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  1. Article ; Online: Mendelian Randomization: A Powerful Tool to Illuminate Pathophysiologic Mechanisms.

    Lieske, John C

    Mayo Clinic proceedings

    2023  Volume 98, Issue 4, Page(s) 500–501

    MeSH term(s) Humans ; Genetic Variation ; Mendelian Randomization Analysis ; Genome-Wide Association Study
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.02.015
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  2. Article: Primary hyperoxaluria type 1: novel therapies at a glance.

    Bacchetta, Justine / Lieske, John C

    Clinical kidney journal

    2022  Volume 15, Issue Suppl 1, Page(s) i17–i22

    Abstract: Primary hyperoxaluria type 1 (PH1) is a rare and severe autosomal recessive disease of oxalate metabolism, resulting from a mutation in ... ...

    Abstract Primary hyperoxaluria type 1 (PH1) is a rare and severe autosomal recessive disease of oxalate metabolism, resulting from a mutation in the
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfab245
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    Zs.A 6587: Show issues Location:
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  3. Article ; Online: New therapeutics for primary hyperoxaluria type 1.

    Dejban, Pegah / Lieske, John C

    Current opinion in nephrology and hypertension

    2022  Volume 31, Issue 4, Page(s) 344–350

    Abstract: Purpose of review: Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder that causes hepatic overproduction of oxalate and, often, nephrocalcinosis, nephrolithiasis, chronic kidney disease, and kidney failure. The purpose of the review is to ... ...

    Abstract Purpose of review: Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder that causes hepatic overproduction of oxalate and, often, nephrocalcinosis, nephrolithiasis, chronic kidney disease, and kidney failure. The purpose of the review is to provide an update on current emerging therapies for the treatment of PH1.
    Recent findings: Use of ribonucleic acid interference (RNAi) therapeutics that target the liver to block production of key enzymes along pathways that generate oxalate is a promising approach. Available evidence supports the efficacy of both Lumasiran (targeting glycolate oxidase) and Nedosiran (targeting hepatic lactate dehydrogenase (LDHa)) to reduce urinary oxalate excretion in PH1. The efficacy of alternative approaches including stiripentol (an anticonvulsant drug that also targets LDHa), lanthanum (a potential gastrointestinal oxalate binder), and Oxalobacter formigenes (a bacterium that can degrade oxalate within the gastrointestinal tract and may also increase its secretion from blood) are all also under study. Genetic editing tools including clustered regularly interspaced short palindromic repeats/Cas9 are also in preclinical study as a potential PH1 therapeutic.
    Summary: Novel treatments can reduce the plasma oxalate concentration and urinary oxalate excretion in PH1 patients. Thus, it is possible these approaches will reduce the need for combined kidney and liver transplantation to significantly decrease the morbidity and mortality of affected patients.
    MeSH term(s) Humans ; Hyperoxaluria, Primary/genetics ; Hyperoxaluria, Primary/therapy ; Kidney Calculi ; L-Lactate Dehydrogenase ; Oxalates/metabolism ; RNA, Small Interfering
    Chemical Substances Oxalates ; RNA, Small Interfering ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; lumasiran (RZT8C352O1)
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000790
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    Zs.A 3686: Show issues Location:
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  4. Article ; Online: Estimating glomerular filtration rate with new equations: can one size ever fit all?

    Kasozi, Ramla N / Meeusen, Jeffrey W / Lieske, John C

    Critical reviews in clinical laboratory sciences

    2023  Volume 60, Issue 7, Page(s) 549–559

    Abstract: Glomerular filtration rate (GFR) is thought to be the best overall indicator of kidney health. On an individual patient basis, a working knowledge of GFR is important to understand the future risk for chronic kidney disease (CKD) progression, enhanced ... ...

    Abstract Glomerular filtration rate (GFR) is thought to be the best overall indicator of kidney health. On an individual patient basis, a working knowledge of GFR is important to understand the future risk for chronic kidney disease (CKD) progression, enhanced risk for cardiovascular disease and death, and for optimal medical management including the dosing of certain drugs. Although GFR can be directly measured using exogenous compounds that are eliminated by the kidney, these methods are not scalable for repeated and routine use in clinical care. Thus, in most circumstances GFR is estimated, termed estimated GFR (eGFR), using serum biomarkers that are eliminated by the kidney. Of these, serum creatinine, and to a lesser extent cystatin C, are most widely employed. However, the resulting number is simply a population average for an individual of that age and sex with a given serum creatinine and/or cystatin C, while the range of potential GFR values is actually quite large. Thus, it is important to consider characteristics of a given patient that might make this estimate better or worse in a particular case. In some circumstances, cystatin C or creatinine might be the better choice. Ultimately it is difficult, if not impossible, to have an eGFR equation that performs equally well in all populations. Thus, in certain cases it might be appropriate to directly measure GFR for high consequence medical decision-making, such as approval for kidney donation or prior to certain chemotherapeutic regimens. In all cases, the eGFR thresholds of CKD stage should not be viewed as absolute numbers. Thus, clinical care should not be determined solely by CKD stage as determined by eGFR alone, but rather by the combination of an individual patient's likely kidney function together with their current clinical situation.
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 280641-1
    ISSN 1549-781X ; 1040-8363 ; 0590-8191
    ISSN (online) 1549-781X
    ISSN 1040-8363 ; 0590-8191
    DOI 10.1080/10408363.2023.2214812
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  5. Article ; Online: Bariatric Surgery and Kidney Health.

    Lieske, John C

    Journal of the American Society of Nephrology : JASN

    2018  Volume 29, Issue 4, Page(s) 1085–1086

    MeSH term(s) Bariatric Surgery ; Humans ; Kidney ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2018-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2018020176
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  6. Article ; Online: New Insights Regarding Organ Transplantation in Primary Hyperoxaluria Type 1.

    Sas, David J / Lieske, John C

    Kidney international reports

    2021  Volume 7, Issue 2, Page(s) 146–148

    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Editorial
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.12.032
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  7. Article ; Online: Back to the Future: The Role of Metabolic Studies in Therapeutic Advances.

    Milliner, Dawn S / Lieske, John C

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 12, Page(s) 2980–2982

    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021101325
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  8. Article ; Online: How We Treat Primary Hyperoxaluria Type 1.

    Breeggemann, Matthew C / Harris, Peter C / Lieske, John C / Tasian, Gregory E / Wood, Kyle D

    Clinical journal of the American Society of Nephrology : CJASN

    2024  

    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000460
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  9. Article: Probiotics for prevention of urinary stones.

    Lieske, John C

    Annals of translational medicine

    2017  Volume 5, Issue 2, Page(s) 29

    Abstract: Background: Urinary supersaturation is one key determinant of calcium oxalate (CaOx) urinary stone formation, and urinary excretions of oxalate and citrate are two key determinants. Each is influenced by gastrointestinal processes.: Methods: Open ... ...

    Abstract Background: Urinary supersaturation is one key determinant of calcium oxalate (CaOx) urinary stone formation, and urinary excretions of oxalate and citrate are two key determinants. Each is influenced by gastrointestinal processes.
    Methods: Open label and randomized placebo studies have examined the effect of oral probiotic preparations on urinary supersaturation and oxalate excretion. Cross sectional studies in humans have studied the association of
    Results: The fecal content of
    Conclusions: Although the intestinal microbiome seems likely to play a role to modify gastrointestinal absorption of lithogenic substances and hence urinary stone risk, whether we can develop tools to manipulate it and decrease this kidney stone risk remains to be determined.
    Language English
    Publishing date 2017-02-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2016.11.86
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  10. Article ; Online: Authors' Reply: Urine Metabolomic Versus Standard Chemistry Analysis: What can Metabolomic Analysis Bring to the Treatment and Prevention of Urolithiasis?

    Thongprayoon, Charat / Lieske, John C / Rule, Andrew D / Denic, Aleksandar

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 6, Page(s) 1124–1125

    MeSH term(s) Humans ; Urolithiasis/prevention & control ; Urolithiasis/therapy ; Metabolomics
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000138
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