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  1. Article ; Online: Reply.

    Lin, Bing-Liang

    Hepatology (Baltimore, Md.)

    2017  Volume 66, Issue 5, Page(s) 1706

    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Letter
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.29492
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  2. Article ; Online: Reply.

    Chen, Jun-Feng / Lin, Bing-Liang

    Hepatology (Baltimore, Md.)

    2018  Volume 68, Issue 4, Page(s) 1661

    MeSH term(s) Acute-On-Chronic Liver Failure ; Hepatitis B virus ; Humans ; Mesenchymal Stem Cells
    Language English
    Publishing date 2018-09-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.30217
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  3. Article: Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation.

    Lei, Zi-Ying / Li, Zhi-Hui / Lin, Deng-Na / Cao, Jing / Chen, Jun-Feng / Meng, Shi-Bo / Wang, Jia-Lei / Liu, Jing / Zhang, Jing / Lin, Bing-Liang

    Cell & bioscience

    2024  Volume 14, Issue 1, Page(s) 54

    Abstract: Background: Extensive hepatocyte mortality and the absence of specific medical therapy significantly contribute to the unfavorable prognosis of acute liver failure (ALF). Ferroptosis is a crucial form of cell death involved in ALF. In this study, we ... ...

    Abstract Background: Extensive hepatocyte mortality and the absence of specific medical therapy significantly contribute to the unfavorable prognosis of acute liver failure (ALF). Ferroptosis is a crucial form of cell death involved in ALF. In this study, we aimed to determine the impact of Mediator complex subunit 1 (Med1) on ferroptosis and its potential hepatoprotective effects in ALF.
    Results: Med1 expression is diminished in the liver of lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced ALF mice, as well as in hepatocytes damaged by H
    Conclusion: Overall, our research findings indicate that Med1 suppresses ferroptosis and alleviates liver injury in LPS/D-GalN-induced ALF through the activation of Nrf2. These findings substantiate the therapeutic viability of targeting the Med1-Nrf2 axis as a means of treating individuals afflicted with ALF.
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-024-01234-4
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  4. Article ; Online: Enhancing current human immunodeficiency virus/hepatitis B and human immunodeficiency virus/hepatitis C virus co-infection management.

    Huang, Zhan-Lian / Chen, Da-Biao / Gao, Zhi-Liang / Lin, Bing-Liang

    Chinese medical journal

    2020  Volume 133, Issue 23, Page(s) 2890–2891

    MeSH term(s) Coinfection/drug therapy ; HIV ; HIV Infections/drug therapy ; Hepacivirus ; Hepatitis B/drug therapy ; Hepatitis C/drug therapy ; Humans ; Prevalence
    Language English
    Publishing date 2020-12-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001149
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  5. Article ; Online: Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure.

    Weng, Wei-Zhen / Chen, Jun-Feng / Peng, Xiao-Hua / Huang, Miao / Zhang, Jing / Xiong, Jing / Cao, Hui-Juan / Lin, Bing-Liang

    Epidemiology and infection

    2022  Volume 150, Page(s) e147

    Abstract: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe and life-threatening complication, characterised by multi-organ failure and high short-term mortality. However, there is limited information on the impact of various ... ...

    Abstract Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe and life-threatening complication, characterised by multi-organ failure and high short-term mortality. However, there is limited information on the impact of various comorbidities on HBV-ACLF in a large population. This study aimed to investigate the relationship between comorbidities, complications and mortality. In this retrospective observational study, we identified 2166 cases of HBV-ACLF hospitalised from January 2010 to March 2018. Demographic data from the patients, medical history, treatment, laboratory indices, comorbidities and complications were collected. The mortality rate in our study group was 47.37%. Type 2 diabetes mellitus was the most common comorbidity, followed by alcoholic liver disease. Spontaneous bacterial peritonitis, pneumonia and hepatic encephalopathy (HE) were common in these patients. Diabetes mellitus and hyperthyroidism are risk factors for death within 90 days, together with gastrointestinal bleeding and HE at admission, HE and hepatorenal syndrome during hospitalisation. Knowledge of risk factors can help identify HBV-ACLF patients with a poor prognosis for HBV-ACLF with comorbidities and complications.
    MeSH term(s) Acute-On-Chronic Liver Failure/etiology ; Acute-On-Chronic Liver Failure/microbiology ; Comorbidity ; Diabetes Mellitus, Type 2 ; Hepatitis B/complications ; Hepatitis B/epidemiology ; Hepatitis B virus ; Hepatitis B, Chronic/complications ; Humans ; Prognosis ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268822001169
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  6. Article ; Online: Mesenchymal Stem Cells Promote Polarization of M2 Macrophages in Mice with Acute-On-Chronic Liver Failure via Mertk/JAK1/STAT6 Signaling.

    Li, Zhi-Hui / Chen, Jun-Feng / Zhang, Jing / Lei, Zi-Ying / Wu, Li-Li / Meng, Shi-Bo / Wang, Jia-Lei / Xiong, Jing / Lin, Deng-Na / Wang, Jun-Yi / Gao, Zhi-Liang / Lin, Bing-Liang

    Stem cells (Dayton, Ohio)

    2023  Volume 41, Issue 12, Page(s) 1171–1184

    Abstract: Acute-on-chronic liver failure (ACLF) is a severe disease with a high mortality. Macrophage-related inflammation plays a crucial role in ACLF development. Mesenchymal stem cells (MSCs) treatment was demonstrated to be beneficial in ACLF in our previous ... ...

    Abstract Acute-on-chronic liver failure (ACLF) is a severe disease with a high mortality. Macrophage-related inflammation plays a crucial role in ACLF development. Mesenchymal stem cells (MSCs) treatment was demonstrated to be beneficial in ACLF in our previous study; however, the underlying mechanisms remain unknown. Therefore, mouse bone marrow-derived MSCs were used to treat an ACLF mouse model or cocultured with RAW264.7/J774A.1 macrophages that were stimulated with LPS. Histological and serological parameters and survival were analyzed to evaluate efficacy. We detected changes of Mer tyrosine kinase (Mertk), JAK1/STAT6, inflammatory cytokines, and markers of macrophage polarization in vitro and in vivo. In ACLF mice, MSCs improved liver function and 48-h survival of ACLF mice and alleviated inflammatory injury by promoting M2 macrophage polarization and elevated Mertk expression levels in macrophages. This is significant, as Mertk regulates M2 macrophage polarization via the JAK1/STAT6 signaling pathway.
    MeSH term(s) Mice ; Animals ; Acute-On-Chronic Liver Failure/metabolism ; Protein-Tyrosine Kinases/metabolism ; Macrophages/metabolism ; Signal Transduction ; Mesenchymal Stem Cells/metabolism ; c-Mer Tyrosine Kinase/genetics ; c-Mer Tyrosine Kinase/metabolism
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Mertk protein, mouse (EC 2.7.10.1) ; c-Mer Tyrosine Kinase (EC 2.7.10.1)
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1093/stmcls/sxad069
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  7. Article ; Online: Mesenchymal stem cell-regulated miRNA-mRNA landscape in acute-on-chronic liver failure.

    Li, Zhi-Hui / Wang, Jun-Yi / Li, Xian-Long / Meng, Shi-Bo / Zheng, Hui-Yuan / Wang, Jia-Lei / Lei, Zi-Ying / Lin, Bing-Liang / Zhang, Jing

    Genomics

    2023  Volume 115, Issue 6, Page(s) 110737

    Abstract: Background: Acute-on-chronic liver failure (ACLF) is a major challenge in the field of hepatology. While mesenchymal stem cell (MSC) therapy can improve the prognosis of patients with ACLF, the molecular mechanisms through which MSCs attenuate ACLF ... ...

    Abstract Background: Acute-on-chronic liver failure (ACLF) is a major challenge in the field of hepatology. While mesenchymal stem cell (MSC) therapy can improve the prognosis of patients with ACLF, the molecular mechanisms through which MSCs attenuate ACLF remain poorly understood. We performed global miRNA and mRNA expression profiling via next-generation sequencing of liver tissues from MSC-treated ACLF mice to identify important signaling pathways and major factors implicated in ACLF alleviation by MSCs.
    Methods: Carbon tetrachloride-induced ACLF mice were treated with saline or mouse bone marrow-derived MSCs. Mouse livers were subjected to miRNA and mRNA sequencing. Related signal transduction pathways were obtained through Gene Set Enrichment Analysis. Functional enrichment, protein-protein interaction, and immune infiltration analyses were performed for the differentially expressed miRNA target genes (DETs). Hub miRNA and mRNA associated with liver injury were analyzed using LASSO regression. The expression levels of hub genes were subjected to Pearson's correlation analysis and verified using RT-qPCR. The biological functions of hub genes were verified in vitro.
    Results: The tricarboxylic acid cycle and peroxisome proliferator-activated receptor pathways were activated in the MSC-treated groups. The proportions of liver-infiltrating NK resting cells, M2 macrophages, follicular helper T cells, and other immune cells were altered after MSC treatment. The expression levels of six miRNAs and 10 transcripts correlated with the degree of liver injury. miR-27a-5p was downregulated in the mouse liver after MSC treatment, while its target gene E2f2 was upregulated. miR-27a-5p inhibited E2F2 expression, suppressed G1/S phase transition and proliferation of hepatocytes, in addition to promoting their apoptosis.
    Conclusions: This is the first comprehensive analysis of miRNA and mRNA expression in the liver tissue of ACLF mice after MSC treatment. The results revealed global changes in hepatic pathways and immune subpopulations. The miR-27a-5p/E2F2 axis emerged as a central regulator of the MSC-induced attenuation of ACLF. The current findings improve our understanding of the molecular mechanisms through which MSCs alleviate ACLF.
    MeSH term(s) Humans ; Mice ; Animals ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Acute-On-Chronic Liver Failure/genetics ; Acute-On-Chronic Liver Failure/therapy ; Acute-On-Chronic Liver Failure/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Mesenchymal Stem Cells/metabolism
    Chemical Substances MicroRNAs ; RNA, Messenger
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356334-0
    ISSN 1089-8646 ; 0888-7543
    ISSN (online) 1089-8646
    ISSN 0888-7543
    DOI 10.1016/j.ygeno.2023.110737
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  8. Article ; Online: Safety and efficacy of Thymosin α1 in the treatment of hepatitis B virus-related acute-on-chronic liver failure: a randomized controlled trial.

    Chen, Jun-Feng / Chen, Shu-Ru / Lei, Zi-Ying / Cao, Hui-Juan / Zhang, Shao-Quan / Weng, Wei-Zhen / Xiong, Jing / Lin, Deng-Na / Zhang, Jing / Zheng, Yu-Bao / Gao, Zhi-Liang / Lin, Bing-Liang

    Hepatology international

    2022  Volume 16, Issue 4, Page(s) 775–788

    Abstract: Background/purpose of the study: Mortality from hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) is high. Severe infection is the most important complication that affects the outcomes of ACLF patients. Thymosin α1 (Tα1) can improve ... ...

    Abstract Background/purpose of the study: Mortality from hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) is high. Severe infection is the most important complication that affects the outcomes of ACLF patients. Thymosin α1 (Tα1) can improve immune imbalance and this study aimed to investigate the safety and efficacy of Tα1 treatment for HBV-related ACLF.
    Methods: From 2017 to 2019, 120 patients with HBV-related ACLF were enrolled in this open-label, randomized, and controlled clinical trial (ClinicalTrial ID: NCT03082885). The control group (N = 58) was treated with standard medical therapy (SMT) only. The experimental group (N = 56) was subcutaneously injected with 1.6 mg of Tα1 once a day for the first week and then twice a week from week 2 to week 12.
    Results: The 90-day cumulated liver transplantation free survival rate of the Tα1 group was 75.0% (95% confidence interval 63.2-86.8%) versus 53.4% (95% confidence interval 39.7-67.1%) for the SMT group (p = 0.030). No significant difference was found in the survival using competitive risk analysis. The incidences of new infection and hepatic encephalopathy in the Tα1 group were much lower than those in the SMT group (32.1% vs 58.6%, p = 0.005; 8.9% vs 24.1%, p = 0.029, respectively). Mortality from severe infection in the SMT group was higher than in the Tα1 group (24.1% vs 8.9%, p = 0.029).
    Conclusion: Tα1 is safe for patients with HBV-related ACLF and significantly improves the 90-day liver transplantation-free survival rate. There may be a subgroup which may benefit from Tα1 therapy by the mechanism of preventing infection.
    MeSH term(s) Acute-On-Chronic Liver Failure/drug therapy ; Acute-On-Chronic Liver Failure/virology ; Hepatic Encephalopathy/drug therapy ; Hepatic Encephalopathy/virology ; Hepatitis B/complications ; Hepatitis B/drug therapy ; Hepatitis B virus ; Humans ; Prognosis ; Survival Rate ; Thymalfasin/therapeutic use
    Chemical Substances Thymalfasin (W0B22ISQ1C)
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-022-10335-6
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  9. Article ; Online: Dietary and lifestyle factors for primary prevention of nephrolithiasis: a systematic review and meta-analysis.

    Lin, Bing-Biao / Lin, Ming-En / Huang, Rong-Hua / Hong, Ying-Kai / Lin, Bing-Liang / He, Xue-Jun

    BMC nephrology

    2020  Volume 21, Issue 1, Page(s) 267

    Abstract: Background: Dietary and lifestyle factors may play an important role in the increasing prevalence of nephrolithiasis. We aimed to review and quantify the associations between lifestyle factors and incident nephrolithiasis and suggest lifestyle changes ... ...

    Abstract Background: Dietary and lifestyle factors may play an important role in the increasing prevalence of nephrolithiasis. We aimed to review and quantify the associations between lifestyle factors and incident nephrolithiasis and suggest lifestyle changes for the primary prevention of nephrolithiasis.
    Methods: PubMed, EMBASE, and Cochrane Library were searched up to May 2019, for observational studies and randomized controlled trials (RCTs) that assessed modifiable lifestyle factors and risk of nephrolithiasis in adults. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were computed using a random effects model. The I
    Results: Fifty relevant articles with 1,322,133 participants and 21,030 cases in total were identified. Prominent risk factors for incident stones were body mass index (1.39,1.27-1.52), dietary sodium (1.38, 1.21-1.56), fructose, meat, animal protein, and soda. In contrast, protective factors included fluid intake (0.55, 0.51-0.60), a Dietary Approaches to Stop Hypertension (DASH) style diet (0.69, 0.64-0.75), alcohol (0.69, 0.56-0.85), water, coffee, tea, vegetables, fruits, dietary fiber, dietary calcium (0.83, 0.76-0.90), and potassium. Vitamin D (1.22, 1.01-1.49) and calcium (1.16, 1.00-1.35) supplementation alone increased the risk of stones in meta-analyses of observational studies, but not in RCTs, where the cosupplementation conferred significant risk.
    Conclusions: Several modifiable factors, notably fluid intake, dietary patterns, and obesity, were significantly associated with nephrolithiasis. Long-term RCTs are required to investigate the cost-effectiveness of dietary patterns for stone prevention. The independent and combined effects of vitamin D and calcium supplementation on nephrolithiasis need further elucidation.
    MeSH term(s) Alcohol Drinking ; Calcium, Dietary ; Carbonated Beverages ; Coffee ; Diet ; Dietary Approaches To Stop Hypertension ; Dietary Fiber ; Dietary Supplements ; Drinking Behavior ; Drinking Water ; Fruit ; Humans ; Life Style ; Nephrolithiasis/prevention & control ; Potassium, Dietary ; Primary Prevention ; Tea ; Vegetables ; Vitamin D
    Chemical Substances Calcium, Dietary ; Coffee ; Dietary Fiber ; Drinking Water ; Potassium, Dietary ; Tea ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2020-07-11
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-020-01925-3
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  10. Article ; Online: Associations between nephrolithiasis and diabetes mellitus, hypertension and gallstones: A meta-analysis of cohort studies.

    Lin, Bing-Biao / Huang, Rong-Hua / Lin, Bing-Liang / Hong, Ying-Kai / Lin, Ming-En / He, Xue-Jun

    Nephrology (Carlton, Vic.)

    2020  Volume 25, Issue 9, Page(s) 691–699

    Abstract: Aim: To review and clarify the strengths and directions of associations between nephrolithiasis and hypertension (HTN), diabetes mellitus (DM) and gallstones (GS) given the inconsistent results reported in cohort studies.: Methods: Relevant ... ...

    Abstract Aim: To review and clarify the strengths and directions of associations between nephrolithiasis and hypertension (HTN), diabetes mellitus (DM) and gallstones (GS) given the inconsistent results reported in cohort studies.
    Methods: Relevant literature was searched in PubMed and EMBASE from inception to July 2019, for cohort studies that examined the relationships between kidney stones and these three diseases among adults. Pooled relative risks (RRs) were calculated by maximally adjusted risk estimates using a random effect model. Subgroup analysis, meta-regression and sensitivity analysis were conducted whenever appropriate.
    Results: Of 3537 papers, 21 articles with each including 1 to 3 cohorts were identified. In this meta-analysis, nephrolithiasis was reciprocally linked to HTN, DM and GS. Kidney stones were significantly associated with 31%, 33% and 46% higher risks of incident HTN, DM and GS whereas GS was associated with a significantly higher risk of nephrolithiasis (RR: 1.49; 95% CI, 1.28-1.73), followed by HTN (RR: 1.30; 95% CI, 1.11-1.52) and DM (RR: 1.18; 95% CI, 1.07-1.29). Also, females with DM (RR: 1.29; 95% CI, 1.08-1.55) were more likely to develop kidney stones than diabetic male patients (RR: 0.91; 95% CI, 0.75-1.10).
    Conclusion: Although additional studies are needed to confirm these findings and elucidate the mechanisms, this study revealed possible bidirectional associations between nephrolithiasis and HTN, diabetes and GS, which reinforced the notion of nephrolithiasis as a systemic disease that requires comprehensive investigations.
    MeSH term(s) Diabetes Mellitus/epidemiology ; Gallstones/epidemiology ; Humans ; Hypertension/epidemiology ; Kidney Calculi/epidemiology ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Risk Factors
    Language English
    Publishing date 2020-07-06
    Publishing country Australia
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.13740
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