure type 2 diabetes mellitus (T2DM), which is one of the main risk factors for NAFLD. Among the most studied is pioglitazone, either alone or in combination with vitamin E, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors. Actually, the most promising category seems to be sodium-glucose cotransporter (SGLT2) inhibitors. Their action is carried out by inhibiting glucose reabsorption in the proximal renal tubule, leading to its increased excretion in urine and decreased levels in plasma. Experimental studies in animal models have suggested that SGLT2 inhibitors may have beneficial modulatory effects on NAFLD/NASH, and several trials in patients have proven their beneficial effects on liver enzymes, BMI, blood lipids, blood glucose, and insulin resistance in NAFLD patients, thus creating strong expectations for their possible use in preventing the evolution of liver damage in these patients. We will review the main pathogenetic mechanisms, diagnostic modalities, and recent therapies of NAFLD, with particular attention to the use of SGLT2 inhibitors.
MeSH term(s)	Animals ; Carcinoma, Hepatocellular/drug therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Glucose/therapeutic use ; Humans ; Hypoglycemic Agents/adverse effects ; Liver/metabolism ; Liver Neoplasms/drug therapy ; Non-alcoholic Fatty Liver Disease/complications ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
Chemical Substances	Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-03-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073668
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Article ; Online: COVID in 2022. Clinical risk management of sars-cov-2 positive patients admitted to an internal medicine ward.

Licata, Anna / Amodeo, Simona / Mirarchi, Luigi / Soresi, Maurizio / Citarrella, Roberto / Barbagallo, Mario / Giannitrapani, Lydia

Clinical and experimental medicine

2022 Volume 23, Issue 4, Page(s) 1345–1347

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Risk Management ; Internal Medicine
Language	English
Publishing date	2022-12-17
Publishing country	Italy
Document type	Letter
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-022-00977-z
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Article: The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?

Licata, Anna / Zerbo, Maddalena / Como, Silvia / Cammilleri, Marcella / Soresi, Maurizio / Montalto, Giuseppe / Giannitrapani, Lydia

Nutrients. 2021 Nov. 10, v. 13, no. 11

2021

Abstract: Over the past few years, growing interest has been shown for the impact of dietary requirements and nutritional factors on chronic diseases. As a result, nutritional programs have been reinforced by public health policies. The precise role of ... ...

Abstract	Over the past few years, growing interest has been shown for the impact of dietary requirements and nutritional factors on chronic diseases. As a result, nutritional programs have been reinforced by public health policies. The precise role of micronutrients in chronic liver disease is currently receiving particular attention since abnormalities in vitamin levels are often detected. At present, treatment programs are focused on correcting vitamin deficiencies, which are frequently correlated to higher rates of comorbidities with poor outcomes. The literature reviewed here indicates that liver diseases are often related to vitamin disorders, due to both liver impairment and abnormal intake. More specific knowledge about the role of vitamins in liver disease is currently emerging from various results and recent evidence. The most significant benefits in this area may be observed when improved vitamin intake is combined with a pharmacological treatment that may also affect the progression of the liver disease, especially in the case of liver tumors. However, further studies are needed.
Keywords	liver ; nutrient intake ; vitamin deficiencies
Language	English
Dates of publication	2021-1110
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13114014
Database	NAL-Catalogue (AGRICOLA)

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Article: COVID-19: The Development and Validation of a New Mortality Risk Score.

Zinna, Giuseppe / Pipitò, Luca / Colomba, Claudia / Scichilone, Nicola / Licata, Anna / Barbagallo, Mario / Russo, Antonio / Almasio, Piero Luigi / Coppola, Nicola / Cascio, Antonio

Journal of clinical medicine

2024 Volume 13, Issue 7

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13071832
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