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  1. Article ; Online: Lemon gum: Non-toxic arabinogalactan isolated from Citrus × latifolia with antiproliferative property against human prostate adenocarcinoma cells.

    Ribeiro, Fábio de Oliveira Silva / Oliveira, Fátima de Cássia Evangelista de / Pessoa, Claudia / Dias, Jhones do Nascimento / Albuquerque, Patrícia / Sousa, Edymilaís da Silva / Lima, Sidney Gonçalo de / Lima, Laís Ramos Monteiro de / Sombra, Venicios G / Paula, Regina Célia Monteiro de / Alves, Even Herlany Pereira / Vasconcelos, Daniel Fernando Pereira / Fontenele, Darllan Damasceno / Iles, Bruno / Medeiros, Jand Venes Rolim / Araújo, Alyne Rodrigues de / da Silva, Durcilene Alves / Leite, José Roberto de Souza de Almeida

    International journal of biological macromolecules

    2023  Volume 232, Page(s) 123058

    Abstract: Lemon gum (LG) obtained from Citrus × latifolia in Brazil was isolated and characterized. In addition, gum biocompatibility was evaluated in vitro and in vivo by Galleria mellonella and mice model. The cytotoxicity against tumor cells was also evaluated. ...

    Abstract Lemon gum (LG) obtained from Citrus × latifolia in Brazil was isolated and characterized. In addition, gum biocompatibility was evaluated in vitro and in vivo by Galleria mellonella and mice model. The cytotoxicity against tumor cells was also evaluated. The ratio of arabinose:galactose: rhamnose:4-OMe-glucuronic acid was 1:0.65:0.06:0.15. Small traces of protein were detected, emphasizing the isolate purity. Molar mass was 8.08 × 10
    MeSH term(s) Male ; Animals ; Mice ; Humans ; Citrus ; Prostate ; Galactans ; Adenocarcinoma/drug therapy
    Chemical Substances arabinogalactan (SL4SX1O487) ; Galactans
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.12.277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiovascular Effect of Diosgenin in Ovariectomized Rats.

    Morais, Ilmara Cecilia Pinheiro de Silva / Moura, Iris Jordânia Luz / Sabino, Carla Kelly Barroso / Nicolau, Lucas Antonio Duarte / Souza, Fabiana de Moura / Silva-Filho, José Couras da / Oliveira, Rita de Cássia Meneses / Medeiros, Jand Venes Rolim / Lima, Sidney Gonçalo de / Oliveira, Aldeidia Pereira de

    Journal of medicinal food

    2019  Volume 22, Issue 3, Page(s) 248–256

    Abstract: Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant ... ...

    Abstract Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Female rats weighing 200-220 g were subjected to sham or OVX operations at 8 weeks of age. Ovariectomy was performed for menopause induction after anesthesia. Diosgenin (10
    MeSH term(s) Animals ; Aorta/drug effects ; Aorta/metabolism ; Dioscorea/chemistry ; Diosgenin/administration & dosage ; Diosgenin/chemistry ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Glutathione/metabolism ; Humans ; In Vitro Techniques ; Male ; Menopause/drug effects ; Menopause/metabolism ; Nitrites/metabolism ; Ovariectomy ; Oxidative Stress/drug effects ; Phytoestrogens/administration & dosage ; Phytoestrogens/chemistry ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Potassium Channels/metabolism ; Rats ; Rats, Wistar ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/chemistry
    Chemical Substances Nitrites ; Phytoestrogens ; Plant Extracts ; Potassium Channels ; Vasodilator Agents ; Glutathione (GAN16C9B8O) ; Diosgenin (K49P2K8WLX)
    Language English
    Publishing date 2019-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2018.0019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5916: Show issues Location:
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  3. Article: Cardiovascular Effect of Diosgenin in Ovariectomized Rats

    Morais, Ilmara Cecilia Pinheiro de Silva / Lima, Sidney Gonçalo de / Medeiros, Jand Venes Rolim / Moura, Iris Jordânia Luz / Nicolau, Lucas Antonio Duarte / Oliveira, Aldeidia Pereira de / Oliveira, Rita de Cássia Meneses / Sabino, Carla Kelly Barroso / Silva-Filho, José Couras da / Souza, Fabiana de Moura

    Journal of medicinal food.

    2018  

    Abstract: Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant ... ...

    Abstract Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Female rats weighing 200–220 g were subjected to sham or OVX operations at 8 weeks of age. Ovariectomy was performed for menopause induction after anesthesia. Diosgenin (10−9 M–3 × 10−4 M) produced a concentration-dependent relaxation in aortic rings precontracted with phenylephrine (1 μM), exhibiting Emax value of 55.34% ± 7.7% (in endothelium-intact rings) and Emax value of 30.30% ± 5.7% (in endothelium-denuded rings). In the endothelium-intact rings, the vasorelaxing effect of diosgenin was reduced by NG-nitro-l-arginine methyl ester (L-NAME) (100 μM), atropine (1 μM), indomethacin (10 μM), 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ) (10 μM), 4-aminopyridine (1 mM), tetraethylammonium (3 mM), glibenclamide (10 μM), apamin (10 μM), and Tiron (1 μM). Diosgenin (10−5 M) inhibited the contractions induced by cumulative addition of phenylephrine (10−9–10−5 M). The 28-days treatment with diosgenin (50 mg/kg, v.o.) did not imply changes in the myeloperoxidase parameter, but increased significantly, levels of glutathione, superoxide dismutase, and nitric oxide, as well as reduced the concentration of malondialdehyde related to lipid peroxidation. Our results suggest that diosgenin induced relaxation in aortic rings via an endothelium-dependent pathway, which involves the EDRF, the opening of potassium channels and antioxidant action.
    Keywords 4-aminopyridine ; anesthesia ; antioxidant activity ; atropine ; Dioscorea ; diosgenin ; females ; glibenclamide ; glutathione ; indomethacin ; lipid peroxidation ; malondialdehyde ; menopause ; myeloperoxidase ; nitric oxide ; ovariectomy ; phenylephrine ; plant estrogens ; potassium channels ; rats ; superoxide dismutase ; tetraethylammonium compounds
    Language English
    Dates of publication 2018-1202
    Publishing place Mary Ann Liebert, Inc.
    Document type Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2018.0019
    Database NAL-Catalogue (AGRICOLA)

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5916: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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