LIVIVO - Search results -

Search results

Result 1 - 10 of total 123

Search options

Article ; Online: Erianin alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation.

Tsai, Sen-Wei / Wang, Jou-Hsuan / Chang, Yu-Kang / Lin, Chi-Chen

2023 Volume 18, Issue 1, Page(s) 20220703

Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder. Its pathogenesis is complicated but highly related to aberrant Th17 overactivation. Uncontrolled Th17 cell expansion and activation in populations and associated activities contribute to the ... ...

Abstract	Rheumatoid arthritis (RA) is a chronic autoimmune disorder. Its pathogenesis is complicated but highly related to aberrant Th17 overactivation. Uncontrolled Th17 cell expansion and activation in populations and associated activities contribute to the progression of RA. Although clinical RA remedies are available, not all RA patients respond to these treatments, and adverse effects are always a concerning issue during treatment. To expand the repertoire of possible anti-RA remedies, we chose the phytochemical compound erianin, isolated from
Language	English
Publishing date	2023-09-04
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2817958-4
ISSN	2391-5412 ; 2391-5412
ISSN (online)	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2022-0703
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen species-dependent inactivation of the PI3K/AKT pathway.

Tan, Kok-Tong / Shih, Yu-Hung / Gong, Jiny Yin / Zhang, Xiang / Huang, Chiung-Yao / Su, Jui-Hsin / Sheu, Jyh-Horng / Lin, Chi-Chen

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

2023 Volume 27, Issue 4, Page(s) 383–398

Abstract: Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral ... ...

Abstract	Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral species
Language	English
Publishing date	2023-06-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	1387595-4
ISSN	2093-3827 ; 1226-4512
ISSN (online)	2093-3827
ISSN	1226-4512
DOI	10.4196/kjpp.2023.27.4.383
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4872: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Guizhi Fuling Wan ameliorates concanavalin A-induced autoimmune hepatitis in mice.

Kuo, Shun-Li / Su, Chun-Han / Lai, Kuei-Hung / Chang, Yu-Chia / You, Jyh-Sheng / Peng, Hsin-Hsin / Chen, Chun-Hong / Lin, Chi-Chen / Chen, Po-Jen / Hwan, Tsong-Long

Biomedical journal

2024 , Page(s) 100731

Abstract: Background: Autoimmune hepatitis (AIH) is an immune-mediated hepatic disease associated with intense complications. AIH is more common in females and needs effective drugs to treat. Guizhi Fuling Wan (GZFLW) is a traditional Chinese herbal formula used ... ...

Abstract	Background: Autoimmune hepatitis (AIH) is an immune-mediated hepatic disease associated with intense complications. AIH is more common in females and needs effective drugs to treat. Guizhi Fuling Wan (GZFLW) is a traditional Chinese herbal formula used to treat various gynecologic diseases. In this study, we aim to extend the new use of GZFLW for AIH. Methods: The tandem MS-based analysis was used to identify secondary metabolites in GZFLW. Therapeutic effects of GZFLW were tested in a concanavalin A (Con A)-induced AIH model in mice. Ethnopharmacological mechanisms underlying the antiapoptotic, antioxidant, and immunomodulatory protective effects were determined. Results: Oral administration of GZFLW attenuates AIH in a Con A-induced hepatotoxic model in vivo. The tandem MS-based analysis identified 15 secondary metabolites in GZFLW. The Con A-induced AIH syndromes, including hepatic apoptosis, inflammation, reactive oxygen species accumulation, function failure, and mortality, were significantly alleviated by GZFLW in mice. Mechanistically, GZFLW restrained the caspase-dependent apoptosis, restored the antioxidant system, and decreased pro-inflammatory cytokine production in the livers of Con A-treated mice. Besides, GZFLW repressed the Con A-induced hepatic infiltration of inflammatory cells, splenic T cell activation, and splenomegaly in mice. Conclusions: Our findings demonstrate the applicable potential of GZFLW in treating AIH. It prompts further investigation of GZFLW as a treatment option for AIH and possibly other hepatic diseases.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698541-X
ISSN	2320-2890 ; 2320-2890
ISSN (online)	2320-2890
ISSN	2320-2890
DOI	10.1016/j.bj.2024.100731
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Effective topical treatments using innovative NNO-tridentate vanadium(IV) complexes-mediated photodynamic therapy in a psoriasis-like mouse model.

Lin, Rong-Kai / Venkatesan, Parthiban / Yeh, Chao-Hsuan / Chien, Ching-Ming / Lin, Te-Shan / Lin, Chi-Chen / Lin, Chu-Chieh / Lai, Ping-Shan

Journal of materials chemistry. B

2022 Volume 10, Issue 25, Page(s) 4759–4770

Abstract: Psoriasis is a chronic inflammatory skin disease that can significantly impact the quality of human life. Various drug treatments are available; however, due to their long-term severe side effects the usage of these drugs is limited. Photodynamic therapy ...

Abstract	Psoriasis is a chronic inflammatory skin disease that can significantly impact the quality of human life. Various drug treatments are available; however, due to their long-term severe side effects the usage of these drugs is limited. Photodynamic therapy (PDT) has been clinically approved for skin diseases due to its non-invasive nature. We present novel NNO-tridentate vanadium(IV) complexes used in PDT for anti-inflammatory effects in an imiquimod-induced psoriasis-like skin disease mouse model. The vanadium(IV) complexes (1-4) were synthesized using the NNO-tridentate ligand with a benzo[
MeSH term(s)	Animals ; Disease Models, Animal ; Imiquimod/therapeutic use ; Mice ; Photochemotherapy ; Psoriasis/chemically induced ; Psoriasis/drug therapy ; Skin ; Vanadium/adverse effects ; Vanadium/chemistry
Chemical Substances	Vanadium (00J9J9XKDE) ; Imiquimod (P1QW714R7M)
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d2tb00344a
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Confocal epifluorescence sensor with an arc-shaped aperture for slide-based PCR quantification

Weng, Jui-Hong / Lin-Chi Chen

Biosensors & bioelectronics. 2018 Feb. 15, v. 100

2018

Abstract: The increasing needs of point-of-care diagnostics, quarantine of epidemic pathogens, and prevention of terrorism's bio-attacks have promised the future of portable real-time quantitative polymerase chain reaction (qPCR) sensors. This work aims at ... ...

Abstract	The increasing needs of point-of-care diagnostics, quarantine of epidemic pathogens, and prevention of terrorism's bio-attacks have promised the future of portable real-time quantitative polymerase chain reaction (qPCR) sensors. This work aims at developing a highly sensitive and low-cost light emitting diode (LED)-based epifluorescence sensor module for qPCR sensor development and relevant bioassay applications. Inspired by the light stop design and dark-field detection of microscopes, this paper first reports a compact confocal LED epifluorescence sensor using a light stop with an arc-shaped aperture for enhancing the flexibility of quick DNA and PCR detection. The sensor features the advantages of the dichroic mirror-free and confocal (shared-focus) characteristics, which benefits size reduction and minimal optics used. It also allows extension to integrate with in situ real-time PCR thermal cycling since the sample slide is placed apart from the epi-sensing module. The epifluorescence sensor can detect as low as sub-ng/Î¼L standard DNA and 101 copies of Salmonella typhimurium InvA gene sequences (cloned in E. coli and after 30-cycle PCR) with SYBRÂ® Green I from non-purified culture samples, having highly sensitive and specific signal responses comparable with that of a commercial qPCR instrument.
Keywords	DNA ; Escherichia coli ; Salmonella Typhimurium ; bioassays ; biosensors ; diagnostic techniques ; microscopes ; nucleotide sequences ; optics ; pathogens ; point-of-care systems ; quantitative polymerase chain reaction ; quarantine
Language	English
Dates of publication	2018-0215
Size	p. 71-78.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2017.08.052
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 2275: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells.

Ho, Shang-Tse / Lin, Chi-Chen / Tung, Yu-Tang / Wu, Jyh-Horng

Cancers

2019 Volume 11, Issue 9

Abstract: Yatein is an antitumor agent isolated ... ...

Abstract	Yatein is an antitumor agent isolated from
Language	English
Publishing date	2019-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers11091384
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Effective topical treatments using innovative NNO-tridentate vanadium(iv) complexes-mediated photodynamic therapy in a psoriasis-like mouse model

Lin, Rong-Kai / Venkatesan, Parthiban / Yeh, Chao-Hsuan / Chien, Ching-Ming / Lin, Te-Shan / Lin, Chi-Chen / Lin, Chu-Chieh / Lai, Ping-Shan

Journal of materials chemistry B. 2022 June 29, v. 10, no. 25

2022

Abstract	Psoriasis is a chronic inflammatory skin disease that can significantly impact the quality of human life. Various drug treatments are available; however, due to their long-term severe side effects the usage of these drugs is limited. Photodynamic therapy (PDT) has been clinically approved for skin diseases due to its non-invasive nature. We present novel NNO-tridentate vanadium(iv) complexes used in PDT for anti-inflammatory effects in an imiquimod-induced psoriasis-like skin disease mouse model. The vanadium(iv) complexes (1–4) were synthesized using the NNO-tridentate ligand with a benzo[i]dipyrido[3,2-a;2′,3′-c]phenazine (dppn) moiety, and were characterized by UV/Visible spectroscopy, EPR spectroscopy, NMR (¹H, and ¹³C) spectroscopy, electrospray ionization mass (ESI-MS) spectrometry and cyclic voltammetry (CV) studies. The photocytotoxicity of vanadium(iv) complexes (1–4) was low under dark conditions and complex (4) showed remarkable photocytotoxicity under blue light (430 nm, 8 W cm⁻², 30 min) irradiation. Moreover, [VO(t-butylL)(dppn)] (4)-mediated PDT down-regulated inflammatory cytokines IL-17A and IL-22 in the psoriasis-like mouse model, which could evidence the significant relieving of the psoriatic-like symptoms in the mouse model. Overall, these results suggested that [VO(t-butylL)(dppn)] (4) could be a potential candidate for the treatment of psoriasis both in vitro and in vivo.
Keywords	blue light ; drugs ; electron paramagnetic resonance spectroscopy ; electrospray ionization mass spectrometry ; humans ; interleukin-17 ; irradiation ; ligands ; mice ; moieties ; photochemotherapy ; psoriasis ; ultraviolet-visible spectroscopy ; vanadium ; voltammetry
Language	English
Dates of publication	2022-0629
Size	p. 4759-4770.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d2tb00344a
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Highly Distorted Multiple Helicenes: Syntheses, Structural Analyses, and Properties.

Huang, Hsiao-Ci / Hsieh, Ya-Chu / Lee, Pei-Lun / Lin, Chi-Chen / Ho, Yeu-Shiuan / Shao, Wei-Kai / Hsieh, Chi-Tien / Cheng, Mu-Jeng / Wu, Yao-Ting

Journal of the American Chemical Society

2023 Volume 145, Issue 18, Page(s) 10304–10313

Abstract: A series of hexapole helicenes (HHs) and nonuple helicenes (NHs) were prepared from 1,3,5-tris[2-(arylethynyl)phenyl]benzene through two steps, namely, iodocyclization and subsequent palladium-catalyzed annulation ... ...

Abstract	A series of hexapole helicenes (HHs) and nonuple helicenes (NHs) were prepared from 1,3,5-tris[2-(arylethynyl)phenyl]benzene through two steps, namely, iodocyclization and subsequent palladium-catalyzed annulation with
Language	English
Publishing date	2023-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c01647
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 55/32: Show issues
Z 7.3: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Anti-Inflammatory Halogenated Monoterpenes from the Red Alga

Wu, Yuan-Jhong / Huang, Tzu-Yin / Huang, Chiung-Yao / Lin, Chi-Chen / Wang, Wei-Lung / Huang, Hui-Chi / Liu, Shang-Yin Vanson / Chao, Chih-Hua / Sheu, Jyh-Horng

Marine drugs

2023 Volume 21, Issue 9

Abstract: The chemical investigation of a red ... ...

Abstract	The chemical investigation of a red alga
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Carbon ; Cell Movement ; Monoterpenes/pharmacology ; Rhodophyta
Chemical Substances	Anti-Inflammatory Agents ; Carbon (7440-44-0) ; Monoterpenes
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21090493
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Assessing EGFR-mutated NSCLC with bone metastasis: Clinical features and optimal treatment strategy.

Chen, Wei-Chun / Cheng, Wen-Chien / Chen, Chieh-Lung / Liao, Wei-Chih / Chen, Chia-Hung / Chen, Hung-Jen / Tu, Chih-Yen / Lin, Chi-Chen / Hsia, Te-Chun

Cancer medicine

2023 Volume 13, Issue 7, Page(s) e7152

Abstract: Background: This study aimed to examine the clinical characteristics of bone metastasis (BoM) in patients with non-small cell lung cancer (NSCLC) who have an epidermal growth factor receptor (EGFR) mutation and to identify the most effective treatment ... ...

Abstract	Background: This study aimed to examine the clinical characteristics of bone metastasis (BoM) in patients with non-small cell lung cancer (NSCLC) who have an epidermal growth factor receptor (EGFR) mutation and to identify the most effective treatment strategy using EGFR-tyrosine kinase inhibitors (TKIs). Methods: The study included patients with stage IV EGFR-mutated NSCLC who were receiving first-line treatment with EGFR-TKIs between January 2014 and December 2020. These patients were divided into two groups based on the presence or absence of BoM at the time of initial diagnosis. The BoM group was further subdivided based on whether they received denosumab or not. Results: The final analysis included 247 patients. Those with BoM at initial diagnosis had shorter progression-free survival (12.6 vs. 10.5 months, p = 0.002) and overall survival (OS) (49.7 vs. 30.9 months, p = 0.002) compared to those without BoM. There was a difference in the location of metastatic sites between the two groups, with a higher incidence of extrathoracic metastasis in the BoM group (p < 0.001). The incidence of T790M was higher in patients with BoM than in those without (47.4% vs. 33.9%, p = 0.042). Multivariate Cox regression analysis revealed that sequential osimertinib treatment and the addition of antiangiogenic therapy (AAT) and denosumab therapy improved OS in patients with BoM. Conclusions: The presence of BoM is a negative prognostic factor for NSCLC patients with an EGFR mutation, possibly due to the presence of extrathoracic metastases. However, adding AAT and denosumab, along with sequential osimertinib, to the treatment regimen for patients with BoM can improve survival outcomes.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; ErbB Receptors/genetics ; Denosumab/therapeutic use ; Protein Kinase Inhibitors/adverse effects ; Mutation ; Retrospective Studies ; Acrylamides ; Aniline Compounds ; Indoles ; Pyrimidines
Chemical Substances	osimertinib (3C06JJ0Z2O) ; ErbB Receptors (EC 2.7.10.1) ; Denosumab (4EQZ6YO2HI) ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; Acrylamides ; Aniline Compounds ; Indoles ; Pyrimidines
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.7152
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito