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  1. Article: First report of

    Hsu, Wen-Yu / Lee, Yi-Jin / Lin, Che-Hung / Chu, Chia-Ching

    Plant disease

    2023  

    Abstract: Bougainvilleas ( ...

    Abstract Bougainvilleas (
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-01-23-0099-PDN
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    In stock of ZB MED Bonn / Germany

    Z 2043: Show issues

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  2. Article ; Online: Combination of Durvalumab and Chemotherapy to Potentially Convert Unresectable Stage IV Penile Squamous Cell Carcinoma to Resectable Disease: A Case Report.

    Chen, Hao Xiang / Lin, Ching-Chan / Lin, Che-Hung / Yang, Chi-Rei

    Current oncology (Toronto, Ont.)

    2022  Volume 30, Issue 1, Page(s) 326–332

    Abstract: Penile squamous cell carcinoma is a rare disease entity with poor overall survival in an advanced stage. Few studies have investigated the role of immunotherapy in advanced penile squamous cell carcinoma. Herein, we report a case of stage IV unresectable ...

    Abstract Penile squamous cell carcinoma is a rare disease entity with poor overall survival in an advanced stage. Few studies have investigated the role of immunotherapy in advanced penile squamous cell carcinoma. Herein, we report a case of stage IV unresectable penile squamous cell carcinoma presenting with anal bleeding and urethra obstruction who responded dramatically to combination therapy of durvalumab and cisplatin-based chemotherapy. The patient had HPV-positive penile squamous cell carcinoma, cT3N3M0, with concomitant anus squamous cell carcinoma. After 2 months of the combination treatment, almost all bulky inguinal lymph nodes shrank, and the main tumor of the anus and penis responded completely. A durable response was seen 16 months after initiating the combination therapy. This case report highlights the potential role of the combination of immunotherapy and chemotherapy in patients with advanced penile cancer. The promising results of this combination resulted in the conversion of unresectable disease to a potentially curable disease.
    MeSH term(s) Male ; Humans ; Penile Neoplasms/drug therapy ; Penile Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Combined Modality Therapy ; Lymph Nodes/pathology
    Chemical Substances durvalumab (28X28X9OKV)
    Language English
    Publishing date 2022-12-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30010026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: An External Coincidence Model for the Lunar Cycle Reveals Circadian Phase-Dependent Moonlight Effects on Coral Spawning.

    Komoto, Hideyuki / Lin, Che-Hung / Nozawa, Yoko / Satake, Akiko

    Journal of biological rhythms

    2022  Volume 38, Issue 2, Page(s) 148–158

    Abstract: Many marine organisms synchronously spawn at specific times to ensure the success of external fertilization in the ocean. Corals are famous examples of synchronized spawning at specific lunar phases, and two distinct spawning patterns have been observed ... ...

    Abstract Many marine organisms synchronously spawn at specific times to ensure the success of external fertilization in the ocean. Corals are famous examples of synchronized spawning at specific lunar phases, and two distinct spawning patterns have been observed in two dominant taxa: merulinid corals spawn at regular lunar phases, several days after the full moon, whereas
    MeSH term(s) Animals ; Anthozoa/physiology ; Moon ; Circadian Rhythm ; Light ; Reproduction
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 896387-3
    ISSN 1552-4531 ; 0748-7304
    ISSN (online) 1552-4531
    ISSN 0748-7304
    DOI 10.1177/07487304221135916
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2872: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: Re-evaluating the role of pelvic radiation in the age of modern precision medicine and systemic therapy.

    Ke, Tao-Wei / Liao, Yu-Min / Chang, Sheng-Chi / Lin, Che-Hung / Chen, William Tzu-Liang / Liang, Ji-An / Chien, Chun-Ru

    World journal of clinical oncology

    2024  Volume 15, Issue 1, Page(s) 1–4

    Abstract: The efficacy of pelvic radiation in the management of locally advanced stage rectal cancer has come under scrutiny in the context of modern precision medicine and systemic therapy as evidenced by recent clinical trials such as FOWARC ( ...

    Abstract The efficacy of pelvic radiation in the management of locally advanced stage rectal cancer has come under scrutiny in the context of modern precision medicine and systemic therapy as evidenced by recent clinical trials such as FOWARC (
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2587357-X
    ISSN 2218-4333
    ISSN 2218-4333
    DOI 10.5306/wjco.v15.i1.1
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  5. Article ; Online: Moonrise timing is key for synchronized spawning in coral

    Lin, Che-Hung / Takahashi, Shunichi / Mulla, Aziz J / Nozawa, Yoko

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 34

    Abstract: Synchronized mass coral spawning typically occurs several days after a full moon once a year. It is expected that spawning day is determined by corals sensing environmental change regulated by the lunar cycle (i.e., tide or moonlight); however, the exact ...

    Abstract Synchronized mass coral spawning typically occurs several days after a full moon once a year. It is expected that spawning day is determined by corals sensing environmental change regulated by the lunar cycle (i.e., tide or moonlight); however, the exact regulatory mechanism remains unknown. Here, we demonstrate how moonlight influences the spawning process of coral,
    MeSH term(s) Animals ; Anthozoa/physiology ; Darkness ; Light ; Moon ; Photoperiod ; Physiological Phenomena ; Reproduction ; Sexual Behavior, Animal
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2101985118
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Chondrosarcoma of Ureter in an Elderly Patient: A Case Report.

    Pan, Szu-Ying / Lai, Chien-Zhi / Chen, Wen-Chi / Chen, Yung-Hsiang / Lin, Che-Hung / Chang, Han / Huang, Chi-Ping / Yeh, Ching-Chung

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 3

    Abstract: Chondrosarcoma is a rare type of cancer that can affect the upper urinary tract. Because of its rarity, the clinical presentation of chondrosarcoma can be similar to other urinary tract conditions, such as renal colic, hematuria, and urothelial carcinoma. ...

    Abstract Chondrosarcoma is a rare type of cancer that can affect the upper urinary tract. Because of its rarity, the clinical presentation of chondrosarcoma can be similar to other urinary tract conditions, such as renal colic, hematuria, and urothelial carcinoma. The primary treatment for chondrosarcoma is the surgical removal of the tumor, and radiation or chemotherapy may be used for advanced cases. However, because of the limited number of patients with this condition, there are no established guidelines for chemotherapy, and the outcomes are unclear. In this case, we present a 71-year-old female patient who was diagnosed with ureteral chondrosarcoma. She presented with abdominal pain and hydronephrosis, and a tumor was found beneath a small stone. The patient underwent nephroureterectomy and received oral fluorouracil chemotherapy due to the advanced stage of the disease. Fortunately, the patient survived, and at the 7 months post-operative follow-up there was no evidence of recurrence. In conclusion, the chondrosarcoma of the upper urinary tract is a rare condition that can be difficult to diagnose due to its similarity to other urinary tract conditions. Treatment typically involves the surgical removal of the tumor, with radiation or chemotherapy reserved for advanced cases. However, because of the limited number of patients, there are no established guidelines for chemotherapy, and the outcomes of treatment are unclear.
    MeSH term(s) Female ; Humans ; Aged ; Ureter/pathology ; Carcinoma, Transitional Cell ; Urinary Bladder Neoplasms ; Nephrectomy ; Ureteral Neoplasms/complications ; Ureteral Neoplasms/diagnosis ; Ureteral Neoplasms/therapy ; Chondrosarcoma/diagnosis ; Chondrosarcoma/surgery ; Bone Neoplasms/pathology ; Retrospective Studies
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59030454
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  7. Article: Venetoclax Plus Azacitidine as a Bridge Treatment to Allogeneic Stem Cell Transplantation in Unfit Patients with Acute Myeloid Leukemia.

    Chen, Tzu-Ting / Lin, Ching-Chan / Lo, Wen-Jyi / Hsieh, Ching-Yun / Lein, Ming-Yu / Lin, Che-Hung / Lin, Chen-Yuan / Bai, Li-Yuan / Chiu, Chang-Fang / Yeh, Su-Peng

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is rarely recommended for unfit patients with newly diagnosed acute myeloid leukemia (AML). Patient survival can improve with venetoclax plus azacitidine (VEN plus AZA). However, the ... ...

    Abstract Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is rarely recommended for unfit patients with newly diagnosed acute myeloid leukemia (AML). Patient survival can improve with venetoclax plus azacitidine (VEN plus AZA). However, the long-term outcome of this treatment strategy is still unsatisfactory. The high response and low treatment toxicity rates of patients receiving VEN plus AZA can provide an opportunity for HSCT among unfit patients. Nevertheless, the outcomes and complications of VEN plus AZA, followed by HSCT, remain unclear.
    Methods: This single-center retrospective study aimed to compare patients with newly diagnosed AML receiving VEN plus AZA as induction therapy (
    Result: The 1-year overall survival, relapse, and non-relapse mortality rates in the two groups were similar. The cytogenetic risks and the hematopoietic cell transplantation-specific comorbidity index are the most significant predictive factors of overall survival.
    Conclusion: In older patients unfit for intensive chemotherapy, a low-intensity regimen with VEN plus AZA is a suitable bridge therapy. Furthermore, allo-HSCT is feasible and can be a curative option.
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061082
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  8. Article ; Online: Bilateral lacrimal glands and paranasal sinus diffuse large B-cell lymphoma following lung mucosa-associated lymphoid tissue lymphoma in one patient.

    Huang, Chun-Hao / Kung, Wei-Hsun / Chang, Cheng-Hsien / Wang, Cheng-Yu / Lin, Che-Hung

    Taiwan journal of ophthalmology

    2021  Volume 12, Issue 1, Page(s) 101–105

    Abstract: We report an atypical case of diffuse large B-cell lymphoma (DLBCL) of bilateral lacrimal glands and paranasal sinus following mucosa-associated lymphoid tissue (MALT) lymphoma of the lung. Bilateral DLBCL is rare in the literature, and only few cases of ...

    Abstract We report an atypical case of diffuse large B-cell lymphoma (DLBCL) of bilateral lacrimal glands and paranasal sinus following mucosa-associated lymphoid tissue (MALT) lymphoma of the lung. Bilateral DLBCL is rare in the literature, and only few cases of DLBCL in bilateral lacrimal gland are reported. A 71-year-old male presented with bilateral, slowly enlarging, and swelling of both eyelids. Computed tomography scan images showed bilateral symmetric, hyperdense, circumferential masses over lacrimal glands occupying most of the orbital compartment. Neither optic nerve involvement nor adjacent orbital walls erosion was noted. Bilateral excisional biopsy and pathological examination confirmed the diagnosis of DLBCL. Since DLBCL of bilateral lacrimal gland can occur in case of systemic MALT lymphoma, excision and pathological examination is mandatory, and further metastatic workup is essential.
    Language English
    Publishing date 2021-04-30
    Publishing country India
    Document type Case Reports
    ZDB-ID 2652841-1
    ISSN 2211-5072 ; 2211-5072
    ISSN (online) 2211-5072
    ISSN 2211-5072
    DOI 10.4103/tjo.tjo_91_20
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  9. Article ; Online: Neoadjuvant Chemotherapy With/Without Radiotherapy for Locally Advanced Rectal Cancer: A Nationwide Retrospective Cohort Study.

    Ke, Tao-Wei / Chang, Sheng-Chi / Liao, Yu-Min / Lin, Che-Hung / Chen, William Tzu-Liang / Liang, Ji-An / Li, Chia-Chin / Chien, Chun-Ru

    Anticancer research

    2023  Volume 43, Issue 12, Page(s) 5713–5722

    Abstract: Background/aim: The role of neoadjuvant radiotherapy in the management of patients with locally advanced rectal cancer (LARC) who have undergone neoadjuvant systemic therapy has been the subject of recent debate.: Patients and methods: We identified ... ...

    Abstract Background/aim: The role of neoadjuvant radiotherapy in the management of patients with locally advanced rectal cancer (LARC) who have undergone neoadjuvant systemic therapy has been the subject of recent debate.
    Patients and methods: We identified eligible rectal cancer patients diagnosed between 2011 and 2020 using data from the Taiwan Cancer Registry. In our primary analysis, we applied propensity score weighting (PSW) to balance observable potential confounders. We then compared the hazard ratio (HR) of death the neoadjuvant concurrent chemoradiotherapy (nCCRT) group and the neoadjuvant chemotherapy without radiotherapy (nCT) group. Additionally, we conducted a comprehensive assessment of other outcomes and performed various supplementary analyses.
    Results: The primary analysis included 2,298 patients. The overall survival did not exhibit statistically significant differences, with a PSW-adjusted HR of 0.72 (95% confidence interval=0.33-1.56, p=0.40) when comparing the nCCRT group to the nCT group. These findings were consistent with those of other long-term outcomes and supplementary analyses.
    Conclusion: In patients with LARC who have undergone neoadjuvant systemic therapy, the addition of radiotherapy did not yield statistically significant differences in long-term clinical outcomes.
    MeSH term(s) Humans ; Neoadjuvant Therapy ; Retrospective Studies ; Chemoradiotherapy ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/radiotherapy ; Treatment Outcome ; Neoplasm Staging
    Language English
    Publishing date 2023-11-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16777
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Enzalutamide Prior to Radium-223 Is Associated with Better Overall Survival in Metastatic Castration-Resistant Prostate Cancer Patients Compared to Abiraterone-A Retrospective Study.

    Chen, Hao Xiang / Tsai, Li-Hsien / Chang, Chao-Hsiang / Wu, Hsi-Chin / Lin, Ching-Chan / Lin, Che-Hung / Yeh, Chin-Chung / Yang, Chi-Rei / Lien, Chi-Shun / Chang, Yi-Huei / Liang, Ji-An / Chen, Guan-Heng / Hsiao, Po-Jen / Hsieh, Po-Fan / Huang, Chi-Ping

    Cancers

    2023  Volume 15, Issue 13

    Abstract: Metastatic castration-resistant prostate cancer (mCRPC) is a progressive stage of prostate cancer that often spreads to the bone. Radium-223, a bone-targeting radiopharmaceutical, has been shown to improve the overall survival in mCRPC in patients ... ...

    Abstract Metastatic castration-resistant prostate cancer (mCRPC) is a progressive stage of prostate cancer that often spreads to the bone. Radium-223, a bone-targeting radiopharmaceutical, has been shown to improve the overall survival in mCRPC in patients without visceral metastasis. However, the impact of prior systemic therapy on the treatment outcome of mCRPC patients receiving radium-223 remains unclear. This study aimed to investigate the optimal choice of systemic therapy before radium-223 in mCRPC patients. The study included 41 mCRPC patients who received radium-223 therapy, with 22 receiving prior enzalutamide and 19 receiving prior abiraterone. The results showed that the median overall survival was significantly longer in the enzalutamide group than in the abiraterone group (25.1 months vs. 14.8 months,
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133516
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