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  1. AU="Lim, Wei-Meng"
  2. AU="Araújo, Filipa"
  3. AU="Castelli, Antonio"
  4. AU="Yoon, Jong Hyun"
  5. AU="Ningaraj, Nagendra S"
  6. AU="Deegan, Patrick"
  7. AU="Jo, Doo Sin"
  8. AU="Adgey, A J"
  9. AU=Liu Hejun
  10. AU="Ferreira, Filipa C"
  11. AU="Losurdo, G"
  12. AU="Dorjsuren, Bilguujin"
  13. AU="Kilgore, Henry R"
  14. AU="Magee, Toni"
  15. AU="Jiang Gui"

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  1. Artikel: Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells.

    Baek, Jeonghun / Mai, Chun Wai / Lim, Wei Meng / Wong, Lai Chun

    International journal of ophthalmology

    2023  Band 16, Heft 1, Seite(n) 40–46

    Abstract: Aim: To compare the effect of vegetable oils on the uptake of lutein and zeaxanthin by adult retinal pigment epithelial (ARPE)-19 cells : Methods: ARPE-19 cells were cultured in Dulbecco's Modified Eagle Medium-F-12 supplemented with 10% foetal ... ...

    Abstract Aim: To compare the effect of vegetable oils on the uptake of lutein and zeaxanthin by adult retinal pigment epithelial (ARPE)-19 cells
    Methods: ARPE-19 cells were cultured in Dulbecco's Modified Eagle Medium-F-12 supplemented with 10% foetal bovine serum and 1% penicillin-streptomycin in a humidified 5% CO
    Results: Among the oils tested, the highest lutein and zeaxanthin uptake was observed with coconut oil while the lowest was observed with linseed oil.
    Conclusion: ARPE-19 uptake of lutein and zeaxanthin are found to be dependent on the type of oils.
    Sprache Englisch
    Erscheinungsdatum 2023-01-18
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2023.01.06
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases.

    Sim, Wynne / Lim, Wei-Meng / Hii, Ling-Wei / Leong, Chee-Onn / Mai, Chun-Wai

    World journal of gastroenterology

    2022  Band 28, Heft 18, Seite(n) 1934–1945

    Abstract: The immune system plays a vital role in maintaining the delicate balance between immune recognition and tumor development. Regardless, it is not uncommon that cancerous cells can intelligently acquire abilities to bypass the antitumor immune responses, ... ...

    Abstract The immune system plays a vital role in maintaining the delicate balance between immune recognition and tumor development. Regardless, it is not uncommon that cancerous cells can intelligently acquire abilities to bypass the antitumor immune responses, thus allowing continuous tumor growth and development. Immune evasion has emerged as a significant factor contributing to the progression and immune resistance of pancreatic cancer. Compared with other cancers, pancreatic cancer has a tumor microenvironment that can resist most treatment modalities, including emerging immunotherapy. Sadly, the use of immunotherapy has yet to bring significant clinical breakthrough among pancreatic cancer patients, suggesting that pancreatic cancer has successfully evaded immunomodulation. In this review, we summarize the impact of genetic alteration and epigenetic modification (especially histone deacetylases, HDAC) on immune evasion in pancreatic cancer. HDAC overexpression significantly suppresses tumor suppressor genes, contributing to tumor growth and progression. We review the evidence on HDAC inhibitors in tumor eradication, improving T cells activation, restoring tumor immunogenicity, and modulating programmed death 1 interaction. We provide our perspective in targeting HDAC as a strategy to reverse immune evasion in pancreatic cancer.
    Mesh-Begriff(e) Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylases/genetics ; Humans ; Immune Evasion ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Tumor Microenvironment ; Pancreatic Neoplasms
    Chemische Substanzen Histone Deacetylase Inhibitors ; Histone Deacetylases (EC 3.5.1.98)
    Sprache Englisch
    Erscheinungsdatum 2022-05-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v28.i18.1934
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Development of

    Wong, Yoke Lan / Pandey, Manisha / Choudhury, Hira / Lim, Wei Meng / Bhattamisra, Subrat Kumar / Gorain, Bapi

    Polymers

    2021  Band 13, Heft 16

    Abstract: Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, ...

    Abstract Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity of 178.50 ± 5.50 cP at 25 °C and 7800 ± 200 cP at 37 °C as the gel set. The optimized formulation was found to be bioadhesive and cytocompatible. Cumulative drug release was 65.05% within the time-frame of 8 h; the release pattern of the drug followed zero-order kinetics with the Higuchi release mechanism. The average zone of inhibition was found to be 43.44 ± 1.34 mm. The properties of F3 formulation reflect to improve residence time at the site of application and can enhance sustained drug release. Therefore, it could be concluded that optimized formulation has better retention and enhanced antimicrobial activity for superior efficacy against HS.
    Sprache Englisch
    Erscheinungsdatum 2021-08-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13162770
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma.

    Pua, Lesley Jia Wei / Mai, Chun-Wai / Chung, Felicia Fei-Lei / Khoo, Alan Soo-Beng / Leong, Chee-Onn / Lim, Wei-Meng / Hii, Ling-Wei

    International journal of molecular sciences

    2022  Band 23, Heft 3

    Abstract: c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members integrate signals that affect proliferation, differentiation, survival, and migration in a cell context- and cell type-specific way. JNK and p38 MAPK activities ... ...

    Abstract c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members integrate signals that affect proliferation, differentiation, survival, and migration in a cell context- and cell type-specific way. JNK and p38 MAPK activities are found upregulated in nasopharyngeal carcinoma (NPC). Studies have shown that activation of JNK and p38 MAPK signaling can promote NPC oncogenesis by mechanisms within the cancer cells and interactions with the tumor microenvironment. They regulate multiple transcription activities and contribute to tumor-promoting processes, ranging from cell proliferation to apoptosis, inflammation, metastasis, and angiogenesis. Current literature suggests that JNK and p38 MAPK activation may exert pro-tumorigenic functions in NPC, though the underlying mechanisms are not well documented and have yet to be fully explored. Here, we aim to provide a narrative review of JNK and p38 MAPK pathways in human cancers with a primary focus on NPC. We also discuss the potential therapeutic agents that could be used to target JNK and p38 MAPK signaling in NPC, along with perspectives for future works. We aim to inspire future studies further delineating JNK and p38 MAPK signaling in NPC oncogenesis which might offer important insights for better strategies in diagnosis, prognosis, and treatment decision-making in NPC patients.
    Mesh-Begriff(e) Animals ; Antineoplastic Agents/pharmacology ; Gene Expression Regulation, Enzymologic/drug effects ; Humans ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/enzymology ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/enzymology ; Nasopharyngeal Neoplasms/pathology ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
    Chemische Substanzen Antineoplastic Agents ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Sprache Englisch
    Erscheinungsdatum 2022-01-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031108
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Histone Deacetylase Inhibitors Restore Cancer Cell Sensitivity towards T Lymphocytes Mediated Cytotoxicity in Pancreatic Cancer.

    Looi, Chin-King / Gan, Li-Lian / Sim, Wynne / Hii, Ling-Wei / Chung, Felicia Fei-Lei / Leong, Chee-Onn / Lim, Wei-Meng / Mai, Chun-Wai

    Cancers

    2022  Band 14, Heft 15

    Abstract: Despite medical advancements, the prognosis of pancreatic ductal adenocarcinoma (PDAC) has not improved significantly over the past 50 years. By utilising the large-scale genomic datasets available from the Australia Pancreatic Cancer Project (PACA-AU) ... ...

    Abstract Despite medical advancements, the prognosis of pancreatic ductal adenocarcinoma (PDAC) has not improved significantly over the past 50 years. By utilising the large-scale genomic datasets available from the Australia Pancreatic Cancer Project (PACA-AU) and The Cancer Genomic Atlas Project (TCGA-PAAD), we studied the immunophenotype of PDAC in silico and identified that tumours with high cytotoxic T lymphocytes (CTL) killing activity were associated with favourable clinical outcomes. Using the STRING protein-protein interaction network analysis, the identified differentially expressed genes with low CTL killing activity were associated with TWIST/IL-6R, HDAC5, and EOMES signalling. Following Connectivity Map analysis, we identified 44 small molecules that could restore CTL sensitivity in the PDAC cells. Further high-throughput chemical library screening identified 133 inhibitors that effectively target both parental and CTL-resistant PDAC cells in vitro. Since CTL-resistant PDAC had a higher expression of histone proteins and its acetylated proteins compared to its parental cells, we further investigated the impact of histone deacetylase inhibitors (HDACi) on CTL-mediated cytotoxicity in PDAC cells in vitro, namely SW1990 and BxPC3. Further analyses revealed that givinostat and dacinostat were the two most potent HDAC inhibitors that restored CTL sensitivity in SW1990 and BxPC3 CTL-resistant cells. Through our in silico and in vitro studies, we demonstrate the novel role of HDAC inhibition in restoring CTL resistance and that combinations of HDACi with CTL may represent a promising therapeutic strategy, warranting its further detailed molecular mechanistic studies and animal studies before embarking on the clinical evaluation of these novel combined PDAC treatments.
    Sprache Englisch
    Erscheinungsdatum 2022-07-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14153709
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Molecular Hybrids Integrated with Benzimidazole and Pyrazole Structural Motifs: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies.

    Sivaramakarthikeyan, Ramar / Iniyaval, Shunmugam / Saravanan, Vadivel / Lim, Wei-Meng / Mai, Chun-Wai / Ramalingan, Chennan

    ACS omega

    2020  Band 5, Heft 17, Seite(n) 10089–10098

    Abstract: Synthesis of a series of benzimidazole-ornamented pyrazoles, ...

    Abstract Synthesis of a series of benzimidazole-ornamented pyrazoles,
    Sprache Englisch
    Erscheinungsdatum 2020-04-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c00630
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Advances in Nanomaterials Used in Co-Delivery of siRNA and Small Molecule Drugs for Cancer Treatment.

    Chung, Shei Li / Yee, Maxine Swee-Li / Hii, Ling-Wei / Lim, Wei-Meng / Ho, Mui Yen / Khiew, Poi Sim / Leong, Chee-Onn

    Nanomaterials (Basel, Switzerland)

    2021  Band 11, Heft 10

    Abstract: Recent advancements in nanotechnology have improved our understanding of cancer treatment and allowed the opportunity to develop novel delivery systems for cancer therapy. The biological complexities of cancer and tumour micro-environments have been ... ...

    Abstract Recent advancements in nanotechnology have improved our understanding of cancer treatment and allowed the opportunity to develop novel delivery systems for cancer therapy. The biological complexities of cancer and tumour micro-environments have been shown to be highly challenging when treated with a single therapeutic approach. Current co-delivery systems which involve delivering small molecule drugs and short-interfering RNA (siRNA) have demonstrated the potential of effective suppression of tumour growth. It is worth noting that a considerable number of studies have demonstrated the synergistic effect of co-delivery systems combining siRNA and small molecule drugs, with promising results when compared to single-drug approaches. This review focuses on the recent advances in co-delivery of siRNA and small molecule drugs. The co-delivery systems are categorized based on the material classes of drug carriers. We discuss the critical properties of materials that enable co-delivery of two distinct anti-tumour agents with different properties. Key examples of co-delivery of drug/siRNA from the recent literature are highlighted and discussed. We summarize the current and emerging issues in this rapidly changing field of research in biomaterials for cancer treatments.
    Sprache Englisch
    Erscheinungsdatum 2021-09-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano11102467
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  8. Artikel: Roles of Inflammasomes in Epstein-Barr Virus-Associated Nasopharyngeal Cancer.

    Looi, Chin King / Hii, Ling-Wei / Chung, Felicia Fei-Lei / Mai, Chun-Wai / Lim, Wei-Meng / Leong, Chee-Onn

    Cancers

    2021  Band 13, Heft 8

    Abstract: Epstein-Barr virus (EBV) infection is recognised as one of the causative agents in most nasopharyngeal carcinoma (NPC) cases. Expression of EBV viral antigens can induce host's antiviral immune response by activating the inflammasomes to produce pro- ... ...

    Abstract Epstein-Barr virus (EBV) infection is recognised as one of the causative agents in most nasopharyngeal carcinoma (NPC) cases. Expression of EBV viral antigens can induce host's antiviral immune response by activating the inflammasomes to produce pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and IL-18. These cytokines are known to be detrimental to a wide range of virus-infected cells, in which they can activate an inflammatory cell death program, called pyroptosis. However, aberrant inflammasome activation and production of its downstream cytokines lead to chronic inflammation that may contribute to various diseases, including NPC. In this review, we summarise the roles of inflammasomes during viral infection, how EBV evades inflammasome-mediated immune response, and progress into tumourigenesis. The contrasting roles of inflammasomes in cancer, as well as the current therapeutic approaches used in targeting inflammasomes, are also discussed in this review. While the inflammasomes appear to have dual roles in carcinogenesis, there are still many questions that remain unanswered. In particular, the exact molecular mechanism responsible for the regulation of the inflammasomes during carcinogenesis of EBV-associated NPC has not been explored thoroughly. Furthermore, the current practical application of inflammasome inhibitors is limited to specific tumour types, hence, further studies are warranted to discover the potential of targeting the inflammasomes for the treatment of NPC.
    Sprache Englisch
    Erscheinungsdatum 2021-04-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13081786
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  9. Artikel: Novel Gemcitabine-Re(I) Bisquinolinyl Complex Combinations and Formulations With Liquid Crystalline Nanoparticles for Pancreatic Cancer Photodynamic Therapy.

    Liew, Hui Shan / Mai, Chun-Wai / Zulkefeli, Mohd / Madheswaran, Thiagarajan / Kiew, Lik Voon / Pua, Lesley Jia Wei / Hii, Ling Wei / Lim, Wei Meng / Low, May Lee

    Frontiers in pharmacology

    2022  Band 13, Seite(n) 903210

    Abstract: With less than 10% of 5-year survival rate, pancreatic ductal adenocarcinoma (PDAC) is known to be one of the most lethal types of cancer. Current literature supports that gemcitabine is the first-line treatment of PDAC. However, poor cellular ... ...

    Abstract With less than 10% of 5-year survival rate, pancreatic ductal adenocarcinoma (PDAC) is known to be one of the most lethal types of cancer. Current literature supports that gemcitabine is the first-line treatment of PDAC. However, poor cellular penetration of gemcitabine along with the acquired and intrinsic chemoresistance of tumor against it often reduced its efficacy and hence necessitates the administration of high gemcitabine dose during chemotherapy. Photodynamic therapy (PDT), a more selective and minimally invasive treatment, may be used synergistically with gemcitabine to reduce the doses utilized and dose-related side effects. This study reports the synergistic use of Re(I) bisquinolinyl complex, a transition metal complex photosensitizer with gemcitabine against PDAC. Re(I) bisquinolinyl complex was found to act synergistically with gemcitabine against PDAC
    Sprache Englisch
    Erscheinungsdatum 2022-07-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.903210
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Impact of Microplastics and Nanoplastics on Human Health.

    Yee, Maxine Swee-Li / Hii, Ling-Wei / Looi, Chin King / Lim, Wei-Meng / Wong, Shew-Fung / Kok, Yih-Yih / Tan, Boon-Keat / Wong, Chiew-Yen / Leong, Chee-Onn

    Nanomaterials (Basel, Switzerland)

    2021  Band 11, Heft 2

    Abstract: Plastics have enormous impacts to every aspect of daily life including technology, medicine and treatments, and domestic appliances. Most of the used plastics are thrown away by consumers after a single use, which has become a huge environmental problem ... ...

    Abstract Plastics have enormous impacts to every aspect of daily life including technology, medicine and treatments, and domestic appliances. Most of the used plastics are thrown away by consumers after a single use, which has become a huge environmental problem as they will end up in landfill, oceans and other waterways. These plastics are discarded in vast numbers each day, and the breaking down of the plastics from micro- to nano-sizes has led to worries about how toxic these plastics are to the environment and humans. While, there are several earlier studies reported the effects of micro- and nano-plastics have on the environment, there is scant research into their impact on the human body at subcellular or molecular levels. In particular, the potential of how nano-plastics move through the gut, lungs and skin epithelia in causing systemic exposure has not been examined thoroughly. This review explores thoroughly on how nanoplastics are created, how they behave/breakdown within the environment, levels of toxicity and pollution of these nanoplastics, and the possible health impacts on humans, as well as suggestions for additional research. This paper aims to inspire future studies into core elements of micro- and nano-plastics, the biological reactions caused by their specific and unusual qualities.
    Sprache Englisch
    Erscheinungsdatum 2021-02-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano11020496
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