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  1. Article ; Online: In Vivo

    Shen, Yingli / Lifante, José / Fernández, Nuria / Jaque, Daniel / Ximendes, Erving

    ACS nano

    2020  Volume 14, Issue 4, Page(s) 4122–4133

    Abstract: Luminescence nanothermometry has emerged over the past decade as an exciting field of research due to its potential applications where conventional methods have demonstrated to be ineffective. Preclinical research has been one of the areas that have ... ...

    Abstract Luminescence nanothermometry has emerged over the past decade as an exciting field of research due to its potential applications where conventional methods have demonstrated to be ineffective. Preclinical research has been one of the areas that have benefited the most from the innovations proposed in the field. Nevertheless, certain questions concerning the reliability of the technique under
    MeSH term(s) Luminescence ; Reproducibility of Results ; Temperature
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.9b08824
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  2. Article ; Online: Medullary thyroid cancer outcomes in patients with undetectable versus normalized postoperative calcitonin levels.

    Fanget, F / Demarchi, M S / Maillard, L / Lintis, A / Decaussin, M / Lifante, J C

    The British journal of surgery

    2021  Volume 108, Issue 9, Page(s) 1064–1071

    Abstract: Background: Calcitonin (Ct) is a sensitive diagnostic biomarker and one of the most important prognostic factors in medullary thyroid cancer (MTC). This study aimed to evaluate progression-free survival and recurrence rates of MTC associated with ... ...

    Abstract Background: Calcitonin (Ct) is a sensitive diagnostic biomarker and one of the most important prognostic factors in medullary thyroid cancer (MTC). This study aimed to evaluate progression-free survival and recurrence rates of MTC associated with undetectable compared with normalized serum Ct levels after surgery.
    Methods: This retrospective observational study included patients operated for MTC at the Digestive and Endocrine Surgery Department of Lyon Sud Hospital Centre between 2000 and 2019. Clinical and pathological factors were correlated with postoperative Ct concentrations. Undetectable and normalized Ct concentrations were defined as below 2 pg/ml and 2-10 pg/ml respectively.
    Results: Overall, 176 patients were treated for MTC, and 127 were considered biochemically cured after surgery. Of these, 24 and 103 had normalized and undetectable Ct concentrations respectively. Patients with Ct level normalization had a 25 per cent risk of disease recurrence, compared with 3 per cent in patients with undetectable Ct levels after surgery. The presence of metastasis in two or more compartments was predictive of failure to achieve undetectable Ct concentrations after surgery and an increased risk of recurrence.
    Conclusion: Among patients with biochemically cured MTC, those with undetectable or normalized Ct concentrations after surgery had different risks of recurrence. Simply assessing postoperative Ct normalization can be falsely reassuring, and long-term follow-up is needed.
    Lay summary: Calcitonin (Ct) is a sensitive diagnostic biomarker and one of the most important prognostic factors for medullary thyroid cancer outcomes; however, the significance of postoperative Ct levels remains controversial. This study evaluated the differences between normal and undetectable postoperative Ct levels in patients who had undergone surgical treatment for medullary thyroid cancer. Patients who experienced postoperative Ct level normalization had a higher risk of disease recurrence than those with undetectable Ct levels after surgery.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/blood ; Calcitonin/blood ; Carcinoma, Neuroendocrine/blood ; Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Postoperative Period ; Retrospective Studies ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery ; Thyroidectomy/methods ; Time Factors
    Chemical Substances Biomarkers, Tumor ; Calcitonin (9007-12-9)
    Language English
    Publishing date 2021-05-19
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab106
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  3. Article ; Online: Corrigendum: The near-infrared autofluorescence fingerprint of the brain.

    Lifante, José / Del Rosal, Blanca / Chaves-Coira, Irene / Fernández, Nuria / Jaque, Daniel / Ximendes, Erving

    Journal of biophotonics

    2021  Volume 14, Issue 9, Page(s) e202100170

    Abstract: In the article by J. Lifante et al (doi: 10.1002/jbio.202000154), published in J. Biophotonics 2020;13:e202000154, a spectral feature corresponding to tissue reflectance was mistakenly attributed to autofluorescence. This corrigendum is published to ... ...

    Abstract In the article by J. Lifante et al (doi: 10.1002/jbio.202000154), published in J. Biophotonics 2020;13:e202000154, a spectral feature corresponding to tissue reflectance was mistakenly attributed to autofluorescence. This corrigendum is published to correct the interpretation of the spectral data and images in the manuscript.
    Language English
    Publishing date 2021-08-03
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202100170
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  4. Article ; Online: Laparoscopic resection of a benign cystic pedicled pancreatic lesion in right lateral position (with video).

    Fanget, F / Thievenaz, R / Lifante, J C

    Journal of visceral surgery

    2018  Volume 155, Issue 4, Page(s) 333–334

    MeSH term(s) Adult ; Cystadenoma/surgery ; Female ; Humans ; Laparoscopy/methods ; Pancreatectomy/methods ; Pancreatic Neoplasms/surgery ; Patient Positioning/methods
    Language English
    Publishing date 2018-07-04
    Publishing country France
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2018.06.004
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  5. Article ; Online: In vivo grading of lipids in fatty liver by near-infrared autofluorescence and reflectance.

    Lifante, José / de la Fuente-Fernández, María / Román-Carmena, Marta / Fernandez, Nuria / Jaque García, Daniel / Granado, Miriam / Ximendes, Erving

    Journal of biophotonics

    2022  Volume 16, Issue 4, Page(s) e202200208

    Abstract: The prevalence of nonalcoholic fatty liver (NAFLD) is rapidly increasing worldwide. When untreated, it may lead to complications such as liver cirrhosis or hepatocarcinoma. The diagnosis of NAFLD is usually obtained by ultrasonography, a technique that ... ...

    Abstract The prevalence of nonalcoholic fatty liver (NAFLD) is rapidly increasing worldwide. When untreated, it may lead to complications such as liver cirrhosis or hepatocarcinoma. The diagnosis of NAFLD is usually obtained by ultrasonography, a technique that can underestimate its prevalence. For this reason, physicians aspire for an accurate, cost-effective, and noninvasive method to determine both the presence and the specific stage of the NAFLD. In this paper, we report an integrated approach for the quantitative estimation of the density of triglycerides in the liver based on the use of autofluorescence and reflectance signals generated by the abdomen of obese C57BL6/J mice. Singular value decomposition is applied to the generated spectra and its corresponding regression model provided a determination coefficient of 0.99 and a root mean square error of 240 mg/dl. This, in turn, enabled the quantitative imaging of triglycerides density in the livers of mice under in vivo conditions.
    MeSH term(s) Animals ; Mice ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Liver/diagnostic imaging ; Liver/pathology ; Liver Neoplasms ; Lipids ; Triglycerides
    Chemical Substances Lipids ; Triglycerides
    Language English
    Publishing date 2022-12-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202200208
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  6. Article ; Online: The near-infrared autofluorescence fingerprint of the brain.

    Lifante, José / Del Rosal, Blanca / Chaves-Coira, Irene / Fernández, Nuria / Jaque, Daniel / Ximendes, Erving

    Journal of biophotonics

    2020  Volume 13, Issue 11, Page(s) e202000154

    Abstract: The brain is a vital organ involved in most of the central nervous system disorders. Their diagnosis and treatment require fast, cost-effective, high-resolution and high-sensitivity imaging. The combination of a new generation of luminescent ... ...

    Abstract The brain is a vital organ involved in most of the central nervous system disorders. Their diagnosis and treatment require fast, cost-effective, high-resolution and high-sensitivity imaging. The combination of a new generation of luminescent nanoparticles and imaging systems working in the second biological window (near-infrared II [NIR-II]) is emerging as a reliable alternative. For NIR-II imaging to become a robust technique at the preclinical level, full knowledge of the NIR-II brain autofluorescence, responsible for the loss of image resolution and contrast, is required. This work demonstrates that the brain shows a peculiar infrared autofluorescence spectrum that can be correlated with specific molecular components. The existence of particular structures within the brain with well-defined NIR autofluorescence fingerprints is also evidenced, opening the door to in vivo anatomical imaging. Finally, we propose a rational selection of NIR luminescent probes suitable for low-noise brain imaging based on their spectral overlap with brain autofluorescence.
    MeSH term(s) Brain/diagnostic imaging ; Nanoparticles
    Language English
    Publishing date 2020-08-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202000154
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  7. Article ; Online: 3D Optical Coherence Thermometry Using Polymeric Nanogels.

    Muñoz-Ortiz, Tamara / Alayeto, Idoia / Lifante, José / Ortgies, Dirk H / Marin, Riccardo / Martín Rodríguez, Emma / Iglesias de la Cruz, María Del Carmen / Lifante-Pedrola, Ginés / Rubio-Retama, Jorge / Jaque, Daniel

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 33, Page(s) e2301819

    Abstract: In nanothermometry, the use of nanoparticles as thermal probes enables remote and minimally invasive sensing. In the biomedical context, nanothermometry has emerged as a powerful tool where traditional approaches, like infrared thermal sensing and ... ...

    Abstract In nanothermometry, the use of nanoparticles as thermal probes enables remote and minimally invasive sensing. In the biomedical context, nanothermometry has emerged as a powerful tool where traditional approaches, like infrared thermal sensing and contact thermometers, fall short. Despite the strides of this technology in preclinical settings, nanothermometry is not mature enough to be translated to the bedside. This is due to two major hurdles: the inability to perform 3D thermal imaging and the requirement for tools that are readily available in the clinics. This work simultaneously overcomes both limitations by proposing the technology of optical coherence thermometry (OCTh). This is achieved by combining thermoresponsive polymeric nanogels and optical coherence tomography (OCT)-a 3D imaging technology routinely used in clinical practice. The volume phase transition of the thermoresponsive nanogels causes marked changes in their refractive index, making them temperature-sensitive OCT contrast agents. The ability of OCTh to provide 3D thermal images is demonstrated in tissue phantoms subjected to photothermal processes, and its reliability is corroborated by comparing experimental results with numerical simulations. The results included in this work set credible foundations for the implementation of nanothermometry in the form of OCTh in clinical practice.
    MeSH term(s) Nanogels ; Reproducibility of Results ; Thermometry ; Thermometers ; Nanoparticles ; Polymers ; Tomography, Optical Coherence/methods
    Chemical Substances Nanogels ; Polymers
    Language English
    Publishing date 2023-07-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202301819
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  8. Article ; Online: Early in vivo detection of denervation-induced atrophy by luminescence transient nanothermometry.

    Lifante, José / Moreno-Rupérez, Álvaro / Ximendes, Erving / Marin, Riccardo / Priego, Teresa / López-Calderón, Asunción / Martín, Ana Isabel / Nieto-Bona, María Paz / Nebot, Elena / Lifante-Pedrola, Ginés / Jaque, Daniel / Monge, Luis / Fernández, Nuria / Granado, Miriam

    Journal of biophotonics

    2023  Volume 17, Issue 2, Page(s) e202300249

    Abstract: Denervation induces skeletal muscle atrophy due to the loss of control and feedback with the nervous system. Unfortunately, muscle atrophy only becomes evident days after the denervation event when it could be irreversible. Alternative diagnosis tools ... ...

    Abstract Denervation induces skeletal muscle atrophy due to the loss of control and feedback with the nervous system. Unfortunately, muscle atrophy only becomes evident days after the denervation event when it could be irreversible. Alternative diagnosis tools for early detection of denervation-induced muscle atrophy are, thus, required. In this work, we demonstrate how the combination of transient thermometry, a technique already used for early diagnosis of tumors, and infrared-emitting nanothermometers makes possible the in vivo detection of the onset of muscle atrophy at short (<1 day) times after a denervation event. The physiological reasons behind these experimental results have been explored by performing three dimensional numerical simulations based on the Pennes' bioheat equation. It is concluded that the alterations in muscle thermal dynamics at the onset of muscle atrophy are consequence of the skin perfusion increment caused by the alteration of peripheral nervous autonomous system. This work demonstrates the potential of infrared luminescence thermometry for early detection of diseases of the nervous system opening the venue toward the development of new diagnosis tools.
    MeSH term(s) Humans ; Luminescence ; Muscular Atrophy/etiology ; Muscular Atrophy/pathology ; Thermometry/methods ; Denervation/adverse effects ; Early Diagnosis
    Language English
    Publishing date 2023-12-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202300249
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  9. Article ; Online: Optomagnetic nanofluids for controlled brain hyperthermia: a critical study.

    Mendez-Gonzalez, Diego / Lifante, José / Zabala Gutierrez, Irene / Marin, Riccardo / Ximendes, Erving / Sanz-de Diego, Elena / Iglesias-de la Cruz, M Carmen / Teran, Francisco J / Rubio-Retama, Jorge / Jaque, Daniel

    Nanoscale

    2022  Volume 14, Issue 43, Page(s) 16208–16219

    Abstract: Optomagnetic nanofluids (OMNFs) are colloidal dispersions of nanoparticles (NPs) with combined magnetic and optical properties. They are especially appealing in biomedicine since they can be used as minimally invasive platforms for controlled ... ...

    Abstract Optomagnetic nanofluids (OMNFs) are colloidal dispersions of nanoparticles (NPs) with combined magnetic and optical properties. They are especially appealing in biomedicine since they can be used as minimally invasive platforms for controlled hyperthermia treatment of otherwise difficultly accessible tumors such as intracranial ones. On the one hand, magnetic NPs act as heating mediators when subjected to alternating magnetic fields or light irradiation. On the other hand, suitably tailored luminescent NPs can provide a precise and remote thermal readout in real time. The combination of heating and thermometric properties allows, in principle, to precisely monitor the increase in the temperature of brain tumors up to the therapeutic level, without causing undesired collateral damage. In this work we demonstrate that this view is an oversimplification since it ignores the presence of relevant interactions between magnetic (γ-Fe
    MeSH term(s) Animals ; Mice ; Cell Line, Tumor ; Hyperthermia, Induced ; Magnetic Fields ; Brain ; Brain Neoplasms/therapy
    Language English
    Publishing date 2022-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr03413a
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  10. Article ; Online: Reliable and Remote Monitoring of Absolute Temperature during Liver Inflammation via Luminescence-Lifetime-Based Nanothermometry.

    Shen, Yingli / Lifante, José / Zabala-Gutierrez, Irene / de la Fuente-Fernández, María / Granado, Miriam / Fernández, Nuria / Rubio-Retama, Jorge / Jaque, Daniel / Marin, Riccardo / Ximendes, Erving / Benayas, Antonio

    Advanced materials (Deerfield Beach, Fla.)

    2022  Volume 34, Issue 7, Page(s) e2107764

    Abstract: Temperature of tissues and organs is one of the first parameters affected by physiological and pathological processes, such as metabolic activity, acute trauma, or infection-induced inflammation. Therefore, the onset and development of these processes ... ...

    Abstract Temperature of tissues and organs is one of the first parameters affected by physiological and pathological processes, such as metabolic activity, acute trauma, or infection-induced inflammation. Therefore, the onset and development of these processes can be detected by monitoring deviations from basal temperature. To accomplish this, minimally invasive, reliable, and accurate measurement of the absolute temperature of internal organs is required. Luminescence nanothermometry is the ideal technology for meeting these requirements. Although this technique has lately undergone remarkable developments, its reliability is being questioned due to spectral distortions caused by biological tissues. In this work, how the use of bright Ag
    MeSH term(s) Animals ; Inflammation/diagnosis ; Liver ; Luminescence ; Mice ; Reproducibility of Results ; Temperature
    Language English
    Publishing date 2022-01-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202107764
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