LIVIVO - Search results -

Search results

Result 1 - 10 of total 126

Search options

Article ; Online: Racial and ethnic disparities in Alzheimer's dementia.

Lim, Unhee / Park, Song-Yi

Aging

2022 Volume 14, Issue 22, Page(s) 8884–8885

MeSH term(s)	Humans ; United States ; Alzheimer Disease ; Racial Groups ; Ethnicity
Language	English
Publishing date	2022-11-29
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204421
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: DNA Methylation as a Biomarker of Aging in Epidemiologic Studies.

Lim, Unhee / Song, Min-Ae

Methods in molecular biology (Clifton, N.J.)

2018 Volume 1856, Page(s) 219–231

Abstract: Cancer is largely an aging disease. Accelerated biological aging may be the strongest predictor of cancer and other chronic disease risks. In the absence of reliable and quantifiable biomarkers of aging to date, it has long been observed that ... ...

Abstract	Cancer is largely an aging disease. Accelerated biological aging may be the strongest predictor of cancer and other chronic disease risks. In the absence of reliable and quantifiable biomarkers of aging to date, it has long been observed that tumorigenesis shares distinct epigenetic alterations with the aging process. Recently, epigenetic age estimates have been developed based on the availability of genome-wide DNA methylation profiles, by applying in the prediction formula the methylation level at a subset of highly predictive methylation sites, called epigenetic clock. These DNA methylation age estimates have produced remarkably strong correlations with chronological age, with a small deviation and high reproducibility across different age groups and study populations. Moreover, an increasing number of epidemiologic studies have demonstrated an independent association of DNA methylation age or the extent of acceleration with mortality and various aging-related conditions, even after accounting for differences in chronological age and other risk factors. Although epigenetic profiles are known to be tissue-specific, both target tissue- and multiple tissue-derived estimates appear to perform well to capture what is thought to be the cumulative epigenetic drift that represents a multifactorial degenerative process across tissues and organisms. Further refinement of the epigenetic age estimates is anticipated over time to accommodate a better technological coverage of the methylome and a better understanding of the biology underlying predictive regions. Epidemiologic principles will remain critical for the evaluation of research findings involving, for example, different study populations, design, follow-up time, and quality of covariate data. Overall, the epigenetic age estimates are an exciting development with useful implications for biomedical research of healthy aging and disease prevention and control.
MeSH term(s)	Aging/genetics ; Biomarkers ; CpG Islands ; DNA Methylation ; Epidemiologic Studies ; Epigenesis, Genetic ; Gene Expression Profiling ; Gene Expression Regulation ; Genetic Association Studies ; Genome-Wide Association Study ; Humans ; Longevity/genetics ; Phenotype ; Sensitivity and Specificity ; Transcriptome
Chemical Substances	Biomarkers
Language	English
Publishing date	2018-08-31
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8751-1_12
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Diet Quality and Body Mass Index Over 20 Years in the Multiethnic Cohort

Tsuzaki, Jenna / Maskarinec, Gertraud / Mapa, Victoria / Shvetsov, Yurii B. / Park, Song-Yi / Monroe, Kristine Robinson / Lim, Unhee / Le Marchand, Loïc / Boushey, Carol J.

Academy of Nutrition and Dietetics Journal of the Academy of Nutrition and Dietetics. 2023 Feb. 07,

2023

Abstract: With increasing rates of overweight/obesity and disparities by ethnicity, it is important to understand the role of diet in ameliorating this health problem. The current study examined the relation of diet quality as measured by the Healthy Eating Index ( ...

Abstract	With increasing rates of overweight/obesity and disparities by ethnicity, it is important to understand the role of diet in ameliorating this health problem. The current study examined the relation of diet quality as measured by the Healthy Eating Index (HEI)-2015 with BMI and obesity among participants of the Multiethnic Cohort (MEC) in cross-sectional analyses at 3 time points (T-1 to T-3) over 20 years. In a subset of 1,860 MEC participants, three cross-sectional analyses at cohort entry (1993-1996, T-1) and follow-ups in 2003-2008 (T-2) and 2013-2016 (T-3) were performed. The cohort consists of African American, Native Hawaiian, Japanese American, Latino, and White adults in Hawaii and California with a mean age of 48 years at T-1. BMI/weight status in relation to diet quality. Linear and multinomial logistic regressions were applied to analyze the relation of diet quality with BMI and obesity while adjusting for known confounders. HEI-2015 increased by 6.1 and 5.1 units for men and women from T-1 to T-3; the respective values for BMI were 1.5 and 2.4 kg/m². Diet quality was inversely associated with BMI across time: BMI was lower by -0.47, -0.72, and -0.92 units for every 10-point increase in HEI-2015 scores at T-1, T-2, and T-3 (p<0.0001 for all). During the 20 years, the association was consistently high among Japanese American participants (-0.79, -0.87, -1.02) and weakest in African American cohort members (-0.34, -0.37,-0.40). Higher diet quality was related to lower odds of having obesity at all 3 time points with prevalence odds ratios of 0.72, 0.57, and 0.60. These findings suggest that consuming a high-quality diet is related to a lower BMI and rates of overweight/obesity but with the strongest association at an older age. To understand the ethnic differences, investigations of dietary habits/behaviors and/or fat distribution patterns will be needed in the future.
Keywords	Hawaii ; Latinos ; body mass index ; diet ; dietetics ; food quality ; obesity ; California ; body mass index (BMI) ; diet quality ; multiethnic populations ; healthy eating index 2015 (HEI-2015)
Language	English
Dates of publication	2023-0207
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2646718-5
ISSN	2212-2672
ISSN	2212-2672
DOI	10.1016/j.jand.2023.02.001
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 2828: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Dietary intake and visceral adiposity in older adults: The Multiethnic Cohort Adiposity Phenotype study.

Merritt, Melissa A / Lim, Unhee / Lampe, Johanna W / Kaenkumchorn, Tanyaporn / Boushey, Carol J / Wilkens, Lynne R / Shepherd, John A / Ernst, Thomas / Le Marchand, Loïc

Obesity science & practice

2024 Volume 10, Issue 1, Page(s) e734

Abstract: Background: There are established links between the accumulation of body fat as visceral adipose tissue (VAT) and the risk of developing obesity-associated metabolic disease. Previous studies have suggested that levels of intake of specific foods and ... ...

Abstract	Background: There are established links between the accumulation of body fat as visceral adipose tissue (VAT) and the risk of developing obesity-associated metabolic disease. Previous studies have suggested that levels of intake of specific foods and nutrients are associated with VAT accumulation after accounting for total energy intake. Objective: This study assessed associations between a priori selected dietary factors on VAT quantified using abdominal magnetic resonance imaging. Methods: The cross-sectional Multiethnic Cohort Adiposity Phenotype Study included Results: There were significant inverse associations with VAT for dietary intake of total vegetables, total fruits (including juice), cereals, whole grains, calcium, copper and dietary fiber ( Conclusions: These results highlight foods and nutrients including SFA, total fruit, whole grains, fiber and copper as potential candidates for future research to inform dietary guidelines for the prevention of chronic disease among older adults.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2836381-4
ISSN	2055-2238 ; 2055-2238
ISSN (online)	2055-2238
ISSN	2055-2238
DOI	10.1002/osp4.734
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias.

Park, Song-Yi / Setiawan, Veronica Wendy / Crimmins, Eileen M / White, Lon R / Wu, Anna H / Cheng, Iona / Darst, Burcu F / Haiman, Christopher A / Wilkens, Lynne R / Le Marchand, Loїc / Lim, Unhee

Neurology

2024 Volume 102, Issue 3, Page(s) e208116

Abstract: Background and objectives: Previous studies estimated that modifiable risk factors explain up to 40% of the dementia cases in the United States and that this population-attributable fraction (PAF) differs by race and ethnicity-estimates of future impact ...

Abstract	Background and objectives: Previous studies estimated that modifiable risk factors explain up to 40% of the dementia cases in the United States and that this population-attributable fraction (PAF) differs by race and ethnicity-estimates of future impact based on the risk factor prevalence in contemporary surveys. The aim of this study was to determine the race-specific and ethnicity-specific PAF of late-onset Alzheimer disease and related dementias (ADRDs) based on the risk factor prevalence and associations observed on the same individuals within a prospective cohort. Methods: Data were from Multiethnic Cohort Study participants (African American, Japanese American, Latino, Native Hawaiian, and White) enrolled in Medicare Fee-for-Service. We estimated the PAF based on the prevalence of risk factors at cohort baseline and their mutually adjusted association with subsequent ADRD incidence. Risk factors included low educational attainment and midlife exposures to low neighborhood socioeconomic status, unmarried status, history of hypertension, stroke, diabetes or heart disease, smoking, physical inactivity, short or long sleep duration, obesity, and low-quality diet, as well as Results: Among 91,881 participants (mean age 59.3 at baseline, 55.0% female participants), 16,507 incident ADRD cases were identified from Medicare claims (1999-2016, mean follow-up 9.3 years). The PAF for nongenetic factors combined was similar in men (24.0% [95% CI 21.3-26.6]) and women (22.8% [20.3-25.2]) but varied across Japanese American (14.2% [11.1-17.2]), White (21.9% [19.0-24.7]), African American (27.8% [22.3-33.0]), Native Hawaiian (29.3% [21.0-36.7]), and Latino (33.3% [27.5-38.5]) groups. The combined PAF was attenuated when accounting for competing risk of death, in both men (10.4%) and women (13.9%) and across racial and ethnic groups (4.7%-25.5%). The combined PAF was also different by age at diagnosis and ADRD subtypes, higher for younger (65-74 years: 43.2%) than older (75-84 years: 32.4%; ≥85 years: 11.3%) diagnoses and higher for vascular or unspecified ADRD than for AD or Lewy body dementia. An additional PAF of 11.8% (9.9-13.6) was associated with Discussion: Known risk factors explained about a third of the ADRD cases but with unequal distributions across racial and ethnic groups.
MeSH term(s)	Male ; Humans ; Female ; Aged ; United States/epidemiology ; Middle Aged ; Alzheimer Disease/epidemiology ; Cohort Studies ; Prospective Studies ; Apolipoprotein E4/genetics ; Medicare
Chemical Substances	Apolipoprotein E4
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000208116
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 18: Show issues
Zs.MO 374: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Diet Quality and Body Mass Index Over 20 Years in the Multiethnic Cohort.

Tsuzaki, Jenna / Maskarinec, Gertraud / Mapa, Victoria / Shvetsov, Yurii B / Park, Song-Yi / Monroe, Kristine R / Lim, Unhee / Le Marchand, Loïc / Boushey, Carol J

Journal of the Academy of Nutrition and Dietetics

2023 Volume 124, Issue 2, Page(s) 194–204

Abstract: Background: With increasing rates of overweight and obesity and disparities by ethnicity, it is important to understand the role of diet in ameliorating this health problem.: Objective: This study examined the relation of diet quality as measured by ... ...

Abstract	Background: With increasing rates of overweight and obesity and disparities by ethnicity, it is important to understand the role of diet in ameliorating this health problem. Objective: This study examined the relation of diet quality as measured by the Healthy Eating Index 2015 with body mass index (BMI; calculated as kg/m Design: In a subset of 1,860 MEC participants, 3 cross-sectional analyses at cohort entry (1993 to 1996, T-1) and follow-ups in 2003 to 2008 (T-2) and 2013 to 2016 (T-3) were performed. Participants/setting: The cohort consists of African American, Native Hawaiian, Japanese American, Latino, and White adults in Hawaii and California; mean age was 48 years at T-1. Main outcome measure: BMI and weight status in relation to diet quality were measured. Statistical analysis: Linear and multinomial logistic regressions were applied to analyze the relation of diet quality with BMI and obesity, while adjusting for known confounders. Results: Healthy Eating Index 2015 increased by 6.1 and 5.1 units for men and women, respectively, from T-1 to T-3; the respective values for BMI were 1.5 and 2.4. Diet quality was inversely associated with BMI across time: BMI was lower by -0.47, -0.72, and -0.92 units for every 10-point increase in Healthy Eating Index 2015 scores at T-1, T-2, and T-3, respectively (P < .0001 for all). During the 20 years, the association was consistently high among Japanese American participants (-0.79, -0.87, and -1.02) and weakest in African American cohort members (-0.34, -0.37, and -0.40). Higher diet quality was related to lower odds of having obesity at all 3 time points; prevalence odds ratios were 0.72, 0.57, and 0.60. Conclusions: These findings suggest that consuming a high-quality diet is related to lower BMI and rates of overweight and obesity but with the strongest association at an older age. To understand the ethnic differences, investigations of dietary habits and behaviors and/or fat distribution patterns will be needed in the future.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Body Mass Index ; Overweight ; Cross-Sectional Studies ; Diet ; Obesity/epidemiology
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2646718-5
ISSN	2212-2672
ISSN	2212-2672
DOI	10.1016/j.jand.2023.02.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 2828: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Association of Habitual Intake of Probiotic Supplements and Yogurt with Characteristics of the Gut Microbiome in the Multiethnic Cohort Adiposity Phenotype Study.

Chai, Weiwen / Maskarinec, Gertraud / Lim, Unhee / Boushey, Carol J / Wilkens, Lynne R / Setiawan, V Wendy / Le Marchand, Loïc / Randolph, Timothy W / Jenkins, Isaac C / Lampe, Johanna W / Hullar, Meredith A J

Gut microbiome (Cambridge, England)

2023 Volume 4

Abstract: Consumption of probiotics and/or yogurt could be a solution for restoring the balance of the gut microbiota. This study examined associations of regular intake of probiotic supplements or yogurt with the gut microbiota among a diverse population of older ...

Abstract	Consumption of probiotics and/or yogurt could be a solution for restoring the balance of the gut microbiota. This study examined associations of regular intake of probiotic supplements or yogurt with the gut microbiota among a diverse population of older adults (N=1,861; 60-72 years). Fecal microbial composition was obtained from 16S rRNA gene sequencing (V1-V3 region). General Linear Models were used to estimate the associations of probiotic supplement or yogurt intake with microbiome measures adjusting for covariates. Compared to non-yogurt consumers (N=1,023), regular yogurt consumers (≥once/week, N=818) had greater
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article
ISSN	2632-2897
ISSN (online)	2632-2897
DOI	10.1017/gmb.2023.10
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The association of a healthy lifestyle index and imaging-based body fat distribution with glycemic status and Type 2 diabetes in the Multi Ethnic Cohort: a cross-sectional analysis.

Klapp, Rebecca / Nimptsch, Katharina / Pischon, Tobias / Wilkens, Lynne R / Lim, Unhee / Guillermo, Cherie / Setiawan, V Wendy / Shepherd, John A / Le Marchand, Loïc / Maskarinec, Gertraud

European journal of clinical nutrition

2023 Volume 78, Issue 3, Page(s) 236–242

Abstract: Introduction: As several behaviors captured by the Lifestyle Risk Factor Index (LSRI) are protective against Type 2 diabetes (T2D) and may affect body fat distribution, we examined its relation with both outcomes.: Methods: In a subset of the ... ...

Abstract	Introduction: As several behaviors captured by the Lifestyle Risk Factor Index (LSRI) are protective against Type 2 diabetes (T2D) and may affect body fat distribution, we examined its relation with both outcomes. Methods: In a subset of the Multiethnic Cohort, participants from five ethnic groups (60-77 years) were assigned LSRI scores (one point each for consuming <1 (women)/<2 (men) alcoholic drinks/day, ≥1.5 physical activity hours/week, not smoking, and adhering to ≥3/7 dietary recommendations). All participants completed an extensive Quantitative Food Frequency Questionnaire to allow estimation of adherence to intake recommendations for fruits, vegetables, refined and whole grains, fish, processed and non-processed meat. Glycemic/T2D status was classified according to self-reports and fasting glucose. We estimated prevalence odds ratios (POR) of LSRI with glycemic/T2D status and DXA- and MRI-based body fat distribution using logistic regression. Results: Of 1713 participants, 43% had normoglycemia, 30% Pre-T2D, 9% Undiagnosed T2D, and 18% T2D. Overall, 39% scored 0-2, 49% 3, and 12% 4 LSRI points. T2D prevalence was 55% (POR 0.45; 95% confidence intervals 0.27, 0.76) lower for 4 vs. 0-2 LSRI points with weaker associations for abnormal glycemic status. Despite the low adherence to dietary recommendations (22%), this was the only component related to lower T2D prevalence. The inverse LSRI-T2D association was only observed among Latinos and Japanese Americans in ethnic-specific models. Visceral fat measures were higher in T2D patients and attenuated the LSRI-T2D association. Conclusion: These findings support the role of a healthy lifestyle, especially diet, in T2D prevention with differences across ethnicity.
MeSH term(s)	Male ; Animals ; Humans ; Female ; Diabetes Mellitus, Type 2/epidemiology ; Cross-Sectional Studies ; Diet ; Risk Factors ; Healthy Lifestyle
Language	English
Publishing date	2023-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-023-01381-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1045: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Dietary and lifestyle factors of DNA methylation.

Lim, Unhee / Song, Min-Ae

Methods in molecular biology (Clifton, N.J.)

2012 Volume 863, Page(s) 359–376

Abstract: Lifestyle factors, such as diet, smoking, physical activity, and body weight management, are known to constitute the majority of cancer causes. Epigenetics has been widely proposed as a main mechanism that mediates the reversible effects of dietary and ... ...

Abstract	Lifestyle factors, such as diet, smoking, physical activity, and body weight management, are known to constitute the majority of cancer causes. Epigenetics has been widely proposed as a main mechanism that mediates the reversible effects of dietary and lifestyle factors on carcinogenesis. This chapter reviews human studies on potential dietary and lifestyle determinants of DNA methylation. Apart from a few prospective investigations and interventions of limited size and duration, evidence mostly comes from cross-sectional observational studies and supports some associations. Studies to date suggest that certain dietary components may alter genomic and gene-specific DNA methylation levels in systemic and target tissues, affecting genomic stability and transcription of tumor suppressors and oncogenes. Most data and supportive evidence exist for folate, a key nutritional factor in one-carbon metabolism that supplies the methyl units for DNA methylation. Other candidate bioactive food components include alcohol and other key nutritional factors of one-carbon metabolism, polyphenols and flavonoids in green tea, phytoestrogen, and lycopene. Some data also support a link of DNA methylation with physical activity and energy balance. Effects of dietary and lifestyle exposures on DNA methylation may be additionally modified by common genetic variants, environmental carcinogens, and infectious agents, an aspect that remains largely unexplored. In addition, growing literature supports that the environmental conditions during critical developmental stages may influence later risk of metabolic disorders in part through persistent programming of DNA methylation. Further research of these modifiable determinants of DNA methylation will improve our understanding of cancer etiology and may present certain DNA methylation markers as attractive surrogate endpoints for prevention research. Considering the plasticity of epigenetic marks and correlated nature of lifestyle factors, more longitudinal studies of healthy individuals of varying age, sex, and ethnic groups are warranted, ideally with comprehensive data collection on various lifestyle factors.
MeSH term(s)	Age Factors ; Animals ; Body Weight ; Continental Population Groups ; DNA Methylation/genetics ; DNA Methylation/physiology ; Diet ; Ethanol ; Folic Acid ; Genomic Instability/genetics ; Humans ; Life Style ; Models, Biological ; Motor Activity/physiology ; Sex Factors ; Smoking
Chemical Substances	Ethanol (3K9958V90M) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2012
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-61779-612-8_23
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: The Gut Microbiome Is Associated with Circulating Dietary Biomarkers of Fruit and Vegetable Intake in a Multiethnic Cohort

Frankenfeld, Cara L. / Hullar, Meredith A.J. / Maskarinec, Gertraud / Monroe, Kristine R. / Shepherd, John A. / Franke, Adrian A. / Randolph, Timothy W. / Wilkens, Lynne R. / Boushey, Carol J. / Le Marchand, Loïc / Lim, Unhee / Lampe, Johanna W.

Academy of Nutrition and Dietetics Journal of the Academy of Nutrition and Dietetics. 2022 Jan., v. 122, no. 1

2022

Abstract: Results from observational studies suggest high diet quality favorably influences the human gut microbiome. Fruit and vegetable consumption is often a key contributor to high diet quality.To evaluate measures of gut bacterial diversity and abundance in ... ...

Abstract	Results from observational studies suggest high diet quality favorably influences the human gut microbiome. Fruit and vegetable consumption is often a key contributor to high diet quality.To evaluate measures of gut bacterial diversity and abundance in relation to serum biomarkers of fruit and vegetable intake.Secondary analysis of cross-sectional data.Men and women from Los Angeles, CA, and Hawai’i who participated in the Multiethnic Cohort–Adiposity Phenotype Study from 2013 to 2016 (N = 1,709).Gut microbiome diversity and composition in relation to dietary biomarkers.Carotenoid (beta carotene, alpha carotene, cryptoxanthins, lutein, lycopene, and zeaxanthin), tocopherol (α, β + γ, and δ), and retinol concentrations were assessed in serum. The α and β diversity and composition of the gut microbiome were classified based on 16S rRNA gene sequencing of bacterial DNA from self-collected fecal samples. Global differences in microbial community profiles in relation dietary biomarkers were evaluated using multivariable permutational analysis of variance. Associations of α diversity (Shannon index), β diversity (weighted and unweighted UniFrac) with center log-ratio–transformed phyla and genera abundances were evaluated using linear regression, adjusted for covariates.Increasing total carotenoid, beta carotene, alpha carotene, cryptoxanthin, and lycopene concentrations were associated with higher gut bacterial diversity (Shannon Index) (P < 0.001). Total tocopherol, α-tocopherol, and δ-tocopherol concentrations contributed significantly to more than 1% of the microbiome variation in gut bacterial community: total tocopherol: 1.74%; α-tocopherol: 1.70%; and δ-tocopherol: 1.16% (P < 0.001). Higher total carotenoid was associated with greater abundance of some genera relevant for microbial macronutrient metabolism (P < 0.001).Objective biomarkers of fruit and vegetable intake, particularly carotenoids, were favorably associated with gut bacterial composition and diversity in this multiethnic population. These observations provide supportive evidence that fruit and vegetable intake is related to gut bacterial composition; more work is needed to elucidate how this influences host health.
Keywords	alpha-tocopherol ; bacterial communities ; beta-carotene ; blood serum ; dietary markers ; dietetics ; digestive system ; food quality ; fruits ; genes ; humans ; intestinal microorganisms ; lutein ; lycopene ; metabolism ; microbiome ; nationalities and ethnic groups ; phenotype ; regression analysis ; vegetable consumption ; vegetables ; vitamin A ; zeaxanthin
Language	English
Dates of publication	2022-01
Size	p. 78-98.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2646718-5
ISSN	2212-2672
ISSN	2212-2672
DOI	10.1016/j.jand.2021.05.023
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 2828: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED