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  1. Book ; Online ; E-Book: Patient-derived xenograft models of human cancer

    Wang, Yuzhuo / Lin, Dong / Gout, Peter W.

    (Molecular and translational medicine)

    2017  

    Author's details Yuzhuo Wang, Dong Lin, Peter W. Gout editors
    Series title Molecular and translational medicine
    Keywords PDX cancer models ; cancer heterogeneity ; Modeling cancer metastasis ; Modeling drug resistance ; PDX and biomarker development
    Subject code 610
    Language English
    Size 1 Online-Ressource (xi, 204 Seiten)
    Publisher Humana Press
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019419102
    ISBN 978-3-319-55825-7 ; 9783319558240 ; 3-319-55825-0 ; 3319558242
    DOI 10.1007/978-3-319-55825-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Public Participation and the Effect of Environmental Governance in China

    Lin Dong / Zuobao Wang / Yuxiang Zhou

    Sustainability, Vol 15, Iss 4442, p

    A Systematic Review and Meta-Analysis

    2023  Volume 4442

    Abstract: The public plays a key role in environmental governance systems. Many studies have discussed the effects of public participation on environmental governance in China from different perspectives. However, there has been no systematic integrated analysis ... ...

    Abstract The public plays a key role in environmental governance systems. Many studies have discussed the effects of public participation on environmental governance in China from different perspectives. However, there has been no systematic integrated analysis of the effects of public participation on environmental governance and the causes of its heterogeneity. To help fill this gap, we developed a comprehensive analysis framework of the regional differences–participation method–pollution type, and 85 effect sizes were tested by the meta-analysis method. The results showed that there was a weak positive correlation between public environmental participation and the environmental governance effect ( ES = 0.044, p < 0.001). The correlation between the two was regulated by regional space and pollution type. The promotion effect of public participation on waste and noise was significantly higher than that of central and western areas. However, there was no significant difference between the different participation methods. Taken together, these results have important significance for increasing public participation and optimizing the effect of environmental governance.
    Keywords public participation ; environmental governance ; meta-analysis ; China’s local government ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 320
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Incidence and risk factors of proximal junctional kyphosis in adolescent idiopathic scoliosis after correction surgery: a meta-analysis and systematic review.

    Ji, XingHua / Wei, LinDong / Xing, ZeJun / Duan, YuChen

    Journal of orthopaedic surgery and research

    2024  Volume 19, Issue 1, Page(s) 217

    Abstract: Aim: To analyze the risk factors of proximal junctional kyphosis (PJK) after correction surgery in patients with adolescent idiopathic scoliosis (AIS).: Methods: PubMed, Medline, Embase, Cochrane Library, Web of Science, CNKI, and EMCC databases were ...

    Abstract Aim: To analyze the risk factors of proximal junctional kyphosis (PJK) after correction surgery in patients with adolescent idiopathic scoliosis (AIS).
    Methods: PubMed, Medline, Embase, Cochrane Library, Web of Science, CNKI, and EMCC databases were searched for retrospective studies utilizing all AIS patients with PJK after corrective surgery to collect preoperative, postoperative, and follow-up imaging parameters, including thoracic kyphosis (TK), lumbar lordosis (LL), proximal junctional angle (PJA), the sagittal vertical axis (SVA), pelvic incidence (PI), pelvic tilt (PT), pelvic incidence-lumbar lordosis (PI-LL), sacral slope (SS), rod contour angle (RCA) and upper instrumented vertebra (UIV).
    Results: Nineteen retrospective studies were included in this meta-analysis, including 550 patients in the intervention group and 3456 patients in the control group. Overall, sex (OR 1.40, 95% CI (1.08, 1.83), P = 0.01), larger preoperative TK (WMD 6.82, 95% CI (5.48, 8.16), P < 0.00001), larger follow-up TK (WMD 8.96, 95% CI (5.62, 12.30), P < 0.00001), larger postoperative LL (WMD 2.31, 95% CI (0.91, 3.71), P = 0.001), larger follow-up LL (WMD 2.51, 95% CI (1.19, 3.84), P = 0.0002), great change in LL (WMD - 2.72, 95% CI (- 4.69, - 0.76), P = 0.006), larger postoperative PJA (WMD 4.94, 95% CI (3.62, 6.26), P < 0.00001), larger follow-up PJA (WMD 13.39, 95% CI (11.09, 15.69), P < 0.00001), larger postoperative PI-LL (WMD - 9.57, 95% CI (- 17.42, - 1.71), P = 0.02), larger follow-up PI-LL (WMD - 12.62, 95% CI (- 17.62, - 7.62), P < 0.00001), larger preoperative SVA (WMD 0.73, 95% CI (0.26, 1.19), P = 0.002), larger preoperative SS (WMD - 3.43, 95% CI (- 4.71, - 2.14), P < 0.00001), RCA (WMD 1.66, 95% CI (0.48, 2.84), P = 0.006) were identified as risk factors for PJK in patients with AIS. For patients with Lenke 5 AIS, larger preoperative TK (WMD 7.85, 95% CI (5.69, 10.00), P < 0.00001), larger postoperative TK (WMD 9.66, 95% CI (1.06, 18.26), P = 0.03, larger follow-up TK (WMD 11.92, 95% CI (6.99, 16.86), P < 0.00001, larger preoperative PJA (WMD 0.72, 95% CI (0.03, 1.41), P = 0.04, larger postoperative PJA (WMD 5.54, 95% CI (3.57, 7.52), P < 0.00001), larger follow-up PJA (WMD 12.42, 95% CI 9.24, 15.60), P < 0.00001, larger follow-up SVA (WMD 0.07, 95% CI (- 0.46, 0.60), P = 0.04), larger preoperative PT (WMD - 3.04, 95% CI (- 5.27, - 0.81), P = 0.008, larger follow-up PT (WMD - 3.69, 95% CI (- 6.66, - 0.72), P = 0.02) were identified as risk factors for PJK.
    Conclusion: Following corrective surgery, 19% of AIS patients experienced PJK, with Lenke 5 contributing to 25%. Prior and post-op measurements play significant roles in predicting PJK occurrence; thus, meticulous, personalized preoperative planning is crucial. This includes considering individualized treatments based on the Lenke classification as our future evaluation standard.
    MeSH term(s) Humans ; Adolescent ; Scoliosis/diagnostic imaging ; Scoliosis/epidemiology ; Scoliosis/surgery ; Lordosis/complications ; Retrospective Studies ; Kyphosis/diagnostic imaging ; Kyphosis/epidemiology ; Kyphosis/etiology ; Sacrum ; Risk Factors ; Spinal Fusion/adverse effects ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Thoracic Vertebrae/surgery
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-024-04638-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Parameter-by-parameter estimation method for adsorption isotherm in hydrophobic interaction chromatography.

    Yang, Yu-Xiang / Chen, Yu-Cheng / Yao, Shan-Jing / Lin, Dong-Qiang

    Journal of chromatography. A

    2024  Volume 1716, Page(s) 464638

    Abstract: Hydrophobic interaction chromatography (HIC) is used as a critical polishing step in the downstream processing of biopharmaceuticals. Normally the process development of HIC is a cumbersome and time-consuming task, and the mechanical models can provide a ...

    Abstract Hydrophobic interaction chromatography (HIC) is used as a critical polishing step in the downstream processing of biopharmaceuticals. Normally the process development of HIC is a cumbersome and time-consuming task, and the mechanical models can provide a powerful tool to characterize the process, assist process design and accelerate process development. However, the current estimation of model parameters relies on the inverse method, which lacks an efficient and logical parameter estimation strategy. In this study, a parameter-by-parameter (PbP) method based on the theoretical derivation and simplifying assumptions was proposed to estimate the Mollerup isotherm parameters for HIC. The method involves three key steps: (1) linear regression (LR) to estimate the salt-protein interaction parameter and the equilibrium constant; (2) linear approximation (LA) to estimate the stoichiometric parameter and the maximum binding capacity; and (3) inverse method to estimate the protein-protein interaction parameter and the kinetic coefficient. The results indicated that the LR step should be used for dilution condition (loading factor below 5%), while the LA step should be conducted when the isotherm is in the transition or nonlinear regions. Six numerical experiments were conducted to implement the PbP method. The results demonstrated that the PbP method developed allows for the systematic estimation of HIC parameters one-by-one, effectively reducing the number of parameters required for inverse method estimation from six to two. This helps prevent non-identifiability of structural parameters. The feasibility of the PbP-HIC method was further validated by real-world experiments. Moreover, the PbP method enhances the mechanistic understanding of adsorption behavior of HIC and shows a promising application to other stoichiometric displacement model-derived isotherms.
    MeSH term(s) Adsorption ; Chromatography/methods ; Hydrophobic and Hydrophilic Interactions ; Sodium Chloride ; Sodium Chloride, Dietary
    Chemical Substances Sodium Chloride (451W47IQ8X) ; Sodium Chloride, Dietary
    Language English
    Publishing date 2024-01-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2024.464638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Solution-Processed Metal Oxide Thin-Film Transistor at Low Temperature via A Combination Strategy of H

    Yang, Jingze / Lin, Dong / Chen, Yushan / Li, Tiejun / Liu, Jing

    Small methods

    2024  , Page(s) e2301739

    Abstract: Solution processing has emerged as a promising technique for the fabrication of oxide thin-film transistors (TFTs), offering advantages such as low cost, high throughput, and exceptional compositional control. However, achieving reasonable electrical ... ...

    Abstract Solution processing has emerged as a promising technique for the fabrication of oxide thin-film transistors (TFTs), offering advantages such as low cost, high throughput, and exceptional compositional control. However, achieving reasonable electrical properties typically demands high annealing temperatures in the fabrication process. In addressing this challenge, a novel combination strategy is proposed that involves integrating the H
    Language English
    Publishing date 2024-03-04
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202301739
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  6. Article ; Online: Super-resolution reconstruction based on two-stage residual neural network

    Lin Dong / Kohei Inoue

    Machine Learning with Applications, Vol 6, Iss , Pp 100162- (2021)

    2021  

    Abstract: With the constant update of deep learning technology, the super-resolution reconstruction technology based on deep learning has also attained a significant breakthrough. This paper primarily discusses the integration of deep learning and super-resolution ...

    Abstract With the constant update of deep learning technology, the super-resolution reconstruction technology based on deep learning has also attained a significant breakthrough. This paper primarily discusses the integration of deep learning and super-resolution reconstruction techniques. Regarding the application of deep learning in super-resolution reconstruction, the improvement is focused on the two dimensions of algorithm efficiency and reconstruction effect. On the basis of the currently available neural network algorithms, this paper puts forward the two-stage residual super-resolution reconstruction network structure. Thereinto, the improvement is mainly embodied in the modification of the image feature extraction network modules and the increase of the residual block into two stages. It is experimentally evidenced by algorithm simulation that the two-stage residual network in this paper shows a certain extent of improvement for the super-resolution reconstruction effect compared with the related methods.
    Keywords Super-resolution reconstruction ; Deep learning ; Two-stage residual network ; Cybernetics ; Q300-390 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 006
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Study on Nonlinear Aerodynamic Characteristics of a Semi-Closed Box Bridge Deck Based on Coupled Amplitude Variation

    Haoyang Lu / Jie Jia / Lixin Zhang / Lin Dong

    Applied Sciences, Vol 12, Iss 7609, p

    2022  Volume 7609

    Abstract: This paper explores the nonlinear characteristics of the self-excited aerodynamic forces of a semi-closed box deck section to perfect the theory of aeroelastic response analysis. A numerical wind tunnel model was established based on the computational ... ...

    Abstract This paper explores the nonlinear characteristics of the self-excited aerodynamic forces of a semi-closed box deck section to perfect the theory of aeroelastic response analysis. A numerical wind tunnel model was established based on the computational fluid dynamics (CFD) method. The heaving-pitching coupled motion is realized by loading user-defined function (UDF) and dynamic grid technology. The self-excited aerodynamic forces varying with amplitude are identified and analyzed, and the reliability of the aerodynamic results obtained by numerical simulation is verified in the wind tunnel test. In the heaving-pitching coupled motion, the results show that the nonlinear characteristics of aerodynamic forces, especially the aerodynamic moment, are mainly affected by the pitching motion. The phenomenon of high-order harmonic energy transfer is observed with the increase in pitching amplitude, and the main component of high-order harmonic can be determined by the pitching amplitude. The contribution of heaving motion to aerodynamic forces nonlinear components is small, but its influence on nonlinear characteristics is complex. Small amplitude heaving motion plays a positive damping role in heaving-pitching coupled motion, and its scope and effect of positive damping action are affected by pitching motion. The extreme value heaving amplitude of positive damping action is observed in the aerodynamic lift.
    Keywords long-span bridge ; nonlinear self-excited aerodynamic force ; flutter ; limit cycle oscillations (LCO) ; computational fluid dynamics (CFD) ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 621
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Transport and Mobility Needs for an Ageing Society from a Policy Perspective: Review and Implications.

    Lin, Dong / Cui, Jianqiang

    International journal of environmental research and public health

    2021  Volume 18, Issue 22

    Abstract: The world population is ageing, and many countries in the world are confronted by significant challenges in adapting their health and social systems to meet the requirements of this demographic change. It is well-accepted that mobility is often closely ... ...

    Abstract The world population is ageing, and many countries in the world are confronted by significant challenges in adapting their health and social systems to meet the requirements of this demographic change. It is well-accepted that mobility is often closely linked to a person's independence, wellbeing and quality of life. Interest has increased across the world with regard to how the mobility needs of an ageing society can be addressed, since an ageing population is confronting nations across the globe and poses long-term challenges on a nation's many aspects, including transport. Questions of how future policies can better respond to the mobility needs of an ageing population and how these policies can be delivered have emerged as major concerns for transport planners, operators and decision-makers. This review explores the way in which implemented policies have addressed the mobility needs of an ageing society, focusing on the provision of accessible, safe and affordable transport. More specifically, the paper reviews legislative and institutional approaches of addressing the mobility needs of an ageing population. The paper discusses the outcomes of these approaches and the remaining challenges in this policy area that relate to elderly people's mobility and provides future research directions. Based on the discussion, clear conclusions about the effectiveness of particular policies are difficult to make. Alternative approaches (e.g., technological innovations) need to be considered in addressing older people's mobility needs.
    MeSH term(s) Aged ; Aging ; Humans ; Policy ; Quality of Life
    Language English
    Publishing date 2021-11-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182211802
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  9. Article ; Online: Clinical and electromyographic signals analysis about the effect of space-adjustment splint on overerupted maxillary molars.

    Lei, Qun / Lin, Dong / Lin, Kaijin / Huang, Wenxiu / Wu, Dong / Liu, Yuyu

    BMC oral health

    2024  Volume 24, Issue 1, Page(s) 296

    Abstract: Background: Overerupted maxillary molars is common in adults, which can lead to insufficient intermaxillary vertical space ,great difficulty in prosthetic reconstruction ,and cause occlusal interference in movements.To reconstruct occlusal function, it ... ...

    Abstract Background: Overerupted maxillary molars is common in adults, which can lead to insufficient intermaxillary vertical space ,great difficulty in prosthetic reconstruction ,and cause occlusal interference in movements.To reconstruct occlusal function, it is necessary to prepare enough space for prostheses. The aim of the present study was to evaluate the effect of space-adjustment occlusal splint on overerupted maxillary molars by clinical and electromyographic signals analysis.
    Methods: Eighteen patients with overerupted maxillary molars were selected to wear space-adjustment occlusal splint suppressing overerupted maxillary molars for three months. Satisfaction was assessed by 5-point Likert; intermaxillary vertical space and the teeth transportation distance were measured in models; clinical periodontal status were evaluated by periodontal probing depth (PPT) and bleeding index (BI); electromyographic recordings of the masseter and anterior temporal muscles were monitored by Cranio-Mandibular K7 Evaluation System.
    Results: All the patients were satisfied with the treatment effect (Likert scale ≧ 4). The intermaxillary space in edentulous areas after treatment showed statistically significant increasing when compared with those before treatment. PPT and BI showed no significant difference. No statistically significant differences were found in electromyographic activity of anterior temporal muscles, while a reduction of muscle activity in masseter in the contralateral side were detected in post-treatment evaluations compared with pre-treatment at mandibular rest position.
    Conclusions: Space-adjustment occlusal splint is an efficient treatment option on overerupted maxillary molars by intruding the maxillary molar to obtain adequate intermaxillary space for prostheses.
    MeSH term(s) Adult ; Humans ; Splints ; Molar/surgery ; Masseter Muscle/physiology ; Temporal Muscle/physiology ; Occlusal Splints ; Electromyography
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-024-04039-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Residence time distribution in continuous virus filtration.

    Chen, Yu-Cheng / Recanati, Gabriele / De Mathia, Fernando / Lin, Dong-Qiang / Jungbauer, Alois

    Biotechnology and bioengineering

    2024  

    Abstract: Regulatory authorities recommend using residence time distribution (RTD) to address material traceability in continuous manufacturing. Continuous virus filtration is an essential but poorly understood step in biologics manufacturing in respect to fluid ... ...

    Abstract Regulatory authorities recommend using residence time distribution (RTD) to address material traceability in continuous manufacturing. Continuous virus filtration is an essential but poorly understood step in biologics manufacturing in respect to fluid dynamics and scale-up. Here we describe a model that considers nonideal mixing and film resistance for RTD prediction in continuous virus filtration, and its experimental validation using the inert tracer NaNO
    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.28696
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