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  1. AU="Lin, Ching-Hao"
  2. AU="Pathare, Varsha S"
  3. AU="Holden, Shelley L"
  4. AU="Cho, Sungkyu"
  5. AU="Gao, Xiya"
  6. AU="Hou, Jiazi"
  7. AU="Mallik, P."

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  1. Article ; Online: Quantification of Gut Microbiota Dysbiosis-Related Organic Acids in Human Urine Using LC-MS/MS.

    Lee, Yu-Tsung / Huang, Sui-Qing / Lin, Ching-Hao / Pao, Li-Heng / Chiu, Chun-Hui

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 17

    Abstract: Urine organic acid contains water-soluble metabolites and/or metabolites—derived from sugars, amino acids, lipids, vitamins, and drugs—which can reveal a human’s physiological condition. These urine organic acids—hippuric acid, benzoic acid, phenylacetic ...

    Abstract Urine organic acid contains water-soluble metabolites and/or metabolites—derived from sugars, amino acids, lipids, vitamins, and drugs—which can reveal a human’s physiological condition. These urine organic acids—hippuric acid, benzoic acid, phenylacetic acid, phenylpropionic acid, 4-hydroxybenzoic acid, 4-hydroxyphenyl acetic acid, 3-hydroxyphenylpropionic acid, 3,4-dihydroxyphenyl propionic acid, and 3-indoleacetic acid—were the eligible candidates for the dysbiosis of gut microbiota. The aim of this proposal was to develop and to validate a liquid chromatography−tandem mass spectrometry (LC-MS/MS) bioanalysis method for the nine organic acids in human urine. Stable-labeled isotope standard (creatinine-d3) and acetonitrile were added to the urine sample. The supernatant was diluted with deionized water and injected into LC-MS/MS. This method was validated with high selectivity for the urine sample, a low limit of quantification (10−40 ng/mL), good linearity (r > 0.995), high accuracy (85.8−109.7%), and high precision (1.4−13.3%). This method simultaneously analyzed creatinine in urine, which calibrates metabolic rate between different individuals. Validation has been completed for this method; as such, it could possibly be applied to the study of gut microbiota clinically.
    MeSH term(s) Chromatography, Liquid/methods ; Creatinine ; Dysbiosis ; Gastrointestinal Microbiome ; Humans ; Organic Chemicals ; Tandem Mass Spectrometry/methods ; Water
    Chemical Substances Organic Chemicals ; Water (059QF0KO0R) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27175363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Incidence and Nature of Short-Term Adverse Events following COVID-19 Second Boosters: Insights from Taiwan's Universal Vaccination Strategy.

    Lin, Ching-Hao / Chen, Tsung-An / Chiang, Pin-Hsuan / Hsieh, Ai-Ru / Wu, Bih-Ju / Chen, Po-Yu / Lin, Kuan-Chen / Tsai, Zih-Syun / Lin, Ming-Hwai / Chen, Tzeng-Ji / Chen, Yu-Chun

    Vaccines

    2024  Volume 12, Issue 2

    Abstract: This study evaluates the incidence and characteristics of adverse events (AEs) following the second COVID-19 booster dose, leveraging Taiwan's distinctive approach of extending booster vaccinations to all citizens, unlike the targeted high-risk group ... ...

    Abstract This study evaluates the incidence and characteristics of adverse events (AEs) following the second COVID-19 booster dose, leveraging Taiwan's distinctive approach of extending booster vaccinations to all citizens, unlike the targeted high-risk group strategies in other countries. Utilizing data from Taipei Veterans General Hospital's Vaccine Adverse Event Reporting System (VAERS) from 27 October 2022 to 19 January 2023, this research examines AEs in 441 out of 1711 booster recipients, considering factors like age, vaccine brands, and booster combinations. The findings revealed incidence rates (IRs) of 25.6% (95% CI: 21.1-30.8) after the first booster and 24.9% (95% CI: 20.5-30.0) after the second, mostly non-serious, with those having AEs post-first booster being five times more likely to report them again (incidence rate ratio, 5.02,
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12020149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Id2 exerts tumor suppressor properties in lung cancer through its effects on cancer cell invasion and migration.

    Chen, Jian-Ting / Hsu, Yuan-Ling / Hsu, Yi-Chiung / Tseng, Yi-Hsin / Liu, Ming-Han / Weng, Chia-Wei / Lin, Ching-Hao / Pan, Szu-Hua / Chen, Jeremy J W / Wang, Chi-Chung

    Frontiers in oncology

    2022  Volume 12, Page(s) 801300

    Abstract: Background: Despite advances in prognosis and treatment of lung adenocarcinoma (LADC), a notable non-small cell lung cancer subtype, patient outcomes are still unsatisfactory. New insight on novel therapeutic strategies for LADC may be gained from a ... ...

    Abstract Background: Despite advances in prognosis and treatment of lung adenocarcinoma (LADC), a notable non-small cell lung cancer subtype, patient outcomes are still unsatisfactory. New insight on novel therapeutic strategies for LADC may be gained from a more comprehensive understanding of cancer progression mechanisms. Such strategies could reduce the mortality and morbidity of patients with LADC. In our previous study, we performed cDNA microarray screening and found an inverse relationship between inhibitor of DNA binding 2 (Id2) expression levels and the invasiveness of LADC cells.
    Materials and methods: To identify the functional roles of Id2 and its action mechanisms in LADC progression, we successfully established several Id2-overexpressing and Id2-silenced LADC cell clones. Subsequently, we examined
    Results: Our data revealed that Id2 overexpression could inhibit LADC cells' migratory, invasive, proliferation, and colony formation capabilities. Silencing Id2 expression in LADC cells reversed the aforementioned inhibitory effects, and knockdown of Id2 increased LADC cells' metastatic abilities
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.801300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration.

    Chen, Yun-Wen / Hsieh, Shu-Chen / Yang, Yi-Chin / Hsu, Shan-Hui / Kung, Mei-Lang / Lin, Pei-Ying / Hsieh, Hsien-Hsu / Lin, Ching-Hao / Tang, Cheng-Ming / Hung, Huey-Shan

    Nanomedicine : nanotechnology, biology, and medicine

    2018  Volume 14, Issue 3, Page(s) 699–711

    Abstract: Vascularization of engineered tissues remains one of the key problems. Here, we described a novel approach to promote vascularization of engineered tissues using fibronectin (FN) incorporated gold nanoparticles (AuNP) coated onto catheters with ... ...

    Abstract Vascularization of engineered tissues remains one of the key problems. Here, we described a novel approach to promote vascularization of engineered tissues using fibronectin (FN) incorporated gold nanoparticles (AuNP) coated onto catheters with mesenchymal stem cells (MSCs) for tissue engineering. We found that the FN-AuNP composite with 43.5 ppm of AuNP exhibited better biomechanical properties and thermal stability than pure FN. FN-AuNP composites promoted MSC proliferation and increased the biocompatibility. Mechanistically, vascular endothelial growth factor (VEGF) promoted MSC migration on FN-AuNP through the endothelial oxide synthase (eNOS)/metalloproteinase (MMP) signaling pathway. Vascular femoral artery tissues isolated from the implanted FN-AuNP-coated catheters with MSCs expressed substantial CD31 and alpha-smooth muscle actin (α-SMA), displayed higher antithrombotic activity, as well as better endothelialization ability than those coated with all other materials. These data suggested that the implantation of FN-AuNP-coated catheter with MSCs could be a novel strategy for vascular biomaterials applications.
    MeSH term(s) Catheters ; Cell Adhesion ; Cell Differentiation ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Femoral Artery/cytology ; Femoral Artery/physiology ; Fibronectins/chemistry ; Gold/chemistry ; Humans ; Materials Testing ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Metal Nanoparticles/administration & dosage ; Metal Nanoparticles/chemistry ; Regeneration ; Tissue Engineering/methods ; Vascular Endothelial Growth Factor A/metabolism ; Wound Healing
    Chemical Substances Fibronectins ; Vascular Endothelial Growth Factor A ; Gold (7440-57-5)
    Language English
    Publishing date 2018-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2183417-9
    ISSN 1549-9642 ; 1549-9634
    ISSN (online) 1549-9642
    ISSN 1549-9634
    DOI 10.1016/j.nano.2017.12.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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