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Article: Overweight and obese youth with type 1 or type 2 diabetes share similar elevation in triglycerides during middle and late adolescence.

Ashour, Dina / AlSubaihin, Abdulmajeed / Lim, Yvonne Yijuan / Legault, Laurent

2022 Volume 16, Issue 2, Page(s) 138–143

Abstract: Background: Overweight and obesity have been observed in children with type 1 diabetes (T1D). This further increases their future risk of Cardiovascular Disease (CVD) as well as the development of other risk factors, such as dyslipidemia.: Aims: To ... ...

Abstract	Background: Overweight and obesity have been observed in children with type 1 diabetes (T1D). This further increases their future risk of Cardiovascular Disease (CVD) as well as the development of other risk factors, such as dyslipidemia. Aims: To compare lipid profiles in children and adolescents with Type 1 diabetes and lean mass (T1L), Type 1 diabetes and overweight or obese (T1OW/OB), and type 2 diabetes (T2D). Methods: This was a cross-sectional study of 669 patients with T1D or T2D aged 2-19 years using retrospective data collected from 2003 to 2014. Included patients were categorized into lean (BMI < 85th ile and overweight or Obese (BMI ≥ 85th ile). Patients were subcategorized into three age groups: < 10 years, 10-14 years, and 15-19 years. Results: 7.6% of patients had T2D. Of the patients with T1D, 58.9% were lean, 26.4% were overweight, and 14.7% were obese. Total Cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C) and Non-HDL-C levels were similar across groups. In the 15-19 years group, Triglycerides (TG) levels were significantly higher in T1OW/OB and similar to T2D. High-density lipoprotein Cholesterol (HDL-C) was significantly lower in T2D. Weight status significantly correlated with TG and HDL-C levels in T1D and T2D groups. Conclusions: T1OW/OB constitutes a significant proportion of the T1D population. Patients with obesity and T1D, especially if in their late adolescence, have an adverse lipid profile pattern that is comparable to adolescents with T2D. Based on these findings, risk for future CVD in T1OW/OB and T2D may be equivalent.
MeSH term(s)	Adolescent ; Cardiovascular Diseases/epidemiology ; Child ; Cholesterol ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Obesity/complications ; Obesity/epidemiology ; Overweight/complications ; Retrospective Studies ; Triglycerides
Chemical Substances	Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-04-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2274031-4
ISSN	1878-0318 ; 1871-403X
ISSN (online)	1878-0318
ISSN	1871-403X
DOI	10.1016/j.orcp.2022.03.003
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Article ; Online: Engineering the Gut Microbiome for Treatment of Obesity: A Review of Current Understanding and Progress.

Lim, Yvonne Yijuan / Lee, Yung Seng / Ooi, Delicia Shu Qin

Biotechnology journal

2020 Volume 15, Issue 10, Page(s) e2000013

Abstract: Obesity is a complex, multifactorial disease that is increasing in prevalence despite extensive research and efforts to curb it. Over the last decade, gut microbiome has emerged as an important contributor to the pathogenesis of obesity. Microbiome ... ...

Abstract	Obesity is a complex, multifactorial disease that is increasing in prevalence despite extensive research and efforts to curb it. Over the last decade, gut microbiome has emerged as an important contributor to the pathogenesis of obesity. Microbiome profile is altered in obese phenotype and the causative role of microbiome in obesity is demonstrated in fecal microbiota transplantation studies. Herein, recent evidences supporting the role of gut microbiome in obesity and the current therapies designed to engineer gut microbiome for treatment of obesity will be reviewed. The microbial enterotypes associated with obesity is outlined, and the gut microbiota-driven metabolism and low-grade inflammation linking gut microbiome and obesity is examined. How the different intrinsic and extrinsic factors such as host genetics, mode of childbirth delivery, diet, lifestyle habits and use of antibiotics influence the composition of the gut microbiome in the development of obesity is evaluated. Also, the efficacy of current microbiome-based therapies in the forms of prebiotics, probiotics and engineered microbes that are used to manipulate gut microbiome in treating obesity is discussed.
MeSH term(s)	Gastrointestinal Microbiome ; Humans ; Microbiota ; Obesity/therapy ; Prebiotics ; Probiotics
Chemical Substances	Prebiotics
Language	English
Publishing date	2020-07-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2221885-3
ISSN	1860-7314 ; 1860-6768
ISSN (online)	1860-7314
ISSN	1860-6768
DOI	10.1002/biot.202000013
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Article ; Online: Screening for obstructive sleep apnea (OSA) in children and adolescents with obesity: A scoping review of national and international pediatric obesity and pediatric OSA management guidelines.

Ng, Nicholas Beng Hui / Lim, Carey Yun Shan / Tan, Sarah Caellainn Hui Lin / Foo, Yu Wah / Tok, Chanel Li Xuan / Lim, Yvonne Yijuan / Goh, Daniel Yam Thiam / Loke, Kah Yin / Lee, Yung Seng

Obesity reviews : an official journal of the International Association for the Study of Obesity

2024 Volume 25, Issue 5, Page(s) e13712

Abstract: Obstructive sleep apnea (OSA) is a prevalent complication that affects up to 60% of children and adolescents with obesity. It is associated with poorer cardiometabolic outcomes and neurocognitive deficits. Appropriate screening and intervention for OSA ... ...

Abstract	Obstructive sleep apnea (OSA) is a prevalent complication that affects up to 60% of children and adolescents with obesity. It is associated with poorer cardiometabolic outcomes and neurocognitive deficits. Appropriate screening and intervention for OSA are crucial in the management of children with obesity. We performed a scoping review of international and national pediatric obesity (n = 30) and pediatric OSA (n = 10) management guidelines to evaluate the recommendations on OSA screening in pediatric obesity. Sixteen (53%) of the pediatric obesity guidelines had incorporated OSA screening to varying extents, with no consistent recommendations on when and how to screen for OSA, and subsequent management of OSA in children with obesity. We provide our recommendations that are based on the strength and certainty of evidence presented. These include a clinical-based screening for OSA in all children with body mass index (BMI) ≥ 85th percentile or those with rapid BMI gain (upward crossing of 2 BMI percentiles) and the use of overnight polysomnography to confirm the diagnosis of OSA in those with high clinical suspicion. We discuss further management of OSA unique to children with obesity. An appropriate screening strategy for OSA would facilitate timely intervention that has been shown to improve cardiometabolic and neurocognitive outcomes.
MeSH term(s)	Adolescent ; Humans ; Child ; Pediatric Obesity/complications ; Pediatric Obesity/diagnosis ; Pediatric Obesity/therapy ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Sleep Apnea, Obstructive/complications ; Body Mass Index ; Polysomnography ; Cardiovascular Diseases/complications
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2147980-X
ISSN	1467-789X ; 1467-7881
ISSN (online)	1467-789X
ISSN	1467-7881
DOI	10.1111/obr.13712
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Article ; Online: Screening for metabolic complications of childhood and adolescent obesity: A scoping review of national and international guidelines.

Lim, Carey Yun Shan / Foo, Yu Wah / Tok, Chanel Li Xuan / Lim, Yvonne Yijuan / Loke, Kah Yin / Lee, Yung Seng / Ng, Nicholas Beng Hui

Obesity reviews : an official journal of the International Association for the Study of Obesity

2022 Volume 23, Issue 12, Page(s) e13513

Abstract: The rise in prevalence of childhood obesity is paralleled by an increase in obesity-related metabolic complications, which add significantly to the population burden of cardiovascular morbidity in the long term. Early detection of obesity-related ... ...

Abstract	The rise in prevalence of childhood obesity is paralleled by an increase in obesity-related metabolic complications, which add significantly to the population burden of cardiovascular morbidity in the long term. Early detection of obesity-related metabolic complications through appropriate screening strategies forms a crucial aspect of obesity management. We performed a scoping review of international and national guidelines on the management of pediatric obesity to evaluate the recommendations on screening for metabolic complications, namely, hypertension, diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Thirty guidelines were included, 23 (76.7%) of which had some guidance on screening for metabolic complications. However, there were significant variations in the extent and details of recommendations for screening for these metabolic complications. There has been no consensus on the body mass index (BMI) thresholds, age of onset, frequency, and screening tests recommended for detecting hypertension, diabetes, dyslipidemia, and non-alcoholic fatty liver disease between guidelines. These variations did not appear to be polarized based on geographical location or population ethnicity. We provide our recommendations on metabolic screening based on the strength of evidence in the guidelines, also incorporating recommendations from key childhood hypertension, diabetes, and lipid guidelines. Appropriate implementation of screening strategies is crucial to improve detection of metabolic complications, to allow for earlier or more intensified interventions for affected children with obesity.
MeSH term(s)	Child ; Adolescent ; Humans ; Pediatric Obesity/complications ; Pediatric Obesity/diagnosis ; Pediatric Obesity/epidemiology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/etiology ; Diabetes Mellitus ; Hypertension ; Dyslipidemias/diagnosis ; Dyslipidemias/epidemiology ; Dyslipidemias/etiology ; Risk Factors
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2147980-X
ISSN	1467-789X ; 1467-7881
ISSN (online)	1467-789X
ISSN	1467-7881
DOI	10.1111/obr.13513
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Article ; Online: Screening for metabolic complications of childhood and adolescent obesity: A scoping review of national and international guidelines

Lim, Carey Yun Shan / Foo, Yu Wah / Tok, Chanel Li Xuan / Lim, Yvonne Yijuan / Loke, Kah Yin / Lee, Yung Seng / Ng, Nicholas Beng Hui

Obesity Reviews. 2022 Dec., v. 23, no. 12 p.e13513-

2022

Abstract: The rise in prevalence of childhood obesity is paralleled by an increase in obesity‐related metabolic complications, which add significantly to the population burden of cardiovascular morbidity in the long term. Early detection of obesity‐related ... ...

Abstract	The rise in prevalence of childhood obesity is paralleled by an increase in obesity‐related metabolic complications, which add significantly to the population burden of cardiovascular morbidity in the long term. Early detection of obesity‐related metabolic complications through appropriate screening strategies forms a crucial aspect of obesity management. We performed a scoping review of international and national guidelines on the management of pediatric obesity to evaluate the recommendations on screening for metabolic complications, namely, hypertension, diabetes, dyslipidemia, and non‐alcoholic fatty liver disease. Thirty guidelines were included, 23 (76.7%) of which had some guidance on screening for metabolic complications. However, there were significant variations in the extent and details of recommendations for screening for these metabolic complications. There has been no consensus on the body mass index (BMI) thresholds, age of onset, frequency, and screening tests recommended for detecting hypertension, diabetes, dyslipidemia, and non‐alcoholic fatty liver disease between guidelines. These variations did not appear to be polarized based on geographical location or population ethnicity. We provide our recommendations on metabolic screening based on the strength of evidence in the guidelines, also incorporating recommendations from key childhood hypertension, diabetes, and lipid guidelines. Appropriate implementation of screening strategies is crucial to improve detection of metabolic complications, to allow for earlier or more intensified interventions for affected children with obesity.
Keywords	adolescents ; body mass index ; childhood ; childhood obesity ; diabetes ; fatty liver ; hyperlipidemia ; hypertension ; lipids ; morbidity ; nationalities and ethnic groups
Language	English
Dates of publication	2022-12
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	2147980-X
ISSN	1467-789X ; 1467-7881
ISSN (online)	1467-789X
ISSN	1467-7881
DOI	10.1111/obr.13513
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Article ; Online: Quality of life and psychosocial outcomes among children with metabolically healthy and unhealthy obesity.

Ooi, Delicia Shu Qin / Ong, Siong Gim / Chia, Jace Ming Xuan / Lim, Yvonne Yijuan / Ho, Cindy Wei Li / Tay, Veronica / Vijaya, K / Loke, Kah Yin / Sng, Andrew Anjian / Griva, Konstadina / Lee, Yung Seng

Pediatric research

2023 Volume 94, Issue 3, Page(s) 1089–1097

Abstract: Background: Obesity and obesity-related morbidities are associated with poor psychosocial adjustment and health-related quality of life (HRQoL). This study aims to examine HRQoL and psychosocial outcomes in children with metabolically healthy obesity ( ... ...

Abstract	Background: Obesity and obesity-related morbidities are associated with poor psychosocial adjustment and health-related quality of life (HRQoL). This study aims to examine HRQoL and psychosocial outcomes in children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO), and the effects of familial health on these outcomes. Methods: Four hundred and six children with BMI for age ≥ 97th percentile were classified as having MHO and MUO based on the absence or presence of metabolic abnormalities. HRQoL and psychosocial outcomes were assessed using validated questionnaires such as PedsQL and DASS-21. Results: There were no significant differences in HRQoL and psychosocial outcomes between children with MHO and children with MUO. Children with MUO and prior knowledge of existing metabolic conditions reported significantly lower total HRQoL (71.18 ± 17.42 vs. 75.34 ± 15.33), and higher depression (12.16 ± 11.80 vs. 8.95 ± 8.52) and stress (12.11 ± 8.21 vs. 10.04 ± 7.92) compared to children with MHO. Children with MUO who had fathers with metabolically unhealthy phenotype reported significantly lower total HRQoL (72.41 ± 15.67 vs. 76.82 ± 14.91) compared to children with MUO who had fathers with metabolically healthy phenotype. Conclusion: Prior knowledge of existing metabolic abnormalities was associated with poorer HRQoL and mental health in children with obesity. Paternal metabolic health status influenced HRQoL in children with MUO. Impact: First study that compared health-related quality of life (HRQoL) and psychosocial outcomes between children with metabolically healthy obesity (MHO) and children with metabolically unhealthy obesity (MUO). No significant differences in HRQoL and psychosocial outcomes between children with metabolically healthy obesity (MHO) and children with metabolically unhealthy obesity (MUO). Children with MUO who had prior knowledge of existing metabolic conditions reported lower HRQoL, higher depression and stress compared to children with MHO. Paternal metabolic health status was found to influence HRQoL in children with MUO. Mental health support intervention with paternal involvement should be provided for children with MUO.
MeSH term(s)	Humans ; Metabolic Syndrome/metabolism ; Obesity, Metabolically Benign ; Quality of Life ; Obesity/complications ; Health Status ; Phenotype ; Body Mass Index ; Risk Factors
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-02572-8
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Article ; Online: The effects of glucagon-like peptide (GLP)-1 receptor agonists on weight and glycaemic control in Prader-Willi syndrome: A systematic review.

Ng, Nicholas Beng Hui / Low, Yue Wey / Rajgor, Dimple Dayaram / Low, Jia Ming / Lim, Yvonne Yijuan / Loke, Kah Yin / Lee, Yung Seng

Clinical endocrinology

2021 Volume 96, Issue 2, Page(s) 144–154

Abstract: Objective: The mainstay management of hyperphagia and obesity in Prader-Willi syndrome (PWS) relies on dietary restrictions, strict supervision and behavioural modifications, which can be stressful for the patient and caregiver. There is no established ... ...

Abstract	Objective: The mainstay management of hyperphagia and obesity in Prader-Willi syndrome (PWS) relies on dietary restrictions, strict supervision and behavioural modifications, which can be stressful for the patient and caregiver. There is no established pharmacological strategy to manage this aspect of PWS. Theoretically, glucagon-like peptide-1 (GLP-1) receptor agonists (GLP1-RA) used in patients with obesity and type 2 diabetes mellitus (T2DM) may be efficacious in weight and glycaemic control of PWS patients. We conducted a systematic review of the literature to summarize the evidence on the use of GLP1-RA in PWS patients. Design: Primary studies were searched in major databases using key concepts 'Prader-Willi syndrome' and 'GLP1 receptor agonist' and outcomes, 'weight control OR glycaemic control OR appetite regulation'. Results: Ten studies included, summarizing GLP1-RA use in 23 PWS patients (age, 13-37 years), who had used either exenatide (n = 14) or liraglutide (n = 9) over a duration of 14 weeks to 4 years. Sixteen (70%) of these patients had T2DM. Ten patients experienced improvement in body mass index, ranging from 1.5 to 16.0 kg/m Conclusions: GLP1-RA appears safe in PWS patients and may have potential benefits for weight, glycaemic and appetite control. Nonetheless, we also highlight a significant gap in the literature on the lack of well-designed studies in this area, which limits the recommendation of GLP1-RA use in PWS patients at present.
MeSH term(s)	Adolescent ; Adult ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor ; Glycemic Control ; Humans ; Liraglutide/therapeutic use ; Prader-Willi Syndrome/drug therapy ; Young Adult
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Liraglutide (839I73S42A) ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2021-08-26
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.14583
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Article ; Online: Prevalence and predictors of metabolically healthy obesity in severely obese Asian children.

Ooi, Delicia Shu Qin / Ong, Siong Gim / Lee, Owen Ming Hao / Chan, Yiong Huak / Lim, Yvonne Yijuan / Ho, Cindy Wei Li / Tay, Veronica / Vijaya, K / Loke, Kah Yin / Sng, Andrew Anjian / Lee, Yung Seng

Pediatric research

2022 Volume 92, Issue 5, Page(s) 1374–1380

Abstract: Background: Obese individuals who have little or no metabolic syndrome components are proposed to be "metabolically healthy obese (MHO)". This study aim to evaluate the prevalence of MHO and examine the predictors associated with MHO in a multi-ethnic ... ...

Abstract	Background: Obese individuals who have little or no metabolic syndrome components are proposed to be "metabolically healthy obese (MHO)". This study aim to evaluate the prevalence of MHO and examine the predictors associated with MHO in a multi-ethnic Asian cohort of severely obese children. Methods: This study included a cross-sectional cohort of 406 Chinese, Malay and Indian children aged 5-20 years old with BMI for age ≥ 97th percentile. Metabolic syndrome (MS) and metabolic health (MH) definitions based on the presence or absence of metabolic abnormalities (High triglycerides, low HDL cholesterol, elevated blood pressure and high glucose) were used to define MHO in the cohort. Results: The prevalence of MHO is 63.5% by MS definition and 22.4% by MH definition. Maternal healthy metabolic status (OR: 2.47), age (OR: 0.83, 0.80), paternal obesity (OR: 0.48, 0.53), Malay (OR: 1.97) and Indian ethnicity (OR: 6.38, 3.21) (compared to Chinese ethnicity) are independent predictors for MHO phenotype based on different MHO definitions. Conclusions: Adiposity measures are not associated with MHO phenotype, but instead younger age, maternal healthy metabolic status, absence of paternal obesity, Malay and Indian ethnicity are independent predictors for MHO phenotype in a multi-ethnic Asian cohort of severely obese children. Impact: The prevalence of metabolically healthy obese (MHO) in our multi-ethnic Asian cohort of severely obese children is 63.5% and 22.4%, respectively, based on different MHO definitions. Adiposity measures are not associated with the MHO phenotype. There are other factors that contribute to the metabolic phenotype in obese individuals. Younger age, maternal healthy metabolic status, absence of paternal obesity, Malay and Indian ethnicity are independent predictors for MHO phenotype. Parental influence is important in predicting metabolic health in obese individuals.
MeSH term(s)	Humans ; Obesity, Metabolically Benign/diagnosis ; Obesity, Metabolically Benign/epidemiology ; Prevalence ; Pediatric Obesity/diagnosis ; Pediatric Obesity/epidemiology ; Cross-Sectional Studies ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Status Epilepticus ; Body Mass Index ; Phenotype ; Risk Factors
Language	English
Publishing date	2022-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-022-01941-z
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Article ; Online: Association of leukocyte telomere length with obesity-related traits in Asian children with early-onset obesity.

Ooi, Delicia Shu Qin / Dorajoo, Rajkumar / Gurung, Resham L / Dehghan, Roghayeh / Lim, Yvonne Yijuan / Ho, Cindy Wei Li / Tay, Veronica / Karuppiah, Vijaya / Loke, Kah Yin / Lim, Su Chi / Liu, Jian-Jun / Sng, Andrew Anjian / Lee, Yung Seng

Pediatric obesity

2021 Volume 16, Issue 8, Page(s) e12771

Abstract: Background: Leukocyte telomere length (LTL) is associated with obesity and obesity-related traits, and there are ethnic-specific determinants of LTL.: Objective: To evaluate LTL associations with obesity and metabolic parameters in Asian children ... ...

Abstract	Background: Leukocyte telomere length (LTL) is associated with obesity and obesity-related traits, and there are ethnic-specific determinants of LTL. Objective: To evaluate LTL associations with obesity and metabolic parameters in Asian children with early-onset obesity. Methods: Genomic DNA was extracted from peripheral blood leukocytes of a cohort of children with (N = 371) and without obesity (N = 23), and LTL was measured using quantitative PCR (qPCR). Blood plasma was used for metabolic phenotyping. Statistical analysis was performed using SPSS and STATA. Results: Children with obesity had shorter LTL (coefficient = -0.683, P Conclusions: We showed for the first time that Asian children with severe obesity had shorter LTL, and the shortening of LTL was associated with other adiposity measures including waist circumference and skin-fold measurements.
MeSH term(s)	Age of Onset ; Asia/epidemiology ; Child ; Humans ; Leukocytes ; Pediatric Obesity/epidemiology ; Pediatric Obesity/genetics ; Telomere
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2655527-X
ISSN	2047-6310 ; 2047-6302
ISSN (online)	2047-6310
ISSN	2047-6302
DOI	10.1111/ijpo.12771
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Article ; Online: Engineering microbes for targeted strikes against human pathogens.

Hwang, In Young / Lee, Hui Ling / Huang, James Guoxian / Lim, Yvonne Yijuan / Yew, Wen Shan / Lee, Yung Seng / Chang, Matthew Wook

Cellular and molecular life sciences : CMLS

2018 Volume 75, Issue 15, Page(s) 2719–2733

Abstract: Lack of pathogen specificity in antimicrobial therapy causes non-discriminant microbial cell killing that disrupts the microflora present. As a result, potentially helpful microbial cells are killed along with the pathogen, altering the biodiversity and ... ...

Abstract	Lack of pathogen specificity in antimicrobial therapy causes non-discriminant microbial cell killing that disrupts the microflora present. As a result, potentially helpful microbial cells are killed along with the pathogen, altering the biodiversity and dynamic interactions within the population. Moreover, the unwarranted exposure of antibiotics to microbes increases the likelihood of developing resistance and perpetuates the emergence of multidrug resistance. Synthetic biology offers an alternative solution where specificity can be conferred to reduce the non-specific, non-targeted activity of currently available antibiotics, and instead provides targeted therapy against specific pathogens and minimising collateral damage to the host's inherent microbiota. With a greater understanding of the microbiome and the available genetic engineering tools for microbial cells, it is possible to devise antimicrobial strategies for novel antimicrobial therapy that are able to precisely and selectively remove infectious pathogens. Herein, we review the strategies developed by unlocking some of the natural mechanisms used by the microbes and how these may be utilised in targeted antimicrobial therapy, with the promise of reducing the current global bane of multidrug antimicrobial resistance.
MeSH term(s)	Anti-Infective Agents/metabolism ; Anti-Infective Agents/therapeutic use ; Bacteria/genetics ; Bacteria/metabolism ; Bacteriophages/genetics ; Bacteriophages/metabolism ; Communicable Diseases/diagnosis ; Communicable Diseases/therapy ; Fecal Microbiota Transplantation ; Genetic Engineering ; Humans ; Microbiota ; Phage Therapy ; Probiotics/therapeutic use
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2018-05-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-018-2827-7
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Kategorien

In stock of ZB MED Cologne/Königswinter

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Full text online

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito