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  1. Book: Postoperative complications

    Lightner, Amy L.

    (Surgical clinics of North America ; volume 101, number 5 (October 2021))

    2021  

    Author's details editors Amy L. Lightner, Phillip R. Fleshner
    Series title Surgical clinics of North America ; volume 101, number 5 (October 2021)
    Collection
    Language English
    Size xviii Seiten, Seite 718-938, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT021200196
    ISBN 978-0-323-81361-7 ; 0-323-81361-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uk I Zs 75 -101,5- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Reply.

    Lightner, Amy L

    Diseases of the colon and rectum

    2023  Volume 67, Issue 3, Page(s) e203

    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000003177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Letter to editor: Comments on rectovagnial fistula.

    Lightner, Amy L

    Surgery

    2023  Volume 175, Issue 5, Page(s) 1464

    MeSH term(s) Humans ; Fistula
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Letter
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Management of Fistulas in Patients With Crohn's Disease.

    Lightner, Amy L

    Gastroenterology & hepatology

    2022  Volume 17, Issue 11, Page(s) 533–535

    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 517: Show issues

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  5. Article ; Online: Expert Commentary on Postoperative Evaluation and Management of Portomesenteric Venous Thrombosis in Patients With Inflammatory Bowel Disease.

    Lightner, Amy L

    Diseases of the colon and rectum

    2021  Volume 65, Issue 1, Page(s) 14–15

    MeSH term(s) Colitis ; Humans ; Inflammatory Bowel Diseases/complications ; Mesenteric Veins ; Venous Thrombosis/diagnosis ; Venous Thrombosis/etiology
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.237: Show issues Location:
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  6. Article ; Online: Bowel Preparation in Inflammatory Bowel Disease-A Necessary Evil?

    Lightner, Amy L

    Crohn's & colitis 360

    2020  Volume 2, Issue 4, Page(s) otaa078

    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Editorial
    ISSN 2631-827X
    ISSN (online) 2631-827X
    DOI 10.1093/crocol/otaa078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Applying Endoscopic Interventions to Inflammatory Bowel Disease-Related Strictures.

    Lightner, Amy L

    Crohn's & colitis 360

    2020  Volume 2, Issue 4, Page(s) otaa066

    Language English
    Publishing date 2020-10-30
    Publishing country England
    Document type Editorial
    ISSN 2631-827X
    ISSN (online) 2631-827X
    DOI 10.1093/crocol/otaa066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Are We Able to Accurately Assess Post IPAA Pathology?

    Lightner, Amy L

    Crohn's & colitis 360

    2020  Volume 2, Issue 3, Page(s) otaa038

    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Editorial ; Comment
    ISSN 2631-827X
    ISSN (online) 2631-827X
    DOI 10.1093/crocol/otaa038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Stem cell therapy for perianal Crohn's.

    Lightner, Amy L

    Current opinion in gastroenterology

    2020  Volume 35, Issue 4, Page(s) 311–320

    Abstract: Purpose of review: Perianal Crohn's disease is a morbid and disabling condition, notoriously difficult to successfully treat with conventional medical and surgical therapies. Mesenchymal stem cells (MSCs) are an emerging novel therapy for perianal Crohn' ...

    Abstract Purpose of review: Perianal Crohn's disease is a morbid and disabling condition, notoriously difficult to successfully treat with conventional medical and surgical therapies. Mesenchymal stem cells (MSCs) are an emerging novel therapy for perianal Crohn's disease.
    Recent findings: Over 300 patients with perianal Crohn's disease have now been treated with MSCs in the context of clinical trials. All trials have demonstrated safety, and efficacy superior to conventional therapy with biologics and surgical intervention. This was consistent despite the heterogeneity in study protocols including variability in cell dosing, mode of delivery, repeat dosing, and allogeneic versus autologous donors. Sustained healing to 1 year has also been demonstrated in a recent extension of the largest phase III study confirming superior efficacy of MSCs to placebo at 1-year follow-up. However, several outstanding questions regarding the use of MSCs for perianal Crohn's disease remain, which, if answered, could enhance MSCs' treatment efficacy. These include defining the optimal MSC donor, optimal MSC source (e.g., bone marrow versus adipose tissue), investigating a potential alloimmune response following allogeneic cellular delivery, and determining the optimal mode for MSC delivery. In addition to these unanswered questions, significant challenges in the required infrastructure and cost required for cell-based therapies may drive future research toward identifying novel acellular therapies.
    Summary: Novel regenerative therapies offer promising new treatment options for perianal Crohn's disease, without the risk of opportunistic infection seen with biologics and incontinence with surgical techniques. Future research will help define the optimal MSC product and treatment protocol, and may even expand our horizon of regenerative medicine into acellular therapy as well as cell-based therapies.
    MeSH term(s) Adipose Tissue ; Crohn Disease/therapy ; Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells ; Treatment Outcome
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2072: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Perianal Crohn's Disease.

    Lightner, Amy L

    Diseases of the colon and rectum

    2020  Volume 63, Issue 8, Page(s) 1023–1026

    Abstract: Case summary: A 22-year-old man presents to your office with a perianal abscess and occasional mild crampy abdominal pain. You take him to the operating room for an examination under anesthesia (EUA) with incision and drainage of the abscess and note a ... ...

    Abstract Case summary: A 22-year-old man presents to your office with a perianal abscess and occasional mild crampy abdominal pain. You take him to the operating room for an examination under anesthesia (EUA) with incision and drainage of the abscess and note a transphincteric fistula tract through which you place a seton and 2 large skin tags. The anal canal and rectum are without ulceration, but there are mild proctitis and nonprolapsing internal hemorrhoids. Because of a concern for Crohn's disease (CD), he undergoes magnetic resonance enterography and colonoscopy. The magnetic resonance enterography shows inflammation in 20 cm of the distal terminal ileum, and colonoscopy reveals approximately 10 ulcers <5 mm in the terminal ileum without significant narrowing. He is seen in consultation for the initiation of a monoclonal antibody and returns to see you in the office after his first 3 infusions. He is feeling well, has significantly decreased drainage from the perianal fistula, but would really like his seton and skin tags removed while you are there.
    MeSH term(s) Abscess/surgery ; Anal Canal/pathology ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/therapeutic use ; Colonoscopy/methods ; Crohn Disease/diagnostic imaging ; Crohn Disease/pathology ; Crohn Disease/therapy ; Drainage/methods ; Humans ; Ileum/pathology ; Infusions, Intravenous ; Magnetic Resonance Imaging/methods ; Male ; Rectal Fistula/diagnosis ; Rectal Fistula/surgery ; Treatment Outcome ; Ulcer/pathology ; Young Adult
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000001748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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