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Article ; Online: IgG4-related autoimmune hepatitis

Yunpeng Li / Lifeng Wang

Journal of International Medical Research, Vol

A case report

2023 Volume 51

Abstract: IgG-4-related autoimmune hepatitis (IgG4-AIH) is a rare disease. We report here a case of IgG4-AIH in an elderly male patient who was admitted to hospital because of unexplained hepatic insufficiency. After excluding viral hepatitis, alcoholic liver ... ...

Abstract	IgG-4-related autoimmune hepatitis (IgG4-AIH) is a rare disease. We report here a case of IgG4-AIH in an elderly male patient who was admitted to hospital because of unexplained hepatic insufficiency. After excluding viral hepatitis, alcoholic liver disease, drug-induced liver disease, parasitic infection, hepatolenticular degeneration and other diseases, and observing elevated levels of IgG-4, humoral immunity index, abnormal liver disease antibody spectrum and liver biopsy results, we made a diagnosis of IgG4-AIH. Following treatment with prednisone and ursodeoxycholic acid, the patient's liver function improved significantly and the patient was discharged from hospital.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Update on Nonhuman Primate Models of Brain Disease and Related Research Tools

Nan Qiao / Lizhen Ma / Yi Zhang / Lifeng Wang

Biomedicines, Vol 11, Iss 2516, p

2023 Volume 2516

Abstract: The aging of the population is an increasingly serious issue, and many age-related illnesses are on the rise. These illnesses pose a serious threat to the health and safety of elderly individuals and create a serious economic and social burden. Despite ... ...

Abstract	The aging of the population is an increasingly serious issue, and many age-related illnesses are on the rise. These illnesses pose a serious threat to the health and safety of elderly individuals and create a serious economic and social burden. Despite substantial research into the pathogenesis of these diseases, their etiology and pathogenesis remain unclear. In recent decades, rodent models have been used in attempts to elucidate these disorders, but such models fail to simulate the full range of symptoms. Nonhuman primates (NHPs) are the most ideal neuroscientific models for studying the human brain and are more functionally similar to humans because of their high genetic similarities and phenotypic characteristics in comparison with humans. Here, we review the literature examining typical NHP brain disease models, focusing on NHP models of common diseases such as dementia, Parkinson’s disease, and epilepsy. We also explore the application of electroencephalography (EEG), magnetic resonance imaging (MRI), and optogenetic study methods on NHPs and neural circuits associated with cognitive impairment.
Keywords	NHPs ; brain disease models ; EEG ; MRI ; optogenetics ; neural circuits ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An ultrawide-zero-frequency bandgap metamaterial with negative moment of inertia and stiffness

Leiyu Yang / Lifeng Wang

New Journal of Physics, Vol 23, Iss 4, p

2021 Volume 043003

Abstract: Metamaterials have demonstrated great potential for controlling wave propagation since they are flexibly adjustable. A new one-dimensional metamaterial model with both a negative effective moment of inertia and negative effective stiffness is proposed. A ...

Abstract	Metamaterials have demonstrated great potential for controlling wave propagation since they are flexibly adjustable. A new one-dimensional metamaterial model with both a negative effective moment of inertia and negative effective stiffness is proposed. A negative effective moment of inertia and negative effective stiffness can be achieved by adjusting the structural parameters in certain frequency ranges. Bandgaps in the low-frequency range with exponential wave attenuation can be generated in the metamaterial. A flat band is obtained that couples two Bragg bandgaps to achieve a wide bandgap in the low-frequency range, where the effective moment of inertia and effective stiffness are both infinite. A zero-frequency bandgap can be achieved by adjusting the structural parameters. Quick attenuation of wave is observed in the zero-frequency ranges with single-negative parameters. Furthermore, an ultrawide-zero-frequency bandgap is obtained by optimizing the structural parameters of the system. In addition, it is easy to switch between the Bragg and locally resonant bandgaps. This new metamaterial can be applied to ultralow-frequency-vibration isolation.
Keywords	metamaterials ; negative effective moment of inertia ; negative effective stiffness ; coupled bandgap ; ultrawide-zero-frequency bandgap ; Science ; Q ; Physics ; QC1-999
Subject code	535
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sinus metastasis of lung adenocarcinoma

Mingyuan Xu / Qi Sun / Xin Lv / Fangjun Chen / Shu Su / Lifeng Wang

Frontiers in Medicine, Vol

a case report

2024 Volume 10

Abstract: Metastatic carcinoma of the paranasal sinuses in lung cancer is an extremely uncommon condition. We report here a 57-year-old female patient with epidermal growth factor receptor (EGFR)-positive stage IV non-small cell lung cancer (NSCLC) with multiple ... ...

Abstract	Metastatic carcinoma of the paranasal sinuses in lung cancer is an extremely uncommon condition. We report here a 57-year-old female patient with epidermal growth factor receptor (EGFR)-positive stage IV non-small cell lung cancer (NSCLC) with multiple bone metastases. After resistance to second- and third-generation EGFR-tyrosine kinase inhibitors (TKIs), the patient presented with headache accompanied by progressively enlarging lesions of the nasal cavity on CT scan. Further endoscopic sinus neoplasmectomy confirmed sinus metastasis of lung adenocarcinoma. Although subsequent chemotherapy and immunotherapy were both administered, the disease continued to progress, and the patient passed away 21 months after diagnosis. Combined with real-time dynamic next-generation sequencing (NGS) during the different generations of EGFR-TKI treatments and dynamic tumour microenvironment analysis, we discussed the clinical manifestations of sinus metastasis and the molecular biology and tumour immune microenvironment changes after resistance to the second-and third- generation of EGFR-TKI therapy.
Keywords	lung adenocarcinoma ; sinus metastasis ; next-generation sequencing ; EGFR-TKI ; immune microenvironment ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of the Van der Waals Force on the Vibration of Typical Multi-layered Two-dimensional Nanostructures

Yiqing Zhang / Lifeng Wang

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 8

Abstract: Abstract Recently, two-dimensional nanostructures have caught much attention because of their magnificent physical characteristics. The vibrational behavior of typical multi-layered two-dimensional nanostructures (TMLTNs) is extraordinary significant to ... ...

Abstract	Abstract Recently, two-dimensional nanostructures have caught much attention because of their magnificent physical characteristics. The vibrational behavior of typical multi-layered two-dimensional nanostructures (TMLTNs) is extraordinary significant to TMLTN-based nanoresonantors. In this investigation, the vibrational behavior of TMLTNs, taking black phosphorus (BP), graphene and BN as examples, is studied adopting molecular dynamics (MD) simulations and the sandwich plate model (SPM). The MD results show that the fundamental resonant frequency of multi-layered BP (MLBP) and multi-layered BN (MLBN) increase obviously with the number of layers. However, the fundamental resonant frequency of a multi-layered graphene sheet (MLGS) rise slightly when the number of layers increases. This phenomenon is caused by the shear modulus in the xz-plane and yz-plane resulted by the vdW force. Hence, an SPM considering the shear modulus in the xz-plane and yz-plane caused by the vdW force is used to investigate the vibration of the TMLTN. Compared with the MD results, it is shown that the SPM can better predict the vibration of the TMLTN.
Keywords	Medicine ; R ; Science ; Q
Subject code	621
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Iron and sulfur reduction caused by different growth seasons inhibits cadmium transfer in the soil-rice system.

Feng, Zhang / Rui, Peng / Lifeng, Wang / Huidan, Jiang

Ecotoxicology and environmental safety

2022 Volume 236, Page(s) 113479

Abstract: Effects of iron and sulfur redox states in the soil caused by different growth seasons on Cd uptake by rice remain unclear. In this study, three early rice cultivars and three late rice cultivars were cultivated in a double-cropping system in Cd- ... ...

Abstract	Effects of iron and sulfur redox states in the soil caused by different growth seasons on Cd uptake by rice remain unclear. In this study, three early rice cultivars and three late rice cultivars were cultivated in a double-cropping system in Cd-contaminated paddy fields. The total Cd accumulation of early rice cultivars was 20.5-51.1 µg plant
MeSH term(s)	Cadmium/metabolism ; Iron/chemistry ; Oryza/metabolism ; Seasons ; Soil/chemistry ; Soil Pollutants/analysis ; Sulfides/metabolism ; Sulfur/metabolism
Chemical Substances	Soil ; Soil Pollutants ; Sulfides ; Cadmium (00BH33GNGH) ; Sulfur (70FD1KFU70) ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113479
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Functionalized MoO3 Nanosheets for High‐Efficiency RhB Removal

Yuxi Ma / Lifeng Wang / Dan Liu / Yuchen Liu / Guoliang Yang / Yijun Qian / Weiwei Lei

Global Challenges, Vol 7, Iss 3, Pp n/a-n/a (2023)

2023

Abstract: Abstract 2D nanostructured materials have been applied for water purification in the past decades due to their excellent separation and adsorption performance. However, the functional 2D nanostructured molybdenum trioxide (MoO3)has rarely been reported ... ...

Abstract	Abstract 2D nanostructured materials have been applied for water purification in the past decades due to their excellent separation and adsorption performance. However, the functional 2D nanostructured molybdenum trioxide (MoO3)has rarely been reported for the removal of dyes. Here, functionalized MoO3 (F‐MoO3) nanosheets are successfully fabricated with a high specific surface area (106 cc g−1) by a one‐step mechanochemical exfoliation method as a highly effective adsorbent for removing dyes from water. According to the Raman, X‐ray photoelectron spectroscopy, Fourier transform infrared (FTIR), and selected area electron diffraction analysis, functional groups (hdroxyl groups, amide groups, amine groups and amino groups) are identified in the as‐prepared F‐MoO3 nanosheets. The attached functional groups not only facilitate the dispersal ability of F‐MoO3 nanosheets but also enhance the adsorption capacities. Thus, the performance (up to 556 mg g−1 when the initial concentration of Rhodamine B solution is 100 mg L−1) of as‐prepared F‐MoO3 nanosheets is almost two times higher than other reported MoO3 materials. Furthermore, the FTIR spectra, isotherm, and several factors (e.g., adsorbent dosage and adsorbate dosage) are also systematically investigated to explore the adsorption mechanism. Therefore, this work demonstrates that the F‐MoO3 nanosheets are a promising candidate for wastewater treatment.
Keywords	adsorption ; ball milling ; F‐MoO 3 nanosheets ; water purification ; Technology ; T ; Environmental sciences ; GE1-350
Subject code	540
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Salinity-Stress on Seed Germination and Growth Physiology of Quinclorac-Resistant Echinochloa crus-galli (L.) Beauv

Lamei Wu / Haona Yang / Zuren Li / Lifeng Wang / Qiong Peng

Agronomy, Vol 12, Iss 1193, p

2022 Volume 1193

Abstract: With the expansion of saline-alkaline tolerant rice in China, the effects of salinity stress (NaCl) on quinclorac-resistant Echinochloa crus -galli (L.) Beauv ( E. crus-galli ) is unclear. In this study, the growth chamber experiment was conducted to ... ...

Abstract	With the expansion of saline-alkaline tolerant rice in China, the effects of salinity stress (NaCl) on quinclorac-resistant Echinochloa crus -galli (L.) Beauv ( E. crus-galli ) is unclear. In this study, the growth chamber experiment was conducted to test the germination and growth physiology of seven populations of E. crus-galli with quinclorac-different resistance levels which were collected from Hunan province. The results showed that a significant decrease of the germination rate and fresh weight of the plants, as well as the length of the roots and young shoots appeared, along with the increased resistance while treated with NaCl. However, no significant differences were detected between quinclorac-resistant and -susceptible E. crus-galli populations while without NaCl treatment. A further study with spectrophotometer showed that the salinity treatment resulted in the increase of the GST activity in all E. crus-galli populations, which are more obvious in those resistant biotypes, and transcriptomics revealed that salt stress reduces the adaptability of quinclorac-resistant E. crus-galli by reducing the biosynthesis, activities of antioxidant enzymes and metabolic enzyme. This study demonstrated that salinity stress (NaCl) may reduce the adaptability of quinclorac-resistant E. crus-galli .
Keywords	quinclorac-resistant E. crus-galli ; seed germination ; seedling growth ; GST activity ; salinity stress ; Agriculture ; S
Subject code	580 ; 630
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Development of a Polysaccharide-Based Hydrogel Encapsulating Tobramycin-Loaded Gelatine Microspheres as an Antibacterial System

Mingsheng Shi / Yongmeng Xu / Shuai Li / Lifeng Wang / Junyao Gu / Yi-Xuan Zhang

Gels, Vol 9, Iss 219, p

2023 Volume 219

Abstract: Bacterial infection contributes to the bioburden of wounds, which is an essential factor in determining whether a wound can heal. Wound dressings with antibacterial properties that can promote wound-healing are highly desired for the treatment of chronic ...

Abstract	Bacterial infection contributes to the bioburden of wounds, which is an essential factor in determining whether a wound can heal. Wound dressings with antibacterial properties that can promote wound-healing are highly desired for the treatment of chronic wound infections. Herein, we fabricated a simple polysaccharide-based hydrogel dressing encapsulating tobramycin-loaded gelatine microspheres with good antibacterial activity and biocompatibility. We first synthesised long-chain quaternary ammonium salts (QAS) by the reaction of tertiary amines with epichlorohydrin. The amino groups of carboxymethyl chitosan were then conjugated with QAS through the ring-opening reaction and QAS-modified chitosan (CMCS) was obtained. The antibacterial analysis showed that both QAS and CMCS could kill E. coli and S. aureus at relatively low concentrations. QAS with 16 carbon atoms has a MIC of 16 μg/mL for E. coli and 2 μg/mL for S. aureus . A series of formulations of tobramycin-loaded gelatine microspheres (TOB-G) were generated and the best formulation was selected by comparing the characters of the microspheres. The microsphere fabricated by 0.1 mL GTA was selected as the optimal candidate. We then used CMCS, TOB-G, and sodium alginate (SA) to prepare physically crosslinking hydrogels using CaCl 2 and investigated the mechanical properties, antibacterial activity, and biocompatibility of the hydrogels. In summary, the hydrogel dressing we produced can be used as an ideal alternative for the management of bacteria-infected wounds.
Keywords	wound infection ; quaternary ammonium salts ; chitosan ; alginate ; tobramycin ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
Subject code	540
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of the association between prenatal exposure to multiple ambient pollutants and preterm birth

Lifeng Wang / Lei Fang / Zhenya Fang / Meihua Zhang / Lin Zhang

Ecotoxicology and Environmental Safety, Vol 232, Iss , Pp 113297- (2022)

A prospective cohort study in Jinan, east China

2022

Abstract: Air pollution has been documented with a series of adverse pregnancy outcomes, yet their reproductive and developmental toxicity on human beings has not been fully elucidated. Here, we analyzed the geographic distribution of Jinan and examined its ... ...

Abstract	Air pollution has been documented with a series of adverse pregnancy outcomes, yet their reproductive and developmental toxicity on human beings has not been fully elucidated. Here, we analyzed the geographic distribution of Jinan and examined its contribution to air pollution. After adjusting demographic variables and environmental co-pollutants, we built statistical models based on 424 couples and checked different air pollutants on their pregnancy outcomes. We find that Jinan is tightly surrounded by mountains from 3 of 4 sides, geographically resulting in a typical basin texture that hinders the diffusion of ambient pollutants. Of 424 pregnant women enrolled in this study, 17 subjects were diagnosed with preterm birth. Using air quality index (AQI) as an integrated indicator of PM10, PM2.5, SO2, NO2, CO, and O3, we found that each interquartile range (IQR) increase in AQI was associated with 11% increased odds of preterm birth. Also, elevating PM2.5, PM10, SO2, and O3 led to different increased risk levels of preterm birth. By running the generalized additive model analyses, the association of AQI and preterm birth was further confirmed. In conclusion, based on samples in Jinan, east China, prenatal exposure to multiple ambient pollutants is associated with reduced gestational age and increased risk of preterm birth.
Keywords	Air pollution ; Preterm birth ; Gestational age ; Air quality index ; Adverse pregnancy outcome ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	610 ; 333
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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