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  1. Book ; Online: Hypergraph Echo State Network

    Lien, Justin

    2023  

    Abstract: A hypergraph as a generalization of graphs records higher-order interactions among nodes, yields a more flexible network model, and allows non-linear features for a group of nodes. In this article, we propose a hypergraph echo state network ( ... ...

    Abstract A hypergraph as a generalization of graphs records higher-order interactions among nodes, yields a more flexible network model, and allows non-linear features for a group of nodes. In this article, we propose a hypergraph echo state network (HypergraphESN) as a generalization of graph echo state network (GraphESN) designed for efficient processing of hypergraph-structured data, derive convergence conditions for the algorithm, and discuss its versatility in comparison to GraphESN. The numerical experiments on the binary classification tasks demonstrate that HypergraphESN exhibits comparable or superior accuracy performance to GraphESN for hypergraph-structured data, and accuracy increases if more higher-order interactions in a network are identified.

    Comment: 28 pages, 5 figures
    Keywords Computer Science - Machine Learning
    Publishing date 2023-10-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Pediatric orthopedic injuries: evidence-based management in the emergency department

    Lien, Jamie

    Pediatric emergency medicine practice

    2017  Volume 14, Issue 9, Page(s) 1–28

    MeSH term(s) Arm Injuries/diagnosis ; Arm Injuries/physiopathology ; Arm Injuries/therapy ; Child ; Child, Preschool ; Diagnosis, Differential ; Emergency Service, Hospital ; Evidence-Based Medicine ; Fracture Fixation/methods ; Fractures, Bone/diagnosis ; Fractures, Bone/physiopathology ; Fractures, Bone/therapy ; Humans ; Infant ; Infant, Newborn ; Leg Injuries/diagnosis ; Leg Injuries/physiopathology ; Leg Injuries/therapy ; Musculoskeletal System/injuries
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1549-9650
    ISSN 1549-9650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enhanced Single-Strand Breaks of a Nucleic Acid by Gold Nanoparticles under X-ray Irradiation.

    Su, Mengqi / Lien, Jennifer / Anilao, Auddy / Guo, Ting

    The journal of physical chemistry letters

    2023  Volume 14, Issue 5, Page(s) 1214–1221

    Abstract: The hydroxyl radical concentration-dependent yield of single-strand breaks (SSBs), obtained through correction of scavenging and hindrance effects caused by gold nanoparticles (AuNPs), for fluorophore- and quencher-labeled DNA on AuNPs was 10 times that ... ...

    Abstract The hydroxyl radical concentration-dependent yield of single-strand breaks (SSBs), obtained through correction of scavenging and hindrance effects caused by gold nanoparticles (AuNPs), for fluorophore- and quencher-labeled DNA on AuNPs was 10 times that of free DNA based on fluorescence measurements of X-ray-irradiated DNA on AuNPs. By comparing the fluorescence data that revealed the number of SSBs with the results of mass spectrometry measurements that detected the total damage to DNA, we found that SSBs dominated DNA damage for DNA on AuNPs whereas non-SSB damage dominated for free DNA. The yield of RNA SSBs under X-ray irradiation was similar to that of DNA in the presence of AuNPs, whereas free RNA was more resistive to radiation than DNA. These results indicated the enhanced SSBs were likely catalyzed through the conversion from nucleobase damage to SSBs by AuNPs. The outcome of this work impacts materials and environmental science, sensing, nanotechnology, biology, and medicine.
    MeSH term(s) Gold ; X-Rays ; Nucleic Acids ; DNA Damage ; Metal Nanoparticles ; DNA/radiation effects ; DNA, Single-Stranded ; RNA
    Chemical Substances Gold (7440-57-5) ; Nucleic Acids ; DNA (9007-49-2) ; DNA, Single-Stranded ; RNA (63231-63-0)
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.2c03885
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  4. Article: The contribution of transport and chemical processes on coastal ozone and emission control strategies to reduce ozone.

    Lien, Justin / Hung, Hui-Ming

    Heliyon

    2021  Volume 7, Issue 10, Page(s) e08210

    Abstract: The interaction between transport and chemistry is pivotal for local ozone ( ... ...

    Abstract The interaction between transport and chemistry is pivotal for local ozone (O
    Language English
    Publishing date 2021-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e08210
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  5. Article: The contribution of transport and chemical processes on coastal ozone and emission control strategies to reduce ozone

    Lien, Justin / Hung, Hui-Ming

    Heliyon. 2021 Oct., v. 7, no. 10

    2021  

    Abstract: The interaction between transport and chemistry is pivotal for local ozone (O₃) concentration, especially for a coastal region where the upstream sources might change diurnally. In the current emission control policy, most pollutants, such as particulate ...

    Abstract The interaction between transport and chemistry is pivotal for local ozone (O₃) concentration, especially for a coastal region where the upstream sources might change diurnally. In the current emission control policy, most pollutants, such as particulate matter, SO₂, NOx, and CO, decrease while the annual O₃ trend might increase due to the complex feedbacks of precursors. In this study, we investigate the influence of transport upon the wintertime O₃ diurnal trend over ZuoYing Kaohsiung, an urban coastal site in southern Taiwan, by constructing a two-dimensional numerical model coupling both physical mechanisms and core chemical processes and provide a feasible emission control strategy. The transport process (i.e., import vs. export) for the daytime is determined using the Leighton Ratio (Φ), the ratio of O₃-production over O₃-loss rate, under the pseudo-steady-state condition. Φ shows a deviation of -9 to +13% from the photo-stationary state, and experiences a transition from import effect before 10:15 to weakening import or net export effect afterward associated with a net O₃ production as sea breeze starts developing. The significantly higher Φ derived from observation than from simulation by a factor of 1.35 might be resulted from the over-reported NO₂ due to NOy contribution on the NO₂ measurement, and the influence of aerosol and cloud possibly reducing ∼30% on applied NO₂ photolysis rate constant, associated with aerosol optical depth of 0.75 ± 0.15 and single scattering albedo of 0.85 ± 0.15. In this studied NOx-saturated regime, the addition of sea breeze convergence over the land enhances the maximal O₃ by ∼10%, mainly due to the O₃ accumulation (∼88%). Furthermore, the ozone isopleth analysis as a function of non-methane hydrocarbons and NOx emissions provides an achievable strategy to decrease both maximum daily ozone and the increment of ozone from morning to maximum by reducing hydrocarbons and NOx emissions, which can also eliminate the additional nitrate contribution on the aerosols.
    Keywords aerosols ; coasts ; exports ; imports ; issues and policy ; mathematical models ; nitrates ; ozone ; particulates ; photolysis ; winter ; Taiwan
    Language English
    Dates of publication 2021-10
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e08210
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  6. Article ; Online: Comparing maternal substance use and perinatal outcomes before and during the COVID-19 pandemic.

    Lien, Joan / Hayes, Tristan / Liu-Smith, Feng / Rana, Divya

    Journal of perinatology : official journal of the California Perinatal Association

    2023  Volume 43, Issue 5, Page(s) 664–669

    Abstract: Objective: To examine the effect of the COVID-19 pandemic on maternal substance abuse and neonatal outcomes.: Study design: Cross-sectional observational study of neonates admitted to the NICU and born to mothers with evidence of substance abuse pre- ... ...

    Abstract Objective: To examine the effect of the COVID-19 pandemic on maternal substance abuse and neonatal outcomes.
    Study design: Cross-sectional observational study of neonates admitted to the NICU and born to mothers with evidence of substance abuse pre-pandemic compared to during the COVID-19 pandemic.
    Result: We noted a significant increase in fentanyl (12% vs. 0.6%, p < 0.001) and tobacco use (64% vs. 33%, p < 0.001) during the pandemic compared to pre-pandemic, including an increase in fentanyl use among mothers enrolled in opioid maintenance therapy (OMT) during the pandemic (32.3% vs. 1.5%, p < 0.001). There was a significant increase in preterm births (58% vs. 48%, p = 0.022) and lower birth weight (2315 ± 815 vs. 2455 ± 861 g, p = 0.049) during pandemic.
    Conclusion: There was a significant increase in maternal fentanyl use during the pandemic, even with OMT enrollment, with an increase in preterm births and lower birth weights among infants born to mothers with substance use.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Infant ; Female ; Humans ; Premature Birth/epidemiology ; COVID-19 ; Pandemics ; Cross-Sectional Studies ; Birth Weight ; Substance-Related Disorders/epidemiology ; Fentanyl
    Chemical Substances Fentanyl (UF599785JZ)
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-023-01613-8
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  7. Article ; Online: Bottom-Up Then Top-Down Synthesis of Gold Nanostructures Using Mesoporous Silica-Coated Gold Nanorods.

    Peck, Kristin A / Lien, Jennifer / Su, Mengqi / Stacy, Aaron D / Guo, Ting

    ACS omega

    2023  Volume 8, Issue 45, Page(s) 42667–42677

    Abstract: Gold nanostructures were synthesized by etching away gold from heat-treated mesoporous silica-coated gold nanorods (AuNR@ ... ...

    Abstract Gold nanostructures were synthesized by etching away gold from heat-treated mesoporous silica-coated gold nanorods (AuNR@mSiO
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05444
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  8. Article ; Online: Severe Acute Respiratory Syndrome Associated Infections.

    Luu, Brent / McCoy-Hass, Virginia / Kadiu, Teuta / Ngo, Victoria / Kadiu, Sara / Lien, Jeffrey

    Physician assistant clinics

    2023  Volume 8, Issue 3, Page(s) 495–530

    Abstract: Viral infections are some of the most common sources of respiratory illness in pediatric and adult populations worldwide. Influenza and coronaviruses are viral pathogens that could lead to severe respiratory illness and death. More recently, respiratory ... ...

    Abstract Viral infections are some of the most common sources of respiratory illness in pediatric and adult populations worldwide. Influenza and coronaviruses are viral pathogens that could lead to severe respiratory illness and death. More recently, respiratory illness from coronaviruses, accounts for more than 1 million deaths in the United States alone. This article will explore the epidemiology, pathogenesis, diagnosis, treatment, and prevention of severe acute respiratory syndrome caused by coronavirus-2, and Middle Eastern respiratory syndrome.
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2405-8009
    ISSN (online) 2405-8009
    DOI 10.1016/j.cpha.2023.03.002
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  9. Article ; Online: Data Preprocessing Method for the Analysis of Spectral Components in the Spectra of Mixtures.

    Jackson, Richard S / Wang, Qian / Lien, John

    Applied spectroscopy

    2021  Volume 76, Issue 1, Page(s) 81–91

    Abstract: This paper describes a data preprocessing algorithm that can be used to mitigate the effects of interfering spectral components when the goal is to detect the spectrum of unknown components in a mixture of known components or to verify the presence of ... ...

    Abstract This paper describes a data preprocessing algorithm that can be used to mitigate the effects of interfering spectral components when the goal is to detect the spectrum of unknown components in a mixture of known components or to verify the presence of suspected components in the spectrum of a mixture of known components. The algorithm is both relatively simple and applicable to a wide range of problems in spectroscopy. The range of applicability can be increased by combining the method with other data preprocessing methods, for example derivative spectra, and can also accommodate variability in the spectra of one or more of the known components. Examples of the application of the algorithm to real problems are given for near-infrared analysis of antibiotic drug formulations inside gelatin capsules and mid-infrared analysis of atmospheric pollutants.
    MeSH term(s) Algorithms ; Spectroscopy, Near-Infrared
    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Journal Article
    ISSN 1943-3530
    ISSN (online) 1943-3530
    DOI 10.1177/00037028211042903
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  10. Article ; Online: Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection.

    Lamba, Vineet / Lien, Joan / Desai, Jay / Talati, Ajay J

    BMC pediatrics

    2021  Volume 21, Issue 1, Page(s) 400

    Abstract: Objective: We report here on the management and outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection.: Study design: In this prospective study, eligible neonates were enrolled in a database to track in-hospital outcomes and ...

    Abstract Objective: We report here on the management and outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection.
    Study design: In this prospective study, eligible neonates were enrolled in a database to track in-hospital outcomes and followed up outpatient periodically till 2 months of age to assess for late onset symptoms of infection.
    Results: From April 2020 to February 2021, 67 mothers with perinatal SARS-CoV-2 infection and 70 at-risk neonates were included. Two neonates (3%) tested positive for SARS-CoV-2 within 48 h of life but remained asymptomatic during hospitalization and at all follow-up periods. Three infants were reported to have a febrile illness in 2 months follow up period, none of which was attributable to SARS-CoV-2.
    Conclusion: Our data supports the emerging evidence which describes a probable low risk of vertical transmission of SARS-CoV-2. We also demonstrate a low risk of post-natal transmission or late-onset symptomatic infection with SARS-CoV-2.
    MeSH term(s) COVID-19 ; Female ; Humans ; Infant, Newborn ; Mothers ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Prospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-021-02872-0
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