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Article: Treatment strategies and treatment-related adverse events in MG according to the age of onset.

Moura, João / Fernandes, Joana / Lima, Maria João / Sousa, Ana Paula / Samões, Raquel / Martins Silva, Ana / Santos, Ernestina

Frontiers in neurology

2024 Volume 15, Page(s) 1277420

Abstract: Introduction: Early-onset (EOMG) and late-onset (LOMG) are distinct groups of MG patients. It is unclear if treatment strategies and treatment-related adverse events may differ according to the age of MG onset.: Methods: This single-center ... ...

Abstract	Introduction: Early-onset (EOMG) and late-onset (LOMG) are distinct groups of MG patients. It is unclear if treatment strategies and treatment-related adverse events may differ according to the age of MG onset. Methods: This single-center retrospective study includes all MG patients followed at a tertiary center since 2007. We reviewed the electronic clinical records. Results: In total, 212 patients were identified, 142 (67.0%) females, with a median disease duration of 10 years. The median age of symptom onset was 42.0 (26.0-64.5) years, with 130 (61.3%) EOMG cases and 82 (38.7%) LOMG. EOMG were more frequently female, had longer disease duration and often more generalized MG ( Conclusion: Our study shows that treatment modalities are similar between EOMG and LOMG, while steroid-related adverse events appear to be distinct.
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1277420
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Role of Social Media Advertisement and Physical Activity on Eating Behaviors among the General Population in Saudi Arabia.

Aleid, Sara / Alshahrani, Najim Z / Alsedrah, Safa / Carvalho, Ana Branca / Lima, Maria João / Teixeira-Lemos, Edite / Raposo, António

Nutrients

2024 Volume 16, Issue 8

Abstract: Over the past few decades, people in Saudi Arabia have become less inclined to adopt active lifestyles and healthy eating habits due to the increasing use of digital technologies such as social media. The objective of this online-based cross-sectional ... ...

Abstract	Over the past few decades, people in Saudi Arabia have become less inclined to adopt active lifestyles and healthy eating habits due to the increasing use of digital technologies such as social media. The objective of this online-based cross-sectional study was to assess the role of social media food advertisements and physical activity on eating behaviors among the general population in Saudi Arabia (n = 471). Data were collected through a structured questionnaire, which consisted of four parts: (i) sociodemographic information, (ii) attitude towards social media, (iii) eating behaviors-related information, and (iv) exposure to and engagement with social media advertisements. The study's outcome variable, eating behaviors (healthy vs. unhealthy), was assessed using the following question: "Are you on a healthy diet (such as a balanced diet, keto, or low carb)?" A multiple binary logistic regression analysis was performed to investigate the factors that influence unhealthy eating behaviors. Approximately 79.6% of the participants had unhealthy eating behaviors. Participants who were not involved in daily physical activity were more likely to have unhealthy eating behaviors compared to their counterparts (adjusted odds ratio, AOR = 4.86). Participants who watched food ads on social media channels 1-3 times a week (AOR = 2.58) or daily (AOR = 3.49) were more likely to have unhealthy eating behaviors than their counterparts. Participants whose appetite to try foods increases always (AOR = 1.42) or usually (AOR = 2.88) after viewing ads on social media were more likely to have unhealthy eating behaviors. These findings suggest that policymakers should take immediate action to regulate food advertising policy to promote a healthy food environment across the country. Saudis should be encouraged to engage in more physical activity, which could support the maintenance of healthy eating patterns and lifestyles.
MeSH term(s)	Humans ; Saudi Arabia ; Social Media/statistics & numerical data ; Male ; Female ; Exercise ; Adult ; Feeding Behavior/psychology ; Advertising/methods ; Advertising/statistics & numerical data ; Cross-Sectional Studies ; Middle Aged ; Young Adult ; Surveys and Questionnaires ; Diet, Healthy/psychology ; Diet, Healthy/statistics & numerical data ; Adolescent ; Health Behavior
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081215
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Article ; Online: Study protocol for a pilot randomised controlled trial evaluating the feasibility and effectiveness of non-pharmacological interventions to recover functionality after a transient ischaemic attack or a minor stroke: the 'Back to Normal' trial.

Gonçalves, Micaela / Lima, Maria João / Fonseca, Ângelo / Duque, Cristina / Costa, Ana Rute / Cruz, Vitor Tedim

BMJ open

2023 Volume 13, Issue 4, Page(s) e069593

Abstract: Introduction: Transient ischaemic attack (TIA) and minor stroke are frequently assumed as temporary or non-disabling events. However, evidence suggests that these patients can experience relevant impairment and functional disability. Therefore, the ... ...

Abstract	Introduction: Transient ischaemic attack (TIA) and minor stroke are frequently assumed as temporary or non-disabling events. However, evidence suggests that these patients can experience relevant impairment and functional disability. Therefore, the present study aims to evaluate the feasibility and effectiveness of a 3-month multidomain intervention programme, composed of five non-pharmacological strategies, aimed at accelerating return to pre-event level of functionality in patients with TIA or minor stroke. Methods and analysis: Patients diagnosed with a TIA or a minor stroke are being recruited at the emergency or neurology departments of the Hospital Pedro Hispano, located in Matosinhos, Portugal (n=70). Those who accept to participate will be randomly allocated to two groups (1:1): (a) Intervention-receives a 3 months combined approach, initiating early post-event, composed of cognitive training, physical exercise, nutrition, psychoeducation and assessment/correction of hearing loss; (b) Control-participants will not be subject to any intervention. Both groups will receive the usual standard of care provided to these diseases. Recruitment began in May 2022 and is expected to continue until March 2023. Socio-demographic characteristics, lifestyles, health status, cognitive function, symptoms of anxiety and depression and quality of life will be assessed; as well as anthropometry, blood pressure and physical condition. Time to complete or partial recovery of instrumental activities of daily living will be assessed using an adapted version of the Frenchay Activities Index. All participants will be evaluated before the intervention and after 3 months. Ethics and dissemination: This study was approved by the Ethics Committee of the Local Health Unit of Matosinhos (Ref. 75/CES/JAS). Written informed consent will be required from all the participants; data protection and confidentiality will be also ensured. The findings of this project are expected to be submitted for publication in scientific articles, and the main results will be presented at relevant scientific meetings. Trial registration number: NCT05369637.
MeSH term(s)	Humans ; Ischemic Attack, Transient/prevention & control ; Quality of Life ; Feasibility Studies ; Pilot Projects ; Activities of Daily Living ; Stroke/prevention & control ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-069593
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Article ; Online: Study of the drying kinetics and calculation of mass transfer properties in hot air drying of Cynara cardunculus

Guiné Raquel P. F. / Lima Maria João

Open Agriculture, Vol 5, Iss 1, Pp 740-

2020 Volume 750

Abstract: In the present work, mass transfer properties of thistle flower (Cynara cardunculus L.) were evaluated for the convective drying carried out at temperatures between 35 and 65°C, with an air flow of 0.5 m/s. The calculations followed two different ... ...

Abstract	In the present work, mass transfer properties of thistle flower (Cynara cardunculus L.) were evaluated for the convective drying carried out at temperatures between 35 and 65°C, with an air flow of 0.5 m/s. The calculations followed two different algorithms, based on mathematical models derived from the thin layer drying equation and Fick’s second law of diffusion. The results obtained indicated that different methodologies resulted in different values of mass transfer properties, which is an alert that care must be taken when choosing which calculation method might be more appropriate in a specific practical application. In all cases, the values of moisture diffusion and mass transfer coefficient were found to increase with increasing operating temperature. The values of diffusivity increased from 2.7866 × 10−9 to 1.4027 × 10−8 m2/s for the thin layer model-based algorithm and from 1.9256 × 10−10 to 1.2033 × 10−9 m2/s for Fick’s equation model. The values of the mass transfer coefficient increased from 8.4335 × 10−8 to 8.4400 × 10−7 m/s and from 5.8277 × 10−9 to 7.2398 × 10−8 m/s, respectively, for the thin layer and Fick’s law-based models.
Keywords	convective drying ; diffusivity ; mass transfer coefficient ; activation energy ; Agriculture ; S ; Agriculture (General) ; S1-972
Subject code	660
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The platelet-to-lymphocyte ratio as an indirect outcome predictor in primary hypertension: a retrospective study.

Pinho, Rita / Ribeiro, Rui / Ferrão, Diana / Medeiros, Rui / Lima, Maria João / Almeida, Jorge / Freitas-Silva, Margarida

Porto biomedical journal

2023 Volume 8, Issue 4, Page(s) e220

Abstract: Background: Nondipper hypertensive patients have higher levels of platelet-to-lymphocyte ratio, a new studied inflammatory biomarker in primary hypertension. Furthermore, these patients have a higher risk of cardiovascular morbidity and mortality. This ... ...

Abstract	Background: Nondipper hypertensive patients have higher levels of platelet-to-lymphocyte ratio, a new studied inflammatory biomarker in primary hypertension. Furthermore, these patients have a higher risk of cardiovascular morbidity and mortality. This study aimed to assess the relationship between platelet-to-lymphocyte ratio and hypertensive pattern (dipper vs nondipper) and the association between the hypertensive pattern and major adverse cardiovascular events. Methods: A retrospective analysis was performed. One hundred fifty-three patients were included and classified as dipper or nondipper according to 24-hour ambulatory blood pressure measurements. Platelet-to-lymphocyte ratio was calculated based on complete blood count data. Results: The dipper group included 109 patients, and the nondipper group included 44 patients. Nondipper patients have 2.11 more risk of presenting a higher platelet-to-lymphocyte ratio than dipper individuals (odds ratio [OR] = 2.11; 95% CI, 1.220-3.664; Conclusions: Nondipper hypertensive individuals registered higher levels of platelet-to-lymphocyte ratio and earlier cardiovascular events than dipper patients. Therefore, platelet-to-lymphocyte ratio could be used as an indirect predictor of cardiovascular risk in primary hypertension and contribute to optimize preventive strategies.
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ISSN	2444-8672
ISSN (online)	2444-8672
DOI	10.1097/j.pbj.0000000000000220
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Article ; Online: Consumer Knowledge about Dietary Relevance of Fruits and Vegetables: A Study Involving Participants from Portugal and France.

Le Turc, Nolwenn / Silva, Ana Jaquelina / Florença, Sofia G / Raposo, António / Gonçalves, João Carlos / Lima, Maria João / Teixeira-Lemos, Edite / Guiné, Raquel P F

Nutrients

2024 Volume 16, Issue 2

Abstract: Fruits and vegetables are recommended as low-calorie foods that contribute to the proper intake of necessary micronutrients, macronutrients, and bioactive compounds with health benefits. However, the recommendations for the dietary intake of these foods ... ...

Abstract	Fruits and vegetables are recommended as low-calorie foods that contribute to the proper intake of necessary micronutrients, macronutrients, and bioactive compounds with health benefits. However, the recommendations for the dietary intake of these foods fail to be attained in most European countries. For this reason, promoting more knowledge about the health effects of fruits and vegetables is essential to decrease the incidence of chronic diseases. This study was conducted to investigate the knowledge of the health benefits of fruits and vegetables among the population of Portugal and France. The present work involved a questionnaire survey of 639 participants (257 from Portugal and 382 from France). The results revealed that most participants were young females (68.9%) with good education (76%) and an average weight range. They consumed a varied diet (57%) but had body dissatisfaction (63.2%). The respondents had good knowledge about the health effects of fruits and vegetables. However, the French population knew more about the theme than the Portuguese. Portuguese individuals were more likely to have incomplete information. Gender and education significantly influenced knowledge levels, with females and highly educated individuals demonstrating greater understanding. Dissatisfaction with body weight drives individuals to seek nutrition information. This investigation enhances our comprehension of the factors that affect knowledge of vegetable and fruit consumption among young adults in Portugal and France. Moreover, it highlights the importance of implementing focused educational programs to enhance nutrition literacy, particularly for less-aware demographic groups. Going forward, a more in-depth analysis of these factors could assist in creating more efficient strategies to encourage healthier dietary habits and improve nutrition literacy among these communities.
MeSH term(s)	Female ; Young Adult ; Humans ; Vegetables ; Fruit ; Portugal ; Diet ; France
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020287
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Article ; Online: Evaluation of texture in Serra da Estrela cheese manufactured in different dairies

Guiné Raquel P. F. / Fontes Luísa / Lima Maria João

Open Agriculture, Vol 4, Iss 1, Pp 475-

2019 Volume 486

Abstract: Serra da Estrela cheese is a traditional product from artisanal manufacture using raw ewe’s milk coagulated with dried, wild thistle flower. The present study aimed to investigate the variation of textural properties in Serra da Estrela cheeses ... ...

Abstract	Serra da Estrela cheese is a traditional product from artisanal manufacture using raw ewe’s milk coagulated with dried, wild thistle flower. The present study aimed to investigate the variation of textural properties in Serra da Estrela cheeses manufactured in different dairies through time, namely from April to June, following the end of the cheese making season. Three types of tests were conducted: compression, puncture and spreadability. These were carried out on samples coming from six different dairies situated in the PDO (Protected Designation of Origin) region of this type of cheese.
Keywords	cheese quality ; compression test ; puncture test ; spreadability ; Agriculture ; S ; Agriculture (General) ; S1-972
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnosis of monogenic small vessel disease-"real-world" application of the consensus recommendation of the European Academy of Neurology.

Carvalho, Vanessa / Ferreira, Paulo / Lima, Maria João / Calejo, Margarida / Tedim Cruz, Vitor

European journal of neurology

2021 Volume 28, Issue 6, Page(s) e38–e39

MeSH term(s)	Academies and Institutes ; Consensus ; Humans ; Neurology ; Vascular Diseases
Language	English
Publishing date	2021-03-24
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.14818
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Article: Physiological and operative severity score for the enumeration of mortality and morbidity, frailty, and perioperative quality of life in the elderly.

Lima, Maria João M / Cristelo, Daniela F M / Mourão, Joana B

Saudi journal of anaesthesia

2019 Volume 13, Issue 1, Page(s) 3–8

Abstract: Background: Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM) is a validated instrument used to predict morbidity. The aim of our study was to evaluate the performance of the POSSUM score system on ... ...

Abstract	Background: Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM) is a validated instrument used to predict morbidity. The aim of our study was to evaluate the performance of the POSSUM score system on predicting perioperative frailty and quality of life (QOL) in elderly surgical patients. Patients and methods: An observational prospective study was conducted during 3 months. POSSUM was used to determine operative morbidity risk. Patients with a POSSUM score ≥26 were considered as having a high POSSUM (PHP). WHODAS 2.0, EuroQOL-5 dimensions (EQ-5D), Charlson score, and the Clinical Frailty Scale were used to assess the QOL and frailty. Chi-square, Fisher's exact, or Mann-Whitney tests were used for comparisons. Results: Two hundred and thirty-five patients were included. Median age was 69 years; 58% were ASA I/II and 42% ASA III/IV. Frailty was present in 53 patients (23%). Median POSSUM score was 26. Patients PHP were older (median age 71 vs. 68, Conclusions: Patients PHP were frailer and had worse perioperative QOL.
Language	English
Publishing date	2019-01-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2562174-9
ISSN	0975-3125 ; 1658-354X
ISSN (online)	0975-3125
ISSN	1658-354X
DOI	10.4103/sja.SJA_275_18
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Article ; Online: Cochrane Corner: Antihypertensive efficacy of beta-1 selective beta blockers for primary hypertension.

Nogueira-Silva, Luís / Marques, Pedro Sousa / Lima, Maria João

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

2017 Volume 36, Issue 5, Page(s) 385–388

Abstract: Beta blockers are commonly used to treat hypertension. This Cochrane systematic review assessed the effect of beta-1 selective beta blockers on blood pressure (BP), pulse pressure (PP), heart rate (HR) and withdrawal due to adverse effects in patients ... ...

Title translation	Cochrane Corner: eficácia anti‐hipertensora dos betabloqueadores seletivos beta‐1 na hipertensão essencial.
Abstract	Beta blockers are commonly used to treat hypertension. This Cochrane systematic review assessed the effect of beta-1 selective beta blockers on blood pressure (BP), pulse pressure (PP), heart rate (HR) and withdrawal due to adverse effects in patients with primary hypertension. Fifty-six randomized placebo-controlled trials were included, with a total of 7812 patients. These drugs reduced systolic/diastolic BP by 10/8 mmHg, PP by 2 mmHg and HR by 11 bpm; no difference was found between treatment and placebo regarding withdrawal due to adverse effects. Differences in efficacy were observed between the various beta-1 selective beta blockers, which may be due to methodological differences in the trials. The choice of an antihypertensive drug should take into account not only its efficacy in reducing BP but also its tolerability, its efficacy in preventing cardiovascular events, and other factors such as undesirable metabolic effects.
Language	Portuguese
Publishing date	2017-05
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	632718-7
ISSN	2174-2030 ; 0870-2551 ; 0304-4750
ISSN (online)	2174-2030
ISSN	0870-2551 ; 0304-4750
DOI	10.1016/j.repc.2016.09.012
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