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  1. Article ; Online: Research on the Geological Sourcing of Raohe Honey by Inductively Coupled Plasma Mass Spectrometry with Primary Composite Analysis and Forecasting Models

    Lijun Mao

    American Journal of Analytical Chemistry , Vol 06, Iss 05, Pp 468-

    2015  Volume 479

    Abstract: Raohe honey (Honey in Raohe) is the only product which has obtained China’s national geographical mark for honey; however, it is always counterfeited by some producers due to its excellent quality. In this research, Raohe honey was identified by ... ...

    Abstract Raohe honey (Honey in Raohe) is the only product which has obtained China’s national geographical mark for honey; however, it is always counterfeited by some producers due to its excellent quality. In this research, Raohe honey was identified by geographical sourcing, where the detection on 166 Raohe honey samples and 31 non-Raohe honey samples was conducted with Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Additionally, the method of Primary Composite Analysis accomplished dimensionality reduction by transforming the abundance ratios variables of 13 isotopes to 4 primary composites, and could explain 91.17% of the total variables. There were five models: Decision Tree, Naive Bayes, Neural Network, Partial Least Square Discriminate and Support Vector Machine, built on the four new variables of primary composites with the Agilent MPP Software. The validation of the models was performed with 11 Raohe honey samples and 5 non-Raohe honey samples randomly selected. The accuracies of the Decision Tree and Support Vector Machine models were both 93.97%, and those of the Naive Bayes and Neural Network models were both 87.5%, while the contribution rate of the Partial Least Square Discriminate model was only 75%. It was concluded that the Decision Tree and Support Vector Machine models could be used for indentifying Raohe honey, and the Naive Bayes and Neural Network models could work as references, while the Partial Least Square Discriminate model was not suitable for identifying Raohe honey.
    Keywords Raohe Honey ; ICP-MS ; Primary Composite Analysis ; Forecasting Model ; Analytical chemistry ; QD71-142 ; Chemistry ; QD1-999 ; Science ; Q
    Language English
    Publishing date 2015-03-01T00:00:00Z
    Publisher Scientific Research Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Suppression of shot noise in a spin–orbit coupled quantum dot

    Zhimei Wang / Lijun Mao / Naitao Xue / Wenting Lu

    Royal Society Open Science, Vol 8, Iss

    2021  Volume 4

    Abstract: We study theoretically the transport properties of electrons in a quantum dot system with spin–orbit coupling. By using the quantum master equation approach, the shot noise and skewness of the transport electrons are calculated. We obtain super-Poisson ... ...

    Abstract We study theoretically the transport properties of electrons in a quantum dot system with spin–orbit coupling. By using the quantum master equation approach, the shot noise and skewness of the transport electrons are calculated. We obtain super-Poisson noise behaviour by investigating the full counting statistics of the transport system. We discover super-Poisson behaviour is more obvious with the spin polarization increasing. More importantly, we discover the suppression of shot noise induced by spin–orbit coupling. The value of shot noise is gradually decreasing when spin–orbit coupling strength increases.
    Keywords super-Poisson noise ; suppression ; spin–orbit coupling ; quantum dot ; Science ; Q
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher The Royal Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Remote Sensing Applications for Monitoring Terrestrial Protected Areas

    Lijun Mao / Mingshi Li / Wenjuan Shen

    Sustainability, Vol 12, Iss 5016, p

    Progress in the Last Decade

    2020  Volume 5016

    Abstract: Terrestrial protected areas (PAs) play an essential role in maintaining biodiversity and ecological processes worldwide, and the monitoring of PAs is a useful tool in assessing the effectiveness of PA management. Advanced remote sensing technologies have ...

    Abstract Terrestrial protected areas (PAs) play an essential role in maintaining biodiversity and ecological processes worldwide, and the monitoring of PAs is a useful tool in assessing the effectiveness of PA management. Advanced remote sensing technologies have been increasingly used for mapping and monitoring the dynamics of PAs. We review the advances in remote sensing-based approaches for monitoring terrestrial PAs in the last decade and identify four types of studies in this field: land use & land cover and vegetation community classification, vegetation structure quantification, natural disturbance monitoring, and land use & land cover and vegetation dynamic analysis. We systematically discuss the satellite data and methods used for monitoring PAs for the four research objectives. Moreover, we summarize the approaches used in the different types of studies. The following suggestions are provided for future studies: (1) development of remote sensing frameworks for local PA monitoring worldwide; (2) comprehensive utilization of multisource remote sensing data; (3) improving methods to investigate the details of PA dynamics; (4) discovering the driving forces and providing measures for PA management. Overall, the integration of remote sensing data and advanced processing methods can support PA management and decision-making procedures.
    Keywords terrestrial protected area ; remote sensing monitoring ; management decisions ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 710
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The influence of beam delivery uncertainty on dose uniformity and penumbra for pencil beam scanning in carbon-ion radiotherapy.

    Yue Li / Yunzhe Gao / Xinguo Liu / Jian Shi / Jiawen Xia / Jiancheng Yang / Lijun Mao

    PLoS ONE, Vol 16, Iss 4, p e

    2021  Volume 0249452

    Abstract: The dose uniformity and penumbra in the treatment field are important factors in radiotherapy, which affects the outcomes of radiotherapy. In this study, the integrated depth-dose-distributions (IDDDs) of 190 MeV/u and 260 MeV/u carbon beams in the ... ...

    Abstract The dose uniformity and penumbra in the treatment field are important factors in radiotherapy, which affects the outcomes of radiotherapy. In this study, the integrated depth-dose-distributions (IDDDs) of 190 MeV/u and 260 MeV/u carbon beams in the active spot-scanning delivery system were measured and calculated by FLUKA Monte Carlo simulation based on the Heavy Ion Medical Machine (HIMM). Considering the dose distributions caused by secondary particles and scattering, we also used different types of pencil beam (PB) models to fit and compare the spatial distributions of PB. We superposed a bunch of PB to form a 20×20 cm2 treatment field with the double Gaussian and double Gaussian logistic beam models and calculated the influence of beam delivery error on the field flatness and penumbra, respectively. The simulated IDDDs showed good agreement with the measured values. The triple Gaussian and double Gaussian logistic beam models have good fitness to the simulated dose distributions. There are different influences on dose uniformity and penumbra resulting from beam uncertainties. These results would be helpful for understanding carbon ion therapy, and physical therapists are more familiar with beam characteristics for active scanning therapy, which provides a reference for commissioning and optimization of treatment plans in radiotherapy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 535 ; 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Histone H4 aggravates inflammatory injury through TLR4 in chlorine gas-induced acute respiratory distress syndrome

    Yanlin Zhang / Jian Zhao / Li Guan / Lijun Mao / Shuqiang Li / Jinyuan Zhao

    Journal of Occupational Medicine and Toxicology, Vol 15, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: Abstract Background Chlorine gas (Cl2) exposure remains a public health concern in household, occupational, and transportation accidents around the world. The death rate associated with acute respiratory distress syndrome (ARDS) caused by high ... ...

    Abstract Abstract Background Chlorine gas (Cl2) exposure remains a public health concern in household, occupational, and transportation accidents around the world. The death rate associated with acute respiratory distress syndrome (ARDS) caused by high concentrations of Cl2 is very high, mainly because the pathogenesis of ARDS remains unclear. Histone H4 has been identified as an important endogenous pro-inflammatory molecule. The present study aimed to examine the pathogenic role of histone H4 in Cl2-induced ARDS. Methods ARDS was induced by Cl2 exposure in male C57BL/6 mice. Circulating histone H4, blood gas, pulmonary edema, endothelial activation, and neutrophil infiltration were measured during acute lung injury (ALI). Histone H4 or anti-H4 antibody was administered through the tail vein 1 h prior to Cl2 exposure to study the pathogenic role of histone H4. Toll-like receptor 2 knock-out (Tlr2-KO) and Tlr4-KO mice were used in conjunction with blocking antibody against TLR1, TLR2, TLR4, or TLR6 to explore the mechanism involved in histone H4-mediated injury. Results Cl2 exposure induced a concentration-dependent ALI. The levels of circulating histone H4 were positively correlated with Cl2 concentrations. Pretreatment with intravenous histone H4 further aggravated lethality rate, blood gas, endothelial activation, and neutrophil infiltration, while anti-H4 antibody showed protective effects. Tlr4 deficiency improved lethality rate, blood gas, and pulmonary edema, and prevented endothelial and neutrophil activation caused by Cl2 exposure. More importantly, Tlr4 gene deletion greatly diminished the effect of histone H4 or anti-H4 antibody observed in wild-type (WT) mice. The impact of Tlr2 on inflammatory injury was not significant. The role of TLRs was also validated by endothelial activation mediated by histone H4 in vitro. Conclusions Circulating histone H4 played a pro-inflammatory role in ARDS caused by Cl2. TLR4 was closely involved in histone H4-mediated inflammatory injury. Therefore, intervention targeting ...
    Keywords Chlorine gas ; Acute respiratory distress syndrome ; Histone H4 ; Toll-like receptor ; Pulmonary inflammation ; Industrial medicine. Industrial hygiene ; RC963-969
    Subject code 572
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Highly efficient synthesis of non-planar macrocycles possessing intriguing self-assembling behaviors and ethene/ethyne capture properties

    Lijun Mao / Yang Hu / Qian Tu / Wei-Ling Jiang / Xiao-Li Zhao / Wenjing Wang / Daqiang Yuan / Jin Wen / Xueliang Shi

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: The design of covalent macrocycles which show characteristic self-assembly behaviour and host-guest properties is challenging. Here, the authors demonstrate the synthesis of diphenylamine[n]arenes through a one-pot synthesis and demonstrate the π-π pi ... ...

    Abstract The design of covalent macrocycles which show characteristic self-assembly behaviour and host-guest properties is challenging. Here, the authors demonstrate the synthesis of diphenylamine[n]arenes through a one-pot synthesis and demonstrate the π-π pi stacking of the non-planar rings as well as ethane/ethyne host-guest interactions.
    Keywords Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Oncological Outcome of Primary and Secondary Muscle-Invasive Bladder Cancer

    Peng Ge / Li Wang / Meng Lu / Lijun Mao / Wang Li / Rumin Wen / Jian Lin / Junqi Wang / Jiacun Chen

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    A Systematic Review and Meta-analysis

    2018  Volume 8

    Abstract: Abstract Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while ... ...

    Abstract Abstract Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while secondary MIBC presumes that non-muscle invasive disease later progressed to MIBC. Due to the varying reports, we conducted a systematic review and meta-analysis to compare survival outcomes between the two groups. Relevant studies were retrieved from Medline, Embase, the Cochrane Library, and Scopus using a comprehensive search approach. Cancer-specific survival (CSS) was the outcome measure. A total of 14 studies involving 4,075 cases were included. Patients with secondary MIBC were significantly correlated with worse CSS in model I (pooled HR: 1.29, 95% CI: 1.07–1.56, P = 0.008). The results of sensitivity analyses indicated that the omission of any single study each time did not have a significant impact on the combined risk estimates. Egger’s test suggested no publication bias among these studies. The European Organization for Research and Treatment of Cancer (EORTC) risk score offers the possibility of stratifying the secondary MIBC patients into different risk groups. In high-risk NMIBC, timely radical cystectomy should be considered. Further study is required to assess the multimodal therapy in both high-risk NMIBC and secondary MIBC patients as well as to evaluate genetic and molecular drivers of tumor induction, promotion, and progression.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population levelResearch in context

    Anouschka Akerman / Vanessa Milogiannakis / Tyra Jean / Camille Esneau / Mariana Ruiz Silva / Timothy Ison / Christina Fichter / Joseph A. Lopez / Deborah Chandra / Zin Naing / Joanna Caguicla / Daiyang Li / Gregory Walker / Supavadee Amatayakul-Chantler / Nathan Roth / Sandro Manni / Thomas Hauser / Thomas Barnes / Anna Condylios /
    Malinna Yeang / Maureen Wong / Charles S.P. Foster / Kenta Sato / Sharon Lee / Yang Song / Lijun Mao / Allison Sigmund / Amy Phu / Ann Marie Vande More / Stephanie Hunt / Mark Douglas / Ian Caterson / Warwick Britton / Kerrie Sandgren / Rowena Bull / Andrew Lloyd / Jamie Triccas / Stuart Tangye / Nathan W. Bartlett / David Darley / Gail Matthews / Damien J. Stark / Kathy Petoumenos / William D. Rawlinson / Ben Murrell / Fabienne Brilot / Anthony L. Cunningham / Anthony D. Kelleher / Anupriya Aggarwal / Stuart G. Turville

    EBioMedicine, Vol 90, Iss , Pp 104545- (2023)

    2023  

    Abstract: Summary: Background: The Omicron era of the COVID-19 pandemic commenced at the beginning of 2022 and whilst it started with primarily BA.1, it was latter dominated by BA.2 and the related sub-lineage BA.5. Following resolution of the global BA.5 wave, a ... ...

    Abstract Summary: Background: The Omicron era of the COVID-19 pandemic commenced at the beginning of 2022 and whilst it started with primarily BA.1, it was latter dominated by BA.2 and the related sub-lineage BA.5. Following resolution of the global BA.5 wave, a diverse grouping of Omicron sub-lineages emerged derived from BA.2, BA.5 and recombinants thereof. Whilst emerging from distinct lineages, all shared similar changes in the Spike glycoprotein affording them an outgrowth advantage through evasion of neutralising antibodies. Methods: Over the course of 2022, we monitored the potency and breadth of antibody neutralization responses to many emerging variants in the Australian community at three levels: (i) we tracked over 420,000 U.S. plasma donors over time through various vaccine booster roll outs and Omicron waves using sequentially collected IgG pools; (ii) we mapped the antibody response in individuals using blood from stringently curated vaccine and convalescent cohorts. (iii) finally we determine the in vitro efficacy of clinically approved therapies Evusheld and Sotrovimab. Findings: In pooled IgG samples, we observed the maturation of neutralization breadth to Omicron variants over time through continuing vaccine and infection waves. Importantly, in many cases, we observed increased antibody breadth to variants that were yet to be in circulation. Determination of viral neutralization at the cohort level supported equivalent coverage across prior and emerging variants with isolates BQ.1.1, XBB.1, BR.2.1 and XBF the most evasive. Further, these emerging variants were resistant to Evusheld, whilst increasing neutralization resistance to Sotrovimab was restricted to BQ.1.1 and XBF. We conclude at this current point in time that dominant variants can evade antibodies at levels equivalent to their most evasive lineage counterparts but sustain an entry phenotype that continues to promote an additional outgrowth advantage. In Australia, BR.2.1 and XBF share this phenotype and, in contrast to global variants, are ...
    Keywords SARS-CoV-2 ; Variants ; TMPRSS2 ; Covid-19 ; Neutralising antibodies ; Sotrovimab ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: N-acetyl-heparin attenuates acute lung injury caused by acid aspiration mainly by antagonizing histones in mice.

    Yanlin Zhang / Zanmei Zhao / Li Guan / Lijun Mao / Shuqiang Li / Xiaoxu Guan / Ming Chen / Lixia Guo / Lihua Ding / Cuicui Cong / Tao Wen / Jinyuan Zhao

    PLoS ONE, Vol 9, Iss 5, p e

    2014  Volume 97074

    Abstract: Acute lung injury (ALI) is the leading cause of death in intensive care units. Extracellular histones have recently been recognized to be pivotal inflammatory mediators. Heparin and its derivatives can bind histones through electrostatic interaction. The ...

    Abstract Acute lung injury (ALI) is the leading cause of death in intensive care units. Extracellular histones have recently been recognized to be pivotal inflammatory mediators. Heparin and its derivatives can bind histones through electrostatic interaction. The purpose of this study was to investigate 1) the role of extracellular histones in the pathogenesis of ALI caused by acid aspiration and 2) whether N-acetyl-heparin (NAH) provides more protection than heparin against histones at the high dose. ALI was induced in mice via intratracheal instillation of hydrochloric acid (HCl). Lethality rate, blood gas, myeloperoxidase (MPO) activity, lung edema and pathological changes were used to evaluate the degree of ALI. Heparin/NAH was administered intraperitoneally, twice a day, for 3 days or until death. Acid aspiration caused an obvious increase in extracellular histones. A significant correlation existed between the concentration of HCl aspirated and the circulating histones. Heparin/NAH (10 mg/kg) improved the lethality rate, blood gas, MPO activity, lung edema and pathological score. At a dose of 20 mg/kg, NAH still provided protection, however heparin tended to aggravate the injury due to hemorrhagic complications. The specific interaction between heparin and histones was verified by the binding assay. In summary, high levels of extracellular histones can be pathogenic in ALI caused by acid aspiration. By neutralizing extracellular histones, heparin/NAH can offer similar protection at the moderate doses. At the high dose, NAH provides better protection than heparin.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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