LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Lievre, Loïc"
  2. AU=Cammack N
  3. AU="Xia, Qin"
  4. AU="Ong, Ju Lynn"
  5. AU="Cullin, Christophe"
  6. AU="Georg K.S. Andersson"
  7. AU="Jeannel, Gaël-François"
  8. AU="Stuart Woods"
  9. AU="Shchegolev, A."
  10. AU="Nadeau, Pierre-Louis"
  11. AU="Gordon, David E A"
  12. AU="Shahid Mahmood"
  13. AU="Rosenblatt, Karin"
  14. AU="Dasgupta, Suvankar"
  15. AU=Nguyen Sylvain AU=Nguyen Sylvain

Suchergebnis

Treffer 1 - 5 von insgesamt 5

Suchoptionen

  1. Artikel ; Online: Mechanisms of paracellular transport of magnesium in intestinal and renal epithelia.

    Houillier, Pascal / Lievre, Loïc / Hureaux, Marguerite / Prot-Bertoye, Caroline

    Annals of the New York Academy of Sciences

    2023  Band 1521, Heft 1, Seite(n) 14–31

    Abstract: Magnesium is the fourth most abundant cation in the body. It plays a critical role in many biological processes, including the process of energy release. Paracellular transport of magnesium is mandatory for magnesium homeostasis. In addition to ... ...

    Abstract Magnesium is the fourth most abundant cation in the body. It plays a critical role in many biological processes, including the process of energy release. Paracellular transport of magnesium is mandatory for magnesium homeostasis. In addition to intestinal absorption that occurs in part across the paracellular pathway, magnesium is reabsorbed by the kidney tubule. The bulk of magnesium is reabsorbed through the paracellular pathway in the proximal tubule and the thick ascending limb of the loop of Henle. The finding that rare genetic diseases due to pathogenic variants in genes encoding specific claudins (CLDNs), proteins located at the tight junction that determine the selectivity and the permeability of the paracellular pathway, led to an awareness of their importance in magnesium homeostasis. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is caused by a loss of function of CLDN16 or CLDN19. Pathogenic CLDN10 variants cause HELIX syndrome, which is associated with a severe renal loss of sodium chloride and hypermagnesemia. The present review summarizes the current knowledge of the mechanisms and factors involved in paracellular magnesium permeability. The review also highlights some of the unresolved questions that need to be addressed.
    Mesh-Begriff(e) Humans ; Magnesium/metabolism ; Nephrocalcinosis/genetics ; Nephrocalcinosis/metabolism ; Hypercalciuria/genetics ; Hypercalciuria/metabolism ; Homeostasis ; Membrane Proteins/metabolism ; Claudins/genetics ; Claudins/metabolism
    Chemische Substanzen Magnesium (I38ZP9992A) ; Membrane Proteins ; Claudins
    Sprache Englisch
    Erscheinungsdatum 2023-01-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.14953
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: The importance of kidney calcium handling in the homeostasis of extracellular fluid calcium.

    Prot-Bertoye, Caroline / Lievre, Loïc / Houillier, Pascal

    Pflugers Archiv : European journal of physiology

    2022  Band 474, Heft 8, Seite(n) 885–900

    Abstract: Extracellular fluid calcium concentration must be maintained within a narrow range in order to sustain many biological functions, encompassing muscle contraction, blood coagulation, and bone and tooth mineralization. Blood calcium value is critically ... ...

    Abstract Extracellular fluid calcium concentration must be maintained within a narrow range in order to sustain many biological functions, encompassing muscle contraction, blood coagulation, and bone and tooth mineralization. Blood calcium value is critically dependent on the ability of the renal tubule to reabsorb the adequate amount of filtered calcium. Tubular calcium reabsorption is carried out by various and complex mechanisms in 3 distinct segments: the proximal tubule, the cortical thick ascending limb of the loop of Henle, and the late distal convoluted/connecting tubule. In addition, calcium reabsorption is tightly controlled by many endocrine, paracrine, and autocrine factors, as well as by non-hormonal factors, in order to adapt the tubular handling of calcium to the metabolic requirements. The present review summarizes the current knowledge of the mechanisms and factors involved in calcium handling by the kidney and, ultimately, in extracellular calcium homeostasis. The review also highlights some of our gaps in understanding that need to be addressed in the future.
    Mesh-Begriff(e) Calcium/metabolism ; Extracellular Fluid/metabolism ; Homeostasis ; Kidney/metabolism ; Kidney Tubules, Distal/metabolism ; Magnesium/metabolism
    Chemische Substanzen Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2022-07-16
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-022-02725-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: Urine-to-plasma creatinine ratio and fractional excretion of urea performance in acute-on-chronic kidney disease patients.

    Lievre, Loïc / Dupont, Vincent / Kanagaratnam, Lukshe / Faroux, Laurent / Debrumetz, Alexandre / Rieu, Philippe / Wynckel, Alain

    Journal of nephrology

    2023  Band 36, Heft 9, Seite(n) 2661–2663

    Mesh-Begriff(e) Humans ; Acute Kidney Injury ; Biomarkers ; Creatinine ; Kidney Function Tests ; Renal Insufficiency ; Renal Insufficiency, Chronic/diagnosis ; Urea ; Urinalysis
    Chemische Substanzen Biomarkers ; Creatinine (AYI8EX34EU) ; Urea (8W8T17847W)
    Sprache Englisch
    Erscheinungsdatum 2023-07-04
    Erscheinungsland Italy
    Dokumenttyp Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01700-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Claudin-10 Expression and the Gene Expression Pattern of Thick Ascending Limb Cells.

    Brideau, Gaelle / Cheval, Lydie / Griveau, Camille / Ling, Wung-Man Evelyne / Lievre, Loïc / Crambert, Gilles / Müller, Dominik / Broćić, Jovana / Cherchame, Emeline / Houillier, Pascal / Prot-Bertoye, Caroline

    International journal of molecular sciences

    2024  Band 25, Heft 7

    Abstract: Many genomic, anatomical and functional differences exist between the medullary (MTAL) and the cortical thick ascending limb of the loop of Henle (CTAL), including a higher expression of claudin-10 (CLDN10) in the MTAL than in the CTAL. Therefore, we ... ...

    Abstract Many genomic, anatomical and functional differences exist between the medullary (MTAL) and the cortical thick ascending limb of the loop of Henle (CTAL), including a higher expression of claudin-10 (CLDN10) in the MTAL than in the CTAL. Therefore, we assessed to what extent the
    Mesh-Begriff(e) Animals ; Mice ; Extremities ; Adrenal Medulla ; Claudins/genetics ; Mice, Knockout ; Gene Expression
    Chemische Substanzen claudin 10 ; Claudins
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25074008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: Differential localization patterns of claudin 10, 16, and 19 in human, mouse, and rat renal tubular epithelia.

    Prot-Bertoye, Caroline / Griveau, Camille / Skjødt, Karsten / Cheval, Lydie / Brideau, Gaëlle / Lievre, Loïc / Ferriere, Elsa / Arbaretaz, Floriane / Garbin, Kevin / Zamani, Reza / Marcussen, Niels / Figueres, Lucile / Breiderhoff, Tilman / Muller, Dominik / Bruneval, Patrick / Houillier, Pascal / Dimke, Henrik

    American journal of physiology. Renal physiology

    2021  Band 321, Heft 2, Seite(n) F207–F224

    Abstract: Functional properties of the paracellular pathway depend critically on the set of claudins (CLDN) expressed at the tight junction. Two syndromes are causally linked to loss-of-function mutations of claudins: hypohidrosis, electrolyte imbalance, lacrimal ... ...

    Abstract Functional properties of the paracellular pathway depend critically on the set of claudins (CLDN) expressed at the tight junction. Two syndromes are causally linked to loss-of-function mutations of claudins: hypohidrosis, electrolyte imbalance, lacrimal gland dysfunction, ichthyosis, and xerostomia (HELIX) syndrome caused by genetic variations in the
    Mesh-Begriff(e) Animals ; Claudins/metabolism ; Epithelium/metabolism ; Humans ; Immunohistochemistry ; Kidney Tubules/metabolism ; Mice ; Rats ; Tight Junctions/metabolism
    Chemische Substanzen CLDN19 protein, human ; Claudins ; claudin 10 ; claudin 16
    Sprache Englisch
    Erscheinungsdatum 2021-06-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00579.2020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang