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Article ; Online: Mechanical Response Analysis for an Active–Passive Pile Adjacent to Surcharge Load

Limin Wei / Kaixin Zhang / Qun He / Chaofan Zhang

Applied Sciences, Vol 13, Iss 4196, p

2023 Volume 4196

Abstract: Due to the complexity of pile–soil interaction, there is little research on active–passive piles that bear the pile-top load transmitted from the superstructure and the pile shaft load caused by the lateral soil movement around the pile simultaneously. ... ...

Abstract	Due to the complexity of pile–soil interaction, there is little research on active–passive piles that bear the pile-top load transmitted from the superstructure and the pile shaft load caused by the lateral soil movement around the pile simultaneously. The purpose of this study is to analyze the displacement and internal force of active–passive piles. Most of the pile design codes in China use the elastic resistance method to describe the relationship between the lateral soil resistance and the horizontal displacement of the pile, but this is not accurate enough to analyze the internal force and deformation of the pile when the pile displacement is large. For this case, the passive load on the pile shaft caused by the adjacent surcharge load can be described in stages, and the p – y curve method can be used to express the relationship between the lateral soil resistance and the horizontal displacement of the pile. Additionally, taking both the active load (vertical force, horizontal force, and bending moment on the pile top) and the passive load into account, the deflection differential equation of the pile shaft is herein established, and a corresponding finite difference method program is implemented to obtain the calculations pursuant to the equation. The correctness of the analysis method and program was verified by two test cases. The results show that our calculation method can effectively judge the flow state of the soil around piles and accurately reflect the nonlinear characteristics of pile-soil interaction. Moreover, the influence depth of the pile displacement under the passive pile condition caused by the adjacent load is significantly greater than that under active pile condition, and the maximum pile-bending moment appears near the interface of soft and hard soil layer.
Keywords	active–passive pile ; adjacent surcharge load ; passive load on pile shaft ; p – y curve ; nonlinear ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Internal Forces and Deformation for a Single Pile in Layered Soil Based on the p-y Curve Method

Limin Wei / Junpeng Wang / Shun Zhai / Qun He

Applied Sciences, Vol 13, Iss 3520, p

2023 Volume 3520

Abstract: The p-y curve method can be used to describe the stress–strain relationship of soil under elastic, elastoplastic, and plastic states, and is more accurate than other methods in dealing with the nonlinearity of pile–soil interaction. However, the p-y ... ...

Abstract	The p-y curve method can be used to describe the stress–strain relationship of soil under elastic, elastoplastic, and plastic states, and is more accurate than other methods in dealing with the nonlinearity of pile–soil interaction. However, the p-y curve method also has several limitations. First, when constructing the p-y curve, undrained shear strength C u is taken to be constant, and the diversity of soil layers around the pile side are also not considered. Second, in the analysis of the internal forces and deformation of the pile, the influence of the vertical load from the top of the pile and the self-weight of the pile, are both ignored. Third, in the analysis of internal forces and deformation, the pile side soil is set equivalent to a homogeneous soil layer, and the layering of the soil is not considered at all. In order to study the nonlinear problem of internal forces and deformation of a single pile in layered soil in greater detail, this paper analyzes a calculation model based on Wang’s calculation model, and compares several commonly used p-y curve calculation models. An internal force and deformation analysis model for a laterally loaded single pile, that explicitly considers the second-order effect is then established, by considering the differences between p-y curves of different soil types, as well as the change in C u with depth. The differential equation of pile deflection for a single pile in layered soil is also presented, together with the corresponding finite differential solution algorithm program. This model was validated using a horizontal load test of a pile, and comparison of the calculated results with the measured results shows that the method outperforms existing p-y curve methods for deformation and internal force analysis of horizontally loaded piles.
Keywords	p-y curve ; layered soil ; laterally loaded piles ; internal force ; deformation ; second-order effect ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of Changes in Gut Microbiota in Wild Boars and Domestic Pigs Using 16S rRNA Gene and Metagenomics Sequencing Technologies

Limin Wei / Weiying Zhou / Zhaojing Zhu

Animals, Vol 12, Iss 2270, p

2022 Volume 2270

Abstract: Gut microbiota diversity is a result of co-evolution between microorganisms and their hosts. However, there are few studies on the evolution of the gut microbiota of wild boars and domestic pigs. Therefore, this study aimed to analyze the composition and ...

Abstract	Gut microbiota diversity is a result of co-evolution between microorganisms and their hosts. However, there are few studies on the evolution of the gut microbiota of wild boars and domestic pigs. Therefore, this study aimed to analyze the composition and function of the gut microbiota of wild boars and domestic pigs using 16S rRNA gene V3-V4 region sequencing, 16S rRNA gene full-length sequencing, and metagenomic sequencing. This study showed that after a long evolution, as compared to wild boars, the domestic pigs exhibited significantly increased relative abundances of Lactobacillus , Lactobacillus reuteri , Lactobacillus johnsonii , Lactobacillus sp.DJF_WC5 , and Lactobacillus s_uncultured bacterium , while the relative abundances of Bifidobacterium and Methanococcaceae decreased significantly. In addition, the relative abundances of “carbohydrate metabolism”, “starch and sucrose metabolism”, “valine, leucine, and isoleucine biosynthesis”, “lysine biosynthesis”, and starch-degrading CAZymes were significantly increased in the domestic pigs, while the relative abundances of “environmental adaptation”, “immune system”, “fatty acid degradation and synthesis”, and cellulose-hemicellulose-degrading CAZymes were significantly increased in the wild boars. Finally, the diversity of ARGs and the “antimicrobial resistance genes” in domestic pigs also increased significantly. This study illustrates that the gut microbiota composition and function of wild boars and domestic pigs changed during the long evolution process. These findings provide a basic research theory for the evolution of gut microbiota and the treatment of health and disease.
Keywords	wild boars ; domestic pigs ; gut microbiota ; 16S rRNA V3-V4 sequencing ; 16S rRNA full-length sequencing ; metagenomics ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synergism of fermented feed and ginseng polysaccharide on growth performance, intestinal development, and immunity of Xuefeng black-bone chickens

Jie Liu / Huan Wang / Junyi Luo / Ting Chen / Qianyun Xi / Jiajie Sun / Limin Wei / Yongliang Zhang

BMC Veterinary Research, Vol 20, Iss 1, Pp 1-

2024 Volume 9

Abstract: Abstract Microbial fermented feed (MF) is considered a valuable strategy to bring advantages to livestock and is widely practiced. Oral supplementation of Ginseng polysaccharide (Gps) eliminated weight loss in chickens following vaccination. This study ... ...

Abstract	Abstract Microbial fermented feed (MF) is considered a valuable strategy to bring advantages to livestock and is widely practiced. Oral supplementation of Ginseng polysaccharide (Gps) eliminated weight loss in chickens following vaccination. This study investigated the effects of the combined use of Gps and MF on growth performance and immune indices in Xuefeng black-bone chickens. A total of 400 Xuefeng black-bone chickens at the age of 1 day were randomly assigned to four groups. Normal feed group (Control group), ginseng polysaccharide (200 mg/kg) group (Gps group), microbially fermented feed (completely replace the normal feed) group (MF group), and microbially fermented feed and add ginseng polysaccharide just before use (MF + Gps group). Each group contained 5 pens per treatment and 20 birds per pen. The body weight and average daily gain in the Gps, MF, and MF + Gps groups increased significantly (P < 0.01), while the feed conversion ratio decreased significantly (P < 0.01). The combined use of MF and Gps showed a synergistic effect. There was no significant difference in villus height (cecal) between the experimental group and the Con group. The crypt depth of the three experimental groups exhibited a significantly lower value compared to the Control group (P < 0.05). The V/C ratio of the Gps group and MF + Gps was significantly increased (P < 0.05), but there was no significant difference in the MF group. Moreover, the diarrhea rate of the Gps and the MF + Gps groups was lower than that of the Con group, while that of the MF + Gps group decreased the mortality rate (P < 0.05). The serum tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) levels in the MF, Gps, and MF + Gps groups decreased significantly (P < 0.01), the serum immunoglobulin G (IgG) levels increased significantly (P < 0.01), while the combination of MF and Gps had a synergistic effect. The combined use of Gps and MF not only further improved growth performance and immune parameters, but also reduced the ...
Keywords	Ginseng polysaccharide ; Growth performance ; Immune parameters ; Microbial fermented feed ; Synergistic effect ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrosion Behavior of High-Cr–Ni Materials in Biomass Incineration Atmospheres

Limin Wei / Shuo Wang / Guangkui Liu / Weixun Hao / Kui Liang / Xisheng Yang / Wangzhan Diao

ACS Omega, Vol 7, Iss 25, Pp 21546-

2022 Volume 21553

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Synergistic Effects of SHR6390 Combined With Pyrotinib on HER2+/HR+ Breast Cancer

Yukun Wang / Xiang Yuan / Jing Li / Zhiwei Liu / Xinyang Li / Ziming Wang / Limin Wei / Yuanpei Li / Xinshuai Wang

Frontiers in Cell and Developmental Biology, Vol

2021 Volume 9

Abstract: HER2+/HR+ breast cancer is a special molecular type of breast cancer. Existing treatment methods are prone to resistance; “precision treatment” is necessary. Pyrotinib is a pan-her kinase inhibitor that can be used in HER2-positive tumors, while SHR6390 ... ...

Abstract	HER2+/HR+ breast cancer is a special molecular type of breast cancer. Existing treatment methods are prone to resistance; “precision treatment” is necessary. Pyrotinib is a pan-her kinase inhibitor that can be used in HER2-positive tumors, while SHR6390 is a CDK4/6 inhibitor that can inhibit ER+ breast cancer cell cycle progression and cancer cell proliferation. In cancer cells, HER2 and CDK4/6 signaling pathways could be nonredundant; co-inhibition of both pathways by combination of SHR6390 and pyrotinib may have synergistic anticancer activity on HER2+/HR+ breast cancer. In this study, we determined the synergy of the two-drug combination and underlying molecular mechanisms. We showed that the combination of SHR6390 and pyrotinib synergistically inhibited the proliferation, migration, and invasion of HER2+/HR+ breast cancer cells in vitro. The combination of two drugs induced G1/S phase arrest and apoptosis in HER2+/HR+ breast cancer cell lines. The combination of two drugs prolonged the time to tumor recurrence in the xenograft model system. By second-generation RNA sequencing technology and enrichment analysis of the pyrotinib-resistant cell line, we found that FOXM1 was associated with induced resistance to HER2-targeted therapy. In HER2+/HR+ breast cancer cell lines, the combination of the two drugs could further reduce FOXM1 phosphorylation, thereby enhancing the antitumor effect to a certain extent. These findings suggest that SHR6390 combination with pyrotinib suppresses the proliferation, migration, and invasion of HER2+/HR+ breast cancers through regulation of FOXM1.
Keywords	CDK 4/6 inhibitor ; HER-2 inhibitor ; HER2+/HR+ breast cancer ; synergy ; FoxM1 ; Biology (General) ; QH301-705.5
Subject code	616 ; 610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Nebulized Amphotericin B in Critically ill Patients With Respiratory Candida spp. De-colonization

Hangxiang Du / Limin Wei / Wenzhe Li / Bixia Huang / Yongan Liu / Xiaofei Ye / Sheng Zhang / Tao Wang / Yizhu Chen / Dechang Chen / Jiao Liu

Frontiers in Medicine, Vol

A Retrospective Analysis

2021 Volume 8

Abstract: The potential relationship among airway Candida spp. de-colonization, nebulized amphotericin B (NAB), and occurrence of ventilator-associated pneumonia (VAP) in patients who are critically ill has not been fully investigated, especially concerning ... ...

Abstract	The potential relationship among airway Candida spp. de-colonization, nebulized amphotericin B (NAB), and occurrence of ventilator-associated pneumonia (VAP) in patients who are critically ill has not been fully investigated, especially concerning effects on survival. In this observational, retrospective, cohort study in a 22-bed central intensive care unit, we included patients aged >18 years who required mechanical ventilation (MV) for >48 h, with at least two consecutive positive Candida spp. test results. Patients were categorized into NAB and no NAB (control) groups. Propensity matching at 1:1 was performed according to strict standards, and multiple Cox proportional hazard model and multivariate analyses were performed to evaluate the effects of NAB treatment. Throughout an 8-year study period, 526 patients had received MV and had positive respiratory tract Candida spp. cultures. Of these, we included 275 patients and excluded 251 patients. In total, we successfully matched 110 patients from the two groups (each group, n = 55; total population median age, 64 years; Acute Physiology and Chronic Health Evaluation II [APACHE II] score, 25.5; sequential organ failure assessment score, 9). The Candida spp. de-colonization rate was 69.1% in patients treated with NAB. VAP incidence did not differ significantly between the NAB (10.91%) and control (16.36%) groups (P = 0.405). Pseudomonas aeruginosa-related VAP rates differed significantly between the NAB (10.91%) and control (25.45%) groups (P = 0.048). Five (9.1%) patients in the NAB group died during hospitalization compared with 17 (30.9%) controls (P = 0.014). At 28 days, 9 (16.4%) and 16 (29.1%) deaths occurred in the NAB and control groups, respectively, (P = 0.088). The cumulative 90-day mortality rate differed significantly between the two groups (23.6 vs. 43.6%, P = 0.015). Multivariate logistic regression analyses indicated a decreased 90-day mortality in the NAB group (adjusted odds ratio 0.413; 95% confidence interval 0.210–0.812; P = 0.01). In ...
Keywords	amphotericin B ; mechanical ventilation ; Candida spp. colonization ; ventilator-associated pneumonia ; Candida score ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants

Jianfeng Wang / Jing Guo / Jingsong Liu / Limin Wei / Gang Wu

International Journal of Molecular Sciences, Vol 15, Iss 6, Pp 10150-

2014 Volume 10168

Abstract: The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; ... ...

Abstract	The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants.
Keywords	bone morphogenetic protein ; coating ; orthopaedic implant ; osteogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prenatal exposure to nanosized zinc oxide in rats: neurotoxicity and postnatal impaired learning and memory ability.

Xiaoli, Feng / Junrong, Wu / Xuan, Lai / Yanli, Zhang / Limin, Wei / Jia, Liu / Longquan, Shao

Nanomedicine (London, England)

2017 Volume 12, Issue 7, Page(s) 777–795

Abstract: Aim: To examine the neurotoxicity of prenatal exposure to ZnO nanoparticles on rat offspring.: Materials & methods: Pregnant Sprague-Dawley rats were exposed to ZnO nanoparticles (NPs) by gavage. Toxicity was assessed including zinc biodistribution, ... ...

Abstract	Aim: To examine the neurotoxicity of prenatal exposure to ZnO nanoparticles on rat offspring. Materials & methods: Pregnant Sprague-Dawley rats were exposed to ZnO nanoparticles (NPs) by gavage. Toxicity was assessed including zinc biodistribution, cerebral histopathology, antioxidant status and learning and memory capability. Results: A significantly elevated concentration of zinc was detected in offspring brains. Transmission electron microscope observations showed abnormal neuron ultrastructures. Histopathologic changes such as decreased proliferation and higher apoptotic death were observed. An obvious imbalanced antioxidant status occurred in brains. Adult experimental offspring exhibited impaired learning and memory behavior in the Morris water maze test compared with control groups. Conclusion: These adverse effects on offspring brain may cause impaired learning and memory capabilities in adulthood, particularly in female rats.
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2277839-1
ISSN	1748-6963 ; 1743-5889
ISSN (online)	1748-6963
ISSN	1743-5889
DOI	10.2217/nnm-2016-0397
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Article ; Online: Ion-shedding zinc oxide nanoparticles induce microglial BV2 cell proliferation via the ERK and Akt signaling pathways.

Jia, Liu / Yiyuan, Kang / Wei, Zheng / Bin, Song / Limin, Wei / Liangjiao, Chen / Longquan, Shao

Toxicological sciences : an official journal of the Society of Toxicology

2017

Abstract: Given the wide application of zinc oxide nanoparticles (ZnO NPs), the health hazards of these particles have attracted extensive worldwide attention. Many more studies on the biological interactions of ZnO NPs have been performed in recent years. In this ...

Abstract	Given the wide application of zinc oxide nanoparticles (ZnO NPs), the health hazards of these particles have attracted extensive worldwide attention. Many more studies on the biological interactions of ZnO NPs have been performed in recent years. In this study, we focused on the biological effects on BV2 microglial cells induced by ZnO NPs at non- or sub-toxic concentrations. We found that ZnO NPs at a concentration of 5 μg/ml could significantly activate cell proliferation, while ZnO NPs at other concentrations did not. We also found that ZnO NPs induced microglial cell activation in a time-dependent manner. Moreover, a potent increase in the ratio of cells in S phase at all ZnO NPs concentrations was observed in a cell cycle analysis. Using inductively coupled plasma mass spectrometry (ICP-MS) and immunocytochemistry techniques, we demonstrated that ZnO dissolution could occur in the culture medium and in the lysosomes of BV2 cells. ZnO NPs significantly induced the phosphorylation of ERK and Akt, which might be involved in promoting cell proliferation. In conclusion, our results demonstrated that ZnO NPs induced BV2 microglial cell proliferation probably via the release of zinc ions from ZnO, which could then activate the ERK and Akt signaling pathways.
Language	English
Publishing date	2017-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kfw241
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