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  1. Book ; Online ; Thesis: Retrospektive Analyse der HPV-Prävalenz bei Kopf-Hals-Tumoren

    Limburg, Ivonne [Verfasser]

    2021  

    Author's details Ivonne Limburg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Johannes Gutenberg-Universität Mainz
    Publishing place Mainz
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article: Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer: Her1-4 and c-Met in Conjunction with the Clinical Features and Human Papillomavirus (p16) Status.

    Deuss, Eric / Gößwein, Dorothee / Gül, Désirée / Zimmer, Stefanie / Foersch, Sebastian / Eger, Claudia S / Limburg, Ivonne / Stauber, Roland H / Künzel, Julian

    Cancers

    2020  Volume 12, Issue 11

    Abstract: This study aimed to assess the distribution of growth factor receptors in oropharyngeal squamous cell cancer (OPSCC) and evaluate their role in the context of human papillomavirus (HPV) status, prognosis and potential relevance for targeted therapy. The ... ...

    Abstract This study aimed to assess the distribution of growth factor receptors in oropharyngeal squamous cell cancer (OPSCC) and evaluate their role in the context of human papillomavirus (HPV) status, prognosis and potential relevance for targeted therapy. The protein expression of human epidermal growth factor receptor (Her)1-4 and c-Met were retrospectively assessed using semiquantitative immunohistochemistry on tissue microarrays and analyzed for correlations as well as differences in the clinicopathological criteria. Her1-4 and c-met were overexpressed compared to normal mucosa in 46%, 4%, 17%, 27% and 23%, respectively. Interestingly, most receptors were coexpressed. Her1 and c-Met were inversely correlated with p16 (
    Language English
    Publishing date 2020-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12113358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Conference proceedings: Einfluss des HPV-Status auf das Metastasierungsmuster bei Kopf-Hals-Tumoren

    Limburg, Ivonne / Gößwein, Dorothee / Künzel, Julian / Stauber, Roland H.

    2016  , Page(s) 16hnod029

    Event/congress 87. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; Düsseldorf; Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 2016
    Keywords Medizin, Gesundheit
    Publishing date 2016-03-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/16hnod029
    Database German Medical Science

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  4. Article ; Online: Staging of oropharyngeal squamous cell carcinoma of the head and neck: Prognostic features and power of the 8th edition of the UICC staging manual.

    Beltz, Anna / Gösswein, Dorothée / Zimmer, Stefanie / Limburg, Ivonne / Wünsch, Desirée / Gribko, Alena / Deichelbohrer, Maximilian / Hagemann, Jan / Stauber, Roland H / Künzel, Julian

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2019  Volume 45, Issue 6, Page(s) 1046–1053

    Abstract: Introduction: Recognizing the prognostic power differentiating HPV-associated oropharyngeal squamous cell cancer (OPSCC) from OPSCC with other causes, the UICC Cancer Staging Manual 8th edition realizes significant changes from the 7th edition. Purpose ... ...

    Abstract Introduction: Recognizing the prognostic power differentiating HPV-associated oropharyngeal squamous cell cancer (OPSCC) from OPSCC with other causes, the UICC Cancer Staging Manual 8th edition realizes significant changes from the 7th edition. Purpose of this study was to evaluate the differences of prognostic impact between the 7th and the latest edition of TNM Classification as well as to examine risk factors like extranodal extension (ENE) and lymph node ratio (LNR) for HPV-mediated OPSCC.
    Material and methods: The study includes 255 patients with OPSCC and initial diagnosis between 2008 and 2015. HPV status was determined according to p16 immunohistochemistry (IHC) and all patients were classified as defined by 7th and 8th edition of UICC. Prognostic influence of ENE and LNR was analyzed for patients with HPV-mediated OPSCC.
    Results: 41.2% of the OPSCC were p16-positive. Implementation of the 8th edition of the UICC lead to a better differentiation between the respective stages. Regarding HPV-positive OPSCC, Kaplan-Meier survival curves showed a significantly better overall survival (OS) for patients with a LNR ≤10% as well as for patients with negative ENE status (p = 0.004, p = 0.008).
    Conclusion: 8th edition of UICC achieves to differentiate properly between the UICC stages. However, the staging rule of ignoring ENE in HPV-mediated OPSCC should be further analyzed. Moreover LNR might be a possible additional prognostic factor - especially regarding HPV-positive tumors.
    MeSH term(s) Female ; Follow-Up Studies ; Germany/epidemiology ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/mortality ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Staging/methods ; Oropharyngeal Neoplasms/diagnosis ; Oropharyngeal Neoplasms/mortality ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/diagnosis ; Squamous Cell Carcinoma of Head and Neck/mortality ; Survival Rate/trends
    Language English
    Publishing date 2019-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2019.02.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 549: Show issues

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  5. Article ; Online: Corrigendum to "Staging of oropharyngeal squamous cell carcinoma of the head and neck: Prognostic features and power of the 8th edition of the UICC staging manual" [Eur. J. Surg. Oncol. 45 (6) (2019) 1046-1053].

    Beltz, Anna / Gösswein, Dorothée / Zimmer, Stefanie / Limburg, Ivonne / Wünsch, Desirée / Gribko, Alena / Deichelbohrer, Maximilian / Hagemann, Jan / Stauber, Roland H / Künzel, Julian

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2019  Volume 45, Issue 9, Page(s) 1755–1756

    Language English
    Publishing date 2019-07-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2019.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 549: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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