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  1. Article: Collaboration between orthopaedic surgeons and infection specialists in bone and joint infections.

    Hedström, Sven Åke / Lidgren, Lars

    Journal of bone and joint infection

    2019  Volume 4, Issue 6, Page(s) 292–294

    Language English
    Publishing date 2019-11-20
    Publishing country Germany
    Document type Editorial
    ISSN 2206-3552
    ISSN 2206-3552
    DOI 10.7150/jbji.41662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Looking back at the start of the Bone And Joint Decade what have we learnt?

    Lidgren, Lars

    Best practice & research. Clinical rheumatology

    2012  Volume 26, Issue 2, Page(s) 169–171

    Abstract: The Bone and Joint Decade 2000-2010 started as a Swedish initiative in 1996 leading to the UN declaration 1999 followed by the WHO launch 2000. A ten year multidisciplinary and global endeavor moving musculoskeletal conditions onto the research and ... ...

    Abstract The Bone and Joint Decade 2000-2010 started as a Swedish initiative in 1996 leading to the UN declaration 1999 followed by the WHO launch 2000. A ten year multidisciplinary and global endeavor moving musculoskeletal conditions onto the research and health agenda is now recognized. Some lessons learned during the journey are presented.
    MeSH term(s) Biomedical Research/trends ; Congresses as Topic ; Global Health ; Humans ; International Cooperation ; Musculoskeletal Diseases ; Population Dynamics ; Retrospective Studies
    Language English
    Publishing date 2012-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2012.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Systemic rifampicin shows accretion to locally implanted hydroxyapatite particles in a rat abdominal muscle pouch model.

    Sebastian, Sujeesh / Huang, Jintian / Liu, Yang / Collin, Mattias / Tägil, Magnus / Raina, Deepak Bushan / Lidgren, Lars

    Journal of bone and joint infection

    2023  Volume 8, Issue 1, Page(s) 19–28

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2023-01-09
    Publishing country Germany
    Document type Journal Article
    ISSN 2206-3552
    ISSN 2206-3552
    DOI 10.5194/jbji-8-19-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Preface: neck pain and the decade of the bone and joint 2000-2010.

    Lidgren, Lars

    Journal of manipulative and physiological therapeutics

    2009  Volume 32, Issue 2 Suppl, Page(s) S2–3

    Language English
    Publishing date 2009-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 761054-3
    ISSN 1532-6586 ; 0161-4754
    ISSN (online) 1532-6586
    ISSN 0161-4754
    DOI 10.1016/j.jmpt.2008.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1859: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion.

    Tian, Xinggui / Vater, Corina / Raina, Deepak Bushan / Findeisen, Lisa / Matuszewski, Lucas-Maximilian / Tägil, Magnus / Lidgren, Lars / Winkler, Anja / Gottwald, Robert / Modler, Niels / Schaser, Klaus-Dieter / Disch, Alexander C / Zwingenberger, Stefan

    Bioactive materials

    2024  Volume 36, Page(s) 256–271

    Abstract: Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been FDA-approved for lumbar fusion, but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast activation have limited its ... ...

    Abstract Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been FDA-approved for lumbar fusion, but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast activation have limited its clinical usage. One strategy to mitigate the pro-osteoclast side effect of rhBMP-2 is to give systemic bisphosphonates, but it presents challenges with systemic side effects and low local bioavailability. The aim of this
    Language English
    Publishing date 2024-03-06
    Publishing country China
    Document type Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2024.02.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recycling implants: a sustainable solution for musculoskeletal research.

    Lidgren, Lars / Raina, Deepak Bushan / Tägil, Magnus / Tanner, K Elizabeth

    Acta orthopaedica

    2020  Volume 91, Issue 2, Page(s) 125

    MeSH term(s) Humans ; Income/statistics & numerical data ; Joint Prosthesis/economics ; Joint Prosthesis/statistics & numerical data ; Metals ; Recycling/economics ; Recycling/statistics & numerical data ; Reoperation/statistics & numerical data ; Sweden
    Chemical Substances Metals
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2180677-9
    ISSN 1745-3682 ; 1745-3674
    ISSN (online) 1745-3682
    ISSN 1745-3674
    DOI 10.1080/17453674.2019.1706301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.99: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Article: Bone mineral as a drug-seeking moiety and a waste dump.

    Raina, Deepak Bushan / Liu, Yang / Jacobson, Otto L P / Tanner, K Elizabeth / Tägil, Magnus / Lidgren, Lars

    Bone & joint research

    2021  Volume 9, Issue 10, Page(s) 709–718

    Abstract: Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual's lifetime. Bone has an important role in homeostasis of ... ...

    Abstract Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual's lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health. Cite this article:
    Language English
    Publishing date 2021-01-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669244-2
    ISSN 2046-3758
    ISSN 2046-3758
    DOI 10.1302/2046-3758.910.BJR-2020-0097.R1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Ortopediska vården varierar över landet.

    Lidgren, Lars

    Lakartidningen

    2007  Volume 104, Issue 19, Page(s) 1489

    Title translation Orthopedic care varies over the country.
    MeSH term(s) Arthroplasty, Replacement, Hip/statistics & numerical data ; Clinical Competence ; Humans ; Orthopedics/standards ; Orthopedics/statistics & numerical data ; Sweden
    Language Swedish
    Publishing date 2007-05
    Publishing country Sweden
    Document type Comparative Study ; Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.411: Show issues Location:
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  9. Article: Extended local release and improved bacterial eradication by adding rifampicin to a biphasic ceramic carrier containing gentamicin or vancomycin.

    Sebastian, Sujeesh / Tandberg, Felix / Liu, Yang / Raina, Deepak B / Tägil, Magnus / Collin, Mattias / Lidgren, Lars

    Bone & joint research

    2022  Volume 11, Issue 11, Page(s) 787–802

    Abstract: Aims: There is a lack of biomaterial-based carriers for the local delivery of rifampicin (RIF), one of the cornerstone second defence antibiotics for bone infections. RIF is also known for causing rapid development of antibiotic resistance when given as ...

    Abstract Aims: There is a lack of biomaterial-based carriers for the local delivery of rifampicin (RIF), one of the cornerstone second defence antibiotics for bone infections. RIF is also known for causing rapid development of antibiotic resistance when given as monotherapy. This in vitro study evaluated a clinically used biphasic calcium sulphate/hydroxyapatite (CaS/HA) biomaterial as a carrier for dual delivery of RIF with vancomycin (VAN) or gentamicin (GEN).
    Methods: The CaS/HA composites containing RIF/GEN/VAN, either alone or in combination, were first prepared and their injectability, setting time, and antibiotic elution profiles were assessed. Using a continuous disk diffusion assay, the antibacterial behaviour of the material was tested on both planktonic and biofilm-embedded forms of standard and clinical strains of
    Results: Following the addition of RIF to CaS/HA-VAN/GEN, adequate injectability and setting of the CaS/HA composites were noted. Sustained release of RIF above the minimum inhibitory concentrations of
    Conclusion: Our in vitro results indicate that biphasic CaS/HA loaded with VAN or GEN could be used as a carrier for RIF for local delivery in clinically demanding bone infections.Cite this article:
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669244-2
    ISSN 2046-3758
    ISSN 2046-3758
    DOI 10.1302/2046-3758.1111.BJR-2022-0101.R1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparative effectiveness research on proximal femoral nail versus dynamic hip screw in patients with trochanteric fractures: a systematic review and meta-analysis of randomized trials.

    Xu, Hong / Liu, Yang / Sezgin, Erdem Aras / Tarasevičius, Šarūnas / Christensen, Robin / Raina, Deepak Bushan / Tägil, Magnus / Lidgren, Lars

    Journal of orthopaedic surgery and research

    2022  Volume 17, Issue 1, Page(s) 292

    Abstract: Background: The treatments for trochanteric fractures try to regain early mobility and limit morbidity and risk of reoperations. The most currently used dynamic hip screw (DHS) and the proximal femoral nail (PFN) are both with pros and cons. We aimed to ...

    Abstract Background: The treatments for trochanteric fractures try to regain early mobility and limit morbidity and risk of reoperations. The most currently used dynamic hip screw (DHS) and the proximal femoral nail (PFN) are both with pros and cons. We aimed to assess the comparative effectiveness of these interventions for trochanteric fractures by evaluating the surgical performance and postoperative outcomes.
    Methods: PubMed, Web of Science and Cochrane Central Register were searched for RCTs comparing DHS and PFN for trochanteric fractures. All selected studies and the risk of bias were assessed. Clinical data including operative time, intraoperative blood loss, intraoperative fluoroscopy time, successful closed reduction and complications like nonunion, implant failure and reoperation were recorded. Random-effects models were used in Review Manager software, and GRADE was applied for the interpretation of the evidence.
    Results: From 286 identified trials, twelve RCTs including 1889 patients were eligible for inclusion; six RCTs directly comparing DHS with PFN, while other six compared DHS with proximal femoral nail antirotation (PFNA). Compared to DHS, PFN had shorter operative time and led to less intraoperative blood loss. However, DHS need less intraoperative fluoroscopy time than PFN. No difference was seen for the achievement of closed reduction. For risk of postoperative complications, no difference was seen between PFN and DHS for non-union, risk of implant failure and revision surgery.
    Conclusions: PFN(A) resulted in a shorter operative time and less intraoperative blood loss compared to DHS. However, no difference was seen for postoperative complications. Trial registration PROSPERO: CRD42021239974.
    MeSH term(s) Blood Loss, Surgical/prevention & control ; Bone Nails ; Bone Screws ; Comparative Effectiveness Research ; Fracture Fixation, Internal/methods ; Fracture Fixation, Intramedullary/methods ; Hip Fractures/surgery ; Humans ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Language English
    Publishing date 2022-06-03
    Publishing country England
    Document type Meta-Analysis ; Systematic Review
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-022-03189-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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