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Article: The Effectiveness of Home-Based Inspiratory Muscle Training on Small Airway Function and Disease-Associated Symptoms in Patients with Chronic Obstructive Pulmonary Disease.

Chang, Wen / Lin, Horng-Chyuan / Liu, Hsueh-Erh / Han, Chin-Yen / Chang, Po-Jui

2023 Volume 11, Issue 16

Abstract: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitations, occurring mainly in the small airways. Weakness in the respiratory muscles contributes to dyspnea and a decreased exercise capacity in COPD patients. This ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitations, occurring mainly in the small airways. Weakness in the respiratory muscles contributes to dyspnea and a decreased exercise capacity in COPD patients. This study aimed to investigate the effectiveness of home-based inspiratory muscle training (IMT) on small airway function and symptoms in COPD patients. This research adopted a non-randomized controlled-study quasi-experimental design. The IMT program consisted of two 15 min sessions·d
Language	English
Publishing date	2023-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11162310
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Article: Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma.

Lin, Ting-Yu / Makrufardi, Firdian / Tung, Nguyen Thanh / Manullang, Amja / Chang, Po-Jui / Lo, Chun-Yu / Chiu, Tzu-Hsuan / Tung, Pi-Hung / Lin, Chiung-Hung / Lin, Horng-Chyuan / Wang, Chun-Hua / Lin, Shu-Min

Journal of asthma and allergy

2024 Volume 17, Page(s) 195–208

Abstract: Background: Early-onset asthma (EOA) and late-onset asthma (LOA) are two distinct phenotypes. Air pollution has been associated with an increase in poorer asthma outcomes. The objective of this study was to examine the effects of traffic-related air ... ...

Abstract	Background: Early-onset asthma (EOA) and late-onset asthma (LOA) are two distinct phenotypes. Air pollution has been associated with an increase in poorer asthma outcomes. The objective of this study was to examine the effects of traffic-related air pollution (TRAP) on asthma outcomes in EOA and LOA patients. Methods: A cross-sectional study was conducted on 675 asthma patients (LOA: 415) recruited from a major medical center in Taiwan. The land-use regression (LUR) model was used to estimate the level of exposure to PM Results: An increase in PM Conclusion: The impact of TRAP on age of onset, eosinophil count, and lung function in EOA patients, and ACT in LOA patients, was affected by the status of allergic sensitization.
Language	English
Publishing date	2024-03-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494877-9
ISSN	1178-6965
ISSN	1178-6965
DOI	10.2147/JAA.S451725
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Article: Anti-Inflammatory Effect of Resveratrol Derivatives via the Downregulation of Oxidative-Stress-Dependent and c-Src Transactivation EGFR Pathways on Rat Mesangial Cells.

Lee, I-Ta / Lin, Horng-Chyuan / Huang, Tse-Hung / Tseng, Chi-Nan / Cheng, Hao-Tsa / Huang, Wen-Chung / Cheng, Ching-Yi

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 5

Abstract: In Taiwan, the root extract ... ...

Abstract	In Taiwan, the root extract of
Language	English
Publishing date	2022-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11050835
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Article ; Online: Epidemiology and outcomes of multidrug-resistant bacterial infection in non-cystic fibrosis bronchiectasis.

Chang, Chih-Hao / Chang, Chiung-Hsin / Huang, Shih-Hao / Lee, Chung-Shu / Ko, Po-Chuan / Lin, Chun-Yu / Hsieh, Meng-Heng / Huang, Yu-Tung / Lin, Horng-Chyuan / Li, Li-Fu / Chung, Fu-Tsai / Wang, Chun-Hua / Huang, Hung-Yu

Annals of clinical microbiology and antimicrobials

2024 Volume 23, Issue 1, Page(s) 15

Abstract: Purpose: Multidrug-resistant (MDR) bacteria impose a considerable health-care burden and are associated with bronchiectasis exacerbation. This study investigated the clinical outcomes of adult patients with bronchiectasis following MDR bacterial ... ...

Abstract	Purpose: Multidrug-resistant (MDR) bacteria impose a considerable health-care burden and are associated with bronchiectasis exacerbation. This study investigated the clinical outcomes of adult patients with bronchiectasis following MDR bacterial infection. Methods: From the Chang Gung Research Database, we identified patients with bronchiectasis and MDR bacterial infection from 2008 to 2017. The control group comprised patients with bronchiectasis who did not have MDR bacterial infection and were propensity-score matched at a 1:2 ratio. The main outcomes were in-hospital and 3-year mortality. Results: In total, 554 patients with both bronchiectasis and MDR bacterial infection were identified. The types of MDR bacteria that most commonly affected the patients were MDR- Acinetobacter baumannii (38.6%) and methicillin-resistant Staphylococcus aureus (18.4%), Extended-spectrum-beta-lactamases (ESBL)- Klebsiella pneumoniae (17.8%), MDR-Pseudomonas (14.8%), and ESBL-E. coli (7.5%). Compared with the control group, the MDR group exhibited lower body mass index scores, higher rate of chronic bacterial colonization, a higher rate of previous exacerbations, and an increased use of antibiotics. Furthermore, the MDR group exhibited a higher rate of respiratory failure during hospitalization (MDR vs. control, 41.3% vs. 12.4%; p < 0.001). The MDR and control groups exhibited in-hospital mortality rates of 26.7% and 7.6%, respectively (p < 0.001); 3-year respiratory failure rates of 33.5% and 13.5%, respectively (p < 0.001); and 3-year mortality rates of 73.3% and 41.5%, respectively (p < 0.001). After adjustments were made for confounding factors, the infection with MDR and MDR bacteria species were determined to be independent risk factors affecting in-hospital and 3-year mortality. Conclusions: MDR bacteria were discovered in patients with more severe bronchiectasis and were independently associated with an increased risk of in-hospital and 3-year mortality. Given our findings, we recommend that clinicians identify patients at risk of MDR bacterial infection and follow the principle of antimicrobial stewardship to prevent the emergence of resistant bacteria among patients with bronchiectasis.
MeSH term(s)	Adult ; Humans ; Escherichia coli ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Bronchiectasis/drug therapy ; Bronchiectasis/epidemiology ; Bacterial Infections/drug therapy ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; Fibrosis ; Respiratory Insufficiency/drug therapy ; Drug Resistance, Multiple, Bacterial
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2097873-X
ISSN	1476-0711 ; 1476-0711
ISSN (online)	1476-0711
ISSN	1476-0711
DOI	10.1186/s12941-024-00675-6
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Article ; Online: Urinary cadmium concentration is associated with the severity and clinical outcomes of COVID-19: a bicenter observational cohort study.

Chiu, Li-Chung / Lee, Chung-Shu / Hsu, Ping-Chih / Li, Hsin-Hsien / Chan, Tien-Ming / Hsiao, Ching-Chung / Kuo, Scott Chih-Hsi / Ko, How-Wen / Lin, Shu-Min / Wang, Chun-Hua / Lin, Horng-Chyuan / Chu, Pao-Hsien / Yen, Tzung-Hai

Environmental health : a global access science source

2024 Volume 23, Issue 1, Page(s) 29

Abstract: Background: Cadmium and nickel exposure can cause oxidative stress, induce inflammation, inhibit immune function, and therefore has significant impacts on the pathogenesis and severity of many diseases. Severe acute respiratory syndrome coronavirus 2 ( ... ...

Abstract	Background: Cadmium and nickel exposure can cause oxidative stress, induce inflammation, inhibit immune function, and therefore has significant impacts on the pathogenesis and severity of many diseases. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can also provoke oxidative stress and the dysregulation of inflammatory and immune responses. This study aimed to assess the potential associations of cadmium and nickel exposure with the severity and clinical outcomes of patients with coronavirus disease 2019 (COVID-19). Methods: We performed a retrospective, observational, bicenter cohort analysis of patients with SARS-CoV-2 infection in Taiwan between June 2022 and July 2023. Cadmium and nickel concentrations in blood and urine were measured within 3 days of the diagnosis of acute SARS-CoV-2 infection, and the severity and clinical outcomes of patients with COVID-19 were analyzed. Results: A total of 574 patients were analyzed and divided into a severe COVID-19 group (hospitalized patients) (n = 252; 43.9%), and non-severe COVID-19 group (n = 322; 56.1%). The overall in-hospital mortality rate was 11.8% (n = 68). The severe COVID-19 patients were older, had significantly more comorbidities, and significantly higher neutrophil/lymphocyte ratio, C-reactive protein, and interleukin-6 than the non-severe COVID-19 patients (all p < 0.05). Blood and urine cadmium and urine nickel concentrations were significantly higher in the severe COVID-19 patients than in the non-severe COVID-19 patients. Among the severe COVID-19 patients, those in higher urine cadmium/creatinine quartiles had a significantly higher risk of organ failure (i.e., higher APACHE II and SOFA scores), higher neutrophil/lymphocyte ratio, lower PaO Conclusions: Urine cadmium concentration in the early course of COVID-19 could predict the severity and clinical outcomes of patients and was independently associated with the risk of severe COVID-19.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Cadmium ; Retrospective Studies ; Creatinine ; Nickel ; Cohort Studies
Chemical Substances	Cadmium (00BH33GNGH) ; Creatinine (AYI8EX34EU) ; Nickel (7OV03QG267)
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2092232-2
ISSN	1476-069X ; 1476-069X
ISSN (online)	1476-069X
ISSN	1476-069X
DOI	10.1186/s12940-024-01070-6
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Article ; Online: Predicting mortality in non-cystic fibrosis bronchiectasis patients using distance-saturation product.

Lin, Chun-Yu / Hsieh, Meng-Heng / Fang, Yueh-Fu / Peng, Chien-Wei / Ju, Jia-Shiuan / Lo, Yu-Lun / Lin, Shu-Min / Lin, Horng-Chyuan

Annals of medicine

2021 Volume 53, Issue 1, Page(s) 2034–2040

Abstract: Background: The bronchiectasis severity index (BSI) and FACED score are currently used in predicting outcomes of non-cystic fibrosis bronchiectasis (NCFB). Distance-saturation product (DSP), the product of distance walked, and lowest oxygen saturation ... ...

Abstract	Background: The bronchiectasis severity index (BSI) and FACED score are currently used in predicting outcomes of non-cystic fibrosis bronchiectasis (NCFB). Distance-saturation product (DSP), the product of distance walked, and lowest oxygen saturation during the 6-min walk test showed strong predictive power of mortality in non-CF bronchiectasis patients. This study aimed to compare the efficacy of these scores and DSP in predicting mortality. Methods and patients: Our retrospective study included NCFB patients from January 2004 to December 2017. We recorded the basic data, pulmonary function, radiologic studies, sputum culture results, acute exacerbations (AE), emergency department (ED) visits, hospitalization, and mortality. Results: A total 130 NCFB patients were analysed. The mean BSI score, FACED score, and DSP were 8.8 ± 4.9, 3.4 ± 1.7, and 413.1 ± 101.5 m%, respectively. BSI and FACED scores had comparable predictive power for AE ( Conclusion: DSP had comparable predictive power for mortality as the well-validated BSI and FACED scores and is relatively easy to use in clinical practice.KEY MESSAGEDistance-saturation product (DSP) comprised with the product of distance walked, and lowest oxygen saturation during the 6-min walk test, which is common used in clinical practice.DSP demonstrated strong and comparable predictive power of mortality as the well-validated BSI and FACED scores in non-CF bronchiectasis patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Bronchiectasis/blood ; Bronchiectasis/mortality ; Female ; Humans ; Male ; Middle Aged ; Oximetry ; Oxygen/blood ; Oxygen Saturation ; Predictive Value of Tests ; Prognosis ; Pulmonary Fibrosis/blood ; Pulmonary Fibrosis/mortality ; Respiratory Function Tests/methods ; Retrospective Studies ; Sensitivity and Specificity ; Severity of Illness Index
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-11-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2021.1999490
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Article: Anticancer Effects of

Tsai, Ming-Ming / Lin, Horng-Chyuan / Yu, Ming-Chin / Lin, Wan-Jung / Chu, Mei-Yi / Tsai, Ching-Ching / Cheng, Ching-Yi

Journal of Cancer

2021 Volume 12, Issue 23, Page(s) 7052–7068

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-10-17
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.64638
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Article ; Online: Chronic Obstructive Pulmonary Disease as a Phenotype of Bronchiectasis for Long-Term Clinical Presentation and Treatment.

Hsu, Chih-Yi / Poon, Yan-Yuen / Chen, Yu-Wei / Hsieh, Meng-Heng / Lin, Horng-Chyuan / Fang, Wen-Feng

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 6

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Bronchiectasis ; Humans ; Lung ; Phenotype ; Pulmonary Disease, Chronic Obstructive ; Retrospective Studies
Language	English
Publishing date	2021-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57060579
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Article: Proximity to Heavy Traffic Roads and Patient Characteristics of Late of Onset Asthma in an Urban Asthma Center.

Lin, Ting-Yu / Lin, Horng-Chyuan / Liu, Yun-Sheng / Lo, Yu-Lun / Wang, Chun-Hua / Chang, Po-Jui / Lo, Chun-Yu / Lin, Shu-Min

Frontiers in medicine

2021 Volume 8, Page(s) 783720

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-12-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.783720
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Article ; Online: Prediction of 30-Day Readmission for COPD Patients Using Accelerometer-Based Activity Monitoring.

Lin, Wen-Yen / Verma, Vijay Kumar / Lee, Ming-Yih / Lin, Horng-Chyuan / Lai, Chao-Sung

Sensors (Basel, Switzerland)

2019 Volume 20, Issue 1

Abstract: Chronic obstructive pulmonary disease (COPD) claimed 3.0 million lives in 2016 and ranked 3rd among the top 10 global causes of death. Moreover, once diagnosed and discharged from the hospital, the 30-day readmission risk in COPD patients is found to be ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) claimed 3.0 million lives in 2016 and ranked 3rd among the top 10 global causes of death. Moreover, once diagnosed and discharged from the hospital, the 30-day readmission risk in COPD patients is found to be the highest among all chronic diseases. The existing diagnosis methods, such as Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019, Body-mass index, airflow Obstruction, Dyspnea, and Exercise (BODE) index, modified Medical Research Council (mMRC), COPD assessment test (CAT), 6-minute walking distance, which are adopted currently by physicians cannot predict the potential readmission of COPD patients, especially within the 30 days after discharge from the hospital. In this paper, a statistical model was proposed to predict the readmission risk of COPD patients within 30-days by monitoring their physical activity (PA) in daily living with accelerometer-based wrist-worn wearable devices. This proposed model was based on our previously reported PA models for activity index (AI) and regularity index (RI) and it introduced a new parameter, quality of activity (QoA), which incorporates previously proposed parameters, such as AI and RI, with other activity-based indices to predict the readmission risk. Data were collected from continuous PA monitoring of 16 COPD patients after hospital discharge as test subjects and readmission prediction criteria were proposed, with a 63% sensitivity and a 37.78% positive prediction rate. Compared to other clinical assessment, diagnosis, and prevention methods, the proposed model showed significant improvement in predicting the 30-day readmission risk.
MeSH term(s)	Accelerometry/instrumentation ; Emergency Service, Hospital ; Humans ; Monitoring, Physiologic/instrumentation ; Patient Readmission ; Pulmonary Disease, Chronic Obstructive/diagnosis
Language	English
Publishing date	2019-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20010217
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