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  1. Article: Oropharyngeal Hemorrhage and Difficult Airway Management: A Decision Not to Intubate.

    Ramos, Rui A / Aguiar, Ana Rita / Lima, Clara Gaio / Resende, Rita

    The Journal of emergency medicine

    2023  Volume 66, Issue 2, Page(s) 133–138

    Abstract: Background: Bleeding in the upper airways is an important cause of airway-related death. A higher incidence of airway management failure and complications after intubation attempts in the emergency department (ED) had been suggested. Airway management ... ...

    Abstract Background: Bleeding in the upper airways is an important cause of airway-related death. A higher incidence of airway management failure and complications after intubation attempts in the emergency department (ED) had been suggested. Airway management of patients with active oropharyngeal hemorrhage may be challenging, leading the clinician to modify the approach.
    Case report: A 57-year-old woman presented to the ED with oropharyngeal hemorrhage after an extensive invasive dental procedure. She was on long-term warfarin therapy due to aortic and mitral valve replacement, which she suspended 5 days prior and restarted the day after the procedure. Besides the active bleeding, swelling, and hematoma of the face, the patient had other signs of "difficult airway," so there were serious questions on when and how to manage the airway. Several strategies to address the airway were considered, the main point being an early versus later intubation. As the patient remained clinically stable, she was conservatively managed with local hemostasis and coagulopathy reversal. The patient was transferred to the intensive care unit, where she remained stable and was successfully discharged after restart on warfarin. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: When faced with an oropharyngeal hemorrhage, emergency physicians may be compelled to secure and protect the airway. This could be achieved by planning several strategies. Nevertheless, in selected patients, and considering the circumstances, not addressing the airway is a reasonable and justifiable alternative.
    MeSH term(s) Female ; Humans ; Middle Aged ; Warfarin/therapeutic use ; Hemorrhage/etiology ; Hemorrhage/therapy ; Airway Management/methods ; Hematoma ; Intubation ; Intubation, Intratracheal/methods
    Chemical Substances Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2023.10.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cerebral Air Embolism Following Transthoracic Lung Biopsy Successfully Treated With Hyperbaric Oxygen.

    Silva, Mafalda / Gaio-Lima, Clara / Camacho, Óscar / Ribeiro, Joana

    Cureus

    2022  Volume 14, Issue 12, Page(s) e32933

    Abstract: Transthoracic lung biopsy is a frequently performed procedure performed worldwide. Although rare, air embolism is a potentially fatal complication. Rapid diagnosis and immediate treatment are essential to prevent patient clinical deterioration. ... ...

    Abstract Transthoracic lung biopsy is a frequently performed procedure performed worldwide. Although rare, air embolism is a potentially fatal complication. Rapid diagnosis and immediate treatment are essential to prevent patient clinical deterioration. Hyperbaric oxygen treatment is the standard of care in air embolism and time referral is critical for patient prognosis. We report a case of a man who underwent a percutaneous transthoracic lung biopsy which was complicated with arterial air embolism and severe neurologic symptoms; he was successfully treated with hyperbaric chamber treatment. Physicians performing such techniques should be aware of this severe complication as immediate support treatment and hyperbaric oxygen may prevent irreversible neurologic lesions.
    Language English
    Publishing date 2022-12-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.32933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Contexto de trabalho e custo humano no trabalho para agentes comunitários de saúde.

    Lima, Clara Cynthia Melo E / Fernandes, Tatiana Fróes / Caldeira, Antônio Prates

    Ciencia & saude coletiva

    2022  Volume 27, Issue 8, Page(s) 3181–3192

    Abstract: The scope of this study was to evaluate the work context and the occupational health cost among Community Health Workers (CHWs). It is a cross-sectional, census study, using a socioeconomic questionnaire, the Work Context Assessment Scale (WCAS) and the ... ...

    Title translation Work context and the occupational health cost for community health workers.
    Abstract The scope of this study was to evaluate the work context and the occupational health cost among Community Health Workers (CHWs). It is a cross-sectional, census study, using a socioeconomic questionnaire, the Work Context Assessment Scale (WCAS) and the Human Cost at Work Scale (HCWS), which make up the Inventory of Work and Illness Risk (IWIR). Descriptive analyses of mean factor scores were performed and comparison of means between items and sociodemographic characteristics of the group, through Mann-Whitney and Kruskal-Wallis's tests with a 5% significance level. A total of 675 CHWs participated in the study. All factors related to working conditions and human cost at work presented a moderate/critical evaluation. Age, length of service and employment ties were variables associated with all factors of WCAS, while only length of service was associated with all factors for CHWs. More negative assessments of the work context and the occupational health cost were more evident among CHWs with longer experience. The results highlight the need to improve working conditions and professional relationships related to CHW.
    MeSH term(s) Community Health Workers ; Cross-Sectional Studies ; Employment ; Humans ; Occupational Health ; Workplace
    Language Portuguese
    Publishing date 2022-03-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2078799-6
    ISSN 1678-4561 ; 1678-4561
    ISSN (online) 1678-4561
    ISSN 1678-4561
    DOI 10.1590/1413-81232022278.19192021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of hyperbaric oxygen therapy in the treatment of radiation lesions.

    Gaio-Lima, Clara / Castedo, João / Cruz, Mafalda / Candeias, Margarida / Camacho, Óscar

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2022  Volume 24, Issue 12, Page(s) 2466–2474

    Abstract: Introduction: Cancer remains one of the leading causes of death worldwide, with 50-60% of patients requiring radiotherapy during the course of treatment. Patients' survival rate has increased significantly, with an inevitable increase in the number of ... ...

    Abstract Introduction: Cancer remains one of the leading causes of death worldwide, with 50-60% of patients requiring radiotherapy during the course of treatment. Patients' survival rate has increased significantly, with an inevitable increase in the number of patients experiencing side effects from cancer therapy. One such effect is late radiation injuries in which hyperbaric oxygen therapy appears as complementary treatment. With this work we intend to divulge the results of applying hyperbaric oxygen therapy among patients presenting radiation lesions in our Hyperbaric Medicine Unit.
    Materials and methods: Retrospective analysis of clinical records of patients with radiation lesions treated at the Hyperbaric Medicine Unit assessed by the scale Late Effects of Normal Tissues-Subjective, Objective, Management, Analytical (LENT-SOMA) before and after treatment, between October 2014 and September 2019 were included. Demographic characteristics, primary tumor site, subjective assessment of the LENT-SOMA scale before and after treatment were collected and a comparative analysis (Students t test) was done.
    Results: 88 patients included: 33 with radiation cystitis, 20 with radiation proctitis, 13 with osteoradionecrosis of the mandible and 22 with radiation enteritis. In all groups, there was a significant decrease (p < 0.005) in the subjective parameter of the LENT-SOMA scale.
    Discussion: Late radiation lesions have a major influence on patients' quality of life. In our study hyperbaric oxygen therapy presents as an effective therapy after the failure of conventional treatments.
    Conclusion: Hyperbaric oxygen therapy is an effective complementary therapy in the treatment of refractory radiation lesions.
    MeSH term(s) Humans ; Hyperbaric Oxygenation/adverse effects ; Hyperbaric Oxygenation/methods ; Neoplasms/complications ; Neoplasms/radiotherapy ; Proctitis/complications ; Proctitis/therapy ; Quality of Life ; Radiation Injuries/etiology ; Radiation Injuries/therapy ; Retrospective Studies
    Language English
    Publishing date 2022-08-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-022-02892-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Working conditions and mental health of community health workers in the COVID-19 pandemic.

    Fernandes, Tatiana Fróes / Lima, Clara Cynthia Melo E / Silva, Patrick Leonardo Nogueira da / Rossi-Barbosa, Luiza Augusta Rosa / Pinho, Lucineia de / Caldeira, Antônio Prates

    Ciencia & saude coletiva

    2023  Volume 28, Issue 10, Page(s) 2931–2940

    Abstract: This study examined the prevalence of anxiety and depression associated with Community Health Workers' (CHWs') working conditions in the context of the COVID-19 pandemic. This cross-sectional study was carried out in the north of Minas Gerais, Brazil by ... ...

    Title translation Condições de trabalho e saúde mental de agentes comunitários de saúde na pandemia de COVID-19.
    Abstract This study examined the prevalence of anxiety and depression associated with Community Health Workers' (CHWs') working conditions in the context of the COVID-19 pandemic. This cross-sectional study was carried out in the north of Minas Gerais, Brazil by applying a questionnaire addressing sociodemographic conditions, command of technologies and working conditions during the pandemic, as well as the State-Trait Anxiety Inventory and the Patient Health Questionnare-9 (PHQ-9). Descriptive and multiple Poisson regression analyses were performed with robust variance, to a 5% level of significance (p < 0.05) for the final model. A total of 1,220 CHWs from 36 municipalities participated in the study. Prevalences were 41.8% and 31.6% for anxiety and depression, respectively, while 22.5% of the group displayed symptoms of both conditions. Being female, up to 40 years old, having more than 500 users registered for monitoring, and inadequate supply of personal protective equipment were associated with anxiety and depression among the CHWs. Prevalence of anxiety and depression was high among CHWs during the pandemic and working conditions figured prominently among the associated factors.
    MeSH term(s) Humans ; Female ; Male ; COVID-19/epidemiology ; Pandemics ; Mental Health ; Community Health Workers ; Cross-Sectional Studies ; Working Conditions ; Depression/epidemiology ; Depression/psychology ; Anxiety/epidemiology ; Anxiety/psychology ; Health Personnel/psychology
    Language English
    Publishing date 2023-06-26
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2078799-6
    ISSN 1678-4561 ; 1678-4561
    ISSN (online) 1678-4561
    ISSN 1678-4561
    DOI 10.1590/1413-812320232810.09802023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Characterization and Proteomic Analysis of Plasma EVs Recovered from Healthy and Diseased Dogs with Canine Leishmaniosis.

    Esteves, Sofia / Lima, Clara / Costa, Inês / Osório, Hugo / Fernandez-Becerra, Carmen / Santarém, Nuno / Cordeiro-da-Silva, Anabela

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Dogs are highly valued companions and work animals that are susceptible to many life-threatening conditions such as canine leishmaniosis (CanL). Plasma-derived extracellular vesicles (EVs), exploited extensively in biomarker discovery, constitute a ... ...

    Abstract Dogs are highly valued companions and work animals that are susceptible to many life-threatening conditions such as canine leishmaniosis (CanL). Plasma-derived extracellular vesicles (EVs), exploited extensively in biomarker discovery, constitute a mostly untapped resource in veterinary sciences. Thus, the definition of proteins associated with plasma EVs recovered from healthy and diseased dogs with a relevant pathogen would be important for biomarker development. For this, we recovered, using size-exclusion chromatography (SEC), EVs from 19 healthy and 20 CanL dogs' plasma and performed proteomic analysis by LC-MS/MS to define their core proteomic composition and search for CanL-associated alterations. EVs-specific markers were identified in all preparations and also non-EVs proteins. Some EVs markers such as CD82 were specific to the healthy animals, while others, such as the Integrin beta 3 were identified in most samples. The EVs-enriched preparations allowed the identification of 529 canine proteins that were identified in both groups, while 465 and 154 were only identified in healthy or CanL samples, respectively. A GO enrichment analysis revealed few CanL-specific terms.
    MeSH term(s) Dogs ; Animals ; Leishmaniasis, Visceral/veterinary ; Chromatography, Liquid ; Proteomics ; Leishmania infantum ; Tandem Mass Spectrometry ; Leishmaniasis/veterinary ; Biomarkers ; Dog Diseases
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065490
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  7. Article ; Online: Consumer acceptability and fragrance quality differentiate on of Mogiana coffee types using the Check-All-That-Apply (CATA) method.

    Benedito, Luiza Z / Lima, Clara Mariana G / Pires, Fabiana C / Amaral, Ana Elisa / Verruck, Silvani / Pereira, Rosemary G F A

    Anais da Academia Brasileira de Ciencias

    2023  Volume 95, Issue 2, Page(s) e20200889

    Abstract: Coffee, one of the most produced and consumed beverage in the world, has a range of variability in its quality. The aim of this work was to evaluate the consumer capacity to perceive the coffee quality through their fragrance and to verify the influence ... ...

    Abstract Coffee, one of the most produced and consumed beverage in the world, has a range of variability in its quality. The aim of this work was to evaluate the consumer capacity to perceive the coffee quality through their fragrance and to verify the influence of previous information about quality on this perception using hedonic scale and Check All That Apply (CATA) sensory tests. The sensory tests were performed in two stages, one without and the other with quality related information of Mogiana coffee samples (Rio, Hard and Soft), and a traditional coffee sample. CATA attributes frequency of occurrence shows that samples discrimination could be done with specific attributes. For Soft coffee the attributes with more occurrence were sweet, caramel, brown sugar, and smooth. The Hard coffee sample was described by the attributes peanut, buttery, and chocolate. While for Rio coffee, the descriptive attributes most often mentioned were strong and burnt. The traditional sample stood out among consumers for its characteristics of old, medicine, sour, burnt, unpleasant and spicy. Therefore, the use of coffee powder fragrance can be alternative to differentiate the quality of the product and its function can be enhanced by passing on information on quality attributes to consumers.
    MeSH term(s) Coffee ; Odorants ; Beverages ; Food ; Arachis
    Chemical Substances Coffee
    Language English
    Publishing date 2023-06-16
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2046885-4
    ISSN 1678-2690 ; 0001-3765
    ISSN (online) 1678-2690
    ISSN 0001-3765
    DOI 10.1590/0001-3765202320200889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Serological and Molecular Survey of

    Lima, Clara M / Santarém, Nuno / Neves, Nuno Costa / Sarmento, Pedro / Carrapato, Carlos / de Sousa, Rita / Cardoso, Luís / Cordeiro-da-Silva, Anabela

    Microorganisms

    2022  Volume 10, Issue 12

    Abstract: Leishmania infantum, the sand fly-transmitted protozoan parasite responsible for leishmaniasis in humans, dogs, and cats, is endemic in the Iberian Peninsula. However, the impact of L. infantum infection on the conservation of the endangered Iberian lynx ...

    Abstract Leishmania infantum, the sand fly-transmitted protozoan parasite responsible for leishmaniasis in humans, dogs, and cats, is endemic in the Iberian Peninsula. However, the impact of L. infantum infection on the conservation of the endangered Iberian lynx (Lynx pardinus) is unknown. Herein, we describe for the first time the occurrence of L. infantum infection among a population of reintroduced and wild-born L. pardinus living in the Portuguese Guadiana Valley Park. The presence of infection was addressed by molecular detection of Leishmania kinetoplast DNA (kDNA) in 35 lynxes, with further confirmation of L. infantum species performed by an internally transcribed spacer (ITS)-1 sequencing. Eight blood samples were positive for kDNA, and ITS-1 sequencing confirmed the presence of L. infantum in two of those samples. Exposure to Leishmania was screened in a group of 36 lynxes using an immunofluorescence antibody test (IFAT) and a multi-antigen enzyme-linked immunosorbent assay (ELISA), using SPLA, rK39, and CPX as Leishmania-specific antigens. Four animals presented a positive IFAT at a dilution of 1:40. Eight samples were considered seropositive to all ELISA Leishmania-specific antigens. Agreement between PCR, IFAT, and all ELISA antigens was found for 1 in 27 samples. These results highlight the susceptibility of autochthonous L. pardinus to L. infantum infection. Further investigation is required to assess the impact of L. infantum infection on this wild species conservation.
    Language English
    Publishing date 2022-12-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10122447
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  9. Article ; Online: Assessment of Immune and Clinical Response in Patients with Mucosal Leishmaniasis Treated with Pentavalent Antimony and Pentoxifylline.

    Cincura, Carolina / Costa, Rubia S / De Lima, Clara Monica F / Oliveira-Filho, Jamary / Rocha, Paulo Novis / Carvalho, Edgar M / Lessa, Marcus M

    Tropical medicine and infectious disease

    2022  Volume 7, Issue 11

    Abstract: Mucosal leishmaniasis (ML) is a severe form of tegumentary leishmaniasis associated with a persistent inflammatory response. High levels of TNF, IFN-γ, CXCL9 and CXCL10 are found in ML patients, and the association of pentoxifylline with antimony is more ...

    Abstract Mucosal leishmaniasis (ML) is a severe form of tegumentary leishmaniasis associated with a persistent inflammatory response. High levels of TNF, IFN-γ, CXCL9 and CXCL10 are found in ML patients, and the association of pentoxifylline with antimony is more effective in decreasing the healing time in ML patients when compared to antimony alone. The present study aimed to investigate the existence of a correlation between cytokine and chemokine production and ML severity and evaluate the potential value of cytokine and chemokine production as marker of therapeutic response in ML patients. This prospective study included 86 subjects in an area of endemic
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed7110383
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  10. Article ; Online: Mucormycosis in the COVID-19 Environment: A Multifaceted Complication.

    Sharma, Rohit / Kumar, Praveen / Rauf, Abdur / Chaudhary, Ashun / Prajapati, Pradeep Kumar / Emran, Talha Bin / Gonçalves Lima, Clara Mariana / Conte-Junior, Carlos Adam

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 937481

    Abstract: The second wave of coronavirus disease 2019 (COVID-19) caused severe infections with high mortality. An increase in the cases of COVID-19-associated mucormycosis (CAM) was reported predominantly in India. Commonly present in immunocompromised individuals, ...

    Abstract The second wave of coronavirus disease 2019 (COVID-19) caused severe infections with high mortality. An increase in the cases of COVID-19-associated mucormycosis (CAM) was reported predominantly in India. Commonly present in immunocompromised individuals, mucormycosis is often a life-threatening condition. Confounding factors and molecular mechanisms associated with CAM are still not well understood, and there is a need for careful research in this direction. In this review, a brief account of the diagnosis, management, and advancement in drug discovery for mucormycosis has been provided. Here, we summarize major factors that dictate the occurrence of mucormycosis in COVID-19 patients through the analysis of published literature and case reports. Major predisposing factors to mucormycosis appear to be uncontrolled diabetes, steroid therapy, and certain cancers. At the molecular level, increased levels of iron in COVID-19 might contribute to mucormycosis. We have also discussed the potential role and regulation of iron metabolism in COVID-19 patients in establishing fungal growth. Other factors including diabetes prevalence and fungal spore burden in India as contributing factors have also been discussed.
    MeSH term(s) COVID-19/complications ; Diabetes Mellitus ; Humans ; Immunocompromised Host ; India/epidemiology ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Mucormycosis/epidemiology
    Language English
    Publishing date 2022-07-18
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.937481
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