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  1. Book ; Online: Advances in the Systemic Therapy and Combined Modality Approaches for Head and Neck Cancer

    Argiris, Athanassios / Licitra, Lisa

    2020  

    Keywords Medicine ; Oncology ; systemic therapy ; chemotherapy ; cetuximab ; head and neck cancer ; squamous cell carcinoma of the head and neck ; human papillomavirus
    Size 1 electronic resource (116 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231416
    ISBN 9782889633289 ; 2889633284
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Next generation platinum salt in nasopharygeal carcinoma.

    Cavalieri, Stefano / Licitra, Lisa

    The Lancet. Oncology

    2021  Volume 22, Issue 5, Page(s) 577–578

    MeSH term(s) Carcinoma ; Chemoradiotherapy ; Cisplatin ; Cyclobutanes ; Fluorouracil ; Humans ; Induction Chemotherapy ; Nasopharyngeal Carcinoma/diagnosis ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Neoplasms ; Organoplatinum Compounds ; Platinum
    Chemical Substances Cyclobutanes ; Organoplatinum Compounds ; Platinum (49DFR088MY) ; lobaplatin (OX5XK1JD8C) ; Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2021-04-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00182-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  3. Article ; Online: An Old but Still Unanswered Question in Recurrent or Metastatic Salivary Duct Carcinoma.

    Cavalieri, Stefano / Locati, Laura Deborah / Licitra, Lisa

    JCO precision oncology

    2022  Volume 5, Page(s) 1526–1527

    MeSH term(s) Carcinoma, Ductal/pathology ; Humans ; Salivary Ducts/pathology ; Salivary Gland Neoplasms/therapy
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.21.00262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Oligometastatic disease from differentiated thyroid cancer: best treatment schemes.

    Colombo, Elena / Ottini, Arianna / Licitra, Lisa

    Current opinion in oncology

    2022  Volume 35, Issue 1, Page(s) 15–21

    Abstract: Purpose of review: Patients with slowly progressive and/or symptomatic oligometastatic radioactive iodine refractory (RAIR) differentiated thyroid carcinomas (DTCs) are candidates to receive locoregional treatment to delay the start of systemic therapy ... ...

    Abstract Purpose of review: Patients with slowly progressive and/or symptomatic oligometastatic radioactive iodine refractory (RAIR) differentiated thyroid carcinomas (DTCs) are candidates to receive locoregional treatment to delay the start of systemic therapy with multikinase inhibitors. Information provided by the recent literature has not been extensively reviewed in previous published works, thus we aim to bridge this gap.
    Recent findings: We present for each metastatic site the different locoregional treatment options, contraindications and potential adverse events. Some techniques can be combined together, whereas others are discouraged in certain situations, requiring a high level of expertise and multidisciplinarity in the treatment algorithm.
    Summary: Different techniques of radiation therapy and interventional radiology allow to control the metastatic spread. However, as no clinical trials are available to compare the treatment schemes in terms of safety and potential impact on the prognosis, the most appropriate option for each patient should be selected within a multidisciplinary decision making, taking into account the clinical conditions and the pattern/rapidity of metastatic disease.
    MeSH term(s) Humans ; Thyroid Neoplasms/therapy ; Iodine Radioisotopes/therapeutic use
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3046: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Which future for de-intensified treatments in HPV-related oropharyngeal carcinoma?

    Cavalieri, Stefano / Nuzzolese, Imperia / Licitra, Lisa

    Seminars in oncology

    2022  Volume 49, Issue 5, Page(s) 405–408

    Abstract: The development of deintensified therapies aiming at reducing the treatment-related toxicity while not impairing the outcome is an unmet need in HPV+ oropharyngeal carcinoma patients. Several deintensification approaches have been explored in this ... ...

    Abstract The development of deintensified therapies aiming at reducing the treatment-related toxicity while not impairing the outcome is an unmet need in HPV+ oropharyngeal carcinoma patients. Several deintensification approaches have been explored in this setting, including induction chemotherapy with reduced chemoradiation dose in responding pts. The findings of the studies conducted so far show that the available deescalated therapy should be based on the disease risk profile. At present, we still lack robust high level data to infer that the cited interventions are equivalent or superior to standard of care treatments. However, literature data suggest that approximately 70% of low-risk patients might receive a deintensified approach by including either surgery or induction chemotherapy. In the context of high-risk disease, more than 80% of patients may undergo a deintensified loco-regional treatment by neoadjuvant systemic therapy. Epidemiological data suggest that in the next decades, most of the HPV-related OPSCC patients will be made of old and possibly frail individuals. However, this patient population was excluded from most of the studies conducted so far. Therefore, there is a strong need for clinical trials to define risk-based deescalation strategies in this population and in younger patients as well.
    MeSH term(s) Humans ; Papillomavirus Infections/complications ; Papillomavirus Infections/therapy ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/surgery ; Chemoradiotherapy ; Combined Modality Therapy ; Carcinoma
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189220-4
    ISSN 1532-8708 ; 0093-7754
    ISSN (online) 1532-8708
    ISSN 0093-7754
    DOI 10.1053/j.seminoncol.2022.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1348: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Induction chemotherapy is the best timekeeper in nasopharyngeal carcinoma.

    Cavalieri, Stefano / Licitra, Lisa

    Cancer

    2020  Volume 126, Issue 16, Page(s) 3624–3626

    MeSH term(s) Epstein-Barr Virus Infections/drug therapy ; Epstein-Barr Virus Infections/epidemiology ; Epstein-Barr Virus Infections/virology ; Herpesvirus 4, Human/pathogenicity ; Humans ; Induction Chemotherapy ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/epidemiology ; Nasopharyngeal Carcinoma/virology ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/epidemiology ; Nasopharyngeal Neoplasms/virology
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.32971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.146: Show issues Location:
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  7. Article: Editorial: Advances in the Systemic Therapy and Combined Modality Approaches for Head and Neck Cancer.

    Argiris, Athanassios / Licitra, Lisa

    Frontiers in oncology

    2019  Volume 9, Page(s) 1190

    Language English
    Publishing date 2019-11-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.01190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Developing a robust two-step machine learning multiclassification pipeline to predict primary site in head and neck carcinoma from lymph nodes.

    Liu, Jiaying / Corti, Anna / Calareso, Giuseppina / Spadarella, Gaia / Licitra, Lisa / Corino, Valentina D A / Mainardi, Luca

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24377

    Abstract: This study aimed to develop a robust multiclassification pipeline to determine the primary tumor location in patients with head and neck carcinoma of unknown primary using radiomics and machine learning techniques. The dataset included 400 head and neck ... ...

    Abstract This study aimed to develop a robust multiclassification pipeline to determine the primary tumor location in patients with head and neck carcinoma of unknown primary using radiomics and machine learning techniques. The dataset included 400 head and neck cancer patients with primary tumor in oropharynx, OPC (n = 162), nasopharynx, NPC (n = 137), oral cavity, OC (n = 63), larynx and hypopharynx, HL (n = 38). Two radiomic-based multiclassification pipelines (P1 and P2) were developed. P1 consisted in a direct identification of the primary sites, whereas P2 was based on a two-step approach: in the first step, the number of classes was reduced by merging the two minority classes which were reclassified in the second step. Diverse correlation thresholds (0.75, 0.80, 0.85), feature selection methods (sequential forwards/backwards selection, sequential floating forward selection, neighborhood component analysis and minimum redundancy maximum relevance), and classification models (neural network, decision tree, naïve Bayes, bagged trees and support vector machine) were assessed. P2 outperformed P1, with the best results obtained with the support vector machine classifier including radiomic and clinical features (accuracies of 75.3 % (HL), 75.4 % (OC), 71.3 % (OPC), 92.9 % (NPC)). These results indicate that the two-step multiclassification pipeline integrating radiomics and clinical information is a promising approach to predict the tumor site of unknown primary.
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The day after De-ESCALaTE and RTOG 1016 trials results.

    Orlandi, Ester / Licitra, Lisa

    Future oncology (London, England)

    2019  Volume 15, Issue 18, Page(s) 2069–2072

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Chemoradiotherapy/methods ; Cisplatin/administration & dosage ; Clinical Trials, Phase III as Topic ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Drug Administration Schedule ; Humans ; Multicenter Studies as Topic ; Papillomaviridae/isolation & purification ; Prognosis ; Progression-Free Survival ; Radiotherapy, Intensity-Modulated/methods ; Randomized Controlled Trials as Topic ; Squamous Cell Carcinoma of Head and Neck/mortality ; Squamous Cell Carcinoma of Head and Neck/therapy ; Squamous Cell Carcinoma of Head and Neck/virology ; Standard of Care
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2019-06-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2019-0168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6478: Show issues Location:
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  10. Article ; Online: PD-1 immunotherapy for recurrent or metastatic HNSCC.

    Ferris, Robert L / Licitra, Lisa

    Lancet (London, England)

    2019  Volume 394, Issue 10212, Page(s) 1882–1884

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Cetuximab ; Head and Neck Neoplasms ; Humans ; Immunotherapy ; Programmed Cell Death 1 Receptor ; Squamous Cell Carcinoma of Head and Neck
    Chemical Substances Antibodies, Monoclonal, Humanized ; Programmed Cell Death 1 Receptor ; pembrolizumab (DPT0O3T46P) ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2019-11-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)32539-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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