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  1. Article ; Online: A Confounder in the Study of a Patient With Infective Endocarditis.

    Suárez, Milagros / Calvo-Iglesias, Francisco / Sousa, Adrián / Lima, Olalla / Longueira, Rebeca / López, Ana / Rubianes, Martín / Pérez-Rodríguez, M Teresa

    JACC. Case reports

    2023  Volume 28, Page(s) 102095

    Abstract: Positron emission tomography ( ...

    Abstract Positron emission tomography (
    Language English
    Publishing date 2023-10-27
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.102095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oral sequential therapy in the treatment of post-surgical epidural abscess and subdural empyema.

    Rubiñán, Pablo / Pérez-Rodríguez, María Teresa / Domínguez, Antía / Sousa, Adrián / Lima, Olalla / Rubianes, Martín / Conde, Cesáreo / Álvarez-Fernández, Maximiliano

    Infection

    2022  Volume 50, Issue 5, Page(s) 1385–1389

    Abstract: Purpose: The management of post-surgical subdural empyema and subdural abscess is not standardised. The objective was to analyse the efficacy and safety of oral sequential therapy (OST).: Methods: Retrospective observational study in a tertiary ... ...

    Abstract Purpose: The management of post-surgical subdural empyema and subdural abscess is not standardised. The objective was to analyse the efficacy and safety of oral sequential therapy (OST).
    Methods: Retrospective observational study in a tertiary hospital in Vigo (Spain). We included adult patients with subdural abscess or epidural empyema with microbiological isolation. Clinical and demographic variables, isolated microorganisms and treatment regimens were included, as well as mortality and adverse effects during the follow-up period.
    Results: Thirty patients were reviewed, two died due to causes other than infection. Six-month recurrence rate was 2/28 and all other patients (26/28) had clinical cure at the end of the treatment. The commonest isolated microorganisms were Gram-positive, especially Staphylococcus aureus. The most widely used oral antibiotic was trimethoprim-sulfamethoxazole (80%). No side effects related to oral treatment were observed.
    Conclusion: After adequate source control, OST can be a safe practice in the management of post-surgical epidural abscess and subdural empyema.
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Empyema, Subdural/drug therapy ; Empyema, Subdural/surgery ; Epidural Abscess/complications ; Epidural Abscess/drug therapy ; Epidural Abscess/surgery ; Humans ; Staphylococcal Infections/complications ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/surgery ; Trimethoprim, Sulfamethoxazole Drug Combination
    Chemical Substances Anti-Bacterial Agents ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2022-04-23
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01814-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 528: Show issues

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  3. Article ; Online: Successful ceftazidime-avibactam therapy in a patient with multidrug-resistant Pseudomonas aeruginosa infective endocarditis.

    Lima, Olalla / Sousa, Adrián / Filgueira, Antón / Otero, Antón / Cabaleiro, Andrea / Martinez-Lamas, Lucía / Vasallo, Francisco / Pérez-Rodríguez, M Teresa

    Infection

    2022  Volume 50, Issue 4, Page(s) 1039–1041

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azabicyclo Compounds/pharmacology ; Azabicyclo Compounds/therapeutic use ; Ceftazidime/pharmacology ; Ceftazidime/therapeutic use ; Drug Combinations ; Drug Resistance, Multiple, Bacterial ; Endocarditis/drug therapy ; Humans ; Microbial Sensitivity Tests ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa
    Chemical Substances Anti-Bacterial Agents ; Azabicyclo Compounds ; Drug Combinations ; avibactam, ceftazidime drug combination ; Ceftazidime (9M416Z9QNR)
    Language English
    Publishing date 2022-04-17
    Publishing country Germany
    Document type Letter
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01834-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 528: Show issues

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  4. Article ; Online: Comparison of dalbavancin with standard of care in the management of infective endocarditis: efficacy, safety, and cost analysis.

    Suárez, Milagros / Pérez-Landeiro, Antonio / Sanjurjo, Ana / Lima, Olalla / Sousa, Adrián / López, Ana / Martínez-Lamas, Lucía / Cabrera, Xurxo / Rubianes, Martín / Pérez-Rodríguez, María Teresa

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 138, Page(s) 41–45

    Abstract: Objectives: Due to its long half-life, dalbavancin offers benefits for long-duration treatments, especially osteoarticular and infective endocarditis (IE). We evaluated the efficacy and costs of IE treatment, comparing dalbavancin with standard of care ( ...

    Abstract Objectives: Due to its long half-life, dalbavancin offers benefits for long-duration treatments, especially osteoarticular and infective endocarditis (IE). We evaluated the efficacy and costs of IE treatment, comparing dalbavancin with standard of care (SOC).
    Methods: Retrospective multicenter cohort study of adult patients with Gram-positive cocci definite IE. Dalbavancin was used as a sequential therapy before discharge. Efficacy was a combined variable of clinical cure and absence of recurrence in 12-month follow-up. Length of hospital stay and the associated costs were analyzed in both groups of treatment.
    Results: Twenty-two patients received dalbavancin and 47 SOC. The efficacy was similar between the groups (dalbavancin 18 [72%] vs SOC 44 [94%], P = 0.198). Hospital stay was shorter in the dalbavancin group (dalbavancin 22 days [16-34] vs SOC 37 days [23-49], P = 0.001), especially in those with E. faecalis IE (dalbavancin 30 days [20-36] vs SOC 65 days [46-74], P <0.001). A reduction of cost was observed between both groups (dalbavancin, 12,206 € [8998-17,283] vs SOC 16,249 € [11,496-22,367], P = 0.032).
    Conclusion: Dalbavancin could be a safe and effective option in the sequential treatment of patients with IE. Also, a cost reduction was detected, due to a significant shortness of hospital stay.
    MeSH term(s) Adult ; Humans ; Anti-Bacterial Agents/adverse effects ; Cohort Studies ; Standard of Care ; Retrospective Studies ; Teicoplanin/adverse effects ; Endocarditis, Bacterial/drug therapy ; Endocarditis/drug therapy ; Costs and Cost Analysis
    Chemical Substances dalbavancin (808UI9MS5K) ; Anti-Bacterial Agents ; Teicoplanin (61036-62-2)
    Language English
    Publishing date 2023-11-04
    Publishing country Canada
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Clinical characteristics, aetiology and mortality/recurrence risk factors of acute cholangitis in patients with and without biliary stent.

    Sousa, Adrián / Alonso-Herrero, Ana / Pérez-Rodríguez, María Teresa / Lima, Olalla / Otero, Antón / Suárez, Milagros / Longueira, Rebeca / Martínez-Lamas, Lucía / Nodar, Andrés / Crespo, Manuel

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2021  Volume 39, Issue 9, Page(s) 445–450

    Abstract: Objectives: Acute cholangitis is one of the most frequent complications in patients carrying biliary stents. The aim of our study is to analyze the demographic and clinical characteristics, as well as the microbiological profile and evolution of ... ...

    Abstract Objectives: Acute cholangitis is one of the most frequent complications in patients carrying biliary stents. The aim of our study is to analyze the demographic and clinical characteristics, as well as the microbiological profile and evolution of patients with acute bacteremic cholangitis, comparing them based upon they were or not biliary stent carriers.
    Methods: We performed a retrospective analysis of all consecutive patients over 18 years-old with a stent placement in our center between 2008 and 2017 were included. We compared them with our prospective cohort of patients with a diagnosis of acute bacteremic cholangitis. Primary outcome was 30-day mortality. Secondary outcome was clinical cure at day 7, 14-day mortality and 90-day recurrence.
    Results: Two hundred and seventy-three patients were analyzed, including 156 in the stent-related (SR) and 117 in the stent not-related (SNR) group, respectively. Stent-related colangitis patients were younger, with more comorbidities and with a greater severity of infection. Escherichia coli and Klebsiella pneumonia were the most frequent isolation. Enterococcus spp. was the third most frequent isolation in SR group but were uncommon in SNR patients; where E. coli was the most prevalent microorganism. Septic shock (HR 3.44, 95% [CI 1.18-8.77]), inadequate empirical treatment (HR 2.65, 95% CI [1.38-.7.98]) and advanced neoplasia (HR 2.41, 95% CI [1.55-6.44]) were independent 30-day mortality risk factors. The 90-day recurrence rate significantly higher in those patients with stent-related cholangitis (29% vs. 13%, p=0.016) and stent replacement was associated with lower recurrence rate (HR 0.38, 95% CI [0.11-0.77]).
    Conclusions: Clinical and microbiological profile, as well as outcome of patients with SR and SNR cholangitis were different. In SR group, recurrence rate was high and stent replacement was associated with a lower risk.
    MeSH term(s) Adolescent ; Cholangitis ; Escherichia coli ; Humans ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Stents
    Language English
    Publishing date 2021-11-04
    Publishing country Spain
    Document type Journal Article
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2020.07.011
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  6. Article ; Online: The benefits and safety of oral sequential antibiotic therapy in non-complicated and complicated Staphylococcus aureus bacteremia.

    Pérez-Rodríguez, M Teresa / Sousa, Adrián / Moreno-Flores, Antonio / Longueira, Rebeca / Diéguez, Patricia / Suárez, Milagros / Lima, Olalla / Vasallo, Francisco J / Álvarez-Fernández, Maximiliano / Crespo, Manuel

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 102, Page(s) 554–560

    Abstract: Background: Treatment optimization for serious infections, such as Staphylococcus aureus bacteremia (SAB), is a challenge for antimicrobial stewardship teams. Currently, SAB guidelines recommend a completely intravenous therapy (CIT).: Objectives: ... ...

    Abstract Background: Treatment optimization for serious infections, such as Staphylococcus aureus bacteremia (SAB), is a challenge for antimicrobial stewardship teams. Currently, SAB guidelines recommend a completely intravenous therapy (CIT).
    Objectives: The objective of the study was to analyze the usefulness and safety of oral sequential therapy (OST) in SAB.
    Patients and methods: We conducted a retrospective, observational study in a tertiary teaching hospital in Spain. The inclusion criteria were complicated and non-complicated monomicrobial SAB and an adequate duration of therapy, with patients classified into OST or CIT. The primary endpoint was the 90-day recurrence of S. aureus infection. We also analyzed the mortality, the length of the hospital stay, and the duration of the intravenous antibiotic administration.
    Results: Of a total of 201 patients with SAB, 125 (62%) underwent OST. The most commonly administered oral antibiotic was trimethoprim-sulfamethoxazole (66% of patients). Of those administered OST, 43% had complicated bacteremia (most with an osteoarticular source of infection), and 6% had an intravascular device. The 90-day recurrence rate was 4%, with no differences between the two groups. The duration of the therapy (22 [16-28] vs. 13 days [8-17] for CIT and OST, respectively; p < 0.001) and the hospital stay (36 [27-71] vs. 18 days [13-29] for CIT and OST, respectively; p < 0.001) were shorter for OST. MRSA was related with mortality (OR 4.4, 95% CI [1.67-11.37]; p = 0.003).
    Conclusions: OST for properly selected patients with SAB could be a safe therapeutic option and can reduce their use of CIT and their hospital stay.
    MeSH term(s) Administration, Intravenous ; Administration, Oral ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Antimicrobial Stewardship ; Bacteremia/drug therapy ; Bacteremia/microbiology ; Bacteremia/mortality ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Retrospective Studies ; Spain ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/mortality ; Staphylococcus aureus/drug effects ; Tertiary Care Centers ; Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage
    Chemical Substances Anti-Bacterial Agents ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2020-11-04
    Publishing country Canada
    Document type Journal Article ; Observational Study
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.10.097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Clinical characteristics, aetiology and mortality/recurrence risk factors of acute cholangitis in patients with and without biliary stent.

    Sousa, Adrián / Alonso-Herrero, Ana / Pérez-Rodríguez, María Teresa / Lima, Olalla / Otero, Antón / Suárez, Milagros / Longueira, Rebeca / Martínez-Lamas, Lucía / Nodar, Andrés / Crespo, Manuel

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2020  

    Abstract: Objectives: Acute cholangitis is one of the most frequent complications in patients carrying biliary stents. The aim of our study is to analyze the demographic and clinical characteristics, as well as the microbiological profile and evolution of ... ...

    Abstract Objectives: Acute cholangitis is one of the most frequent complications in patients carrying biliary stents. The aim of our study is to analyze the demographic and clinical characteristics, as well as the microbiological profile and evolution of patients with acute bacteremic cholangitis, comparing them based upon they were or not biliary stent carriers.
    Methods: We performed a retrospective analysis of all consecutive patients over 18 years-old with a stent placement in our center between 2008 and 2017 were included. We compared them with our prospective cohort of patients with a diagnosis of acute bacteremic cholangitis. Primary outcome was 30-day mortality. Secondary outcome was clinical cure at day 7, 14-day mortality and 90-day recurrence.
    Results: Two hundred and seventy-three patients were analyzed, including 156 in the stent-related (SR) and 117 in the stent not-related (SNR) group, respectively. Stent-related colangitis patients were younger, with more comorbidities and with a greater severity of infection. Escherichia coli and Klebsiella pneumonia were the most frequent isolation. Enterococcus spp. was the third most frequent isolation in SR group but were uncommon in SNR patients; where E. coli was the most prevalent microorganism. Septic shock (HR 3.44, 95% [CI 1.18-8.77]), inadequate empirical treatment (HR 2.65, 95% CI [1.38-.7.98]) and advanced neoplasia (HR 2.41, 95% CI [1.55-6.44]) were independent 30-day mortality risk factors. The 90-day recurrence rate significantly higher in those patients with stent-related cholangitis (29% vs. 13%, p=0.016) and stent replacement was associated with lower recurrence rate (HR 0.38, 95% CI [0.11-0.77]).
    Conclusions: Clinical and microbiological profile, as well as outcome of patients with SR and SNR cholangitis were different. In SR group, recurrence rate was high and stent replacement was associated with a lower risk.
    Language Spanish
    Publishing date 2020-09-23
    Publishing country Spain
    Document type Journal Article
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2020.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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