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Article ; Online: Application of a Nursing Data-Driven Model for Continuous Improvement of PICC Care Quality

Juzhen Zhou / Lihua Wang

Journal of Healthcare Engineering, Vol

2022 Volume 2022

Abstract: A PICC catheter maintenance network was established and managed to monitor the maintenance of catheters in placed patients throughout the process, providing homogeneous PICC catheter continuity of care for patients. Model-driven thinking is an idea for ... ...

Abstract	A PICC catheter maintenance network was established and managed to monitor the maintenance of catheters in placed patients throughout the process, providing homogeneous PICC catheter continuity of care for patients. Model-driven thinking is an idea for simulation system development. Model-driven architecture (MDA) is a design methodology that implements model-driven thinking and is widely used in simulation system development. Based on the requirements of nursing, the data-driven model is mainly divided into interface layer and functional service layer; this study adopts MDA technology which can detach the functions of the system from the platform, based on domain knowledge, and the metamodel adopts XSD-based data model to generate the PIM model, which is stored in the model library. The results showed that the number of nurses at maintenance sites increased from 79 to 232, the PICC placement rate for oncology patients increased from 35.0% to 76.0%, the nurse maintenance operation pass rate increased from 53.9% to 88.4%, and the maintenance default rate decreased from 40.0% to 10.9%.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Case of AML1-ETO Positive Acute Myeloid Leukemia Morphologically Similar to Chronic Myelogenous Leukemia.

Li, Ruimin / Wu, Yiping / Zhang, Xiaofang / LihuaWang / Huo, Shuang

Clinical laboratory

2023 Volume 69, Issue 5

Abstract: Background: The goal was to study the role of the morphology, immunophenotype, karyotype and fusion gene expression in a patient with diagnosis of AML1-ETO positive acute myeloid leukemia.: Methods: A case of AML1-ETO positive acute myeloid leukemia ... ...

Abstract	Background: The goal was to study the role of the morphology, immunophenotype, karyotype and fusion gene expression in a patient with diagnosis of AML1-ETO positive acute myeloid leukemia. Methods: A case of AML1-ETO positive acute myeloid leukemia morphologically similar to chronic myelogenous leukemia was reported. The results of the morphology, immunophenotype, karyotype and fusion gene expression were analyzed by reviewing relevant literature. Results: The patient was a young boy, at the age of 13, with clinical manifestations of intermittent fatigue and fever. Blood routine: White blood cell 142.6 x 109/L, Red blood cell 0.89 x 1012/L, Hemoglobin 41 g/L, Platelet 23 x 109/L, primitive cells account for 5%. Bone marrow smear: Granulocyte system hyperplasia is obvious, visible at each stage, primitive cells account for 17%, eosinophils, basophils, and phagocytic blood cells were observed. Flow cytometry showed myeloid primitive cell population was 4.14%, immature and mature granulocytes cell population was 85.22%, and eosinophil cell population was 0.61%. The results showed that the proportion of myeloid primitive cell was high, the expression of CD34 was enhanced, the expression of CD117 was partially absent, the expression of CD38 was weakened, the expression of CD19 was weak, and a few cells expressed CD56, and the phenotype was abnormal. The proportion of granulocyte series increased and the nucleus shifted to the left. The proportion of erythroid series was decreased, and the expression of CD71 was weakened. The results of fusion gene showed AML1-ETO positive. Karyotype analysis showed clonogenic abnormality t(8;21)(q22;q22). Conclusions: The peripheral blood and bone marrow images of patients with t(8;21)(q22;q22) AML1-ETO positive are the manifestations of chronic myelogenous leukemia, suggesting that cytogenetics and molecular genetics play an irreplaceable role in the diagnosis of acute myeloid leukemia, and the comprehensive diagnostic efficiency is significantly better than that of morphology.
MeSH term(s)	Humans ; RUNX1 Translocation Partner 1 Protein/genetics ; Core Binding Factor Alpha 2 Subunit/genetics ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Bone Marrow/metabolism ; Chronic Disease ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Oncogene Proteins, Fusion/genetics ; Chromosomes, Human, Pair 8/genetics ; Chromosomes, Human, Pair 8/metabolism
Chemical Substances	RUNX1 Translocation Partner 1 Protein ; Core Binding Factor Alpha 2 Subunit ; Oncogene Proteins, Fusion ; AML1-ETO fusion protein, human
Language	English
Publishing date	2023-05-05
Publishing country	Germany
Document type	Case Reports
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2022.220914
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Article ; Online: Awareness of Dysphagia-Related Complications and Risks and the Importance of Early Intervention in Patients with Parkinson’s Disease

Kaifeng Yao / Lihua Wang / Lihua Zhang

International Journal of Clinical Practice, Vol

A Qualitative Study

2023 Volume 2023

Abstract: Objective. To investigate the awareness of dysphagia-related complications and risks and the importance of early intervention in patients with Parkinson’s disease (PD). Methods. Using the phenomenological approach of the qualitative study, 18 patients ... ...

Abstract	Objective. To investigate the awareness of dysphagia-related complications and risks and the importance of early intervention in patients with Parkinson’s disease (PD). Methods. Using the phenomenological approach of the qualitative study, 18 patients with PD in a Grade A tertiary hospital in Nantong were selected, and semistructured personal in-depth interviews were conducted. The interview content was analyzed using Colaizzi’s seven-step method, and the topics and subtopics were further refined. Results. Awareness of dysphagia-related complications and risks and the importance of early intervention in patients with PD can be summarized into three topics: lack of knowledge about PD and dysphagia, changes in emotional cognition, and low need for early intervention for dysphagia. Conclusions. Patients with PD have a low awareness of dysphagia, do not follow any preventative measures, and have difficulty in recognizing the disease symptoms; hence, there is a vital need for early intervention. Medical staff need to create awareness among patients and their families, provide health education through multiple channels, popularize the knowledge of PD complications such as dysphagia, improve patient compliance with respect to medication, regular consultation, and medical treatment, guide the transformation of negative emotions in patients to positive emotions, and help patients with PD to actively prevent dysphagia and other complications and improve their quality of life.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Yupingfeng granules combined with glucocorticoid on eosinophil infiltration and inflammatory factors of lavage fluid in nasal secretion of patients with allergic rhinitis

Rong HU / Yu GUO / Lihua WANG

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, Vol 51, Iss

2023 Volume 4

Abstract: The purpose of this study was to investigate the effect of Yupingfeng granules, a well-known traditional Chinese medication, combined with glucocorticoids on eosinophil (EOS) number and inflammatory factors in nasal secretions of patients with allergic ... ...

Abstract	The purpose of this study was to investigate the effect of Yupingfeng granules, a well-known traditional Chinese medication, combined with glucocorticoids on eosinophil (EOS) number and inflammatory factors in nasal secretions of patients with allergic rhinitis (AR). 76 patients with AR were randomly divided into controls (nasal inhaled corticosteroids alone) and experimental group (combined with Yupingfeng granules orally). The efficacy, symptoms, number of EOS and levels of inflammatory factors in nasal secretions were compared between the two groups after 2 months of treatment. The results showed that in the experimental group (94.73%, 0.48 ± 0.25 points), the effective rate of treatment was obviously higher and the physical sign score was clearly lower compared with controls (81.57%, 0.97 ± 0.36 points); the EOS count in the experimental group was clearly less than that in the controls; the tumor necrosis factor-α (TNF-α) (0.76 ± 0.44 ng/mL), interleukin-6 (IL-6) (11.83 ± 3.72 pg/mL), and interleukin-8 (IL-8) (17.45 ± 6.53 pg/mL) levels were evidently lower in the experimental group than in the controls (1.48 ± 0.72 ng/mL, 14.62 ± 5.19 pg/mL, 22.86 ± 9.35 pg/mL) (P < 0.05). In summary, compared with nasal inhalation of glucocorticoids alone, combined with oral administration of Yupingfeng granules, it can more significantly improve the symptoms of nasal obstruction and rhinorrhea in AR patients, reduce nasal mucosal edema, reduce the number of EOS in nasal secretions, and reduce the level of inflammatory factors, which is of positive significance for the clinical treatment of AR patients.
Keywords	AR ; EOS ; Glucocorticoids ; inflammatory factors ; Yupingfeng granules ; Forestry ; SD1-669.5 ; Agriculture (General) ; S1-972
Subject code	610
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	AcademicPres
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An investigation of inversion method to measure the radial velocity of Kuroshio from Sentinel-1 SAR data

Benhua Tan / Lihua Wang / Dechen Ge / Zhen Fang / Weiwei Sun / Tian Feng

GIScience & Remote Sensing, Vol 61, Iss

2024 Volume 1

Abstract: ABSTRACTStudies on the retrieval of ocean surface current by Synthetic Aperture Radar (SAR) mainly concentrate on coastal regions with land coverage, allowing for continuous land to estimate non-geophysical Doppler shifts. As a strong western boundary in ...

Abstract	ABSTRACTStudies on the retrieval of ocean surface current by Synthetic Aperture Radar (SAR) mainly concentrate on coastal regions with land coverage, allowing for continuous land to estimate non-geophysical Doppler shifts. As a strong western boundary in the Western Pacific, the Kuroshio flows through mostly islands or open sea, and lacks land coverage for range bias correction. We propose a non-geophysical Doppler shift correction algorithm suitable for Kuroshio observation. Three solutions matching different land coverage were adopted in the range direction, and the scalloping was removed by using average filtering in the azimuth direction. Comparison between SAR radial velocity and Global Surface Lagrangian Drifter (GLD) reveals that the correlation coefficient (R2) increase to 0.686, and root mean square error (RMSE) of 0.215 m/s after non-geophysical corrections, while the wind-wave bias corrections make R2 increase to 0.806 and RMSE decrease to 0.13 m/s. There is also a good consistency between SAR inversion and Regional Ocean Circulation Model (ROMS). Sensitivity analysis illustrates that ascending pass is more suitable for monitoring Kuroshio, and high incidence angles are less affected by ocean conditions and non-geophysical factors. The algorithm can be used in regions with discontinuous or absent land.
Keywords	SAR ; Doppler shift ; non-geophysical ; ocean current ; Kuroshio ; Mathematical geography. Cartography ; GA1-1776 ; Environmental sciences ; GE1-350
Subject code	551
Language	English
Publishing date	2024-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cardiovascular and kidney outcomes of uric acid-lowering therapy in patients with different kidney functions

Lihua Wang / Yaqing Zhang / Xiaole Su / Ying Hua / Runxia Song

BMJ Open, Vol 13, Iss

study protocol for a systematic review, pairwise and network meta-analysis

2023 Volume 2

Abstract: Introduction Hyperuricaemia has been implicated in the development of kidney function in populations with chronic kidney disease; however, the benefits of urate-lowering therapy (ULT) remain uncertain in different clinical studies. The different kidney ... ...

Abstract	Introduction Hyperuricaemia has been implicated in the development of kidney function in populations with chronic kidney disease; however, the benefits of urate-lowering therapy (ULT) remain uncertain in different clinical studies. The different kidney functions of enrolled populations and distinct pharmacokinetic characteristics of ULT might be of the essence for the contrasting results. In this study, we will synthesise all available data from randomised controlled trials (RCTs) and cohort studies, then evaluate the outcomes of ULT in patients stratified by different estimated glomerular filtration rate (eGFR) stratifications. Furthermore, we will attempt to explore a relatively optimal ULT regimen using a Bayesian network meta-analysis in different eGFRs.Methods and analysis We searched published and unpublished data from MEDLINE, EMBASE, the Cochrane Central Register of Controlled trials and ClinicalTrials.gov website (before March 2022) for RCTs and cohort studies without language restriction. In the pairwise meta-analysis, all regimens of ULT will be pooled as a whole and compared with controls in different eGFRs. The random-effects model will be applied to generate the summary values using the software Stata V.12.0 (StataCorp). Network meta-analysis within a Bayesian framework will be conducted to explore the relative efficacy profiles of different ULTs and to find optimal ULT in different eGFRs. The software of WinBUGS V.1.4.3 and R2WinBUGS package of R V.3.1.1 will be used in the network meta-analysis. Primary outcomes will be the occurrence of major cardiovascular events and kidney failure events. Secondary outcomes will include the rate of change in eGFR per year, all-cause death, changes in serum uric acid level and major adverse events. Two authors will independently review study selection, data extraction and quality assessment.Ethics and dissemination The meta-analysis does not require ethical certification. The results will be disseminated through publication in a peer-reviewed journal and ...
Keywords	Medicine ; R
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advancing pathogen detection for airborne diseases

Tingting Zhai / Yuhan Wei / Lihua Wang / Jiang Li / Chunhai Fan

Fundamental Research, Vol 3, Iss 4, Pp 520-

2023 Volume 524

Abstract: Airborne diseases including SARS, bird flu, and the ongoing Coronavirus Disease 2019 (COVID-19) have stimulated the demand for developing novel bioassay methods competent for early-stage diagnosis and large-scale screening. Here, we briefly summarize the ...

Abstract	Airborne diseases including SARS, bird flu, and the ongoing Coronavirus Disease 2019 (COVID-19) have stimulated the demand for developing novel bioassay methods competent for early-stage diagnosis and large-scale screening. Here, we briefly summarize the state-of-the-art methods for the detection of infectious pathogens and discuss key challenges. We highlight the trend for next-generation technologies benefiting from multidisciplinary advances in microfabrication, nanotechnology and synthetic biology, which allow sensitive, rapid yet inexpensive pathogen assays with portable intelligent device.
Keywords	Infectious disease ; Pathogen assay ; Biosensor ; Synthetic biological circuit ; Smart device ; Science (General) ; Q1-390
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	KeAi Communications Co. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum to “HD-13 Induces Swine Pneumonia Progression via Activation of TLR9”

Jing Liu / Jiayi Xu / Honglei Zhou / Lihua Wang

Computational and Mathematical Methods in Medicine, Vol

2022 Volume 2022

Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and Safety of PD-1/PD-L1 Inhibitor Chemotherapy Combined with Lung Cancer Fang No. 1 in Relapsed and Refractory SCLC

Lihua Wang / Xiaoxia Lei / Xin Wang

Computational and Mathematical Methods in Medicine, Vol

A Retrospective Observational Study

2022 Volume 2022

Abstract: Background. Relapsed and refractory small cell lung cancer (SCLC) accounts for about 15% of all lung cancers. The prognosis of patients is poor. The 5-year survival rate is almost 0. The average survival time of patients who refuse to receive treatment ... ...

Abstract	Background. Relapsed and refractory small cell lung cancer (SCLC) accounts for about 15% of all lung cancers. The prognosis of patients is poor. The 5-year survival rate is almost 0. The average survival time of patients who refuse to receive treatment is only 2-4 months. For patients with extensive-stage SCLC, the current first-line treatment regimens are mainly platinum-containing double-drug chemotherapy. Poside combined with cisplatin/carboplatin and irinotecan combined with cisplatin/carboplatin are commonly used clinical regimens for the treatment of patients with extensive-stage SCLC. Although SCLC is very sensitive to radiotherapy and chemotherapy, most patients will develop recurrence and metastasis after initial treatment. Therefore, it is necessary to study clinically effective therapeutic drugs for relapsed and refractory SCLC. Objective. To investigate the relationship between programmed death receptor-1 (programmed death receptor-1 (PD-1)) and programmed death receptor-ligand 1 (programmed death-ligand 1 (PD-L1)) inhibitors and Lung Cancer No. 1 efficacy and safety of Lung Cancer Fang No. 1 in the treatment of relapsed and refractory SCLC. Methods. 80 patients with refractory SCLC were selected and randomly divided into control group and treatment group with 40 cases in each group. Among them, the control group received PD-1/PD-L1 inhibitor chemotherapy, and the treatment group received PD-1/PD-L1 inhibitor chemotherapy combined with Lung Cancer Fang No. 1 treatment. The differences in immune and tumor marker levels, clinical efficacy, and prognostic complications between the two groups before and after treatment were observed and compared. Results. Before treatment, there was no significant difference in clinical improvement between the two groups. After treatment, the clinical symptom scores and body weight changes in the treatment group were significantly improved. The clinical symptom scores in the treatment group were lower than those in the control group, but the body weight changes were ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: HD-13 Induces Swine Pneumonia Progression via Activation of TLR9

Jing Liu / Jiayi Xu / Honglei Zhou / Lihua Wang

Computational and Mathematical Methods in Medicine, Vol

2022 Volume 2022

Abstract: Swine pneumonia commonly known as swine pasteurellosis is an infectious disease of swine caused by Pasteurella multocida infection. It has been reported that Toll-like receptors (TLRs) play a vital role in swine pneumonia progression. However, the ... ...

Abstract	Swine pneumonia commonly known as swine pasteurellosis is an infectious disease of swine caused by Pasteurella multocida infection. It has been reported that Toll-like receptors (TLRs) play a vital role in swine pneumonia progression. However, the underlying mechanism has not been elucidated. This research was aimed at investigating the molecular mechanism by which TLR9 regulates swine pneumonia progression. Our findings illustrated that the HD-13 strain of Pasteurella multocida D (HD-13) accelerated TLR9 expression in porcine alveolar macrophage 3D4/21 cells; HD-13 activated the inflammatory response via accelerating TLR9 expression. Mechanistically, HD-13 activated mitogen-activated protein kinase (MAPK) and nuclear factor kB (NF-κB) signals. In conclusion, HD-13 may activate MAPK and NF-κB pathways via accelerating TLR9 expression, thereby accelerating the inflammatory response in the progression of swine pneumonia. TLR9 may serve as a novel therapeutic target for swine pneumonia. Our research may provide a theoretical basis for the prevention and treatment of swine pneumonia.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	570
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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