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Article: [Serum ALT is incapable to act as an essential prerequisite for initiating antiviral therapy in patients with chronic HBV infection].

Lin, B L

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2022 Volume 29, Issue 12, Page(s) 1209–1210

MeSH term(s)	Alanine Transaminase/blood ; Antiviral Agents/therapeutic use ; Hepatitis B, Chronic/drug therapy ; Humans
Chemical Substances	Antiviral Agents ; Alanine Transaminase (EC 2.6.1.2)
Language	Chinese
Publishing date	2022-01-16
Publishing country	China
Document type	Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.cn501113-20211201-00586
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Article: [Summary of community smoking cessation intervention theory].

Lin, B L / Xie, X Y / Xiao, L

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2022 Volume 43, Issue 10, Page(s) 1677–1680

Abstract: This paper analyzes the literatures about community-based smoking cessation interventions in recent decades and introduces the effectiveness of cessation interventions developed under different theoretical frameworks applied in the community. Because of ... ...

Abstract	This paper analyzes the literatures about community-based smoking cessation interventions in recent decades and introduces the effectiveness of cessation interventions developed under different theoretical frameworks applied in the community. Because of the severe smoking prevalence in China and the shortage of existing smoking cessation services, the application of smoking cessation services in reducing the smoking rate in Chinese is discussed to provide a reference for the theoretical framework and practical application of community smoking cessation intervention research in China.
MeSH term(s)	Humans ; Smoking Cessation ; Behavior Therapy ; Tobacco Smoking ; Smoking ; Asians
Language	Chinese
Publishing date	2022-11-17
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20211217-00994
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Article: [Multi-omics combined test performance effectiveness on opportunistic screening of high-risk liver cancer population].

Xie, C / Lin, B L / Deng, H / Zhang, X H / Zhao, Q Y / Gao, Z L

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2023 Volume 32, Issue 2, Page(s) 140–147

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Liver Neoplasms/diagnosis ; alpha-Fetoproteins ; Carcinoma, Hepatocellular/diagnosis ; Multiomics ; Early Detection of Cancer ; Biomarkers ; Precancerous Conditions ; Biomarkers, Tumor
Chemical Substances	alpha-Fetoproteins ; Biomarkers ; Biomarkers, Tumor
Language	Chinese
Publishing date	2023-08-03
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.cn501113-20231125-00235
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Article: Root contraction in hyacinth. II. Changes in tubulin levels, microtubule number and orientation associated with differential cell expansion.

Cyr, R J / Lin, B L / Jernstedt, J A

Planta

2013 Volume 174, Issue 4, Page(s) 446–452

Abstract: Root contraction in hyacinth (Hyacinthus orientalis L.) is marked by reoriented cell growth in the cortex of the contractile region. Cellular volume of the inner cortex enlarges fourfold during root contraction. This is associated with large increases in ...

Abstract	Root contraction in hyacinth (Hyacinthus orientalis L.) is marked by reoriented cell growth in the cortex of the contractile region. Cellular volume of the inner cortex enlarges fourfold during root contraction. This is associated with large increases in the radial and tangential dimensions and decreases in the longitudinal dimension of the cells. In order to determine the possible role of microtubules (MTs) in these changes we compared tubulin levels and MT numbers and orientation in contracted and non-contracted regions of hyacinth roots. Tubulin content was analysed by a radioimmunoassay; MT numbers and orientation were analyzed by counting profiles in sectioned material using transmission electron microscopy. Contracted tissue was found to have significantly higher levels of tubulin on a per-cell basis than non-contracted tissue, and also increased tubulin levels relative to total protein. The spatial MT frequencies were the same in contracted and non-contracted tissues, indicating a proportional increase in MT numbers in the expanded cells. Although the absolute spatial frequency of MTs was constant, the orientation, as determined by morphometric analysis of MT profiles, was not. While in the longitudinal section plane 42% of the MTs in the non-contracted cells were oblique, in the contracted cells the percentage of MTs presenting oblique profiles increased to 87%. Additionally, a qualitative difference in MTs was observed in contracted cells; electron-opaque material was seen peripherally associated with the MTs of the inner cortex. The changes in tubulin levels and in MT numbers as well as the qualitative differences in the MTs of contracted and non-contracted root regions indicate that, in hyacinth, reoriented cellular enlargement associated with root contraction cannot be explained simply by shifts in the arrangement of preexisting cortical MT arrays, but involves more complex changes in the cytoskeleton.
Language	English
Publishing date	2013-11-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/BF00634472
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Article: The technique of rollerball endometrial ablation.

Lin, B L

The Journal of the American Association of Gynecologic Laparoscopists

1996 Volume 3, Issue 3, Page(s) 482–483

MeSH term(s)	Catheter Ablation ; Electrosurgery ; Female ; Humans ; Hysteroscopy ; Uterine Diseases/surgery
Language	English
Publishing date	1996-05
Publishing country	United States
Document type	Letter
ZDB-ID	1220649-0
ISSN	1074-3804
ISSN	1074-3804
DOI	10.1016/s1074-3804(96)80089-2
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Article: Effects of freezing rates and cryoprotectant on thermal expansion of articular cartilage during freezing process.

Xu, Y / Sun, H J / Lv, Y / Zou, J C / Lin, B L / Hua, T C

Cryo letters

2013 Volume 34, Issue 4, Page(s) 313–323

Abstract: The intact articular cartilage has not yet been successfully preserved at low temperature most likely due to the volume expansion from water to ice during freezing. The objective of this current study focuses on examining thermal expansion behavior of ... ...

Abstract	The intact articular cartilage has not yet been successfully preserved at low temperature most likely due to the volume expansion from water to ice during freezing. The objective of this current study focuses on examining thermal expansion behavior of articular cartilage (AC) during freezing from 0 degree C to -100 degree C. Thermo Mechanical Analysis (TMA) was used to investigate the effects of different concentrations of dimethyl sulphoxide (DMSO) (0%, 10%, 30% and 60% v/v) and different freezing rates (1 C/min, 3 C/min and 5 C/min). The results showed that: (1) the inhomogeneous thermal expansion (or contraction) presents due to inhomogeneous water distributions in articular cartilage during freezing, which also may be the most likely reason that the matrix has been damaged in cryopreserved intact articular cartilage; (2) at the phase transition temperature range, the maximum thermal strain change value for 5C/min is approximately 1.45 times than that for 1 C/min, but the maximum thermal expansion coefficient of the later is about six times than that of the former; (3) the thermal expansion coefficient decreases with increasing cooling rate at the unfrozen temperature region, but some opposite results are obtained at the frozen temperature region; (4) the higher the DMSO concentration is, at the phase change temperature region, the smaller the thermal strain change as well as the maximum thermal expansion coefficient are, but DMSO concentration exhibits little effect on the thermal expansion coefficient at both unfrozen and frozen region. Once the DMSO concentration increasing enough, e.g. 60% v/v, the thermal strain decreases linearly and smoothly without any abrupt change due to little or no ice crystal forms (i.e. vitrification) in frozen articular cartilage. This study may improve our understanding of the thermal expansion (or contraction) behavior of cryopreserved articular cartilage and it may be useful for the future study on cryopreservation of intact articular cartilage.
MeSH term(s)	Animals ; Biomechanical Phenomena/drug effects ; Cartilage, Articular/anatomy & histology ; Cartilage, Articular/chemistry ; Cartilage, Articular/drug effects ; Cartilage, Articular/metabolism ; Cryopreservation ; Cryoprotective Agents/metabolism ; Dimethyl Sulfoxide/metabolism ; Freezing ; Phase Transition ; Stress, Mechanical ; Swine ; Temperature ; Vitrification ; Water/metabolism
Chemical Substances	Cryoprotective Agents ; Water (059QF0KO0R) ; Dimethyl Sulfoxide (YOW8V9698H)
Language	English
Publishing date	2013-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	756781-9
ISSN	0143-2044
ISSN	0143-2044
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Article: Lateral root initiation in Marsilea quadrifolia. I. Origin and histogensis of lateral roots.

Lin, B L / Raghavan, V

Canadian journal of botany. Journal canadien de botanique

2001 Volume 69, Page(s) 123–135

Abstract: In Marsilea quadrifolia, lateral roots arise from modified single cells of the endodermis located opposite the protoxylem poles within the meristematic region of the parent root. The initial cell divides in four specific planes to establish a five- ... ...

Abstract	In Marsilea quadrifolia, lateral roots arise from modified single cells of the endodermis located opposite the protoxylem poles within the meristematic region of the parent root. The initial cell divides in four specific planes to establish a five-celled lateral root primordium, with a tetrahedral apical cell in the centre and the oldest merophytes and the root cap along the sides. The cells of the merophyte divide in a precise pattern to give rise to the cells of the cortex, endodermis, pericycle, and vascular tissues of the emerging lateral root. Although the construction of the parent root is more complicated than that of lateral roots, patterns of cell division and tissue formation are similar in both types of roots, with the various tissues being arranged in similar positions in relation to the central axis. Vascular connection between the lateral root primordium and the parent root is derived from the pericycle cells lying between the former and the protoxylem members of the latter. It is proposed that the central axis of the root is not only a geometric centre, but also a physiological centre which determines the fate of the different cell types.
MeSH term(s)	Cell Differentiation/physiology ; Cell Division/physiology ; Cell Wall/physiology ; Gravitropism/physiology ; Plant Cells ; Plant Development ; Plant Physiological Phenomena ; Plant Root Cap/cytology ; Plant Root Cap/growth & development ; Plant Root Cap/physiology ; Plant Roots/cytology ; Plant Roots/growth & development ; Plant Roots/physiology
Language	English
Publishing date	2001-08-07
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1481926-0
ISSN	1480-3305 ; 0008-4026
ISSN (online)	1480-3305
ISSN	0008-4026
DOI	10.1139/b91-018
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Article: Changes in myometrial thickness during hysteroscopic resection of deeply invasive submucous myomas.

Yang, J H / Lin, B L

The Journal of the American Association of Gynecologic Laparoscopists

2001 Volume 8, Issue 4, Page(s) 501–505

Abstract: Study objective: To evaluate the efficacy of hysteroscopy in resecting submucous myomas with deep intramural invasion.: Design: Prospective, observational study (Canadian Task Force classification II-2).: Setting: Department of gynecology at a ... ...

Abstract	Study objective: To evaluate the efficacy of hysteroscopy in resecting submucous myomas with deep intramural invasion. Design: Prospective, observational study (Canadian Task Force classification II-2). Setting: Department of gynecology at a general hospital. Patients: Sixteen women with a solitary submucous myoma, in which myometrial thickness between the outer edge of the myoma and inner edge of the serosa was between 5 and 10 mm. Intervention: One-step hysteroscopic myomectomy. Measurements and main results: Median myoma diameter and weight were 3.3 cm and 30 g, respectively. Myometrial thickness between the myoma and serosa increased gradually and significantly from 6.7 mm before, to 8.9 mm during, to 16.1 mm immediately after hysteroscopic myomectomy (p <0.001). The thickness of the opposite uterine wall increased from 10.1 mm before, to 11.4 mm during, to 18.8 mm after operation (p <0.001). Conclusion: One-step hysteroscopic myomectomy may be performed to remove deeply infiltrating submucous myomas when myometrial thickness at the implantation site is as thin as 5 mm.
MeSH term(s)	Adult ; Female ; Humans ; Hysteroscopy/adverse effects ; Hysteroscopy/methods ; Leiomyoma/pathology ; Leiomyoma/surgery ; Middle Aged ; Myometrium/pathology ; Neoplasm Invasiveness/pathology ; Probability ; Prospective Studies ; Risk Assessment ; Sampling Studies ; Severity of Illness Index ; Statistics, Nonparametric ; Treatment Outcome ; Uterine Neoplasms/pathology ; Uterine Neoplasms/surgery
Language	English
Publishing date	2001-11
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1220649-0
ISSN	1074-3804
ISSN	1074-3804
DOI	10.1016/s1074-3804(05)60611-1
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Article ; Online: Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies?

Sugiura-Ogasawara, M / Lin, B L / Aoki, K / Maruyama, T / Nakatsuka, M / Ozawa, N / Sugi, T / Takeshita, T / Nishida, M

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

2015 Volume 35, Issue 2, Page(s) 155–158

Abstract: We found that congenital uterine anomalies have a negative impact on reproductive outcome in recurrent-miscarriage couples, being associated with further miscarriage with a normal embryonic karyotype. There has been no study comparing live birth rates ... ...

Abstract	We found that congenital uterine anomalies have a negative impact on reproductive outcome in recurrent-miscarriage couples, being associated with further miscarriage with a normal embryonic karyotype. There has been no study comparing live birth rates between patients with and without surgery. We conducted a prospective study to prove that surgery for a bicornuate or septate uterus might improve the live birth rate. A total of 170 patients with congenital uterine anomalies suffering two or more miscarriages were examined. The live birth rate after ascertainment of anomalies, cumulative live birth rate and infertility rate, were compared between patients with and without surgery. In patients with a septate uterus, the live birth rate (81.3%) at the first pregnancy after ascertainment of anomalies with surgery tended to be higher than that (61.5%) in those without surgery. The infertility rates were similar in both groups, while the cumulative live birth rate (76.1%) tended to be higher than without surgery (60.0%). Surgery showed no benefit in patients with a bicornuate uterus for having a baby, but tended to decrease the preterm birth rate and the low birth weight. The possibility that surgery has benefits for having a baby in patients with a septate uterus suffering recurrent miscarriage could not be excluded.
MeSH term(s)	Abortion, Habitual/epidemiology ; Adult ; Female ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infertility, Female/epidemiology ; Live Birth/epidemiology ; Pregnancy ; Premature Birth/epidemiology ; Prospective Studies ; Urogenital Abnormalities/surgery ; Uterus/abnormalities ; Uterus/surgery
Language	English
Publishing date	2015-02
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	604639-3
ISSN	1364-6893 ; 0144-3615
ISSN (online)	1364-6893
ISSN	0144-3615
DOI	10.3109/01443615.2014.936839
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Article ; Online: Interferon-β gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting AKT/FOXO3a pathway.

Xie, C / Xie, D-Y / Lin, B-L / Zhang, G-L / Wang, P-P / Peng, L / Gao, Z-L

British journal of cancer

2013 Volume 109, Issue 5, Page(s) 1198–1205

Abstract: Objective: This study aims to investigate the using of bone marrow mesenchymal stem cells (BMSCs) genetically engineered to produce interferon-β (IFN-β) as a gene delivery system to treat hepatocellular carcinoma (HCC) in vitro and in vivo.: Methods: ...

Abstract	Objective: This study aims to investigate the using of bone marrow mesenchymal stem cells (BMSCs) genetically engineered to produce interferon-β (IFN-β) as a gene delivery system to treat hepatocellular carcinoma (HCC) in vitro and in vivo. Methods: To measure the effects on tumour cell growth in vitro, IFN-β-producing BMSCs (BMSC/IFN-β) were co-cultured with the HCC cell line HepG2 and Huh7. Enzyme-linked immunosorbent assay (ELISA) was used to detect the IFN-β secretion in the BMSC culture condition medium (CM). The effect of BMSC/IFN-β on HCC cells proliferation was examined both in vitro and in vivo by using MTT, colony formation assay, BrdU staining, cell cycle analysis, and xenografted NOD/SCID mouse tumour model. To examine the impact of BMSC/IFN-β on the AKT/FOXO3a signalling, RT-PCR and western blotting were performed. Results: The BMSC/IFN-β cells can stably secrete high levels of IFN-β. Both MTT and colony forming assay showed that HCC cells had a lower growth rate when cultured in BMSC/IFN-β-CM as compared with that in BMSC/vector-CM or DMEM culture group. Co-culture with BMSC/IFN-β-CM dramatically decreased the percentages of cells with incorporated BrdUrd. In BMSC/IFN-β-CM-treated HCC cells, the proportion of G1-phase cells increased but it decreased in the S phase of the cell. The BMSC/IFN-β inhibited HCC growth in NOD/SCID mice and proved the survival period of these mice. Compared with the control group, p21 and p27 expression of hepatoma cells increased, whereas cyclin D1 and phosphorylation of Rb expression decreased when co-cultured with BMSC/IFN-β-CM. It was associated with suppression of Akt activity and enhanced transcriptional activity of FOXO3a. Conclusion: The IFN-β gene-modified BMSCs can effectively inhibit the proliferation of HCC cells in vitro and in vivo through inhibiting AKT/FOXO3a pathway. These results indicate that BMSC/IFN-β are a powerful anticancer cytotherapeutic tool for HCC.
MeSH term(s)	Animals ; Bone Marrow Cells/metabolism ; Carcinoma, Hepatocellular/therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coculture Techniques ; Cyclin D1/biosynthesis ; Cyclin-Dependent Kinase Inhibitor p21/biosynthesis ; Drug Delivery Systems ; Forkhead Box Protein O3 ; Forkhead Transcription Factors/antagonists & inhibitors ; Forkhead Transcription Factors/metabolism ; Humans ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Liver Neoplasms/therapy ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Transplantation ; Phosphorylation ; Proliferating Cell Nuclear Antigen/biosynthesis ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; Retinoblastoma Protein/metabolism ; Transcription, Genetic/drug effects ; Xenograft Model Antitumor Assays
Chemical Substances	Cyclin-Dependent Kinase Inhibitor p21 ; FOXO3 protein, human ; Forkhead Box Protein O3 ; Forkhead Transcription Factors ; Proliferating Cell Nuclear Antigen ; Retinoblastoma Protein ; p27 antigen ; Cyclin D1 (136601-57-5) ; Interferon-beta (77238-31-4) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2013-07-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/bjc.2013.422
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