LIVIVO - Search results -

Search results

Result 1 - 10 of total 56

Search options

Article: Understanding the Modulatory Effects of Cannabidiol on Alzheimer's Disease.

Xiong, Yinyi / Lim, Chae-Seok

2021 Volume 11, Issue 9

Abstract: Alzheimer's disease (AD), the most common neurodegenerative disease, is characterized by progressive cognitive impairment. The deposition of amyloid beta (Aβ) and hyperphosphorylated tau is considered the hallmark of AD pathology. Many therapeutic ... ...

Abstract	Alzheimer's disease (AD), the most common neurodegenerative disease, is characterized by progressive cognitive impairment. The deposition of amyloid beta (Aβ) and hyperphosphorylated tau is considered the hallmark of AD pathology. Many therapeutic approaches such as Food and Drug Administration-approved cholinesterase inhibitors and
Language	English
Publishing date	2021-09-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11091211
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder.

Kim, Hyopil / Lim, Chae-Seok / Kaang, Bong-Kiun

Behavioral and brain functions : BBF

2016 Volume 12, Issue 1, Page(s) 3

Abstract: Autism spectrum disorder (ASD) refers to a broad spectrum of neurodevelopmental disorders characterized by three central behavioral symptoms: impaired social interaction, impaired social communication, and restricted and repetitive behaviors. However, ... ...

Abstract	Autism spectrum disorder (ASD) refers to a broad spectrum of neurodevelopmental disorders characterized by three central behavioral symptoms: impaired social interaction, impaired social communication, and restricted and repetitive behaviors. However, the symptoms are heterogeneous among patients and a number of ASD mouse models have been generated containing mutations that mimic the mutations found in human patients with ASD. Each mouse model was found to display a unique set of repetitive behaviors. In this review, we summarize the repetitive behaviors of the ASD mouse models and variations found in their neural mechanisms including molecular and electrophysiological features. We also propose potential neuronal mechanisms underlying these repetitive behaviors, focusing on the role of the cortico-basal ganglia-thalamic circuits and brain regions associated with both social and repetitive behaviors. Further understanding of molecular and circuitry mechanisms of the repetitive behaviors associated with ASD is necessary to aid the development of effective treatments for these disorders.
MeSH term(s)	Animals ; Autism Spectrum Disorder/physiopathology ; Autism Spectrum Disorder/psychology ; Basal Ganglia Diseases/physiopathology ; Basal Ganglia Diseases/psychology ; Behavior/physiology ; Compulsive Behavior/physiopathology ; Compulsive Behavior/psychology ; Disease Models, Animal ; Humans ; Mice
Language	English
Publishing date	2016-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1744-9081
ISSN (online)	1744-9081
DOI	10.1186/s12993-016-0087-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Assessments of cognitive abilities in a mouse model of Parkinson's disease with a touch screen test.

Kwak, Chuljung / Lim, Chae-Seok / Kaang, Bong-Kiun

Behavioural brain research

2016 Volume 301, Page(s) 63–71

Abstract: Patients with Parkinson's disease (PD) experience both motor output deficits and cognitive disabilities. Various PD rodent models have been developed to investigate the genetic and brain circuit-related causes of PD and have contributed to the basic and ... ...

Abstract	Patients with Parkinson's disease (PD) experience both motor output deficits and cognitive disabilities. Various PD rodent models have been developed to investigate the genetic and brain circuit-related causes of PD and have contributed to the basic and clinical research and to therapeutic strategies for this disease. Most studies using PD rodent models have focused on the motor output deficits, rather than cognitive disabilities due to the lack of appropriate testing tools that do not require significant motor abilities. In this study, we assessed the cognitive disabilities of PD model mice using a touch screen test that required only little motor ability. We found that the PD model mice, which had motor deficits caused by unilateral striatal dopaminergic degeneration, successfully underwent operant conditioning with a touch screen test. Additionally, we found that the PD model mice demonstrated impaired location discrimination, but intact attention and reversal learning in the cognitive tests. Therefore, the touch screen test is useful for assessing hidden cognitive disabilities in disease model animals with decreased motor function.
MeSH term(s)	Animals ; Cognition ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Computers ; Conditioning, Operant ; Discrimination (Psychology) ; Exploratory Behavior ; Mice, Inbred C57BL ; Motor Activity ; Neuropsychological Tests ; Oxidopamine ; Parkinsonian Disorders/diagnosis ; Parkinsonian Disorders/physiopathology ; Parkinsonian Disorders/psychology ; Reversal Learning ; Rotarod Performance Test ; Visual Perception
Chemical Substances	Oxidopamine (8HW4YBZ748)
Language	English
Publishing date	2016-03-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2015.12.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1599: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cell type-specific gene expression profiling in brain tissue: comparison between TRAP, LCM and RNA-seq.

Kim, TaeHyun / Lim, Chae-Seok / Kaang, Bong-Kiun

BMB reports

2015 Volume 48, Issue 7, Page(s) 388–394

Abstract: The brain is an organ that consists of various cell types. As our knowledge of the structure and function of the brain progresses, cell type-specific research is gaining importance. Together with advances in sequencing technology and bioinformatics, cell ...

Abstract	The brain is an organ that consists of various cell types. As our knowledge of the structure and function of the brain progresses, cell type-specific research is gaining importance. Together with advances in sequencing technology and bioinformatics, cell type-specific transcriptome studies are providing important insights into brain cell function. In this review, we discuss 3 different cell type-specific transcriptome analyses i.e., Laser Capture Microdissection (LCM), Translating Ribosome Affinity Purification (TRAP)/RiboTag, and single cell RNA-Seq, that are widely used in the field of neuroscience.
MeSH term(s)	Animals ; Brain/metabolism ; Chromatography, Affinity/methods ; Gene Expression Profiling/methods ; Humans ; Laser Capture Microdissection/methods ; Organ Specificity/genetics ; Sequence Analysis, RNA/methods
Language	English
Publishing date	2015-01-20
Publishing country	Korea (South)
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
DOI	10.5483/bmbrep.2015.48.7.218
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4202: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Development of a touch-screen-based paradigm for assessing working memory in the mouse.

Kwak, Chuljung / Lim, Chae-Seok / Kaang, Bong-Kiun

Experimental neurobiology

2014 Volume 24, Issue 1, Page(s) 84–89

Abstract: Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing ... ...

Abstract	Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working memory in the mouse. In this study, we developed a touch-screen testing paradigm in which mice were trained to choose a location that is matched to a sample location after a time delay. Consistent with previous studies, this study showed that mice could not only learn the rule in the delayed matched to position (DMTP), but also could retain a transitory memory of the sample position during delay. This indicates that a touch-screen system can provide a DMTP testing platform to assess working memory in the mouse.
Language	English
Publishing date	2014-12-17
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2639017-6
ISSN	2093-8144 ; 1226-2560
ISSN (online)	2093-8144
ISSN	1226-2560
DOI	10.5607/en.2015.24.1.84
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Endoplasmic Reticulum Stress Increases DUSP5 Expression via PERK-CHOP Pathway, Leading to Hepatocyte Death.

Jo, Hye Jin / Yang, Jin Won / Park, Ji Hye / Choi, Eul Sig / Lim, Chae-Seok / Lee, Seoul / Han, Chang Yeob

International journal of molecular sciences

2019 Volume 20, Issue 18

Abstract: Hepatocyte death is critical for the pathogenesis of liver disease progression, which is closely associated with endoplasmic reticulum (ER) stress responses. However, the molecular basis for ER stress-mediated hepatocyte injury remains largely unknown. ... ...

Abstract	Hepatocyte death is critical for the pathogenesis of liver disease progression, which is closely associated with endoplasmic reticulum (ER) stress responses. However, the molecular basis for ER stress-mediated hepatocyte injury remains largely unknown. This study investigated the effect of ER stress on dual-specificity phosphatase 5 (DUSP5) expression and its role in hepatocyte death. Analysis of Gene Expression Omnibus (GEO) database showed that hepatic DUSP5 levels increased in the patients with liver fibrosis, which was verified in mouse models of liver diseases with ER stress. DUSP5 expression was elevated in both fibrotic and acutely injured liver of mice treated with liver toxicants. Treatment of ER stress inducers enhanced DUSP5 expression in hepatocytes, which was validated in vivo condition. The induction of DUSP5 by ER stress was blocked by either treatment with a chemical inhibitor of the protein kinase RNA-like endoplasmic reticulum kinase (PERK) pathway, or knockdown of C/EBP homologous protein (CHOP), whereas it was not affected by the silencing of IRE1 or ATF6. In addition, DUSP5 overexpression decreased extracellular-signal-regulated kinase (ERK) phosphorylation, but increased cleaved caspase-3 levels. Moreover, the reduction of cell viability under ER stress condition was attenuated by DUSP5 knockdown. In conclusion, DUSP5 expression is elevated in hepatocytes by ER stress through the PERK-CHOP pathway, contributing to hepatocyte death possibly through ERK inhibition.
MeSH term(s)	Animals ; Apoptosis/genetics ; Cell Death/genetics ; Dual-Specificity Phosphatases/genetics ; Endoplasmic Reticulum Stress ; Gene Expression ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Liver Diseases/etiology ; Liver Diseases/metabolism ; Mice ; Signal Transduction ; Transcription Factor CHOP/metabolism ; eIF-2 Kinase/metabolism
Chemical Substances	DDIT3 protein, human ; Transcription Factor CHOP (147336-12-7) ; EIF2AK3 protein, human (EC 2.7.11.1) ; eIF-2 Kinase (EC 2.7.11.1) ; DUSP5 protein, human (EC 3.1.3.48) ; Dual-Specificity Phosphatases (EC 3.1.3.48)
Language	English
Publishing date	2019-09-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20184369
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Erratum: Single-molecule force measurement via optical tweezers reveals different kinetic features of two BRaf mutants responsible for cardio-facial-cutaneous (CFC) syndrome: errata.

Wen, Cheng / Lim, Chae-Seok / Ye, Anpei / Zhu, J Julius

Biomedical optics express

2014 Volume 6, Issue 1, Page(s) 244

Abstract: We correct the omission of the construct and protein purification method in our recent paper [Biomed. Opt. Express 4(12), 2835-2845 (2013)].[This corrects the article on p. 2835 in vol. 4, PMID: 24409384.]. ...

Abstract	We correct the omission of the construct and protein purification method in our recent paper [Biomed. Opt. Express 4(12), 2835-2845 (2013)].[This corrects the article on p. 2835 in vol. 4, PMID: 24409384.].
Language	English
Publishing date	2014-12-22
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2572216-5
ISSN	2156-7085
ISSN	2156-7085
DOI	10.1364/BOE.6.000244
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transcription-independent expression of PKMζ in the anterior cingulate cortex contributes to chronically maintained neuropathic pain.

Ko, Hyoung-Gon / Ye, Sanghyun / Han, Dae-Hee / Park, Pojeong / Lim, Chae-Seok / Lee, Kyungmin / Zhuo, Min / Kaang, Bong-Kiun

Molecular pain

2018 Volume 14, Page(s) 1744806918783943

Abstract: Protein kinase M ζ is well known for its role in maintaining memory and pain. Previously, we revealed that the activation of protein kinase M ζ in the anterior cingulate cortex plays a role in sustaining neuropathic pain. However, the mechanism by which ... ...

Abstract	Protein kinase M ζ is well known for its role in maintaining memory and pain. Previously, we revealed that the activation of protein kinase M ζ in the anterior cingulate cortex plays a role in sustaining neuropathic pain. However, the mechanism by which protein kinase M ζ is expressed in the anterior cingulate cortex by peripheral nerve injury, and whether blocking of protein kinase M ζ using its inhibitor, zeta inhibitory peptide, produces analgesic effects in neuropathic pain maintained chronically after injury, have not previously been resolved. In this study, we show that protein kinase M ζ expression in the anterior cingulate cortex is enhanced by peripheral nerve injury in a transcription-independent manner. We also reveal that the inhibition of protein kinase M ζ through zeta inhibitory peptide treatment is enough to reduce mechanical allodynia responses in mice with one-month-old nerve injuries. However, the zeta inhibitory peptide treatment was only effective for a limited time.
MeSH term(s)	Animals ; Chronic Pain/enzymology ; Chronic Pain/genetics ; Chronic Pain/pathology ; Gyrus Cinguli/enzymology ; Gyrus Cinguli/pathology ; Lipopeptides/pharmacology ; Long-Term Potentiation ; Male ; Mice, Inbred C57BL ; Neuralgia/enzymology ; Neuralgia/genetics ; Neuralgia/pathology ; Peripheral Nerves/pathology ; Protein Kinase C/metabolism ; Receptors, AMPA ; Synapses/metabolism ; Transcription, Genetic/drug effects
Chemical Substances	Lipopeptides ; Receptors, AMPA ; zeta-inhibitory peptide ; Protein Kinase C (EC 2.7.11.13) ; glutamate receptor ionotropic, AMPA 2 (P6W5IXV8V9)
Language	English
Publishing date	2018-06-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/1744806918783943
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: β-Adrenergic signaling is required for the induction of a labile state during memory reconsolidation.

Lim, Chae-Seok / Kim, Jae-Ick / Kwak, Chuljung / Lee, Jaehyun / Jang, Eun Hae / Oh, Jihae / Kaang, Bong-Kiun

Brain research bulletin

2018 Volume 141, Page(s) 50–57

Abstract: Memory reconsolidation is the process by which previously consolidated memories reenter a labile state through reactivation of the memory trace and are actively consolidated through de novo protein synthesis. Although extensive studies have shown that β- ... ...

Abstract	Memory reconsolidation is the process by which previously consolidated memories reenter a labile state through reactivation of the memory trace and are actively consolidated through de novo protein synthesis. Although extensive studies have shown that β-adrenergic signaling plays a critical role in the restabilization of reactivated memory, its role in the destabilization of long-term memory is not well-studied. In this study, we found that membrane excitability increased in hippocampal CA1 neurons immediately after the retrieval of contextual fear memory. Interestingly, this increase in membrane excitability diminished after treatment with propranolol (a β-adrenergic receptor antagonist), an NMDA receptor antagonist, and a PKA inhibitor. In addition, we found that administration of propranolol prior to, but not after, the retrieval of fear memory ameliorated the memory impairment caused by anisomycin, indicating that inhibition of β-adrenergic signaling blocks the destabilization of contextual fear memory. Taken together, these results indicate that β-adrenergic signaling via NMDA receptors and PKA signaling pathway induces a labile state of long-term memory through increased neuronal membrane excitability.
MeSH term(s)	Animals ; CA1 Region, Hippocampal/drug effects ; CA1 Region, Hippocampal/physiology ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Fear/drug effects ; Fear/physiology ; Male ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Memory Consolidation/drug effects ; Memory Consolidation/physiology ; Mental Recall/drug effects ; Mental Recall/physiology ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/physiology ; Neurotransmitter Agents/pharmacology ; Propranolol/pharmacology ; Receptors, Adrenergic, beta/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism ; Signal Transduction/drug effects ; Tissue Culture Techniques
Chemical Substances	Neurotransmitter Agents ; Receptors, Adrenergic, beta ; Receptors, N-Methyl-D-Aspartate ; Propranolol (9Y8NXQ24VQ) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)
Language	English
Publishing date	2018-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2018.04.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1243: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder.

Lee, Yong-Seok / Yu, Nam-Kyung / Chun, Jeewan / Yang, Jung-Eun / Lim, Chae-Seok / Kim, Hyopil / Park, Gaeun / Lee, Jin-A / Lee, Kyungmin / Kaang, Bong-Kiun / Lee, Jae-Hyung

Molecular brain

2020 Volume 13, Issue 1, Page(s) 54

Abstract: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that are highly heterogeneous in clinical symptoms as well as etiologies. Mutations in SHANK2 are associated with ASD and accordingly, Shank2 knockout mouse shows ASD-like ... ...

Abstract	Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that are highly heterogeneous in clinical symptoms as well as etiologies. Mutations in SHANK2 are associated with ASD and accordingly, Shank2 knockout mouse shows ASD-like behavioral phenotypes, including social deficits. Intriguingly, two lines of Shank2 knockout (KO) mouse generated by deleting different exons (exon 6-7 or exon 7) showed distinct cellular phenotypes. Previously, we compared gene expressions between Shank2 KOs lacking exon 6-7 (e6-7 KO) and KOs lacking exon 7 (e7 KO) by performing RNA-seq. In this study, we expanded transcriptomic analyses to identify novel transcriptional variants in the KO mice. We found prominent expression of a novel exon (exon 4' or e4') between the existing exons 4 and 5 in the Shank2 e6-7 KO model. Expression of the transcriptional variant harboring this novel exon was confirmed by RT-PCR and western blotting. These findings suggest that the novel variant may function as a modifier gene, which contributes to the differences between the two Shank2 mutant lines. Furthermore, our result further represents an example of genetic compensation that may lead to phenotypic heterogeneity among ASD patients with mutations in the same gene.
MeSH term(s)	Animals ; Autism Spectrum Disorder/genetics ; Brain/metabolism ; Exons/genetics ; Gene Expression Regulation ; Genome ; Mice, Knockout ; Nerve Tissue Proteins/deficiency ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription, Genetic
Chemical Substances	Nerve Tissue Proteins ; RNA, Messenger ; Shank2 protein, mouse
Language	English
Publishing date	2020-04-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2436057-0
ISSN	1756-6606 ; 1756-6606
ISSN (online)	1756-6606
ISSN	1756-6606
DOI	10.1186/s13041-020-00595-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito