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Article ; Online: Retraction Note: Preconditioning with pitavastatin, an HMG-CoA reductase inhibitor, attenuates C-Jun N-terminal kinase activation in experimental subarachnoid hemorrhage-induced apoptosis.

Chang, Chih-Zen / Wu, Shu-Chuan / Kwan, Aij-Lie / Lin, Chih-Lung

2024 Volume 166, Issue 1, Page(s) 8

Language	English
Publishing date	2024-01-13
Publishing country	Austria
Document type	Retraction of Publication
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-05917-2
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Article: Development and Validation of the Osteoporosis Knowledge, Attitude, and Behaviors Questionnaire for Female Osteoporosis Patients in Taiwan: A Mediation Model.

Huang, I-Chin / Wu, Hui-Chuan / Lin, Chih-Lung / Wang, Hsiu-Hung

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 7

Abstract: This research develops the Osteoporosis Knowledge, Attitude and Behaviors Questionnaire (OKABQ) with the intent to evaluate the levels of osteoporosis knowledge, attitude and behavior change by developing and validating the OKABQ while establishing a ... ...

Abstract	This research develops the Osteoporosis Knowledge, Attitude and Behaviors Questionnaire (OKABQ) with the intent to evaluate the levels of osteoporosis knowledge, attitude and behavior change by developing and validating the OKABQ while establishing a mediation model of the research. A quantitative, descriptive and instrumental study was conducted in two phases: Phase I-development of the scale through Delphi Method by osteoporosis experts; and Phase II-evaluation of the validity and reliability of the scale and construction of a mediation model using SmartPLS. In Phase I, the content validity index (CVI) of the questionnaire was higher than 0.96 and the inter-rater reliability (IRR) kappa was 1.00. In Phase II, exploratory factor analysis showed that two predominating factors of attitude as a mediation were addressed by the 26-item OKABQ. The indirect effect results from the estimated model indicate that attitude mediates the relationship between knowledge and behaviors (β = 0.114,
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11071023
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Article: Middle Cerebral Artery Compromise Associated With Post-traumatic Hydrocephalus: A Case Report.

Chen, Tzu-Ning / Kuo, Keng-Liang / Lin, Chih-Lung / Su, Yu-Feng

Korean journal of neurotrauma

2023 Volume 19, Issue 4, Page(s) 466–470

Abstract: Post-traumatic hydrocephalus (PTH) is a commonly encountered complication following decompressive craniectomy, and is usually characterized by symptoms including headache, nausea, vomiting, and papilledema. Extracranial herniation accompanied by ... ...

Abstract	Post-traumatic hydrocephalus (PTH) is a commonly encountered complication following decompressive craniectomy, and is usually characterized by symptoms including headache, nausea, vomiting, and papilledema. Extracranial herniation accompanied by hemiplegia is a rare complication in patients with PTH who underwent craniectomy after subdural hematoma removal. We report a case of PTH that presented with extracranial herniation within one month of decompressive craniectomy. Following ventriculoperitoneal shunt implantation, left hemiplegia improved dramatically with restoration of the left middle cerebral artery blood flow, which was evident on serial imaging. Vascular compromise is often overshadowed by increased intracranial pressure when clinicians are dealing with traumatic brain injury patients. Delicate neurological and radiological examinations and prompt early interventions could lead to optimal outcomes in patients receiving decompressive craniectomy.
Language	English
Publishing date	2023-11-14
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	3028579-3
ISSN	2288-2243 ; 2234-8999
ISSN (online)	2288-2243
ISSN	2234-8999
DOI	10.13004/kjnt.2023.19.e57
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Article: Retraction Note: Valproic acid attenuates intercellular adhesion molecule-1 and E-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model.

Chang, Chih-Zen / Wu, Shu-Chuan / Lin, Chih-Lung / Kwan, Aij-Lie

Journal of inflammation (London, England)

2023 Volume 20, Issue 1, Page(s) 45

Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	2164385-4
ISSN	1476-9255
ISSN	1476-9255
DOI	10.1186/s12950-023-00370-x
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Article ; Online: Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway.

Su, Hui-Yuan / Tsai, Yi-Cheng / Tsai, Hung-Pei / Lin, Chih-Lung

International journal of molecular sciences

2022 Volume 23, Issue 9

Abstract: M1 microglia induce neuroinflammation-related neuronal death in animal models of spontaneous subarachnoid haemorrhage. Zileuton is a 5-lipoxygenase inhibitor that reduces the levels of downstream pro-inflammatory cytokines. This study aimed to ... ...

Abstract	M1 microglia induce neuroinflammation-related neuronal death in animal models of spontaneous subarachnoid haemorrhage. Zileuton is a 5-lipoxygenase inhibitor that reduces the levels of downstream pro-inflammatory cytokines. This study aimed to investigate whether zileuton inhibits microglial activation and describe its underlying mechanisms. BV-2 cells were exposed to 1 mg/mL haemolysate for 30 min, followed by treatment with different concentrations (5, 10, 15, or 20 μM) of zileuton for 24 h. The cells were then assessed for viability, polarisation, and protein expression levels. Haemolysate increases the viability of BV-2 cells and induces M1 polarisation. Subsequent exposure to high concentrations of zileuton decreased the viability of BV-2 cells, shifted the polarisation to the M2 phenotype, suppressed the expression of 5-lipoxygenase, decreased tumour necrosis factor α levels, and increased interleukin-10 levels. Furthermore, high concentrations of zileuton suppressed the expression of myeloid differentiation primary response protein 88 and reduced the phosphorylated-nuclear factor-kappa B (NF-kB)/NF-kB ratio. Therefore, phenotype reversal from M1 to M2 is a possible mechanism by which zileuton attenuates haemolysate-induced neuroinflammation after spontaneous subarachnoid haemorrhage.
MeSH term(s)	Animals ; Hydroxyurea/analogs & derivatives ; Lipopolysaccharides/metabolism ; Lipoxygenase Inhibitors/metabolism ; Lipoxygenase Inhibitors/pharmacology ; Microglia/metabolism ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Signal Transduction ; Subarachnoid Hemorrhage/metabolism
Chemical Substances	Lipopolysaccharides ; Lipoxygenase Inhibitors ; Myeloid Differentiation Factor 88 ; NF-kappa B ; zileuton (V1L22WVE2S) ; Hydroxyurea (X6Q56QN5QC)
Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23094910
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Article ; Online: AKR1B1 Represses Glioma Cell Proliferation through p38 MAPK-Mediated Bcl-2/BAX/Caspase-3 Apoptotic Signaling Pathways.

Huang, Yu-Kai / Chang, Kun-Che / Li, Chia-Yang / Lieu, Ann-Shung / Lin, Chih-Lung

Current issues in molecular biology

2023 Volume 45, Issue 4, Page(s) 3391–3405

Abstract: This study aimed to investigate the regulatory role of Aldo-keto reductase family 1 member B1 (AKR1B1) in glioma cell proliferation through p38 MAPK activation to control Bcl-2/BAX/caspase-3 apoptosis signaling. AKR1B1 expression was quantified in normal ...

Abstract	This study aimed to investigate the regulatory role of Aldo-keto reductase family 1 member B1 (AKR1B1) in glioma cell proliferation through p38 MAPK activation to control Bcl-2/BAX/caspase-3 apoptosis signaling. AKR1B1 expression was quantified in normal human astrocytes, glioblastoma multiforme (GBM) cell lines, and normal tissues by using quantitative real-time polymerase chain reaction. The effects of AKR1B1 overexpression or knockdown and those of AKR1B1-induced p38 MAPK phosphorylation and a p38 MAPK inhibitor (SB203580) on glioma cell proliferation were determined using an MTT assay and Western blot, respectively. Furthermore, the AKR1B1 effect on BAX and Bcl-2 expression was examined in real-time by Western blot. A luminescence detection reagent was also utilized to identify the effect of AKR1B1 on caspase-3/7 activity. The early and late stages of AKR1B1-induced apoptosis were assessed by performing Annexin V-FITC/PI double-staining assays. AKR1B1 expression was significantly downregulated in glioma tissues and GBM cell lines (T98G and 8401). Glioma cell proliferation was inhibited by AKR1B1 overexpression but was slightly increased by AKR1B1 knockdown. Additionally, AKR1B1-induced p38 MAPK phosphorylation and SB203580 reversed AKR1B1's inhibitory effect on glioma cell proliferation. AKR1B1 overexpression also inhibited Bcl-2 expression but increased BAX expression, whereas treatment with SB203580 reversed this phenomenon. Furthermore, AKR1B1 induced caspase-3/7 activity. The induction of early and late apoptosis by AKR1B1 was confirmed using an Annexin V-FITC/PI double-staining assay. In conclusion, AKR1B1 regulated glioma cell proliferation through the involvement of p38 MAPK-induced BAX/Bcl-2/caspase-3 apoptosis signaling. Therefore, AKR1B1 may serve as a new therapeutic target for glioma therapy development.
Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb45040222
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Article: Accurate Intervertebral Disc Segmentation Approach Based on Deep Learning.

Cheng, Yu-Kai / Lin, Chih-Lung / Huang, Yi-Chi / Lin, Guo-Shiang / Lian, Zhen-You / Chuang, Cheng-Hung

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 2

Abstract: Automatically segmenting specific tissues or structures from medical images is a straightforward task for deep learning models. However, identifying a few specific objects from a group of similar targets can be a challenging task. This study focuses on ... ...

Abstract	Automatically segmenting specific tissues or structures from medical images is a straightforward task for deep learning models. However, identifying a few specific objects from a group of similar targets can be a challenging task. This study focuses on the segmentation of certain specific intervertebral discs from lateral spine images acquired from an MRI scanner. In this research, an approach is proposed that utilizes MultiResUNet models and employs saliency maps for target intervertebral disc segmentation. First, a sub-image cropping method is used to separate the target discs. This method uses MultiResUNet to predict the saliency maps of target discs and crop sub-images for easier segmentation. Then, MultiResUNet is used to segment the target discs in these sub-images. The distance maps of the segmented discs are then calculated and combined with their original image for data augmentation to predict the remaining target discs. The training set and test set use 2674 and 308 MRI images, respectively. Experimental results demonstrate that the proposed method significantly enhances segmentation accuracy to about 98%. The performance of this approach highlights its effectiveness in segmenting specific intervertebral discs from closely similar discs.
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14020191
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Article ; Online: Effects of chronic daily headache with subclinical depression on brain volume: A systematic review and meta-analysis.

Lin, Chih-Lung / Lane, Hsien-Yuan / Sun, Cheuk-Kwan / Chen, Meng-Hsiang / Lee, Chiao-Yu / Li, Lin / Lee, Jia-Jie / Yeh, Pin-Yang

European journal of pain (London, England)

2024

Abstract: Background and objective: The relationship between chronic daily headache (CDH), depression symptoms, and brain volume remains unclear.: Methods: To investigate the effects of CDH on brain volume and the impact of depressive symptoms (DSs) as well as ...

Abstract	Background and objective: The relationship between chronic daily headache (CDH), depression symptoms, and brain volume remains unclear. Methods: To investigate the effects of CDH on brain volume and the impact of depressive symptoms (DSs) as well as the effects of demography and medication overuse, PubMed, Embase, and Web of Science databases were systematically searched using appropriate keyword strings to retrieve observational studies from inception to May 2023. Results: Two distinct comparisons were made in CDH patients: (1) those with DSs versus their pain-free counterparts and (2) those without DSs versus pain-free controls. The first comprised nine studies enrolling 225 CDH patients with DSs and 234 controls. Beck depression inventory, Hamilton depression scale, and Hospital anxiety/depression scale were used to assess DSs, revealing significantly more DSs in CDH patients with DSs compared to their controls (all p < 0.05). Besides, the second analysed four studies involving 117 CDH patients without DSs and 155 comparators. Compared to CDH patients without DSs, those with DSs had a smaller brain volume than controls (p = 0.03). Furthermore, CDH patients with DSs who did not overuse medications showed a smaller right cerebral cortical volume than overusers (p = 0.003). A significant inverse correlation between female prevalence and brain volume (p = 0.02) was revealed using regression analysis. Conclusions: Pain-induced persistent depressive symptoms not only incur structural alterations but also encompass affective-motivational changes, involving medication use and gender-specific health concerns. Significance: This study highlighted the importance of an integrated CDH treatment, emphasizing psychological interventions for the affective-motivational component alongside pain management.
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1002/ejp.2270
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Article: Identification of a Case with Heterozygous Mutations in the FUT1 Gene Leading to a Para-Bombay Phenotype.

Lin, Chih-Lung / Er, Tze-Kiong

Clinical laboratory

2019 Volume 65, Issue 12

Abstract: Background: A case of a para-Bombay phenotype caused by a compound heterozygous mutation in the FUT1 gene was identified in this study.: Methods: We performed an agglutination examination of anti-H serum and secretor status to assess the presence of ... ...

Abstract	Background: A case of a para-Bombay phenotype caused by a compound heterozygous mutation in the FUT1 gene was identified in this study. Methods: We performed an agglutination examination of anti-H serum and secretor status to assess the presence of soluble blood group substances. Genotyping of ABO and FUT1 genes was also performed. Results: Our results showed the presence of A and H antigens in saliva. Based on these results, the patient in the present case was diagnosed with the para-Bombay A phenotype. Direct DNA sequencing of the ABO gene indicated A1v/O1vgenotype. FUT1 gene sequence analysis revealed that the patient harbored the compound heterozygous mutation, c.881_882delTT (p.Phe294Cysfs40) and c.658C>T (p.Arg220Cys). Conclusions:* Improper identification of this phenotype may cause inappropriate transfusions because this particular blood group may be mislabeled as group O. Therefore, blood bank staff should be well trained to solve the discrepancy between cell and serum grouping in the para-Bombay phenotype.
MeSH term(s)	ABO Blood-Group System/genetics ; Aged ; Female ; Fucosyltransferases/genetics ; Genotype ; Heterozygote ; Humans ; Mutation ; Phenotype ; Galactoside 2-alpha-L-fucosyltransferase
Chemical Substances	ABO Blood-Group System ; Fucosyltransferases (EC 2.4.1.-)
Language	English
Publishing date	2019-08-15
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2019.190602
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Article ; Online: CDDO regulates central and peripheral sensitization to attenuate post-herpetic neuralgia by targeting TRPV1/PKC-δ/p-Akt signals.

Lu, Chun-Ching / Lin, Chia-Yang / Lu, Ying-Yi / Tsai, Hung-Pei / Lin, Chih-Lung / Wu, Chieh-Hsin

Journal of cellular and molecular medicine

2024 Volume 28, Issue 6, Page(s) e18131

Abstract: Postherpetic neuralgia (PHN) is a notorious neuropathic pain featuring persistent profound mechanical hyperalgesia with significant negative impact on patients' life quality. CDDO can regulate inflammatory response and programmed cell death. Its ... ...

Abstract	Postherpetic neuralgia (PHN) is a notorious neuropathic pain featuring persistent profound mechanical hyperalgesia with significant negative impact on patients' life quality. CDDO can regulate inflammatory response and programmed cell death. Its derivative also protects neurons from damages by modulating microglia activities. As a consequence of central and peripheral sensitization, applying neural blocks may benefit to minimize the risk of PHN. This study aimed to explore whether CDDO could generate analgesic action in a PHN-rats' model. The behavioural test was determined by calibrated forceps testing. The number of apoptotic neurons and degree of glial cell reaction were assessed by immunofluorescence assay. Activation of PKC-δ and the phosphorylation of Akt were measured by western blots. CDDO improved PHN by decreasing TRPV1-positive nociceptive neurons, the apoptotic neurons, and reversed glial cell reaction in adult rats. It also suppressed the enhanced PKC-δ and p-Akt signalling in the sciatic nerve, dorsal root ganglia (DRG) and spinal dorsal horn. Our research is the promising report demonstrating the analgesic and neuroprotective action of CDDO in a PHN-rat's model by regulating central and peripheral sensitization targeting TRPV1, PKC-δ and p-Akt. It also is the first study to elucidate the role of oligodendrocyte in PHN.
MeSH term(s)	Humans ; Adult ; Rats ; Animals ; Neuralgia, Postherpetic/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Neuralgia/metabolism ; Analgesics ; Ganglia, Spinal/metabolism ; TRPV Cation Channels/metabolism ; Oleanolic Acid/analogs & derivatives
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; bardoxolone (7HT68L8941) ; Analgesics ; TRPV1 protein, human ; TRPV Cation Channels ; Oleanolic Acid (6SMK8R7TGJ)
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.18131
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