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Article: Efficacy and safety of computed tomography-guided microwave ablation with fine needle-assisted puncture positioning technique for hepatocellular carcinoma.

Hao, Ming-Zhi / Hu, Yu-Bin / Chen, Qi-Zhong / Chen, Zhang-Xian / Lin, Hai-Lan

World journal of gastrointestinal oncology

2022 Volume 14, Issue 9, Page(s) 1727–1738

Abstract: Background: In microwave ablation (MWA), although computed tomography (CT) scanning can overcome gas interference, it cannot achieve real-time localization. Therefore, the puncture technique is more important in CT-guided ablation.: Aim: To compare ... ...

Abstract	Background: In microwave ablation (MWA), although computed tomography (CT) scanning can overcome gas interference, it cannot achieve real-time localization. Therefore, the puncture technique is more important in CT-guided ablation. Aim: To compare the fine needle-assisted puncture (FNP) positioning technique and the conventional puncture (CP) technique for the safety and efficacy of CT-guided MWA in treating hepatocellular carcinoma (HCC). Methods: This retrospective study included 124 patients with 166 tumor nodules from February 2018 and June 2021. Seventy patients received CT-guided MWA under the FNP technique (FNP group), and 54 patients received MWA under the CP technique (CP group). Intergroup comparisons were made regarding local tumor progression (LTP), recurrence-free survival (RFS), overall survival (OS), and complications. The influencing variables of LTP and RFS were analyzed through univariate and multivariate regressions. Results: The 1-, 2-, and 3-year cumulative incidences of LTP in the FNP group were significantly lower than those in the CP group (7.4%, 12.7%, 21.3% Conclusion: The FNP technique used in CT-guided MWA may improve outcomes in terms of LTP, RFS, and procedure-related complications for HCC.
Language	English
Publishing date	2022-09-08
Publishing country	China
Document type	Journal Article
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v14.i9.1727
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Article: The efficacy and safety of

He, Xiao-Jian / Wang, Xiao-Ling / Sun, Dong-Jie / Huang, Xiao-Yan / Liu, Gang / Li, Da-Zhou / Lin, Hai-Lan / Zeng, Xiang-Peng / Li, Dong-Liang / Wang, Wen

Therapeutic advances in gastroenterology

2023 Volume 16, Page(s) 17562848221147763

Abstract: Background: We previously reported that antofloxacin-based bismuth quadruple therapy was safe and effective for : Objective: To investigate the effect of adding : Design: Single-center, prospective randomized controlled study.: Methods: A total ...

Abstract	Background: We previously reported that antofloxacin-based bismuth quadruple therapy was safe and effective for Objective: To investigate the effect of adding Design: Single-center, prospective randomized controlled study. Methods: A total of 172 patients with Results: There were no statistically significant differences in the eradication rates of Conclusion: Although the addition of Trial registration number: ChiCTR2200056931.
Language	English
Publishing date	2023-01-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2440710-0
ISSN	1756-2848 ; 1756-283X
ISSN (online)	1756-2848
ISSN	1756-283X
DOI	10.1177/17562848221147763
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Article ; Online: Novel beagle model of gastric local fibrotic target lesions for the evaluation and training of endoscopic techniques.

He, Xiao-Jian / Wang, Xiao-Ling / Jiang, Chuan-Shen / Hong, Dong-Gui / Lin, Hai-Lan / Zheng, Yun-Ping / Li, Han / Chen, Xin-Jiang / Huang, Jian-Xiao / Dai, Ling-Shuang / Liu, Mei-Yan / Luo, Bao-Xiang / Li, Dong-Liang / Li, Da-Zhou / Wang, Wen

BMC gastroenterology

2023 Volume 23, Issue 1, Page(s) 412

Abstract: Background: Novel endoscopic techniques used in the treatment of gastric lesions with local submucosal fibrosis need preclinical evaluation and training due to safety limitations. Therefore, the purpose of our study was to establish an animal model of ... ...

Abstract	Background: Novel endoscopic techniques used in the treatment of gastric lesions with local submucosal fibrosis need preclinical evaluation and training due to safety limitations. Therefore, the purpose of our study was to establish an animal model of gastric local fibrotic target lesions and assess its feasibility in the evaluation and training of endoscopic techniques. Methods: In six experimental beagles, a 50% glucose solution was injected into three submucosal areas of the fundus, body, and antrum of the stomach to create gastric local fibrotic target lesions (experimental group). On post-injection day (PID) 7, the injection sites were assessed endoscopically to confirm the presence of submucosal fibrosis formation, and the dental floss clip traction assisted endoscopic submucosal dissection (DFC-ESD) procedure was performed on the gastric local fibrotic target lesions to confirm its feasibility after endoscopic observation. The normal gastric mucosa of six control beagles underwent the same procedure (control group). All the resected specimens were evaluated by histological examination. Results: All 12 beagles survived without postoperative adverse events. On PID 7, 16 ulcer changes were observed at the injection sites (16/18) under the endoscope, and endoscopic ultrasonography confirmed the local submucosal fibrosis formation in all ulcer lesions. The subsequent DFC-ESD was successfully performed on the 32 gastric target lesions, and the mean submucosal dissection time in the ulcer lesions was greater than that in the normal gastric mucosa (15.3 ± 5.6 vs. 6.8 ± 0.8 min; P < 0.001). There was no difference in rates of en bloc resection, severe hemorrhage, or perforation between the two groups. Histological analysis of the ulcer lesions showed the absence of epithelial or muscularis mucosae and extensive submucosal fibrous tissue proliferations compared with normal gastric mucosa. Overall, endoscopists had high satisfaction with the realism and feasibility of the animal model. Conclusion: We developed a novel animal model of gastric local fibrotic target lesions to simulate difficult clinical situations, which strongly appeared to be suitable for the preclinical evaluation and learning of advanced endoscopic techniques.
MeSH term(s)	Dogs ; Animals ; Ulcer/pathology ; Oral Submucous Fibrosis/pathology ; Gastric Mucosa/pathology ; Endoscopy ; Stomach Neoplasms/pathology ; Endoscopic Mucosal Resection/methods ; Treatment Outcome
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-023-03055-0
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Article: Aminocalix[4]arene monolayers as magnetoelastic sensor sensing elements for selective detection of benzo[a]pyrene

Lin, Hai-Lan / Zhi-Huang Li / Pei Liu / Bing-Bing Song / Qing-Yun Cai / Craig A. Grimes

Analytical methods. 2016 Jan. 21, v. 8, no. 4

2016

Abstract: A wireless magnetoelastic-sensing device for the selective detection of benzo[a]pyrene (BaP) is reported using aminocalix[4]arene (AC₄) monolayers as the sensor sensing elements and AC₄-modified Au nanoparticles (AC₄-Au NPs) as signal-amplifying tags. A ... ...

Abstract	A wireless magnetoelastic-sensing device for the selective detection of benzo[a]pyrene (BaP) is reported using aminocalix[4]arene (AC₄) monolayers as the sensor sensing elements and AC₄-modified Au nanoparticles (AC₄-Au NPs) as signal-amplifying tags. A sandwich-type detection strategy involves the AC₄ self-assembled on the Au-protected sensor surface and AC₄-Au NPs, both of which flank the BaP target in sequence. As the AC₄-Au NPs combined BaP absorbs on the sensor's surface, there is an increase in the mass load on the sensor, and consequently a decrease in resonance frequency. Under optimal conditions, the sensor shows a linear response to the concentration of BaP in the range of 1.04 × 10⁻⁷ M to 1.04 × 10⁻¹¹ M, with a detection limit of 5.0 × 10⁻¹¹ M. Other polycyclic aromatic hydrocarbons (PAHs) and environmental pollutants show no interference on the detection.
Keywords	analytical methods ; benzo(a)pyrene ; gold ; nanogold ; pollutants ; polycyclic aromatic hydrocarbons
Language	English
Dates of publication	2016-0121
Size	p. 912-918.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/c5ay02540k
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Article: Determination of Beryllium in Soil and Sediment by Graphite Furnace Atomic Absorption with a Microwave-Acid Digestion Method.

Lin, Hai-lan / Gan, Jie / Yu, Lei / Zhu, Ri-long / Tian, Yun / Luo, Yue-ping

Guang pu xue yu guang pu fen xi = Guang pu

2015 Volume 35, Issue 11, Page(s) 3275–3280

Abstract: A method for determination of beryllium in soils and sediments by microwave-acid digestion/graphite furnace atomic absorption (GFAA) is described. In this paper, the working conditions of the instrument are optimized, the drawing of calibration curve is ... ...

Abstract	A method for determination of beryllium in soils and sediments by microwave-acid digestion/graphite furnace atomic absorption (GFAA) is described. In this paper, the working conditions of the instrument are optimized, the drawing of calibration curve is expounded, the pretreatment process of soil and sediments (including microwave heating process and the selection of digestion system) is discussed, and the interference of coexisting elements is examined. The sample was pretreated by microwave digestion parameters using HNO₃/ HCl/HF mixed acid system. The method is fast and simple without matrix modifier, and has no interference by coexisting ions, and has high repeatability and reproducibility. Under the optimal experimental conditions, the limit of detection (LOD) is 0.004 9 mg · kg⁻¹ (sample quantity 0.200 0 g, sample volume 25 mL), and the limits of quantitation (LOQ) is 0.20 mg · kg⁻¹. This method is used to measure the standard samples and actual samples, whether in the laboratory, or between laboratories, has good accuracy and precision.
Language	English
Publishing date	2015-11
Publishing country	China
Document type	Journal Article
ISSN	1000-0593
ISSN	1000-0593
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Article ; Online: Safety and efficacy of transcatheter arterial chemoembolization with embospheres in treatment of hepatocellular carcinoma.

Hao, Ming Zhi / Lin, Hai Lan / Chen, Qi Zhong / Hu, Yu Bin / Chen, Jian Bin / Zheng, Jian Xiong / Zhou, Dong / Zhang, Hui

Journal of digestive diseases

2017 Volume 18, Issue 1, Page(s) 31–39

Abstract: Objective: To investigate the safety and efficacy of transcatheter arterial chemoembolization (TACE) with embospheres for the treatment of unresectable hepatocellular carcinoma (HCC).: Methods: Patients with unresectable HCC who were treated with ... ...

Abstract	Objective: To investigate the safety and efficacy of transcatheter arterial chemoembolization (TACE) with embospheres for the treatment of unresectable hepatocellular carcinoma (HCC). Methods: Patients with unresectable HCC who were treated with TACE followed by embosphere treatment (Embo-TACE) or conventional TACE (cTACE) between May 2010 and March 2014 were retrospectively included in this study. The Embo-TACE group received lipiodol and chemotherapeutic agent emulsion, followed by embospheres. The cTACE group received lipiodol and chemotherapeutic agent emulsion, followed by gelatin sponge pellets. Time to progression (TTP), overall survival (OS), overall response rate (ORR), and safety were compared between the two groups. Univariate and multivariate regression analyses of the factors affecting survival were conducted. Results: The median TTP and OS in the Embo-TACE group were significantly longer than those in the cTACE group (TPP: 7.0 months vs 5.4 months, P = 0.035; OS: 15 months vs 12 months, P = 0.032). Seven days after the first TACE treatment, alanine aminotransferase level was higher in the cTACE group than in the Embo-TACE group (P = 0.015). The ORR did not significantly differ between the two groups (P = 0.827). Additional therapy and local responses one month after the first TACE treatment were associated with OS. Conclusions: Embo-TACE resulted in a significant improvement in TTP and OS for patients with unresectable HCC, compared with cTACE. Furthermore, Embo-TACE was better tolerated. Additional therapy and local responses one month after the first TACE were independent prognostic factors for OS.
MeSH term(s)	Acrylic Resins/adverse effects ; Acrylic Resins/therapeutic use ; Acute Lung Injury/etiology ; Adolescent ; Adult ; Aged ; Angiography ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/methods ; Ethiodized Oil/adverse effects ; Ethiodized Oil/therapeutic use ; Female ; Gelatin/adverse effects ; Gelatin/therapeutic use ; Hepatic Artery/diagnostic imaging ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome ; Young Adult
Chemical Substances	Acrylic Resins ; trisacryl gelatin microspheres ; Ethiodized Oil (8008-53-5) ; Gelatin (9000-70-8)
Language	English
Publishing date	2017-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2317117-0
ISSN	1751-2980 ; 1751-2972
ISSN (online)	1751-2980
ISSN	1751-2972
DOI	10.1111/1751-2980.12435
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Article ; Online: Immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma (CHANCE2201): a target trial emulation study.

Jin, Zhi-Cheng / Chen, Jian-Jian / Zhu, Xiao-Li / Duan, Xu-Hua / Xin, Yu-Jing / Zhong, Bin-Yan / Chen, Jin-Zhang / Tie, Jun / Zhu, Kang-Shun / Zhang, Lan / Huang, Ming / Piao, Ming-Jian / Li, Xiao / Shi, Hai-Bin / Liu, Rui-Bao / Xu, Ai-Bing / Ji, Fanpu / Wu, Jian-Bing / Shao, Guo-Liang /

Li, Hai-Liang / Huang, Ming-Sheng / Peng, Zhi-Yi / Ji, Jian-Song / Yuan, Chun-Wang / Liu, Xiu-Feng / Hu, Zhou-Chao / Yang, Wei-Zhu / Yin, Guo-Wen / Huang, Jin-Hua / Ge, Nai-Jian / Qi, Xiaolong / Zhao, Yang / Zhou, Jia-Wei / Xu, Guo-Hui / Tu, Qiang / Lin, Hai-Lan / Zhang, Yao-Jun / Jiang, Hua / Shao, Hai-Bo / Su, Yong-Jie / Chen, Ting-Song / Shi, Bao-Qi / Zhou, Xiang / Zhao, Hai-Tao / Zhu, Hai-Dong / Ren, Zheng-Gang / Teng, Gao-Jun

EClinicalMedicine

2024 Volume 72, Page(s) 102622

Abstract: Background: The role of transarterial chemoembolization (TACE) in the treatment of advanced hepatocellular carcinoma (HCC) is unconfirmed. This study aimed to assess the efficacy and safety of immune checkpoint inhibitors (ICIs) plus anti-vascular ... ...

Abstract	Background: The role of transarterial chemoembolization (TACE) in the treatment of advanced hepatocellular carcinoma (HCC) is unconfirmed. This study aimed to assess the efficacy and safety of immune checkpoint inhibitors (ICIs) plus anti-vascular endothelial growth factor (anti-VEGF) antibody/tyrosine kinase inhibitors (TKIs) with or without TACE as first-line treatment for advanced HCC. Methods: This nationwide, multicenter, retrospective cohort study included advanced HCC patients receiving either TACE with ICIs plus anti-VEGF antibody/TKIs (TACE-ICI-VEGF) or only ICIs plus anti-VEGF antibody/TKIs (ICI-VEGF) from January 2018 to December 2022. The study design followed the target trial emulation framework with stabilized inverse probability of treatment weighting (sIPTW) to minimize biases. The primary outcome was overall survival (OS). Secondary outcomes included progression-free survival (PFS), objective response rate (ORR), and safety. The study is registered with ClinicalTrials.gov, NCT05332821. Findings: Among 1244 patients included in the analysis, 802 (64.5%) patients received TACE-ICI-VEGF treatment, and 442 (35.5%) patients received ICI-VEGF treatment. The median follow-up time was 21.1 months and 20.6 months, respectively. Post-application of sIPTW, baseline characteristics were well-balanced between the two groups. TACE-ICI-VEGF group exhibited a significantly improved median OS (22.6 months [95% CI: 21.2-23.9] vs 15.9 months [14.9-17.8]; P < 0.0001; adjusted hazard ratio [aHR] 0.63 [95% CI: 0.53-0.75]). Median PFS was also longer in TACE-ICI-VEGF group (9.9 months [9.1-10.6] vs 7.4 months [6.7-8.5]; P < 0.0001; aHR 0.74 [0.65-0.85]) per Response Evaluation Criteria in Solid Tumours (RECIST) version 1.1. A higher ORR was observed in TACE-ICI-VEGF group, by either RECIST v1.1 or modified RECIST (41.2% vs 22.9%, P < 0.0001; 47.3% vs 29.7%, P < 0.0001). Grade ≥3 adverse events occurred in 178 patients (22.2%) in TACE-ICI-VEGF group and 80 patients (18.1%) in ICI-VEGF group. Interpretation: This multicenter study supports the use of TACE combined with ICIs and anti-VEGF antibody/TKIs as first-line treatment for advanced HCC, demonstrating an acceptable safety profile. Funding: National Natural Science Foundation of China, National Key Research and Development Program of China, Jiangsu Provincial Medical Innovation Center, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Nanjing Life Health Science and Technology Project.
Language	English
Publishing date	2024-05-06
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2024.102622
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Article: [Determination of Bi in Soils and Sediments by Atomic Fluorescence Spectrometry].

Lin, Hai-lan / Li, Zhi-huan / Zhu, Ri-long / Song, Bing-bing / Liu, Pei / Bi, Jun-ping / Luo, Yue-ping

Guang pu xue yu guang pu fen xi = Guang pu

2016 Volume 36, Issue 4, Page(s) 1217–1220

Abstract: A method for determination of the contents of Bi in soils and sediments by atomic fluorescence spectrophotometry (AFS) was established by using aqua regia as the dissolved medium. In this paper, the instrument parameters, load flow and reducing agent ... ...

Abstract	A method for determination of the contents of Bi in soils and sediments by atomic fluorescence spectrophotometry (AFS) was established by using aqua regia as the dissolved medium. In this paper, the instrument parameters, load flow and reducing agent concentration were optimized. Compared with microwave digestion and electric heating plate digestion, water bath digestion demonstrated the better digestion efficiency and was most commonly used. Under the optimal experimental conditions, the detection limit (LOD) was 0.01 mg·kg-1 (sample quantity 0.500 0 g, sample volume 50 mL), and the limit of quantitation (LOQ) was 0.04 mg·kg-1. The results were in good agreement with the centified value, and the relative error was -4.7%~-2.0%. For determination of soil and sediment actual samples, the relative standard deviation (RSD) were 2.5%~3.4% and 3.1%~3.4%, respectively, and the recoveries of the method respectively ranged from 97.6%~102% and 99.5%~104%.
Language	Chinese
Publishing date	2016-04
Publishing country	China
Document type	Journal Article
ISSN	1000-0593
ISSN	1000-0593
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Article: Processing and assessment of high-performance poly(butylene terephthalate) nanocomposites reinforced with microwave exfoliated graphite oxide nanosheets

Bian, Jun / Lin, Hai Lan / He, Fei Xiong / Wang, Ling / Wei, Xiao Wei / Chang, I-Ta / Sancaktar, Erol

European polymer journal. 2013 June, v. 49, no. 6

2013

Abstract: To improve the physical properties of poly(butylenes terephthalate) (PBT), a series of nanocomposites based on PBT and microwave exfoliated graphite oxide nanosheets (MEGONSs) are prepared via melt compounding technique, and their structures, thermal ... ...

Abstract	To improve the physical properties of poly(butylenes terephthalate) (PBT), a series of nanocomposites based on PBT and microwave exfoliated graphite oxide nanosheets (MEGONSs) are prepared via melt compounding technique, and their structures, thermal stabilities, mechanical, rheological and electrical properties are reported. Scanning electron microscope and X-ray diffraction exhibit that graphene platelets of MEGONS are well dispersed and exfoliated in the PBT matrix even at high MEGONS content of 4.0wt.%. DSC cooling and following heating thermograms of the nanocomposites demonstrate that graphene platelets of MEGONS play a role as effective nucleating agents for PBT a-phase crystals and thus lead to accelerating the overall crystallization of the nanocomposites. Thermal stability of PBT/MEGONS nanocomposites improved substantially due to the gas barrier effect of graphene platelets of MEGONS dispersed in the PBT matrix. The rheological analysis shows the low frequency plateau of shear modulus and the shear thinning behavior of the nanocomposites. The mechanical modulus of the nanocomposites enhanced significantly with increasing MEGONS content. The electrical conductivity test shows a pronounced increase in electrical conductivity from an insulator to almost a semiconductor with increasing MEGONS content. The electrical percolation threshold of the nanocomposites is found to be formed at the MEGONS concentration between 1.0 and 2.0wt.%.
Keywords	X-ray diffraction ; cooling ; crystallization ; crystals ; electrical conductivity ; graphene ; heat ; melting ; modulus of elasticity ; nanocomposites ; scanning electron microscopes ; semiconductors ; thermal stability
Language	English
Dates of publication	2013-06
Size	p. 1406-1423.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1483529-0
ISSN	0014-3057
ISSN	0014-3057
DOI	10.1016/j.eurpolymj.2013.02.027
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Article ; Online: Arterial chemotherapy for hepatocellular carcinoma in China: consensus recommendations.

Zhao, Ming / Guo, Zhi / Zou, Ying-Hua / Li, Xiao / Yan, Zhi-Ping / Chen, Min-Shan / Fan, Wei-Jun / Li, Hai-Liang / Yang, Ji-Jin / Chen, Xiao-Ming / Xu, Lin-Feng / Zhang, Yue-Wei / Zhu, Kang-Shun / Sun, Jun-Hui / Li, Jia-Ping / Jin, Yong / Yu, Hai-Peng / Duan, Feng / Xiong, Bin /

Hepatology international

2023 Volume 18, Issue 1, Page(s) 4–31

Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third leading cause of cancer-related deaths globally. Hepatic arterial infusion chemotherapy (HAIC) treatment is widely accepted as one of the alternative therapeutic ... ...

Abstract	Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third leading cause of cancer-related deaths globally. Hepatic arterial infusion chemotherapy (HAIC) treatment is widely accepted as one of the alternative therapeutic modalities for HCC owing to its local control effect and low systemic toxicity. Nevertheless, although accumulating high-quality evidence has displayed the superior survival advantages of HAIC of oxaliplatin, fluorouracil, and leucovorin (HAIC-FOLFOX) compared with standard first-line treatment in different scenarios, the lack of standardization for HAIC procedure and remained controversy limited the proper and safe performance of HAIC treatment in HCC. Therefore, an expert consensus conference was held on March 2023 in Guangzhou, China to review current practices regarding HAIC treatment in patients with HCC and develop widely accepted statements and recommendations. In this article, the latest evidence of HAIC was systematically summarized and the final 22 expert recommendations were proposed, which incorporate the assessment of candidates for HAIC treatment, procedural technique details, therapeutic outcomes, the HAIC-related complications and corresponding treatments, and therapeutic scheme management.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Treatment Outcome ; Hepatic Artery/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Fluorouracil/therapeutic use ; Infusions, Intra-Arterial
Chemical Substances	Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2270316-0
ISSN	1936-0541 ; 1936-0533
ISSN (online)	1936-0541
ISSN	1936-0533
DOI	10.1007/s12072-023-10599-6
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