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Article ; Online: Sandwich excision in patients with placenta percreta involving maternal bladder.

Feng, J-P / Fan, D-Z / Lin, D-X / Zhang, H-S / Rao, J-M / Liu, Z-P

European review for medical and pharmacological sciences

2022 Volume 26, Issue 12, Page(s) 4252–4257

Abstract: Objective: Our aim is to describe and assess a Sandwich Excision (placenta-uterine-bladder excision together) surgical technique for women with clinically confirmed placenta percreta involving the maternal bladder.: Patients and methods: A ... ...

Abstract	Objective: Our aim is to describe and assess a Sandwich Excision (placenta-uterine-bladder excision together) surgical technique for women with clinically confirmed placenta percreta involving the maternal bladder. Patients and methods: A retrospective cohort study was performed on all patients with clinically confirmed placenta percreta involving the maternal bladder who underwent Sandwich Excision at our large academic institution from January 1, 2014, to June 30, 2019. Results: Twenty-three patients were included. Four patients underwent hysterectomy, and one patient underwent subhysterectomy. The mean duration of surgery was 228.04 ± 85.59 minutes (range, 90.00-503.00 minutes). The mean estimated blood loss was 5,269.57 ± 2,745.81 mL (range, 1,000.00-12,500.00 mL). No thromboembolic events occurred, and there were no maternal or neonatal deaths among the subjects in this study. Conclusions: Sandwich excision is associated with a low rate of hysterectomy in women with placenta percreta involving the maternal bladder. The procedure is a relatively safe technique and can be performed safely by experienced obstetricians who are familiar with the uterus-bladder space. Meanwhile, the success rates and complications of the Sandwich Excision in these patients also need to be evaluated in prospective studies.
MeSH term(s)	Cesarean Section ; Female ; Humans ; Infant, Newborn ; Placenta Accreta/surgery ; Pregnancy ; Prospective Studies ; Retrospective Studies ; Urinary Bladder/surgery
Language	English
Publishing date	2022-07-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202206_29062
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Article: [Associations of genetic variations in pyroptosis related genes with acute adverse events in postoperative rectal cancer patients receiving concurrent chemoradiotherapy].

Chen, H X / Ren, N X / Yang, J / Chen, J N / Lu, Q X / Feng, Y R / Huang, Y / Yin, L L / Lin, D X / Li, Y X / Jin, J / Tan, W

Zhonghua zhong liu za zhi [Chinese journal of oncology

2023 Volume 45, Issue 2, Page(s) 146–152

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Pyroptosis ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Gasdermins ; Chemoradiotherapy/adverse effects ; Rectal Neoplasms/genetics ; Rectal Neoplasms/surgery ; Caspases/genetics ; Caspases/metabolism ; Diarrhea/chemically induced ; Leukopenia/chemically induced ; Leukopenia/genetics ; Genetic Variation ; Dermatitis
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; Gasdermins ; Caspases (EC 3.4.22.-)
Language	Chinese
Publishing date	2023-02-11
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.cn112152-20220622-00447
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Article: [Genetic variations in apoptosis genes are associated with acute adverse events in postoperative rectal cancer patients receiving concurrent chemoradiotherapy].

Yin, L L / Yang, J / Feng, Y R / Huang, Y / Feng, T / Chen, J N / Chen, H X / Lin, D X / Li, Y X / Jin, J / Tan, W

Zhonghua zhong liu za zhi [Chinese journal of oncology

2020 Volume 42, Issue 5, Page(s) 376–382

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis ; Chemoradiotherapy ; Female ; Gastrectomy/adverse effects ; Humans ; Male ; Neoadjuvant Therapy/adverse effects ; Neoplasm Staging ; Postoperative Period ; Rectal Neoplasms/surgery ; Rectal Neoplasms/therapy ; Treatment Outcome
Language	Chinese
Publishing date	2020-05-28
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.cn112152-112152-20190801-00488
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Article ; Online: A molecular epidemiological study of methicillin-resistant Staphylococci environmental contamination in railway stations and coach stations in Guangzhou of China.

Lin, J L / Peng, Y / Ou, Q T / Lin, D X / Li, Y / Ye, X H / Zhou, J L / Yao, Z J

Letters in applied microbiology

2017 Volume 64, Issue 2, Page(s) 131–137

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has caused a series of public health problems since it was first found in 1961. However, there are few research studies on the MRSA environmental contamination in railway stations and coach stations. ... ...

Abstract	Methicillin-resistant Staphylococcus aureus (MRSA) has caused a series of public health problems since it was first found in 1961. However, there are few research studies on the MRSA environmental contamination in railway stations and coach stations. Therefore, the aim of this study was to determine MRSA environmental contamination in public transport stations. Between December 2013 and January 2014, 380 surface samples from three railway stations (180) and four coach stations (200) in Guangzhou were collected to isolate and determine the prevalence and characteristics of Staphylococci strains. 39·21% of all samples were Staphylococci isolates, 1·58% of Staphylococci isolates were MRSA isolates, and 6·05% were methicillin-susceptible S. aureus. The proportion of multidrug resistant among 149 Staphylococci isolates was 75·84%. None of MRSA isolates was identified with the Panton-Valentine Leukocidin (PVL) genes, and one of them was identified with the qac gene. Four MRSA isolates were Staphylococcal Cassette Chromosome mec IVa, and the other two were nontypeable. Staphylococcus aureus isolates were classified into several sequence types (STs), and STs showed possible cross-transmissions of isolates from various sources. Methicillin-resistant Staphylococci contamination prevalence was high, and the environment of stations may be the vectors transmitting the Staphylococci to passengers. Significance and impact of the study: This is the first study to comprehensively report the prevalence, antibiotic resistance, and molecular characteristics of contamination of Staphylococci isolates in railway stations and coach stations of China. It will have great public health implications on infection control in community settings because of the serious hazard of Staphylococci, especially methicillin-resistant Staphylococci. Our findings have provided evidence for relevant departments to reduce the contamination of Staphylococci in environment of public transport stations.
MeSH term(s)	Bacterial Toxins/genetics ; China/epidemiology ; Drug Resistance, Multiple, Bacterial ; Environment ; Epidemiologic Studies ; Exotoxins/genetics ; Humans ; Leukocidins/genetics ; Methicillin Resistance/genetics ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Microbial Sensitivity Tests ; Molecular Epidemiology ; Multilocus Sequence Typing ; Prevalence ; Railroads ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/transmission
Chemical Substances	Bacterial Toxins ; Exotoxins ; Leukocidins ; Panton-Valentine leukocidin
Language	English
Publishing date	2017-02
Publishing country	England
Document type	Journal Article
ZDB-ID	632584-1
ISSN	1472-765X ; 0266-8254
ISSN (online)	1472-765X
ISSN	0266-8254
DOI	10.1111/lam.12700
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Article: [Genetic variation in DNA polymerase kappa gene is associated with the prognosis after platinum-based chemotherapy in small cell lung cancer patients].

Chen, J N / Feng, T / Yang, J / Li, H M / Yuan, P / Ma, F / Yin, L L / Lin, D X / Xu, B H / Tan, W

Zhonghua zhong liu za zhi [Chinese journal of oncology

2019 Volume 41, Issue 2, Page(s) 112–117

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/administration & dosage ; DNA-Directed DNA Polymerase/genetics ; Etoposide/administration & dosage ; Genetic Variation ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Platinum ; Polymorphism, Single Nucleotide ; Prognosis ; Regression Analysis ; Small Cell Lung Carcinoma/drug therapy ; Small Cell Lung Carcinoma/genetics ; Small Cell Lung Carcinoma/mortality ; Treatment Outcome
Chemical Substances	Platinum (49DFR088MY) ; Etoposide (6PLQ3CP4P3) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; POLK protein, human (EC 2.7.7.7) ; Cisplatin (Q20Q21Q62J)
Language	Chinese
Publishing date	2019-03-09
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.issn.0253-3766.2019.02.007
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Article: [Effects of harman and norharman on aflatoxin B1 and aminopyrine metabolism by phenobarbital and 3-methylcholanthrene-induced rat liver microsomes].

Lin, D X

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

1992 Volume 26, Issue 4, Page(s) 209–212

Abstract: Harman and norharman are two beta-carboline derivatives known to be present in certain foods and are formed during pyrolysis of amino-acids. Their effects on the metabolism of aflatoxin B1 and aminopyrine by 3-methylcholanthrene and phenobarbital-induced ...

Abstract	Harman and norharman are two beta-carboline derivatives known to be present in certain foods and are formed during pyrolysis of amino-acids. Their effects on the metabolism of aflatoxin B1 and aminopyrine by 3-methylcholanthrene and phenobarbital-induced rat liver microsomes were studied. Both harman and norharman markedly inhibited the metabolism of aflatoxin B1 to its hydroxylated derivative, aflatoxin M1. However, only norharman showed an inhibitory effect on aminopyrine N-demethylation; harman had no effect. Harman and norharman inhibited aflatoxin B1 binding to DNA, mediated by hepatic microsomes in vitro.
MeSH term(s)	Aflatoxin B1/antagonists & inhibitors ; Aflatoxin B1/metabolism ; Aminopyrine N-Demethylase/metabolism ; Animals ; Carbolines ; Harmine/analogs & derivatives ; Harmine/pharmacology ; Male ; Methylcholanthrene ; Microsomes, Liver/metabolism ; Phenobarbital ; Rats ; Rats, Wistar
Chemical Substances	Carbolines ; Harmine (4FHH5G48T7) ; Methylcholanthrene (56-49-5) ; harman (82D6J0535P) ; norharman (94HMA1I78O) ; Aflatoxin B1 (9N2N2Y55MH) ; Aminopyrine N-Demethylase (EC 1.5.3.-) ; Phenobarbital (YQE403BP4D)
Language	Chinese
Publishing date	1992-07
Publishing country	China
Document type	Journal Article
ZDB-ID	604575-3
ISSN	0253-9624
ISSN	0253-9624
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Article: [Genetic variations in MLH3 and MSH2 genes are associated with the sensitivity and prognosis in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy].

Yang, J / Wang, X / Zou, S M / Li, H M / Xiao, Q / Feng, Y R / Huang, Y / Feng, T / Chen, J N / Lin, D X / Li, Y X / Jin, J / Tan, W

Zhonghua zhong liu za zhi [Chinese journal of oncology

2018 Volume 40, Issue 6, Page(s) 433–440

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Antimetabolites, Antineoplastic/therapeutic use ; Capecitabine/therapeutic use ; Chemoradiotherapy ; DNA Mismatch Repair/genetics ; Genetic Variation ; Genotype ; Haplotypes ; Humans ; MutL Protein Homolog 1/genetics ; MutL Proteins/genetics ; MutS Homolog 2 Protein/genetics ; Neoadjuvant Therapy ; Odds Ratio ; Polymorphism, Single Nucleotide ; Prognosis ; Proportional Hazards Models ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/genetics ; Rectal Neoplasms/pathology
Chemical Substances	Antimetabolites, Antineoplastic ; MLH1 protein, human ; MLH3 protein, human ; Capecitabine (6804DJ8Z9U) ; MSH2 protein, human (EC 3.6.1.3) ; MutL Protein Homolog 1 (EC 3.6.1.3) ; MutL Proteins (EC 3.6.1.3) ; MutS Homolog 2 Protein (EC 3.6.1.3)
Language	Chinese
Publishing date	2018-06-23
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.issn.0253-3766.2018.06.007
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Article: Dependence of uterine cyclooxygenase2 expression on luteinizing hormone signaling.

Lin, D X / Lei, Z M / Rao, Ch V

Biology of reproduction

2005 Volume 73, Issue 2, Page(s) 256–260

Abstract: Several previous studies have demonstrated that uterine Cox2 (also known as Ptgs2) is required for implantation. Luteinizing hormone (LH) released from anterior pituitary gland and human chorionic gonadotropin released from placenta (hCG) can upregulate ... ...

Abstract	Several previous studies have demonstrated that uterine Cox2 (also known as Ptgs2) is required for implantation. Luteinizing hormone (LH) released from anterior pituitary gland and human chorionic gonadotropin released from placenta (hCG) can upregulate the uterine Cox2 gene expression. The Lhcgr knockout (herein designated LHRKO) animals have implantation failure even after estradiol and progesterone therapy. These findings led us to investigate the dependence of uterine Cox2 gene expression on LH signaling in LHRKO animals. The results revealed that, while Cox1 (also known as Ptgs1) mRNA levels were similar, Cox2 mRNA levels were lower in uterus of null animals than in wild-type siblings. Treatment with hCG did not increase Cox2 mRNA levels in null endometrial stromal or myometrial smooth-muscle cells unless gene therapy was performed to introduce native LHCGR. The Cox1 mRNA levels, on the other hand, did not change regardless of the introduction of native or activated Lhcgr or hCG treatment. The Cox2 mRNA increase paralleled the cAMP raise, suggesting that LH uses the cAMP second messenger system. Treating the wild-type uterine cells with hCG resulted in a Cox2 but not Cox1 mRNA increase. This increase became exaggerated when additional native LHCGR were introduced by gene therapy. In conclusion, deletion and reinsertion of Lhcgr further support that uterine Cox2 gene expression is dependent on LH signaling.
MeSH term(s)	Animals ; Chorionic Gonadotropin/pharmacology ; Cyclooxygenase 1 ; Cyclooxygenase 2 ; Enzyme Activation ; Female ; Gene Expression Regulation, Enzymologic ; Genetic Therapy ; Luteinizing Hormone/physiology ; Male ; Membrane Proteins ; Mice ; Mice, Knockout ; Prostaglandin-Endoperoxide Synthases/biosynthesis ; Prostaglandin-Endoperoxide Synthases/genetics ; Prostaglandin-Endoperoxide Synthases/metabolism ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Receptors, LH/genetics ; Receptors, LH/physiology ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/physiology ; Stromal Cells/enzymology ; Stromal Cells/physiology ; Uterus/cytology ; Uterus/enzymology
Chemical Substances	Chorionic Gonadotropin ; Membrane Proteins ; RNA, Messenger ; Receptors, LH ; Luteinizing Hormone (9002-67-9) ; Cyclooxygenase 1 (EC 1.14.99.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1) ; Ptgs1 protein, mouse (EC 1.14.99.1)
Language	English
Publishing date	2005-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1095/biolreprod.105.040667
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Article: [Correlations between genetic variations of glutathione synthetase gene and the response to platinum-based chemotherapy and prognosis of small cell lung cancer patients].

Feng, T / Li, H M / Yuan, P / Yu, D K / Ma, F / Tan, W W / Du, Z L / Yang, J / Huang, Y / Lin, D X / Xu, B H / Tan, W

Zhonghua zhong liu za zhi [Chinese journal of oncology

2017 Volume 39, Issue 2, Page(s) 115–120

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Aged ; Alleles ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carboplatin/administration & dosage ; Cisplatin/administration & dosage ; Etoposide/administration & dosage ; Female ; Genetic Variation ; Genotype ; Glutathione Synthase/genetics ; Haplotypes ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/enzymology ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Odds Ratio ; Platinum Compounds/therapeutic use ; Polymorphism, Single Nucleotide ; Prognosis ; Proportional Hazards Models ; Risk ; Small Cell Lung Carcinoma/drug therapy ; Small Cell Lung Carcinoma/enzymology ; Small Cell Lung Carcinoma/genetics ; Small Cell Lung Carcinoma/mortality ; Treatment Outcome
Chemical Substances	Platinum Compounds ; Etoposide (6PLQ3CP4P3) ; Carboplatin (BG3F62OND5) ; Glutathione Synthase (EC 6.3.2.3) ; Cisplatin (Q20Q21Q62J)
Language	Chinese
Publishing date	2017-02-23
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.issn.0253-3766.2017.02.008
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Article: [Genetic variation in DNA repair gene RAD52 is associated with the response to platinum-based chemotherapy in SCLC patients].

Li, H M / Yuan, P / Yu, D K / Ma, F / Tan, W W / Feng, T / Yang, J / Huang, Y / Lin, D X / Xu, B H / Tan, W

Zhonghua zhong liu za zhi [Chinese journal of oncology

2016 Volume 38, Issue 7, Page(s) 504–509

Abstract: Objective: To explore the associations between genetic variations of DNA repair gene RAD52 and response to platinum-based chemotherapy of small cell lung cancer (SCLC), and to analyze the influencing factors on survival.: Methods: Nine haplotype- ... ...

Abstract	Objective: To explore the associations between genetic variations of DNA repair gene RAD52 and response to platinum-based chemotherapy of small cell lung cancer (SCLC), and to analyze the influencing factors on survival. Methods: Nine haplotype-tagging single nucleotide polymorphisms (htSNPs) of RAD52 were genotyped by Sequenom Mass ARRAY technology in 939 SCLC patients who received platinum-based chemotherapy, and had different response and survival time. The associations between genotypes and platinum-based chemotherapy response were analyzed by odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for sex, age, smoking, KPS, staging and chemotherapy regimens, by unconditional logistic regression model. The relative ratios (RRs) were estimated using Cox proportional hazards regression model. Results: Among the 939 cases, 483 (51.4%) cases received cis-platinum and etoposide treatment while others treated with carboplatin and etoposide. Six hundred and eighty two patients were chemotherapy responders in the study with a response rate of 72.6%. Patients were followed up to get their survival information. The median survival time (MST) of these patients was 25 months. We found that rs10774474 SNP which located in the 5'-flanking region of RAD52 was significantly associated with chemotherapy response. Compared with the TT genotype, patients with TA and AA genotype had a worse chemotherapy response and increased risk of no-response (P=0.004). Correlation analysis showed that patients with KPS >80 had a better chemotherapy response than those with KPS≤80 (P=0.001). The patients with extensive-stage had a worse chemotherapy response than those with limited-stage (P<0.001). Cox proportional hazards regression model analysis showed that nine htSNPs of RAD52 were not associated with the overall survival (OS) of SCLC patients who received platinum-based chemotherapy. Age≤56, KPS>80, limited-stage, chemotherapy response and radiation therapy can remarkably prolong OS (allP<0.05). Conclusions: These results suggest that RAD52 genetic polymorphism rs10774474 plays an important role in the response to platinum-based chemotherapy, and may be a potential genetic biomarker for SCLC personalized treatment.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Carboplatin/therapeutic use ; Cisplatin/therapeutic use ; Etoposide/therapeutic use ; Genetic Variation ; Genotype ; Haplotypes ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Odds Ratio ; Polymorphism, Single Nucleotide ; Proportional Hazards Models ; Rad52 DNA Repair and Recombination Protein/genetics ; Regression Analysis ; Risk ; Small Cell Lung Carcinoma/drug therapy ; Small Cell Lung Carcinoma/genetics ; Small Cell Lung Carcinoma/mortality ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; RAD52 protein, human ; Rad52 DNA Repair and Recombination Protein ; Etoposide (6PLQ3CP4P3) ; Carboplatin (BG3F62OND5) ; Cisplatin (Q20Q21Q62J)
Language	Chinese
Publishing date	2016-07
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.issn.0253-3766.2016.07.005
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